Ligand-induced changes in the structure and dynamics of Escherichia coli peptide deformylase

Biochemistry

Volumn 48, Issue 32, 2009, Pages 7595-7607

  Amero, Carlos D ^a   Byerly, Douglas W ^a   McElroy, Craig A ^a   Simmons, Amber ^a   Foster, Mark P ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY INTERACTIONS; ANTIBACTERIAL AGENT; COMBINATORIAL CHEMISTRY; DYNAMIC EFFECTS; FORMYL GROUP; GLOBAL MINIMA; HYDROGEN-DEUTERIUM EXCHANGE; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; LIGAND-BINDING SITES; MEDICINAL CHEMISTRY; NATURALLY OCCURRING; NMR SPECTROSCOPY; PEPTIDE DEFORMYLASE; POTENT INHIBITOR; REMOTE SITES; RESIDUAL DIPOLAR COUPLINGS; STRUCTURAL APPROACH; STRUCTURE AND DYNAMICS; STRUCTURE-BASED DRUG DESIGN;

AMIDES; AMINES; BINDING ENERGY; BIOASSAY; BIOCHEMISTRY; BIOCHIPS; DEUTERIUM; ENZYMES; ESCHERICHIA COLI; HYDROGEN; LIGANDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES; POLYPEPTIDES; PROBABILITY DISTRIBUTIONS; TARGETS;

BINDING SITES;

ACTINONIN; DEUTERIUM; HYDROGEN; NITROGEN 15; PEPTIDE DEFORMYLASE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DEUTERIUM HYDROGEN EXCHANGE; ENZYME BINDING; ENZYME STRUCTURE; ESCHERICHIA COLI; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MOLECULAR DYNAMICS; NITROGEN NUCLEAR MAGNETIC RESONANCE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; THERMODYNAMICS;

AMIDES; AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; CALORIMETRY; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROXAMIC ACIDS; LIGANDS; METALS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS;

ESCHERICHIA COLI;

EID: 68849114935     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900600b     Document Type: Article

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