Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors

Journal of Medicinal Chemistry

Volumn 48, Issue 19, 2005, Pages 6066-6083

  Dai, Yujia ^a,b   Guo, Yan ^a   Frey, Robin R ^a   Ji, Zhiqin ^a   Curtin, Michael L ^a   Ahmed, Asma A ^a   Albert, Daniel H ^a   Arnold, Lee ^a   Arries, Shannon S ^a   Barlozzari, Teresa ^a   Bauch, Joy L ^a   Bouska, Jennifer J ^a   Bousquet, Peter F ^a   Cunha, George A ^a   Glaser, Keith B ^a   Guo, Jun ^a   Li, Junling ^a   Marcotte, Patrick A ^a   Marsh, Kennan C ^a   Moskey, Maria D ^a   Pease, Lori J ^a   Stewart, Kent D ^a   Stoll, Vincent S ^a   Tapang, Paul ^a   Wishart, Neil ^a   Davidsen, Steven K ^a   Michaelides, Michael R ^a   more..

^a ABBOTT LABORATORIES   (United States)

^b Cancer Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; ESTRADIOL; FLT3 LIGAND; MESSENGER RNA; N [4 (4 AMINO 6 METHYLTHIENO[2,3 D]PYRIMIDIN 5 YL)PHENY] N' [2 FLUORO 5 (TRIFLUOROMETHYL)PHENYL]UREA; N [4 (4 AMINOTHIENO[2,3 D]PYRIMIDIN 5 YL)PHENYL] N' (3 METHYLPHENYL)UREA; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; STEM CELL FACTOR RECEPTOR; SUNITINIB; THIENO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD VESSEL PERMEABILITY; CANCER INHIBITION; CONTROLLED STUDY; DISTRIBUTION VOLUME; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CONFORMATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROSARCOMA; FLUORESCENCE; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VIVO STUDY; MONKEY; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT; UTERUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; EDEMA; ESTRADIOL; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MICE, SCID; MODELS, MOLECULAR; NIH 3T3 CELLS; PHOSPHORYLATION; PYRIMIDINES; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; UREA; UTERUS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 24944543833     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050458h     Document Type: Article

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