4-Aminopyrimidine-5-carbaldehyde oximes as potent VEGFR-2 inhibitors. Part II

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 6, 2011, Pages 1815-1818

  Huang, Shenlin ^a   Li, Ronghua ^a   Lamontagne, Kenneth R ^a   Greenberger, Lee M ^a   Connolly, Peter J ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

4 Aminopyrimidine 5 carbaldehyde oxime; VEGFR 2 inhibitor

Indexed keywords

4 AMINOPYRIMIDINE 5 CARBALDEHYDE OXIME DERIVATIVE; ANTINEOPLASTIC AGENT; BEVACIZUMAB; JNJ 38158471; PAZOPANIB; PHOSPHOTRANSFERASE; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 2 INHIBITOR;

AREA UNDER THE CURVE; ARTICLE; CANCER INHIBITION; CHEMICAL REACTION; COLORECTAL CARCINOMA; CONCENTRATION RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; HUMAN; IC 50; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MELANOMA; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN FUNCTION; SQUAMOUS CELL CARCINOMA; STRUCTURE ACTIVITY RELATION; TUMOR VASCULARIZATION;

ANIMALS; MICE; OXIMES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 79952359745     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.053     Document Type: Article

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