Synthesis and biological study of 4-aminopyrimidine-5-carboxaldehyde oximes as antiproliferative VEGFR-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 23, 2006, Pages 6063-6066

  Huang, Shenlin ^a   Li, Ronghua ^a   Connolly, Peter J ^a   Xu, Guozhang ^a   Gaul, Michael D ^a   Emanuel, Stuart L ^a   LaMontagne, Kenneth R ^a   Greenberger, Lee M ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Angiogenesis; Antiproliferative; VEGFR 2 kinase inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; OXIME DERIVATIVE; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 2;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOSIS; STRUCTURE ACTIVITY RELATION;

CELL PROLIFERATION; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; OXIMES; PROTEIN KINASE INHIBITORS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 33751032849     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.107     Document Type: Article

References (12)

1. Carmeliet P., and Jain R.K. Nature 407 (2000) 249
2. Folkman J. Nat. Med. 1 (1995) 27
3. Ferrara N., Gerber H.P., and LeCouter J. Nat. Med. 9 (2003) 669
4. Dvorak H.F. J. Clin. Oncol. 20 (2002) 4368
5. Strumberg D. Drugs of Today 41 (2005) 773
6. Motzer R.J., Michaelson M.D., Redman B.G., Hudes G.R., Wilding G., Figlin R.A., Ginsberg M.S., Kim S.T., Baum C.M., DePrimo S.E., Li J.Z., Bello C.L., Theuer C.P., George D.J., and Rini B.I. J. Clin. Oncol. 24 (2006) 16
7. Connell R.D. Expert Opin. Ther. Pat. 12 (2002) 1763
8. Boyer S.J. Curr. Top. Med. Chem. 2 (2002) 973
9. Traxler P. Expert Opin. Ther. Targets 2 (2003) 215
10. Ho C.Y., Ludovici D.W., Maharoof U.S., Mei J., Sechler J.L., Tuman R.W., Strobel E.D., Andraka L., Yen H.K., Leo G., Li J., Almond H., Lu H., DeVine A., Tominovich R.M., Baker J., Emanuel S., Gruninger R.H., Middleton S.A., Johnson D.L., and Gelemmo Jr. R.A. J. Med. Chem. 48 (2005) 8163
11. Manley P.W., Bold G., Bruggen J., Fendrich G., Furet P., Mestan J., Schnell C., Stolz B., Meyer T., Meyhack B., Stark W., Strauss A., and Wood J. Biochim. Biophys. Acta 1697 (2004) 17
12. Upstate Cell Signaling Solutions, Charlottesville, VA.