-
1
-
-
0033304698
-
Regulation of angiogenic growth factors in the female reproductive tract by estrogens and progestins
-
Hyder, S.M. and G.M. Stancel, Regulation of angiogenic growth factors in the female reproductive tract by estrogens and progestins. Mol Endocrinol, 1999. 13(6): p. 806-11.
-
(1999)
Mol Endocrinol
, vol.13
, Issue.6
, pp. 806-811
-
-
Hyder, S.M.1
Stancel, G.M.2
-
2
-
-
0028929803
-
Angiogenesis in cancer, vascular, rheumatoid and other disease
-
Folkman, J., Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med, 1995. 1(1): p. 27-31.
-
(1995)
Nat Med
, vol.1
, Issue.1
, pp. 27-31
-
-
Folkman, J.1
-
3
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet, P. and R.K. Jain, Angiogenesis in cancer and other diseases. Nature, 2000. 407(6801): p. 249-57.
-
(2000)
Nature
, vol.407
, Issue.6801
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
4
-
-
0032907687
-
Vascular endothelial growth factor (VEGF) and its receptors
-
Neufeld, G., T. Cohen, S. Gengrinovitch, et al., Vascular endothelial growth factor (VEGF) and its receptors. Faseb J, 1999. 13(1): p. 9-22.
-
(1999)
Faseb J
, vol.13
, Issue.1
, pp. 9-22
-
-
Neufeld, G.1
Cohen, T.2
Gengrinovitch, S.3
-
5
-
-
0033047875
-
VEGFs, receptors and angiogenesis
-
Veikkola, T. and K. Alitalo, VEGFs, receptors and angiogenesis. Semin Cancer Biol, 1999. 9(3): p. 211-20.
-
(1999)
Semin Cancer Biol
, vol.9
, Issue.3
, pp. 211-220
-
-
Veikkola, T.1
Alitalo, K.2
-
6
-
-
0034703039
-
Receptor-selective variants of human vascular endothelial growth factor. Generation and characterization
-
Li, B., G. Fuh, G. Meng, et al., Receptor-selective variants of human vascular endothelial growth factor. Generation and characterization. J Biol Chem, 2000. 275(38): p. 29823-8.
-
(2000)
J Biol Chem
, vol.275
, Issue.38
, pp. 29823-29828
-
-
Li, B.1
Fuh, G.2
Meng, G.3
-
7
-
-
0035793623
-
Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants
-
Gille, H., J. Kowalski, B. Li, et al., Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants. J Biol Chem, 2001. 276(5): p. 3222-30.
-
(2001)
J Biol Chem
, vol.276
, Issue.5
, pp. 3222-3230
-
-
Gille, H.1
Kowalski, J.2
Li, B.3
-
8
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
Leung, D.W., G. Cachianes, W.J. Kuang, et al., Vascular endothelial growth factor is a secreted angiogenic mitogen. Science, 1989. 246(4935): p. 1306-9.
-
(1989)
Science
, vol.246
, Issue.4935
, pp. 1306-1309
-
-
Leung, D.W.1
Cachianes, G.2
Kuang, W.J.3
-
9
-
-
0034075041
-
Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients
-
Lee, J.C., N.H. Chow, S.T. Wang, et al., Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. Eur J Cancer, 2000. 36(6): p. 748-53.
-
(2000)
Eur J Cancer
, vol.36
, Issue.6
, pp. 748-753
-
-
Lee, J.C.1
Chow, N.H.2
Wang, S.T.3
-
10
-
-
3242700400
-
The prognostic significance of vascular endothelial growth factor levels in sera of non-small cell lung cancer patients
-
Kaya,A., A. Ciledag, B.E. Gulbay, et al., The prognostic significance of vascular endothelial growth factor levels in sera of non-small cell lung cancer patients. Respir Med, 2004. 98(7): p. 632-6.
-
(2004)
Respir Med
, vol.98
, Issue.7
, pp. 632-636
-
-
Kaya, A.1
Ciledag, A.2
Gulbay, B.E.3
-
11
-
-
0035879113
-
Wingless capture by Frizzled and Frizzled2 in Drosophila embryos
-
Lecourtois, M., C. Alexandre, L. Dubois, et al., Wingless capture by Frizzled and Frizzled2 in Drosophila embryos. Dev Biol, 2001. 235(2): p. 467-75.
-
(2001)
Dev Biol
, vol.235
, Issue.2
, pp. 467-475
-
-
Lecourtois, M.1
Alexandre, C.2
Dubois, L.3
-
12
-
-
0028090642
-
Vascular endothelial growth factor and glioma angiogenesis: Coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms
-
Plate, K.H., G. Breier, H.A. Weich, et al., Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int J Cancer, 1994. 59(4): p. 520-9.
-
(1994)
Int J Cancer
, vol.59
, Issue.4
, pp. 520-529
-
-
Plate, K.H.1
Breier, G.2
Weich, H.A.3
-
13
-
-
0031870832
-
Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/KDR) as an anti-angiogenic therapeutic strategy
-
Witte, L., D.J. Hicklin, Z. Zhu, et al., Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/KDR) as an anti-angiogenic therapeutic strategy. Cancer Metastasis Rev, 1998. 17(2): p. 155- 61.
-
(1998)
Cancer Metastasis Rev
, vol.17
, Issue.2
, pp. 155-161
-
-
Witte, L.1
Hicklin, D.J.2
Zhu, Z.3
-
14
-
-
0033396950
-
Inhibition of tumor growth and metastasis by targeting tumor-associated angiogenesis with antagonists to the receptors of vascular endothelial growth factor
-
Zhu, Z. and L. Witte, Inhibition of tumor growth and metastasis by targeting tumor-associated angiogenesis with antagonists to the receptors of vascular endothelial growth factor. Invest New Drugs, 1999. 17(3): p. 195-212.
-
(1999)
Invest New Drugs
, vol.17
, Issue.3
, pp. 195-212
-
-
Zhu, Z.1
Witte, L.2
-
15
-
-
0036279804
-
Clinical development of angiogenesis inhibitors to vascular endothelial growth factor and its receptors as cancer therapeutics
-
Zhu, Z., P. Bohlen, and L. Witte, Clinical development of angiogenesis inhibitors to vascular endothelial growth factor and its receptors as cancer therapeutics. Curr Cancer Drug Targets, 2002. 2(2): p. 135-56.
-
(2002)
Curr Cancer Drug Targets
, vol.2
, Issue.2
, pp. 135-156
-
-
Zhu, Z.1
Bohlen, P.2
Witte, L.3
-
16
-
-
0035253739
-
Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
-
This is a phase 1 study of bevacizumab
-
Gordon, M.S., K. Margolin, M. Talpaz, et al., Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol, 2001. 19(3): p. 843-50. This is a phase 1 study of bevacizumab.
-
(2001)
J Clin Oncol
, vol.19
, Issue.3
, pp. 843-850
-
-
Gordon, M.S.1
Margolin, K.2
Talpaz, M.3
-
17
-
-
0037143764
-
VEGF-Trap: A VEGF blocker with potent antitumor effects
-
Holash, J., S. Davis, N. Papadopoulos, et al., VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci U S A, 2002. 99(17): p. 11393-8.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.17
, pp. 11393-11398
-
-
Holash, J.1
Davis, S.2
Papadopoulos, N.3
-
18
-
-
0345060442
-
Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
-
Byrne, A.T., L. Ross, J. Holash, et al., Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin Cancer Res, 2003. 9(15): p. 5721-8.
-
(2003)
Clin Cancer Res
, vol.9
, Issue.15
, pp. 5721-5728
-
-
Byrne, A.T.1
Ross, L.2
Holash, J.3
-
19
-
-
0037934449
-
Regression of established tumors and metastases by potent vascular endothelial growth factor blockade
-
Huang, J., J.S. Frischer, A. Serur, et al., Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc Natl Acad Sci U S A, 2003. 100(13): p. 7785-90.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.13
, pp. 7785-7790
-
-
Huang, J.1
Frischer, J.S.2
Serur, A.3
-
20
-
-
2542450942
-
Vascular endothelial growth factortrap suppresses tumorigenicity of multiple pancreatic cancer cell lines
-
Fukasawa, M. and M. Korc, Vascular endothelial growth factortrap suppresses tumorigenicity of multiple pancreatic cancer cell lines. Clin Cancer Res, 2004. 10(10): p. 3327-32.
-
(2004)
Clin Cancer Res
, vol.10
, Issue.10
, pp. 3327-3332
-
-
Fukasawa, M.1
Korc, M.2
-
21
-
-
74949101370
-
Phase 1 study of aflibercept administered subcutaneously to patients with advanced solid tumors
-
Tew, W.P., M. Gordon, J. Murren, et al., Phase 1 study of aflibercept administered subcutaneously to patients with advanced solid tumors. Clin Cancer Res, 2010. 16(1): p. 358-66.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.1
, pp. 358-366
-
-
Tew, W.P.1
Gordon, M.2
Murren, J.3
-
22
-
-
74949119167
-
Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors
-
Lockhart, A.C., M.L. Rothenberg, J. Dupont, et al., Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors. J Clin Oncol. 28(2): p. 207-14.
-
J Clin Oncol
, vol.28
, Issue.2
, pp. 207-214
-
-
Lockhart, A.C.1
Rothenberg, M.L.2
Dupont, J.3
-
23
-
-
65349186800
-
Aflibercept (AVE0005): An alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors
-
Chu, Q.S., Aflibercept (AVE0005): an alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors. Expert Opin Biol Ther, 2009. 9(2): p. 263-71.
-
(2009)
Expert Opin Biol Ther
, vol.9
, Issue.2
, pp. 263-271
-
-
Chu, Q.S.1
-
24
-
-
20344362911
-
Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/ 7 days off in patients with advanced, refractory solid tumours
-
This is a phase 1 study of sorafenib
-
Awada, A., A. Hendlisz, T. Gil, et al., Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/ 7 days off in patients with advanced, refractory solid tumours. Br J Cancer, 2005. 92(10): p. 1855-61. This is a phase 1 study of sorafenib.
-
(2005)
Br J Cancer
, vol.92
, Issue.10
, pp. 1855-1861
-
-
Awada, A.1
Hendlisz, A.2
Gil, T.3
-
25
-
-
33644847440
-
Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
-
This is a phase 1 study of sunitinib
-
Faivre, S., C. Delbaldo, K. Vera, et al., Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol, 2006. 24(1): p. 25-35. This is a phase 1 study of sunitinib.
-
(2006)
J Clin Oncol
, vol.24
, Issue.1
, pp. 25-35
-
-
Faivre, S.1
Delbaldo, C.2
Vera, K.3
-
26
-
-
37249072373
-
A phase I and pharmacokinetic study of sunitinib administered daily for 2 weeks, followed by a 1-week off period
-
This is a phase 1 study of sunitinib
-
Britten, C.D., F. Kabbinavar, J.R. Hecht, et al., A phase I and pharmacokinetic study of sunitinib administered daily for 2 weeks, followed by a 1-week off period. Cancer Chemother Pharmacol, 2008. 61(3): p. 515-24. This is a phase 1 study of sunitinib.
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, Issue.3
, pp. 515-524
-
-
Britten, C.D.1
Kabbinavar, F.2
Hecht, J.R.3
-
27
-
-
20044382799
-
Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
-
This is a phase 1 study of sorafenib
-
Strumberg, D., H. Richly, R.A. Hilger, et al., Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J Clin Oncol, 2005. 23(5): p. 965-72. This is a phase 1 study of sorafenib.
-
(2005)
J Clin Oncol
, vol.23
, Issue.5
, pp. 965-972
-
-
Strumberg, D.1
Richly, H.2
Hilger, R.A.3
-
28
-
-
27144527372
-
Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors
-
This is a phase 1 study of sorafenib
-
Moore, M., H.W. Hirte, L. Siu, et al., Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors. Ann Oncol, 2005. 16 (10): p. 1688-94. This is a phase 1 study of sorafenib.
-
(2005)
Ann Oncol
, vol.16
, Issue.10
, pp. 1688-1694
-
-
Moore, M.1
Hirte, H.W.2
Siu, L.3
-
29
-
-
37249026685
-
Phase I evaluation of CDP791, a PEGylated di-Fab' conjugate that binds vascular endothelial growth factor receptor 2
-
Ton, N.C., G.J. Parker, A. Jackson, et al., Phase I evaluation of CDP791, a PEGylated di-Fab' conjugate that binds vascular endothelial growth factor receptor 2. Clin Cancer Res, 2007. 13 (23): p. 7113-8.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.23
, pp. 7113-7118
-
-
Ton, N.C.1
Parker, G.J.2
Jackson, A.3
-
30
-
-
0037386937
-
A phase I study of antikinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma
-
Posey, J.A., T.C. Ng, B. Yang, et al., A phase I study of antikinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma. Clin Cancer Res, 2003. 9(4): p. 1323-32.
-
(2003)
Clin Cancer Res
, vol.9
, Issue.4
, pp. 1323-1332
-
-
Posey, J.A.1
Ng, T.C.2
Yang, B.3
-
31
-
-
0037137903
-
Selection of high affinity human neutralizing antibodies to VEGFR2 from a large antibody phage display library for antiangiogenesis therapy
-
Lu, D., X. Jimenez, H. Zhang, et al., Selection of high affinity human neutralizing antibodies to VEGFR2 from a large antibody phage display library for antiangiogenesis therapy. Int J Cancer, 2002. 97(3): p. 393-9.
-
(2002)
Int J Cancer
, vol.97
, Issue.3
, pp. 393-399
-
-
Lu, D.1
Jimenez, X.2
Zhang, H.3
-
33
-
-
0242353266
-
Tailoring in vitro selection for a picomolar affinity human antibody directed against vascular endothelial growth factor receptor 2 for enhanced neutralizing activity
-
Lu, D., J. Shen, M.D. Vil, et al., Tailoring in vitro selection for a picomolar affinity human antibody directed against vascular endothelial growth factor receptor 2 for enhanced neutralizing activity. J Biol Chem, 2003. 278(44): p. 43496-507.
-
(2003)
J Biol Chem
, vol.278
, Issue.44
, pp. 43496-43507
-
-
Lu, D.1
Shen, J.2
Vil, M.D.3
-
34
-
-
0344839087
-
Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity
-
Zhu, Z., K. Hattori, H. Zhang, et al., Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity. Leukemia, 2003. 17(3): p. 604-11.
-
(2003)
Leukemia
, vol.17
, Issue.3
, pp. 604-611
-
-
Zhu, Z.1
Hattori, K.2
Zhang, H.3
-
35
-
-
77649213706
-
Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2
-
This is a phase 1 study of ramucirumab administered weekly
-
Spratlin, J.L., R.B. Cohen, M. Eadens, et al., Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. J Clin Oncol. 28(5): p. 780-7. This is a phase 1 study of ramucirumab administered weekly.
-
J Clin Oncol
, vol.28
, Issue.5
, pp. 780-787
-
-
Spratlin, J.L.1
Cohen, R.B.2
Eadens, M.3
-
36
-
-
79955818684
-
Phase I dose-escalation study of the anti-VEGFR-1 recombinant human IgG1 MAb IMC-1121B administered every other weeks (q2W) or every 3 (q3w) in patients (pts) with advanced cancers
-
Abstract B15. This is a phase 1 study of ramucirumab administered every 2 or 3 weeks
-
Chiorean, E., C. Sweeney, H. Hurwitz, et al., Phase I dose-escalation study of the anti-VEGFR-1 recombinant human IgG1 MAb IMC-1121B administered every other weeks (q2W) or every 3 (q3w) in patients (pts) with advanced cancers. Molecular Targets and Cancer Therapeutics, 2007. Conference Proceedings Abstract B15. This is a phase 1 study of ramucirumab administered every 2 or 3 weeks.
-
Molecular Targets and Cancer Therapeutics, 2007. Conference Proceedings
-
-
Chiorean, E.1
Sweeney, C.2
Hurwitz, H.3
-
37
-
-
77955873586
-
Phase II study of IMC-1121B in patients with metastatic renal cancer (mRCC) following VEGFR-2 tyrosine kinase inhibitor (TKI) therapy (IMCL CP12-0605/NCT00515697)
-
This is a phase 2 study of ramucirumab in RCC
-
Garcia, J.A., G.R. Hudes, T.K. Choueiri, et al. Phase II study of IMC-1121B in patients with metastatic renal cancer (mRCC) following VEGFR-2 tyrosine kinase inhibitor (TKI) therapy (IMCL CP12-0605/NCT00515697). in 2010 Genitourinary Cancers Symposium 2010. This is a phase 2 study of ramucirumab in RCC.
-
(2010)
2010 Genitourinary Cancers Symposium
-
-
Garcia, J.A.1
Hudes, G.R.2
Choueiri, T.K.3
-
38
-
-
79955549964
-
A phase II, open-label study of ramucirumab (IMC-1121B), an IgG1 fully human monoclonal antibody (MAb) targeting VEGFR-2, in combination with paclitaxel and carboplatin as first-line therapy in patients (pts) with stage IIIb/IV non-small cell lung cancer (NSCLC)
-
2010 abstr 7588. This is a phase 2 study of ramucirumab in lung cancer
-
Camidge, D.R., M.S. Ballas, S. Dubey, et al., A phase II, open-label study of ramucirumab (IMC-1121B), an IgG1 fully human monoclonal antibody (MAb) targeting VEGFR-2, in combination with paclitaxel and carboplatin as first-line therapy in patients (pts) with stage IIIb/IV non-small cell lung cancer (NSCLC). J Clin Oncol 2010. 28:15s, 2010 (suppl; abstr 7588). This is a phase 2 study of ramucirumab in lung cancer.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
-
-
Camidge, D.R.1
Ballas, M.S.2
Dubey, S.3
-
39
-
-
79955795408
-
A phase II randomized study of ramucirumab (IMC-1121B) with or without dacarbazine (DTIC) in patients (pts) with metastatic melanoma (MM)
-
2010 abstr 8519∧ This is a phase 2 study of ramucirumab in malignant melanoma
-
Carvajal, R.D., M.K. Wong, J.A. Thompson, et al., A phase II randomized study of ramucirumab (IMC-1121B) with or without dacarbazine (DTIC) in patients (pts) with metastatic melanoma (MM). J Clin Oncol 2010. 28:15s, 2010 (suppl; abstr 8519∧) This is a phase 2 study of ramucirumab in malignant melanoma.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
-
-
Carvajal, R.D.1
Wong, M.K.2
Thompson, J.A.3
-
40
-
-
79955861421
-
A phase 2 study of ramucirumab as first-line monotherapy in patients (pts) with advanced hepatocellular carcinoma (HCC): Updated results (CP12-0710/NCT00627042)
-
This is a phase 2 study of ramucirumab in HCC
-
Zhu, A.X., R.S. Finn, M. Mulcahy, et al. A phase 2 study of ramucirumab as first-line monotherapy in patients (pts) with advanced hepatocellular carcinoma (HCC): Updated results (CP12-0710/NCT00627042). in International Liver Cancer Association Fourth Annual Conference 2010. Montreal, Quebec, Canada. This is a phase 2 study of ramucirumab in HCC.
-
International Liver Cancer Association Fourth Annual Conference 2010. Montreal, Quebec, Canada
-
-
Zhu, A.X.1
Finn, R.S.2
Mulcahy, M.3
|