Naphthofuroquinone derivatives: Inhibition of receptor tyrosine kinases

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 3, 2006, Pages 737-742

  Lee, Kee In ^a   Park, Youmie ^b   Park, Su Jin ^a   Hwang, Jung Hwan ^a   Lee, Sung Jin ^a   Kim, Gun Do ^a   Park, Woo Kyu ^a   Lee, Sunghou ^a   Jeong, Daeyoung ^a   Kong, Jae Yang ^a   Kang, Hee Kyoung ^c   Cho, Heeyeong ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Jeju National University   (South Korea)

Author keywords

Docking study; Naphthofuroquinone; Receptor tyrosine kinase

Indexed keywords

5 (2 DIETHYLAMINOETHOXY) 7,12 DIOXO 7,12 DIHYDRODINAPHTHO[1,2 B;2',3' D]FURAN 6 CARBOXYLIC ACID METHYL ESTER; DINAPHTHO[1,2 B;2',3']FURAN 7,12 DIONE; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; QUINONE DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR;

ARTICLE; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS;

ENZYME INHIBITORS; FURANS; NAPHTHOQUINONES; QUINAZOLINES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 29544435867     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.08.115     Document Type: Article

References (22)

1. O.M. Fischer, S. Streit, S. Hart, and A. Ullrich Curr. Opin. Chem. Biol. 7 2003 490
2. L. Sun, and G. McMahon Drug Discovery Today 5 2000 344
3. P. Traxler Expert Opin. Ther. Target 7 2003 215
4. N. Prenzel, O.M. Fischer, S. Streit, S. Hart, and A. Ullrich Endocr. Relat. Cancer 8 2001 11
5. S.R. Hubbard Curr. Opin. Struct. Biol. 12 2002 735
6. M.V. Blagosklonny, and Z. Darzynkiewicz Cancer Biol. Ther. 2 2003 137
7. C.N. Cavasotto, and R.A. Abagyan J. Mol. Biol. 337 2004 209
8. R.S. Herbst Int. J. Radiat. Oncol. Biol. Phys. 59 2004 21
9. M.H. Cohen, G.A. Williams, R. Sridhara, G. Chen, and R. Pazdur Oncologist 8 2003 303
10. J. Adams, P. Huang, and D. Patrick Curr. Opin. Chem. Biol. 6 2002 486
11. L.M. Toledo, N.B. Lydon, and D. Elbaum Curr. Med. Chem. 6 1999 775
12. I.A. Shaikh, F. Johnson, and A.P. Grollman J. Med. Chem. 29 1986 1329
13. K.H. Kang, H. Huh, B.K. Kim, and C.K. Lee Phytother. Res. 13 1999 624
14. S.K. Jang, Y.M. Park, Y.S. Kim, K.H. Kang, Y.S. Kim, and B.-K. Kim Yakhak Hoeji 35 1991 483
15. Y.H. Woo, K.H. Kang, J.S. Shin, S.H. Jang, and B.-K. Kim Yakhak Hoeji 38 1994 516
16. C.C. Cheng, Q. Dong, D.F. Liu, Y.L. Luo, L.F. Liu, A.Y. Chen, C. Yu, N. Savaraj, and T.C. Chou J. Med. Chem. 36 1993 4108
17. K.J. Kim, B. Li, J. Winer, M. Armanini, N. Gillett, and H.S. Phillips Nature 362 1993 841
18. 50, μM) for the selected compounds against lung cancer cell line A431: 7 (1.1), 8 (1.7), 10 (1.1), and 11 (4.3).
19. J. Stamos, M.X. Sliwkowski, and C. Eigenbrot J. Biol. Chem. 277 2002 46265
20. 4: C, 66.05; H, 4.62. Found: C, 65.72; H, 4.78.
21. 6: C, 70.97; H, 3.25. Found: C, 70.09; H, 3.13.
22. +), 456 (17), 372 (5), 340 (27), 228 (7), 200 (9), 99 (40), 86 (100), 58 (8).