ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis

Journal of Biological Chemistry

Volumn 279, Issue 17, 2004, Pages 17996-18007

  Towler, Paul ^a   Staker, Bart ^b   Prasad, Sridhar G ^b,c   Menon, Saurabh ^a   Tang, Jin ^a   Parsons, Thomas ^a   Ryan, Dominic ^a   Fisher, Martin ^a   Williams, David ^a   Dales, Natalie A ^a   Patane, Michael A ^a   Pantoliano, Michael W ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

^b Emerald BioStructures Inc   (United States)

^c Takeda San Diego Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CATALYSIS; CRYSTAL STRUCTURE; ENZYME INHIBITION; OPTICAL RESOLVING POWER; PROTEINS; SUBSTITUTION REACTIONS;

ANGIOTENSIN-CONVERTING ENZYMES (ACE); BINDING INTERACTIONS; HEART FUNCTION; RECEPTORS;

BIOCHEMISTRY;

2 [1 CARBOXY 2 [3 (3,5 DICHLOROBENZYL) 3H IMIDAZOL 4 YL]ETHYLAMINO] 4 METHYLPENTANOIC ACID; AMINO ACID; ANGIOTENSIN CONVERTING ENZYME RELATED CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MEMBRANE PROTEIN; MLN 4760; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE; ZINC;

ARTICLE; BINDING SITE; CATALYSIS; CONSENSUS SEQUENCE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME STRUCTURE; HEART FUNCTION; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME;

AMINO ACID SEQUENCE; AMINO ACIDS; BINDING SITES; CARBOXYPEPTIDASES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; LEUCINE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDYL-DIPEPTIDASE A; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, VIRUS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; ZINC;

CORONAVIRUS; SARS CORONAVIRUS;

EID: 2342418543     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M311191200     Document Type: Article

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