Trapping conformational states along ligand-binding dynamics of peptide deformylase: The impact of induced fit on enzyme catalysis

PLoS Biology

Volumn 9, Issue 5, 2011, Pages

  Fieulaine, Sonia ^a   Boularot, Adrien ^a   Artaud, Isabelle ^b,c   Desmadril, Michel ^d,e   Dardel, Frédéric ^b,c   Meinnel, Thierry ^a   Giglione, Carmela ^a  

^a INSTITUT DES SCIENCES DU VÉGÉTAL   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c CNRS   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINONIN; PEPTIDE DEFORMYLASE; AMIDASE; ARABIDOPSIS PROTEIN; ENZYME INHIBITOR; HYDROXAMIC ACID; PEPTIDE DEFORMYLASE 1B, ARABIDOPSIS;

ARTICLE; BINDING KINETICS; BINDING SITE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STRUCTURE; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; ARABIDOPSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; HYDROGEN BOND; KINETICS; MISSENSE MUTATION; PROTEIN BINDING; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

AMIDOHYDROLASES; AMINO ACID MOTIFS; ARABIDOPSIS; ARABIDOPSIS PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HYDROGEN BONDING; HYDROXAMIC ACIDS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PROTEIN BINDING; THERMODYNAMICS;

EID: 79958074211     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001066     Document Type: Article

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