Biology of vascular endothelial growth factors

FEBS Letters

Volumn 580, Issue 12, 2006, Pages 2879-2887

  Roy, Himadri ^a   Bhardwaj, Shalini ^a   Ylä Herttuala, Seppo ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Angiogenesis; Diseases; Signaling; VEGF

Indexed keywords

ADENOVIRUS VECTOR; BEVACIZUMAB; NEUROPILIN 1; NEUROPILIN 2; PEGAPTANIB; PLACENTAL GROWTH FACTOR; PROTEIN VASCULAR ENDOTHELIAL GROWTH FACTOR E; PROTEIN VASCULAR ENDOTHELIAL GROWTH FACTOR F; SOMATOMEDIN; TRINAM; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN D; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

ANGIOGENESIS; ARTERY DISEASE; ARTERY INTIMA PROLIFERATION; ATHEROSCLEROSIS; DIABETIC RETINOPATHY; GENE OVEREXPRESSION; GENE THERAPY; GENE TRANSFER; HEART MUSCLE ISCHEMIA; HUMAN; LYMPHANGIOGENESIS; LYMPHEDEMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PSORIASIS; RETINA MACULA DEGENERATION; RETROLENTAL FIBROPLASIA; RHEUMATOID ARTHRITIS; SHORT SURVEY; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; VASCULAR ENDOTHELIUM; VIRAL GENE THERAPY; WOUND HEALING;

ARTHRITIS, RHEUMATOID; HUMANS; LYMPHATIC VESSELS; LYMPHEDEMA; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 33646569993     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.03.087     Document Type: Short Survey

References (70)

1. Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat Med. 9 (2003) 669-676
2. Klagsbrun M., Takashima S., and Mamluk R. The role of neuropilin in vascular and tumor biology. Adv. Exp. Med. Biol. 515 (2002) 33-48
3. Rissanen T.T., Markkanen J.E., Gruchala M., Heikura T., Puranen A., Kettunen M.I., Kholova I., Kauppinen R.A., Achen M.G., Stacker S.A., Alitalo K., and Yla-Herttuala S. VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses. Circ. Res. 92 (2003) 1098-1106
4. Bhardwaj S., Roy H., Gruchala M., Viita H., Kholova I., Kokina I., Achen M.G., Stacker S.A., Hedman M., Alitalo K., and Yla-Herttuala S. Angiogenic responses of vascular endothelial growth factors in periadventitial tissue. Human Gene Ther. 14 (2003) 1451-1462
5. Rissanen T.T., Rutanen J., and Yla-Herttuala S. Gene transfer for therapeutic vascular growth in myocardial and peripheral ischemia. Adv Genet. 52 (2004) 117-164
6. Senger D.R., Galli S.J., Dvorak A.M., Perruzzi C.A., Harvey V.S., and Dvorak H.F. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219 (1983) 983-985
7. Bates D.O., and Harper S.J. Regulation of vascular permeability by vascular endothelial growth factors. Vascul. Pharmacol. 39 (2002) 225-237
8. Bootle-Wilbraham C.A., Tazzyman S., Thompson W.D., Stirk C.M., and Lewis C.E. Fibrin fragment E stimulates the proliferation, migration and differentiation of human microvascular endothelial cells in vitro. Angiogenesis 4 (2001) 269-275
9. Kroll J., and Waltenberger J. A novel function of VEGF receptor-2 (KDR), rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells. Biochem. Biophys. Res. Commun. 265 (1999) 636-699
10. Gerber H.P., Dixit V., and Ferrara N. Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J. Biol. Chem. 273 (1998) 13313-13316
11. Takahashi H., and Shibuya M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin. Sci. 109 (2005) 227-241
12. Bhardwaj S., Roy H., Heikura T., and Yla-Herttuala S. VEGF-A, VEGF-D and VEGF-D (DeltaNDeltaC) induced intimal hyperplasia in carotid arteries. Eur. J. Clin. Invest. 35 (2005) 669-676
13. Gerber H.P., Malik A., Solar G.P., Sherman D., Liang X.H., Meng G., Hong K., Marsters J., and Ferrara N. Vascular endothelial growth factor regulates hematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 417 (2002) 954-958
14. Clauss M., Gerlach M., Gerlach H., Brett J., Wang F., Familletti P.C., Pan Y.C., Olander J.V., Connolly D.T., and Stern D. Vascular permeability factor, a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J. Exp. Med. 172 (1990) 1535-1545
15. Tammela T., Enholm B., Alitalo K., and Paavonen K. The biology of vascular endothelial growth factors. Cardiovasc. Res. 65 (2005) 550-563
16. Mole D.R., Maxwell P.H., Pugh C.W., and Ratcliffe P.J. Regulation of HIF by the von Hippel-Lindau tumour suppressor, implications for cellular oxygen sensing. IUBMB Life 52 (2001) 43-47
17. Ferrara N. Vascular endothelial growth factor, basic science and clinical progress. Endocr. Rev. 25 (2004) 581-611
18. Tjwa M., Luttun A., Autiero M., and Carmeliet P. VEGF and PlGF, two pleiotropic growth factors with distinct roles in development and homeostasis. Cell Tissue Res. 314 (2003) 5-14
19. Yla-Herttuala S., and Alitalo K. Gene transfer as a tool to induce therapeutic vascular growth. Nat. Med. 9 (2003) 694-701
20. Roy H., Bhardwaj S., Babu M., Jauhiainen S., Herzig K.H., Bellu A.R., Haisma H.J., Carmeliet P., Alitalo K., and Yla-Herttuala S. Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A. Human Gene Ther. 16 (2005) 1422-1428
21. Ahmed A., Dunk C., Ahmad S., and Khaliq A. Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen - a review. Placenta 21 (2000) S16-S24
22. Auterio M., Waltenberger J., Communi D., Kranz A., Moons L., Lam Ambrechts D., Kroll J., Plaisance S., De Mol M., Bono F., Kliche S., Fellbrich G., Ballmer-Hofer K., Maglione D., Mayr-Beyrle U., Dewerchin M., Dombrowski S., Stanimirovic D., Van Hummelen P., Dehio C., Hicklin D.J., Persico G., Herbert J.M., Communi D., Shibuya M., Collen D., Conway E.M., and Carmeliet P. Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat. Med. 9 (2003) 936-943
23. Luttun A., Tjwa M., Moons L., Wu Y., Angelillo-Scherrer A., Liao F., Nagy J.A., Hooper A., Priller J., De Klerck B., Compernolle V., Daci E., Bohlen P., Dewerchin M., Herbert J.M., Fava R., Matthys P., Carmeliet G., Collen D., Dvorak H.F., Hicklin D.J., and Carmeliet P. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. 8 (2002) 831-840
24. Pipp F., Heil M., Issbrucker K., Ziegelhoeffer T., Martin S., van den Heuvel J., Weich H., Fernandez B., Golomb G., Carmeliet P., Schaper W., and Clauss M. VEGFR-1-selective VEGF homologue PlGF is arteriogenic, evidence for a monocyte-mediated mechanism. Circ Res. 92 (2003) 378-385
25. Khurana R., Moons L., Shafi S., Luttun A., Collen D., Martin J.F., Carmeliet P., and Zachary I.C. Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation. Circulation 31 (2005) 2828-2836
26. Enholm B., Paavonen K., Ristimaki A., Kumar V., Gunji Y., Klefstrom J., Kivinen L., Laiho M., Olofsson B., Joukov V., Eriksson U., and Alitalo K. Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia. Oncogene 14 (1997) 2475-2483
27. Nash A.D., Baca M., Wright C., and Scotney P.D. The biology of vascular endothelial growth factor-B (VEGF-B). Pulm. Pharmacol. Ther. 19 (2005) 61-69
28. Bellomo D., Headrick J.P., Silins G.U., Paterson C.A., Thomas P.S., Gartside M., Mould A., Cahill M.M., Tonks I.D., Grimmond S.M., Townson S., Wells C., Little M., Cummings M.C., Hayward N.K., and Kay G.F. Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Circ. Res. 86 (2000) E29-E35
29. Mould A.W., Tonks I.D., Cahill M.M., Pettit A.R., Thomas R., Hayward N.K., and Kay G.F. VEGF-B gene knockout mice display reduced pathology and synovial angiogenesis in both antigen-induced and collagen-induced models of arthritis. Arthritis Rheum. 48 (2003) 2660-2669
30. Enholm B., Karpanen T., Jeltsch M., Kubo H., Stenback F., Prevo R., Jackson D.G., Yla-Herttuala S., and Alitalo K. Adenoviral expression of vascular endothelial growth factor-c induces lymphangiogenesis in the skin. Circ. Res. 88 (2001) 623-629
31. Karkkainen M.J., Haiko P., Sainio K., Partanen J., Taipale J., Petrova T.V., Jeltsch M., Jackson D.G., Talikka M., Rauvala H., Betsholtz C., and Alitalo K. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol. 5 (2004) 74-80
32. Jeltsch M., Kaipainen A., Joukov V., Meng X., Lakso M., Rauvala H., Swartz M., Fukumura D., Jain R.K., and Alitalo K. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science 276 (1997) 1423-1425
33. Baldwin M.E., Halford M.M., Roufail S., Williams R.A., Hibbs M.L., Grail D., Kubo H., Stacker S.A., and Achen M.G. Vascular endothelial growth factor D is dispensable for development of the lymphatic system. Mol. Cell. Biol. 25 (2005) 2441-2449
34. Stacker S.A., Caesar C., Baldwin M.E., Thornton G.E., Williams R.A., Prevo R., Jackson D.G., Nishikawa S., Kubo H., and Achen M.G. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat. Med. 7 (2001) 186-191
35. Achen M.G., Williams R.A., Minekus M.P., Thornton G.E., Stenvers K., Rogers P.A., Lederman F., Roufail S., and Stacker S.A. Localization of vascular endothelial growth factor-D in malignant melanoma suggests a role in tumor angiogenesis. J. Pathol. 193 (2001) 147-154
36. Lyttle D.J., Fraser K.M., Fleming S.B., Mercer A.A., and Robinson A.J. Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus. J. Virol. 68 (1994) 84-92
37. Shibuya M. Vascular endothelial growth factor receptor-2, its unique signaling and specific ligand, VEGF-E. Cancer Sci. 94 (2003) 751-756
38. Wise L.M., Veikkola T., Mercer A.A., Savory L.J., Fleming S.B., Caesar C., Vitali A., Makinen T., Alitalo K., and Stacker S.A. The vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1. Proc. Natl. Acad. Sci. USA 96 (1999) 3071-3076
39. Suto K., Yamazaki Y., Morita T., and Mizuno H. Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms. J. Biol. Chem. 280 (2005) 2126-2131
40. Yamazaki Y., Tokunaga Y., Takani K., and Morita T. Identification of the heparin-binding region of snake venom vascular endothelial growth factor (VEGF-F) and its blocking of VEGF-A165. Biochemistry 44 (2005) 8858-8864
41. Zachary I., and Gliki G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc. Res. 49 (2001) 568-581
42. Huang K., Andersson C., Roomans G.M., Ito N., and Claesson-Welsh L. Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers. Int. J. Biochem. Cell Biol. 33 (2001) 315-324
43. Maynard S.E., Min J.Y., Merchan J., Lim K.H., Li J., Mondal S., Libermann T.A., Morgan J.P., Sellke F.W., Stillman I.E., Epstein F.H., Sukhatme V.P., and Karumanchi S.A. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest. 111 (2003) 649-658
44. Hutchings H., Ortega N., and Plouet J. Extracellular matrix-bound vascular endothelial growth factor promotes endothelial cell adhesion, migration and survival through integrin ligation. FASEB J. 17 (2003) 1520-1522
45. Kaipainen A., Korhonen J., Mustonen T., van Hinsbergh V.W., Fang G.H., Dumont D., Breitman M., and Alitalo K. Expression of the fms-like tyrosine kinase FLT4 gene becomes restricted to endothelium of lymphatic vessels during development. Proc. Natl. Acad. Sci. USA 92 (1995) 3566-3570
46. Makinen T., Jussila L., Veikkola T., Karpanen T., Kettunen M.I., Pulkkanen K.J., Kauppinen R., Jackson D.G., Kubo H., Nishikawa S., Yla-Herttuala S., and Alitalo K. Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Nat. Med. 7 (2001) 199-205
47. Kitsukawa T., Shimono A., Kawakami A., Kondoh H., and Hajime F. Over expression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs. Development 121 (1995) 4309-4318
48. Herzog Y., Kalcheim C., Kahane N., Reshef R., and Neufeld G. Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins. Mech. Dev. 109 (2001) 115-119
49. Yuan L., Moyon D., Pardanaud L., Breant C., Karkkainen M.J., Alitalo K., and Eichmann A. Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development 129 (2002) 4797-4806
50. Yla-Herttuala S., and Martin J.F. Role of VEGFs in cardiovascular pathology. Lancet 355 (2000) 213-222
51. Gruchala M., Roy H., Bhardwaj S., and Yla-Herttuala S. Gene therapy for cardiovascular diseases. Curr. Pharm. Des. 10 (2004) 407-423
52. Bhardwaj S., Roy H., Karpanen T., He Y., Jauhiainen S., Hedman M., Alitalo K., and Yla-Herttuala S. Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries. Gene Ther. 12 (2005) 388-394
53. Shibata M., Suzuki H., Nakatani M., Koba S., Geshi E., Katagiri T., and Takeyama Y. The involvement of vascular endothelial growth factor and flt-1 in the process of neointimal proliferation in pig coronary arteries following stent implantation. Histochem. Cell Biol. 116 (2001) 471-481
54. Celletti F.L., Waugh J.M., Amabile P.G., Brendolan A., Hilfiker P.R., and Dake M.D. Vascular endothelial growth factor enhances atherosclerotic plaque progression. Nat. Med. 7 (2001) 425-429
55. Leppänen P., Koota S., Kholová I., Fieber C., Eriksson U., Alitalo K., and Ylä-Herttuala S. Gene transfers of VEGF-A, VEGF-B, VEGF-C, and VEGF-D have no effects on atherosclerosis in hypercholesterolemic LDL-receptor/ApoB48- deficient mice. Circulation 112 (2005) 1347-1352
56. Carmeliet P., and Jain R.K. Angiogenesis in cancer and other diseases. Nature 407 (2000) 249-257
57. Stacker S.A., Achen M.G., Jussila L., Baldwin M.E., and Alitalo K. Lymphangiogenesis and cancer metastasis. Nat. Rev. Cancer 2 (2002) 573-583
58. Karkkainen M.J., Ferrell R.E., Lawrence E.C., Kimak M.A., Levinson K.L., McTigue M.A., Alitalo K., and Finegold D.N. Missense mutations interfere with VEGFR-3 signaling in primary lymphoedema. Nat. Genet. 25 (2000) 153-159
59. Bates D.O., and Jones R.O. The role of vascular endothelial growth factor in wound healing. Int. J. Low Extrem. Wounds 2 (2003) 107-120
60. Saaristo A., Tammela T., Timonen J., Yla-Herttuala S., Tukiainen E., Asko-Seljavaara S., and Alitalo K. Vascular endothelial growth factor-C gene therapy restores lymphatic flow across incision wounds. FASEB J. 18 (2004) 1707-1709
61. Odorisio T., Cianfarani F., Failla C.M., and Zambruno G. The placenta growth factor in skin angiogenesis. J. Dermatol. Sci. 4 (2006) 111-119
62. Hirohata S., and Sakakibara J. Angioneogenesis as a possible elusive triggering factor in rheumatoid arthritis. Lancet 353 (1999) 1331
63. Taylor P.C., and Sivakumar B. Hypoxia and angiogenesis in rheumatoid arthritis. Curr. Opin. Rheumatol. 17 (2005) 293-298
64. Lainer D.T., and Brahn E. New antiangiogenic strategies for the treatment of proliferative synovitis. Expert Opin. Investig. Drugs. 14 (2005) 1-17
65. Frank R.N. Diabetic retinopathy. N Engl. J. Med. 350 (2004) 48-58
66. Witmer A.N., Vrensenb G.F.J.M., Van Noordenc C.J.F., and Schlingemann R.O. Vascular endothelial growth factors and angiogenesis in eye disease. Prog. Retina Eye Res. 22 (2003) 1-29
67. Kulkarni A.D., and Kuppermann B.D. Wet age-related macular degeneration. Adv. Drug Deliv. Rev. 57 (2005) 1994-2009
68. Saint-Geniez M., and D'amore P.A. Development and pathology of the hyaloid, choroidal and retinal vasculature. Int. J. Dev. Biol. 48 (2004) 1045-1058
69. Detmar M., Brown L.F., Claffey K.P., Yeo K.T., Kocher O., Jackman R.W., Berse B., and Dvorak H.F. Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J. Exp. Med. 180 (1994) 1141-1146
70. Young H.S., Summers A.M., Bhushan M., Brenchley P.E.C., and Griffiths C.E.M. Single nucleotide polymorphisms of vascular endothelial growth factor (VEGF) in psoriasis of early onset. J. Invest. Dermatol. 122 (2004) 209-215