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Volumn 6, Issue 2, 2009, Pages 206-217

Angiogenesis in the treatment of non-small cell lung cancer

Author keywords

Angiogenesis; Oral multikinase inhibitors; Targeted therapy; Vascular endothelial growth factor

Indexed keywords

AXITINIB; BEVACIZUMAB; CARBOPLATIN; CEDIRANIB; CISPLATIN; DOCETAXEL; ERLOTINIB; GEFITINIB; GEMCITABINE; MOTESANIB; NAVELBINE; OXALIPLATIN; PACLITAXEL; PANITUMUMAB; PAZOPANIB; PEMETREXED; PLACEBO; SORAFENIB; SUNITINIB; TYROSINE KINASE RECEPTOR; VANDETANIB; VASCULOTROPIN RECEPTOR; XL 647;

EID: 65349189877     PISSN: 15463222     EISSN: None     Source Type: Journal    
DOI: 10.1513/pats.200807-066LC     Document Type: Conference Paper
Times cited : (33)

References (107)
  • 3
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005; 438:932-936.
    • (2005) Nature , vol.438 , pp. 932-936
    • Carmeliet, P.1
  • 4
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 5
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86:353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 6
    • 33744466541 scopus 로고    scopus 로고
    • Antiangiogenic therapy: A universal chemosensitization strategy for cancer?
    • Kerbel RS. Antiangiogenic therapy: a universal chemosensitization strategy for cancer? Science 2006;312:1171-1175.
    • (2006) Science , vol.312 , pp. 1171-1175
    • Kerbel, R.S.1
  • 7
    • 12344312042 scopus 로고    scopus 로고
    • Cellular abnormalities of blood vessels as targets in cancer
    • Baluk P, Hashizume H, McDonald DM. Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev 2005;15:102-111.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 102-111
    • Baluk, P.1    Hashizume, H.2    McDonald, D.M.3
  • 10
    • 0028951043 scopus 로고
    • Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
    • Holmgren L, O'Reilly MS, Folkman J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1995;1:149-153.
    • (1995) Nat Med , vol.1 , pp. 149-153
    • Holmgren, L.1    O'Reilly, M.S.2    Folkman, J.3
  • 13
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS. Tumor angiogenesis. N Engl J Med 2008;358:2039-2049.
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 14
    • 0031966682 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in non-small-cell lung cancer: Prognostic significance in squamous cell carcinoma
    • Imoto H, Osaki T, Taga S, Ohgami A, Ichiyoshi Y, Yasumoto K. Vascular endothelial growth factor expression in non-small-cell lung cancer: prognostic significance in squamous cell carcinoma. J Thorac Cardiovasc Surg 1998;115:1007-1014.
    • (1998) J Thorac Cardiovasc Surg , vol.115 , pp. 1007-1014
    • Imoto, H.1    Osaki, T.2    Taga, S.3    Ohgami, A.4    Ichiyoshi, Y.5    Yasumoto, K.6
  • 15
    • 1842328560 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer
    • Volm M, Koomagi R, Mattern J. Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer. Int J Cancer 1997;74:64-68.
    • (1997) Int J Cancer , vol.74 , pp. 64-68
    • Volm, M.1    Koomagi, R.2    Mattern, J.3
  • 16
    • 18244364180 scopus 로고    scopus 로고
    • A high vascular count and overexpression of vascular endothelial growth factor are associated with unfavourable prognosis in operated small cell lung carcinoma
    • Fontanini G, Faviana P, Lucchi M, Boldrini L, Mussi A, Camacci T, Mariani MA, Angeletti CA, Basolo F, Pingitore R. A high vascular count and overexpression of vascular endothelial growth factor are associated with unfavourable prognosis in operated small cell lung carcinoma. Br J Cancer 2002;86:558-563.
    • (2002) Br J Cancer , vol.86 , pp. 558-563
    • Fontanini, G.1    Faviana, P.2    Lucchi, M.3    Boldrini, L.4    Mussi, A.5    Camacci, T.6    Mariani, M.A.7    Angeletti, C.A.8    Basolo, F.9    Pingitore, R.10
  • 18
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004;3:391-400.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 19
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothe- lial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta LG, Chen H, O'Connor SJ, Chisholm V, Meng YG, Krummen L, Winkler M, Ferrara N. Humanization of an anti-vascular endothe- lial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997;57:4593-4599.
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3    Chisholm, V.4    Meng, Y.G.5    Krummen, L.6    Winkler, M.7    Ferrara, N.8
  • 20
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF, Herbst RS, Nemunaitis JJ, Jablons DM, Langer CJ, DeVore RF, 3rd, Gaudreault J, et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004;22:2184-2191.
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3    Herbst, R.S.4    Nemunaitis, J.J.5    Jablons, D.M.6    Langer, C.J.7    DeVore 3rd, R.F.8    Gaudreault, J.9
  • 22
    • 34247509357 scopus 로고    scopus 로고
    • Prospective correlative assessment of biomarkers in E4599 randomized phase II/III trial of carboplatin and paclitaxel {+/-} bevacizumab in advanced non-small cell lung cancer (NSCLC) [abstract]
    • Dowlati A, Gray R, Johnson DH, Schiller JH, Brahmer J, Sandler AB. Prospective correlative assessment of biomarkers in E4599 randomized phase II/III trial of carboplatin and paclitaxel {+/-} bevacizumab in advanced non-small cell lung cancer (NSCLC) [abstract]. ASCO Meeting Abstracts 2006;24:7027.
    • (2006) ASCO Meeting Abstracts , vol.24 , pp. 7027
    • Dowlati, A.1    Gray, R.2    Johnson, D.H.3    Schiller, J.H.4    Brahmer, J.5    Sandler, A.B.6
  • 23
    • 37849052774 scopus 로고    scopus 로고
    • Outcomes for elderly, advanced-stage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: Analysis of Eastern Cooperative Oncology Group Trial 4599
    • Ramalingam SS, Dahlberg SE, Langer CJ, Gray R, Belani CP, Brahmer JR, Sandler AB, Schiller JH, Johnson DH. Outcomes for elderly, advanced-stage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: analysis of Eastern Cooperative Oncology Group Trial 4599. J Clin Oncol 2008;26:60-65.
    • (2008) J Clin Oncol , vol.26 , pp. 60-65
    • Ramalingam, S.S.1    Dahlberg, S.E.2    Langer, C.J.3    Gray, R.4    Belani, C.P.5    Brahmer, J.R.6    Sandler, A.B.7    Schiller, J.H.8    Johnson, D.H.9
  • 25
    • 65349089475 scopus 로고    scopus 로고
    • Manegold C, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsch V, Leighl N, Mezger J, Archer V, Reck M, et al.: BO17704 Study Group. Randomised, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naive patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704 [abstract]. ASCO Meeting Abstracts 2007;25: LBA7514.
    • Manegold C, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsch V, Leighl N, Mezger J, Archer V, Reck M, et al.: BO17704 Study Group. Randomised, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naive patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704 [abstract]. ASCO Meeting Abstracts 2007;25: LBA7514.
  • 26
    • 42649143421 scopus 로고    scopus 로고
    • An open-label, phase II trial of nanoparticle albumin bound paclitaxel (nab-paclitaxel), carboplatin, and bevacizumab in first-line patients with advanced non- squamous non-small cell lung cancer (NSCLC) [abstract]
    • Reynolds C, Barrera D, Vu DQ, Jotte R, Spira AI, Weissman CH, Boehm KA, Ilegbodu D, Pritchard S, Asmar L. An open-label, phase II trial of nanoparticle albumin bound paclitaxel (nab-paclitaxel), carboplatin, and bevacizumab in first-line patients with advanced non- squamous non-small cell lung cancer (NSCLC) [abstract]. ASCO Meeting Abstracts 2007;25:7610.
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 7610
    • Reynolds, C.1    Barrera, D.2    Vu, D.Q.3    Jotte, R.4    Spira, A.I.5    Weissman, C.H.6    Boehm, K.A.7    Ilegbodu, D.8    Pritchard, S.9    Asmar, L.10
  • 28
    • 65349106546 scopus 로고    scopus 로고
    • Bevacizu- mab in combination with cisplatin and docetaxel as first line treatment of patients (pts) with advanced or metastatic, non squamous, non-small- cell lung cancer (NSCLC) [abstract]
    • Ferrer N, Paredes A, Munoz-Langa JM, Mendez M, Cobo M, de-Portugal T, Giner V, Garcia S, Gallego R, Torrego J. Bevacizu- mab in combination with cisplatin and docetaxel as first line treatment of patients (pts) with advanced or metastatic, non squamous, non-small- cell lung cancer (NSCLC) [abstract]. ASCO Meeting Abstracts 2008;26: 19109.
    • (2008) ASCO Meeting Abstracts , vol.26 , pp. 19109
    • Ferrer, N.1    Paredes, A.2    Munoz-Langa, J.M.3    Mendez, M.4    Cobo, M.5    de-Portugal, T.6    Giner, V.7    Garcia, S.8    Gallego, R.9    Torrego, J.10
  • 29
    • 35948932525 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus pemetrexed and carboplatin in previously untreated advanced nonsquamous non-small cell lung cancer [abstract]
    • Dalsania CJ, Hageboutros A, Harris E, Krieger K, Vora C, Stevenson J. Phase II trial of bevacizumab plus pemetrexed and carboplatin in previously untreated advanced nonsquamous non-small cell lung cancer [abstract]. ASCO Meeting Abstracts 2007;25:18163.
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 18163
    • Dalsania, C.J.1    Hageboutros, A.2    Harris, E.3    Krieger, K.4    Vora, C.5    Stevenson, J.6
  • 30
    • 35948938878 scopus 로고    scopus 로고
    • Pemetrexed and carboplatin plus bevacizumab for advanced non-squamous non-small cell lung cancer (NSCLC): Preliminary results [abstract]
    • Patel JD, Hensing TA, Villafor V, Hart E, Bonomi P. Pemetrexed and carboplatin plus bevacizumab for advanced non-squamous non-small cell lung cancer (NSCLC): preliminary results [abstract]. ASCO Meeting Abstracts 2007;25:7601.
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 7601
    • Patel, J.D.1    Hensing, T.A.2    Villafor, V.3    Hart, E.4    Bonomi, P.5
  • 31
    • 57349104030 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin, pemetrexed, and bevacizumab in previously- treated advanced non-small cell lung cancer (NSCLC) [abstract]
    • Heist RS, Fidias P, Huberman M, Temel J, Sequist L, Lynch TJ. Phase II trial of oxaliplatin, pemetrexed, and bevacizumab in previously- treated advanced non-small cell lung cancer (NSCLC) [abstract]. ASCO Meeting Abstracts 2007;25:7700.
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 7700
    • Heist, R.S.1    Fidias, P.2    Huberman, M.3    Temel, J.4    Sequist, L.5    Lynch, T.J.6
  • 32
    • 35949004337 scopus 로고    scopus 로고
    • International Oncology Network. A phase II study of oxaliplatin and pemetrexed plus bevacizumab in advanced non-squamous non-small cell lung cancer [abstracts]
    • Waples JM, Auerbach M, Boccia R, Wiggans RG, Steis R; International Oncology Network. A phase II study of oxaliplatin and pemetrexed plus bevacizumab in advanced non-squamous non-small cell lung cancer [abstracts]. ASCO Meeting Abstracts 2007;25:18025.
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 18025
    • Waples, J.M.1    Auerbach, M.2    Boccia, R.3    Wiggans, R.G.4    Steis, R.5
  • 33
    • 34547427567 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin and gemcitabine with bevacizumab in first-line advanced non-small cell lung cancer (NSCLC) [abstracts]
    • Davila E, Lilenbaum R, Raez L, Seigel L, Tseng J, Graham P. Phase II trial of oxaliplatin and gemcitabine with bevacizumab in first-line advanced non-small cell lung cancer (NSCLC) [abstracts]. ASCO Meeting Abstracts 2006;24:17009.
    • (2006) ASCO Meeting Abstracts , vol.24 , pp. 17009
    • Davila, E.1    Lilenbaum, R.2    Raez, L.3    Seigel, L.4    Tseng, J.5    Graham, P.6
  • 34
    • 65349131852 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and carboplatin plus bevacizumab for stage III/IV non-small cell lung cancer: Preliminary safety data [abstract]
    • Kraut MJ. Phase II study of gemcitabine and carboplatin plus bevacizumab for stage III/IV non-small cell lung cancer: preliminary safety data [abstract]. ASCO Meeting Abstracts 2006;24:17091.
    • (2006) ASCO Meeting Abstracts , vol.24 , pp. 17091
    • Kraut, M.J.1
  • 35
    • 35948995260 scopus 로고    scopus 로고
    • Single agent bevacizumab and bevacizumab in combination with docetaxel and cisplatin as induction therapy for resectable IB-IIIA non-small cell lung cancer [abstract]
    • Rizvi NA, Rusch V, Zhao B, Senturk E, Schwartz L, Fury M, Downey R, Rizk N, Krug L, Kris MG. Single agent bevacizumab and bevacizumab in combination with docetaxel and cisplatin as induction therapy for resectable IB-IIIA non-small cell lung cancer [abstract]. ASCO Meeting Abstracts 2007;25:18045.
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 18045
    • Rizvi, N.A.1    Rusch, V.2    Zhao, B.3    Senturk, E.4    Schwartz, L.5    Fury, M.6    Downey, R.7    Rizk, N.8    Krug, L.9    Kris, M.G.10
  • 39
    • 49749096080 scopus 로고    scopus 로고
    • Safety of bevacizumab-based therapy as first-line treatment of patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): MO19390 (SAiL) [abstract]
    • Dansin E, Mezger J, Isla D, Barlesi F, Bearz A, Lopez PG, Laskin JJ, Pavlakis N, Thatcher N, Crino L. Safety of bevacizumab-based therapy as first-line treatment of patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): MO19390 (SAiL) [abstract]. ASCO Meeting Abstracts 2008;26:8085.
    • (2008) ASCO Meeting Abstracts , vol.26 , pp. 8085
    • Dansin, E.1    Mezger, J.2    Isla, D.3    Barlesi, F.4    Bearz, A.5    Lopez, P.G.6    Laskin, J.J.7    Pavlakis, N.8    Thatcher, N.9    Crino, L.10
  • 40
    • 49749113288 scopus 로고    scopus 로고
    • MO19390 Study Group. Safety of firstline bevacizumab-based therapy with concomitant cardiovascular or anticoagulation medication in advanced or recurrent non-squamous non-small cell lung cancer (NSCLC) in MO19390 (SAiL) [abstract]
    • Griesinger F, Laskin JJ, Pavlakis N; MO19390 Study Group. Safety of firstline bevacizumab-based therapy with concomitant cardiovascular or anticoagulation medication in advanced or recurrent non-squamous non-small cell lung cancer (NSCLC) in MO19390 (SAiL) [abstract]. ASCO Meeting Abstracts 2008;26:8049.
    • (2008) ASCO Meeting Abstracts , vol.26 , pp. 8049
    • Griesinger, F.1    Laskin, J.J.2    Pavlakis, N.3
  • 41
    • 65349154564 scopus 로고    scopus 로고
    • ARIES Investigators. Preliminary treatment patterns and safety outcomes for non-small cell lung cancer (NSCLC) from ARIES, a bevacizumab treatment observational cohort study (OCS) [abstract]
    • Lynch TJ, Brahmer J, Fischbach N, Garst J, Kumar P, Spigel DR, Teng S, Vidaver R, Wang L, Navarro W; ARIES Investigators. Preliminary treatment patterns and safety outcomes for non-small cell lung cancer (NSCLC) from ARIES, a bevacizumab treatment observational cohort study (OCS) [abstract]. ASCO Meeting Abstracts 2008;26:8077.
    • (2008) ASCO Meeting Abstracts , vol.26 , pp. 8077
    • Lynch, T.J.1    Brahmer, J.2    Fischbach, N.3    Garst, J.4    Kumar, P.5    Spigel, D.R.6    Teng, S.7    Vidaver, R.8    Wang, L.9    Navarro, W.10
  • 43
    • 33746911955 scopus 로고    scopus 로고
    • Combining targeted agents: Blocking the epidermal growth factor and vascular endothelial growth factor pathways
    • Sandler A, Herbst R. Combining targeted agents: blocking the epidermal growth factor and vascular endothelial growth factor pathways. Clin Cancer Res 2006;12:4421s-4425s.
    • (2006) Clin Cancer Res , vol.12
    • Sandler, A.1    Herbst, R.2
  • 44
    • 20244381389 scopus 로고    scopus 로고
    • Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1 epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer
    • Herbst RS, Johnson DH, Mininberg E, Carbone DP, Henderson T, Kim ES, Blumenschein G Jr, Lee JJ, Liu DD, Truong MT, et al. Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1 epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer. J Clin Oncol 2005;23: 2544-2555.
    • (2005) J Clin Oncol , vol.23 , pp. 2544-2555
    • Herbst, R.S.1    Johnson, D.H.2    Mininberg, E.3    Carbone, D.P.4    Henderson, T.5    Kim, E.S.6    Blumenschein Jr, G.7    Lee, J.J.8    Liu, D.D.9    Truong, M.T.10
  • 45
    • 46149112447 scopus 로고    scopus 로고
    • MALDI-TOF mass spectrometry proteomic profiling to discriminate response to the combination of bevacizumab and erlotinib in non-small cell lung cancer (NSCLC) [abstract]
    • Salmon JS, Sandler A, Billheimer D, Herbst RS, Tran HT, Tsao A, Dang TP. MALDI-TOF mass spectrometry proteomic profiling to discriminate response to the combination of bevacizumab and erlotinib in non-small cell lung cancer (NSCLC) [abstract]. ASCO Meeting Abstracts 2005;23:7022.
    • (2005) ASCO Meeting Abstracts , vol.23 , pp. 7022
    • Salmon, J.S.1    Sandler, A.2    Billheimer, D.3    Herbst, R.S.4    Tran, H.T.5    Tsao, A.6    Dang, T.P.7
  • 46
    • 36048982143 scopus 로고    scopus 로고
    • Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer
    • Herbst RS, O'Neill VJ, Fehrenbacher L, Belani CP, Bonomi PD, Hart L, Melnyk O, Ramies D, Lin M, Sandler A. Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. J Clin Oncol 2007;25: 4743-4750.
    • (2007) J Clin Oncol , vol.25 , pp. 4743-4750
    • Herbst, R.S.1    O'Neill, V.J.2    Fehrenbacher, L.3    Belani, C.P.4    Bonomi, P.D.5    Hart, L.6    Melnyk, O.7    Ramies, D.8    Lin, M.9    Sandler, A.10
  • 47
    • 49749101701 scopus 로고    scopus 로고
    • Safety of bevacizumab (Bv) therapy in combination with chemotherapy in subjects with non-small cell lung cancer (NSCLC) treated on ATLAS [abstract]
    • Polikoff J, Hainsworth JD, Fehrenbacher L, Royer-Joo S, Mu Y, Strickland DK, Miller VA. Safety of bevacizumab (Bv) therapy in combination with chemotherapy in subjects with non-small cell lung cancer (NSCLC) treated on ATLAS [abstract]. ASCO Meeting Abstracts 2008;26:8079.
    • (2008) ASCO Meeting Abstracts , vol.26 , pp. 8079
    • Polikoff, J.1    Hainsworth, J.D.2    Fehrenbacher, L.3    Royer-Joo, S.4    Mu, Y.5    Strickland, D.K.6    Miller, V.A.7
  • 48
    • 35948989620 scopus 로고    scopus 로고
    • A phase II study of erlotinib (E) and bevacizumab (B) in patients (pts) with previously untreated stage IIIB/IV non-small cell lung cancer (NSCLC) [abstract]
    • Groen HJ, Smit EF, Dingemans A. A phase II study of erlotinib (E) and bevacizumab (B) in patients (pts) with previously untreated stage IIIB/IV non-small cell lung cancer (NSCLC) [abstract]. ASCO Meeting Abstracts 2007;25:7625.
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 7625
    • Groen, H.J.1    Smit, E.F.2    Dingemans, A.3
  • 49
    • 65349111301 scopus 로고    scopus 로고
    • Phase II trial of sequential bevacizumab (B), erlotinib (E) and chemotherapy for first line treatment of clinical stage IIIB or IV non-small cell lung cancer (NSCLC) [abstract]
    • Faoro L, Cohen EE, Govindan R, Kozloff MF, Hoffman PC, Maitland ML, Verel K, Szeto L, Salgia R, Vokes EE. Phase II trial of sequential bevacizumab (B), erlotinib (E) and chemotherapy for first line treatment of clinical stage IIIB or IV non-small cell lung cancer (NSCLC) [abstract]. ASCO Meeting Abstracts 2008;26:19130.
    • (2008) ASCO Meeting Abstracts , vol.26 , pp. 19130
    • Faoro, L.1    Cohen, E.E.2    Govindan, R.3    Kozloff, M.F.4    Hoffman, P.C.5    Maitland, M.L.6    Verel, K.7    Szeto, L.8    Salgia, R.9    Vokes, E.E.10
  • 50
    • 4644259265 scopus 로고    scopus 로고
    • Kinase inhibition with BAY 43-9006 in renal cell carcinoma
    • Ahmad T, Eisen T. Kinase inhibition with BAY 43-9006 in renal cell carcinoma. Clin Cancer Res 2004;10:6388S-6392S.
    • (2004) Clin Cancer Res , vol.10
    • Ahmad, T.1    Eisen, T.2
  • 51
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-7109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3    Wilkie, D.4    McNabola, A.5    Rong, H.6    Chen, C.7    Zhang, X.8    Vincent, P.9    McHugh, M.10
  • 52
    • 65349162168 scopus 로고    scopus 로고
    • Murphy DA, Makonnen S, Lassoued W, Feldman MD, Carter C, Lee WM. Inhibition of tumor endothelial ERK activation, angiogenesis
    • Murphy DA, Makonnen S, Lassoued W, Feldman MD, Carter C, Lee WM. Inhibition of tumor endothelial ERK activation, angiogenesis,
  • 53
    • 34147161209 scopus 로고    scopus 로고
    • and tumor growth by sorafenib (BAY43-9006). Am J Pathol 2006; 169:1875-1885.
    • and tumor growth by sorafenib (BAY43-9006). Am J Pathol 2006; 169:1875-1885.
  • 54
    • 33845371047 scopus 로고    scopus 로고
    • Sorafenib is efficacious and tolerated in combination with cytostatic agents in preclinical models of human non-small cell lung carcinoma
    • Carter C, Chen C, Brink C, Vincent P, Maxuitenko YY, Gilbert KS, Waud WR, Zhang X. Sorafenib is efficacious and tolerated in combination with cytostatic agents in preclinical models of human non-small cell lung carcinoma. Cancer Chemother Pharmacol 2007;59:183-195.
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 183-195
    • Carter, C.1    Chen, C.2    Brink, C.3    Vincent, P.4    Maxuitenko, Y.Y.5    Gilbert, K.S.6    Waud, W.R.7    Zhang, X.8
  • 55
    • 0036401105 scopus 로고    scopus 로고
    • BAY 43-9006: Preclinical data
    • Wilhelm S, Chien DS. BAY 43-9006: preclinical data. Curr Pharm Des 2002;8:2255-2257.
    • (2002) Curr Pharm Des , vol.8 , pp. 2255-2257
    • Wilhelm, S.1    Chien, D.S.2
  • 56
    • 44449142019 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of sorafenib, an oral multikinase inhibitor, in Japanese patients with advanced refractory solid tumors
    • Minami H, Kawada K, Ebi H, Kitagawa K, Kim YI, Araki K, Mukai H, Tahara M, Nakajima H, Nakajima K. Phase I and pharmacokinetic study of sorafenib, an oral multikinase inhibitor, in Japanese patients with advanced refractory solid tumors. Cancer Sci 2008;99:1492-1498.
    • (2008) Cancer Sci , vol.99 , pp. 1492-1498
    • Minami, H.1    Kawada, K.2    Ebi, H.3    Kitagawa, K.4    Kim, Y.I.5    Araki, K.6    Mukai, H.7    Tahara, M.8    Nakajima, H.9    Nakajima, K.10
  • 59
    • 33845321649 scopus 로고    scopus 로고
    • NCI Bay 43-9006 Working Group. A phase II study of BAY 43-9006 (Sorafenib) in patients with relapsed non-small cell lung cancer (NSCLC) [abstract]
    • Liu B, Barrett T, Choyke P, Maynard K, Wright J, Kummar S, Murgo A, Doroshow J, Gutierrez M; NCI Bay 43-9006 Working Group. A phase II study of BAY 43-9006 (Sorafenib) in patients with relapsed non-small cell lung cancer (NSCLC) [abstract]. ASCO Meeting Abstracts 2006;24:17119.
    • (2006) ASCO Meeting Abstracts , vol.24 , pp. 17119
    • Liu, B.1    Barrett, T.2    Choyke, P.3    Maynard, K.4    Wright, J.5    Kummar, S.6    Murgo, A.7    Doroshow, J.8    Gutierrez, M.9
  • 60
    • 34250026980 scopus 로고    scopus 로고
    • Effects of sorafenib on symptoms and quality of life: Results from a large randomized placebo- controlled study in renal cancer
    • Bukowski R, Cella D, Gondek K, Escudier B. Effects of sorafenib on symptoms and quality of life: results from a large randomized placebo- controlled study in renal cancer. Am J Clin Oncol 2007;30:220-227.
    • (2007) Am J Clin Oncol , vol.30 , pp. 220-227
    • Bukowski, R.1    Cella, D.2    Gondek, K.3    Escudier, B.4
  • 62
    • 35548976756 scopus 로고    scopus 로고
    • A front-line window of opportunity phase II study of sorafenib in patients with advanced non-small cell lung cancer: A North Central Cancer Treatment Group study [abstract]
    • Adjei AA, Molina JR, Hillman SL, Luyun RF, Reuter NF, Rowland KM Jr, Jett JR, Mandrekar SJ, Schild SE. A front-line window of opportunity phase II study of sorafenib in patients with advanced non-small cell lung cancer: A North Central Cancer Treatment Group study [abstract]. ASCO Meeting Abstracts 2007;25:7547.
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 7547
    • Adjei, A.A.1    Molina, J.R.2    Hillman, S.L.3    Luyun, R.F.4    Reuter, N.F.5    Rowland Jr, K.M.6    Jett, J.R.7    Mandrekar, S.J.8    Schild, S.E.9
  • 63
    • 65349161533 scopus 로고    scopus 로고
    • A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501 [abstract]
    • Schiller JH, Lee JW, Hanna NH, Traynor AM, Carbone DP. A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501 [abstract]. ASCO Meeting Abstracts 2008;26:8014.
    • (2008) ASCO Meeting Abstracts , vol.26 , pp. 8014
    • Schiller, J.H.1    Lee, J.W.2    Hanna, N.H.3    Traynor, A.M.4    Carbone, D.P.5
  • 66
    • 65349142536 scopus 로고    scopus 로고
    • Scagliotti G, VonPawelJ, Reck M, CupitL, CihonF, DiMatteo S, O'Leary J, Hanna N. Phase III trial comparing carboplatin and paclitaxel with or without sorafenib in chemonaive patients with stage IIIB (with effusion) or IV non-small cell lung cancer. First IASLC-ESMO European Lung Cancer Conference 2008; Geneva, April 23-26, 2008:48.
    • Scagliotti G, VonPawelJ, Reck M, CupitL, CihonF, DiMatteo S, O'Leary J, Hanna N. Phase III trial comparing carboplatin and paclitaxel with or without sorafenib in chemonaive patients with stage IIIB (with effusion) or IV non-small cell lung cancer. First IASLC-ESMO European Lung Cancer Conference 2008; Geneva, April 23-26, 2008:48.
  • 69
    • 0842289982 scopus 로고    scopus 로고
    • Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepider- mal growth factor receptor therapy
    • Ciardiello F, Bianco R, Caputo R, Damiano V, Troiani T, Melisi D, De Vita F, De Placido S, Bianco AR, et al. Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepider- mal growth factor receptor therapy. Clin Cancer Res 2004;10:784-793.
    • (2004) Clin Cancer Res , vol.10 , pp. 784-793
    • Ciardiello, F.1    Bianco, R.2    Caputo, R.3    Damiano, V.4    Troiani, T.5    Melisi, D.6    De Vita, F.7    De Placido, S.8    Bianco, A.R.9
  • 72
    • 41749097667 scopus 로고    scopus 로고
    • A randomized, double-blind, phase IIa dose-finding study of Vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer
    • Kiura K, Nakagawa K, Shinkai T, Eguchi K, Ohe Y, Yamamoto N, Tsuboi M, Yokota S, Seto T, Jiang H, et al. A randomized, double-blind, phase IIa dose-finding study of Vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer. J Thorac Oncol 2008;3:386-393.
    • (2008) J Thorac Oncol , vol.3 , pp. 386-393
    • Kiura, K.1    Nakagawa, K.2    Shinkai, T.3    Eguchi, K.4    Ohe, Y.5    Yamamoto, N.6    Tsuboi, M.7    Yokota, S.8    Seto, T.9    Jiang, H.10
  • 76
    • 35948978403 scopus 로고    scopus 로고
    • Randomized phase II study of vandetanib (VAN) alone or in combination with carboplatin and paclitaxel (CP) as first-line treatment for advanced non-small cell lung cancer (NSCLC) [abstract]
    • Heymach J, Paz-Ares L, De Braud F, Sebastian M, Stewart DJ, Eberhardt W, Herbst RS, Krebs A, Langmuir P, Johnson BE. Randomized phase II study of vandetanib (VAN) alone or in combination with carboplatin and paclitaxel (CP) as first-line treatment for advanced non-small cell lung cancer (NSCLC) [abstract]. ASCO Meeting Abstracts 2007;25:7544.
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 7544
    • Heymach, J.1    Paz-Ares, L.2    De Braud, F.3    Sebastian, M.4    Stewart, D.J.5    Eberhardt, W.6    Herbst, R.S.7    Krebs, A.8    Langmuir, P.9    Johnson, B.E.10
  • 78
    • 5044236157 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in tumor angiogenesis
    • viii
    • Ellis LM. Epidermal growth factor receptor in tumor angiogenesis. Hematol Oncol Clin North Am 2004;18:1007-1021. (viii).
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 1007-1021
    • Ellis, L.M.1
  • 80
    • 34147130694 scopus 로고    scopus 로고
    • The role of VEGF and EGFR inhibition: Implications for combining anti-VEGF and anti-EGFR agents
    • Tabernero J. The role of VEGF and EGFR inhibition: implications for combining anti-VEGF and anti-EGFR agents. Mol Cancer Res 2007; 5:203-220.
    • (2007) Mol Cancer Res , vol.5 , pp. 203-220
    • Tabernero, J.1
  • 81
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
    • Abrams TJ, Lee LB, Murray LJ, Pryer NK, Cherrington JM. SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther 2003;2:471-478.
    • (2003) Mol Cancer Ther , vol.2 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3    Pryer, N.K.4    Cherrington, J.M.5
  • 82
    • 36049026182 scopus 로고    scopus 로고
    • Role of anti-angiogenesis agents in treating NSCLC: Focus on bevacizumab and VEGFR tyrosine kinase inhibitors
    • Cabebe E, Wakelee H. Role of anti-angiogenesis agents in treating NSCLC: focus on bevacizumab and VEGFR tyrosine kinase inhibitors. Curr Treat Options Oncol 2007;8:15-27.
    • (2007) Curr Treat Options Oncol , vol.8 , pp. 15-27
    • Cabebe, E.1    Wakelee, H.2
  • 83
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003;9:327-337.
    • (2003) Clin Cancer Res , vol.9 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3    Louie, S.G.4    Christensen, J.G.5    Li, G.6    Schreck, R.E.7    Abrams, T.J.8    Ngai, T.J.9    Lee, L.B.10
  • 84
  • 87
    • 65349099972 scopus 로고    scopus 로고
    • A phase 1 dose escalation study of sunitinib in combination with gemcitabine + cisplatin for advanced non-small cell lung cancer (NSCLC) [abstract]
    • Reck M, Frickhofen N, Gatzemeier U, Fuhr H, Lanzalone S, Lechuga MJ, Wang E, Chao R, Felip E. A phase 1 dose escalation study of sunitinib in combination with gemcitabine + cisplatin for advanced non-small cell lung cancer (NSCLC) [abstract]. ASCO Meeting Abstracts 2007;25:18057.
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 18057
    • Reck, M.1    Frickhofen, N.2    Gatzemeier, U.3    Fuhr, H.4    Lanzalone, S.5    Lechuga, M.J.6    Wang, E.7    Chao, R.8    Felip, E.9
  • 88
    • 35548988774 scopus 로고    scopus 로고
    • A phase I dose-escalation and pharmacokinetic (PK) study of sunitinib (SU) plus docetaxel (D) in patients (pts) with advanced solid tumors (STs) [abstract]
    • Robert F, Sandler A, Schiller JH, Ilagan J, VerMeulen W, Harper K, Liu G, Tye L, Chao R, Traynor A. A phase I dose-escalation and pharmacokinetic (PK) study of sunitinib (SU) plus docetaxel (D) in patients (pts) with advanced solid tumors (STs) [abstract]. ASCO Meeting Abstracts 2007;25:3543.
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 3543
    • Robert, F.1    Sandler, A.2    Schiller, J.H.3    Ilagan, J.4    VerMeulen, W.5    Harper, K.6    Liu, G.7    Tye, L.8    Chao, R.9    Traynor, A.10
  • 90
    • 33750359418 scopus 로고    scopus 로고
    • Phase I evaluation of AZD2171, a highly potent and selective inhibitor of VEGFR signaling, in combination with selected chemotherapy regimens in patients with advanced solid tumors [abstract]
    • Lorusso PM, Heath E, Valdivieso M, Pilat M, Wozniak A, Gadgeel S, Shields A, Puchalski T, Ewesuedo R. Phase I evaluation of AZD2171, a highly potent and selective inhibitor of VEGFR signaling, in combination with selected chemotherapy regimens in patients with advanced solid tumors [abstract]. ASCO Meeting Abstracts 2006;24:3034.
    • (2006) ASCO Meeting Abstracts , vol.24 , pp. 3034
    • Lorusso, P.M.1    Heath, E.2    Valdivieso, M.3    Pilat, M.4    Wozniak, A.5    Gadgeel, S.6    Shields, A.7    Puchalski, T.8    Ewesuedo, R.9
  • 92
    • 42949105645 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: The National Cancer Institute of Canada clinical trials group
    • Laurie SA, Gauthierl, Arnold A, ShepherdFA, Ellis PM, Chen E, Goss G, Powers J, Walsh W, Tu D, et al. Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: the National Cancer Institute of Canada clinical trials group. JClin Oncol 2008;26:1871-1878.
    • (2008) JClin Oncol , vol.26 , pp. 1871-1878
    • Laurie, S.A.1    Gauthierl2    Arnold, A.3    Shepherd, F.A.4    Ellis, P.M.5    Chen, E.6    Goss, G.7    Powers, J.8    Walsh, W.9    Tu, D.10
  • 93
    • 35948990764 scopus 로고    scopus 로고
    • IND. 175: Phase I study of daily oral AZD2171, a vascular endothelial growth factor receptor inhibitor (VEGFRI), in combination with gemcitabine and cisplatin (G/C) in patients with advanced non-small cell lung cancer (ANSCLC): a study of the NCIC Clinical Trials Group [abstract]
    • Goss GD, Laurie S, Shepherd F, Leighl N, Chen E, Gauthier I, Reaume N, Feld R, Powers J, Seymour L. IND. 175: Phase I study of daily oral AZD2171, a vascular endothelial growth factor receptor inhibitor (VEGFRI), in combination with gemcitabine and cisplatin (G/C) in patients with advanced non-small cell lung cancer (ANSCLC): a study of the NCIC Clinical Trials Group [abstract]. ASCO Meeting Abstracts 2007;25:7649.
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 7649
    • Goss, G.D.1    Laurie, S.2    Shepherd, F.3    Leighl, N.4    Chen, E.5    Gauthier, I.6    Reaume, N.7    Feld, R.8    Powers, J.9    Seymour, L.10
  • 94
    • 33749000911 scopus 로고    scopus 로고
    • AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts
    • Polverino A, Coxon A, Starnes C, Diaz Z, DeMelfi T, Wang L, Bready J, Estrada J, Cattley R, Kaufman S, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res 2006;66:8715-8721.
    • (2006) Cancer Res , vol.66 , pp. 8715-8721
    • Polverino, A.1    Coxon, A.2    Starnes, C.3    Diaz, Z.4    DeMelfi, T.5    Wang, L.6    Bready, J.7    Estrada, J.8    Cattley, R.9    Kaufman, S.10
  • 97
    • 33750940321 scopus 로고    scopus 로고
    • Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and carboplatin/ paclitaxel (CP) for the treatment of patients (pts) with advanced non- small cell lung cancer (NSCLC) [abstract]
    • Blumenschein G Jr, Sandler A, O'Rourke T, Eschenberg M, Sun Y, Gladish G, Salgia R, Alden, C, Herbst RS, Reckamp K. Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and carboplatin/ paclitaxel (CP) for the treatment of patients (pts) with advanced non- small cell lung cancer (NSCLC) [abstract]. ASCO Meeting Abstracts 2006;24:7119.
    • (2006) ASCO Meeting Abstracts , vol.24 , pp. 7119
    • Blumenschein Jr, G.1    Sandler, A.2    O'Rourke, T.3    Eschenberg, M.4    Sun, Y.5    Gladish, G.6    Salgia, R.7    Alden, C.8    Herbst, R.S.9    Reckamp, K.10
  • 102
    • 65349122441 scopus 로고    scopus 로고
    • Analyses of plasma cytokine/angiogenic factors (C/AFs) profile during preopera- tive treatment with pazopanib (GW786034) in early-stage non-small cell lung cancer [abstract]
    • Nikolinakos P, Altorki N, Guarino M, Tran H, Rajagopalan D, Swann S, Bordogna W, Ottesen L, Yankelevitz D, Heymach JV. Analyses of plasma cytokine/angiogenic factors (C/AFs) profile during preopera- tive treatment with pazopanib (GW786034) in early-stage non-small cell lung cancer [abstract]. J Clin Oncol 2008;26:7568.
    • (2008) J Clin Oncol , vol.26 , pp. 7568
    • Nikolinakos, P.1    Altorki, N.2    Guarino, M.3    Tran, H.4    Rajagopalan, D.5    Swann, S.6    Bordogna, W.7    Ottesen, L.8    Yankelevitz, D.9    Heymach, J.V.10
  • 103
    • 44649125425 scopus 로고    scopus 로고
    • A phase I dose-escalation and pharmacokinetic (PK) study of a novel spectrum selective kinase inhibitor, XL647, in patients with advanced solid malignancies (ASM) [abstract]
    • Wakelee HA, Adjei AA, Halsey J, Lensing JL, Dugay JD, Hanson LJ, Reid JM, Piens JR, Sikic BI. A phase I dose-escalation and pharmacokinetic (PK) study of a novel spectrum selective kinase inhibitor, XL647, in patients with advanced solid malignancies (ASM) [abstract]. ASCO Meeting Abstracts 2006;24:3044.
    • (2006) ASCO Meeting Abstracts , vol.24 , pp. 3044
    • Wakelee, H.A.1    Adjei, A.A.2    Halsey, J.3    Lensing, J.L.4    Dugay, J.D.5    Hanson, L.J.6    Reid, J.M.7    Piens, J.R.8    Sikic, B.I.9
  • 104
    • 84860562516 scopus 로고    scopus 로고
    • A phase I dose-escalation and phar- macokinetic (PK) study of a novel multiple-targeted receptor tyro- sine kinase (RTK) inhibitor, XL647, in patients with advanced solid malignancies [abstract]
    • Wakelee H, Adjei AA, Keer H, Halsey J, Hanson L, Reid J, Hutchison S, Piens J, Lacy S, Sikic BI. A phase I dose-escalation and phar- macokinetic (PK) study of a novel multiple-targeted receptor tyro- sine kinase (RTK) inhibitor, XL647, in patients with advanced solid malignancies [abstract]. ASCO Meeting Abstracts 2005;23: 3142.
    • (2005) ASCO Meeting Abstracts , vol.23 , pp. 3142
    • Wakelee, H.1    Adjei, A.A.2    Keer, H.3    Halsey, J.4    Hanson, L.5    Reid, J.6    Hutchison, S.7    Piens, J.8    Lacy, S.9    Sikic, B.I.10
  • 105
    • 59349102359 scopus 로고    scopus 로고
    • A phase I study of XL647, an EGFR, HER2, VEGFR2 inhibitor, administered orally daily to patients (pts) with advanced solid malignancies (ASM) [abstract]
    • Wakelee HA, Fehling JM, Molina JR, Lensing JL, Funke RP, Miles D, Sikic BI. A phase I study of XL647, an EGFR, HER2, VEGFR2 inhibitor, administered orally daily to patients (pts) with advanced solid malignancies (ASM) [abstract]. ASCO Meeting Abstracts 2008; 26:3528
    • (2008) ASCO Meeting Abstracts , vol.26 , pp. 3528
    • Wakelee, H.A.1    Fehling, J.M.2    Molina, J.R.3    Lensing, J.L.4    Funke, R.P.5    Miles, D.6    Sikic, B.I.7


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