1H, 13C and 15N NMR assignments of the E. coli peptide deformylase in complex with a natural inhibitor called actinonin

Biomolecular NMR Assignments

Volumn 3, Issue 1, 2009, Pages 153-155

  Larue, Valéry ^a,b   Seijo, Bili ^a,b   Tisne, Carine ^a,b   Dardel, Frédéric ^a,b  

^a CNRS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Actinonin; Antibiotic; NMR; Peptide deformylase

Indexed keywords

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

ACTINONIN; AMIDASE; CARBON; HYDROXAMIC ACID; MULTIPROTEIN COMPLEX; NITROGEN; PEPTIDE DEFORMYLASE; PROTEIN SUBUNIT; PROTON;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; METHODOLOGY; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; BINDING SITES; CARBON ISOTOPES; HYDROXAMIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; NITROGEN ISOTOPES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; PROTONS;

EID: 67349101195     PISSN: 18742718     EISSN: 1874270X     Source Type: Journal    
DOI: 10.1007/s12104-009-9164-6     Document Type: Article

References (10)

1. A Boularot C Giglione I Artaud 2004 Structure-activity relationship analysis and therapeutic potential of peptide deformylase inhibitors Curr Opin Investig Drugs 8 809 822
2. A Boularot C Giglione S Petit 2007 Discovery and refinement of a new structural class of potent peptide deformylase inhibitors J Med Chem 50 10 20 10.1021/jm060910c (Pubitemid 46105496)
3. DZ Chen DV Patel CJ Hackbarth 2000 Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor Biochemistry 39 1256 1262 10.1021/bi992245y (Pubitemid 30090692)
4. F Dardel S Ragusa C Lazennec 1998 Solution structure of nickel-peptide deformylase J Mol Biol 280 501 513 10.1006/jmbi.1998.1882 (Pubitemid 28327286)
5. F Delaglio S Grzesiek GW Vuister 1995 NMRPipe: a multidimensional spectral processing system based on UNIX pipes J Biomol NMR 6 277 293 10.1007/BF00197809
6. C Giglione M Pierre T Meinnel 2000 Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents Mol Microbiol 36 1197 1205 10.1046/j.1365-2958.2000.01908.x (Pubitemid 30449958)
7. Goddard TD, Kneller DG. SPARKY 3. University of California, San Francisco
8. JP Guilloteau M Mathieu C Giglione 2002 The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents J Mol Biol 5 951 962 10.1016/S0022-2836(02)00549-1
9. T Meinnel S Blanquet F Dardel 1996 A new subclass of the zinc metalloproteases superfamily revealed by the solution structure of peptide deformylase J Mol Biol 262 375 386 10.1006/jmbi.1996.0521 (Pubitemid 126353206)
10. S Petit Y Duroc V Larue 2008 Structure-activity relationship analysis of the peptide deformylase inhibitor 5-bromo-1H-indole-3-acetohydroxamic acid Chem Med Chem 4 261 275 10.1002/cmdc.200800251