N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 9, 2002, Pages 2752-2764

  Hackbarth, Corinne J ^a   Chen, Dawn Z ^a   Lewis, Jason G ^a   Clark, Kirk ^a   Mangold, James B ^a   Cramer, Jeffrey A ^a   Margolis, Peter S ^a   Wang, Wen ^a   Koehn, Jim ^a   Wu, Charlotte ^a   Lopez, S ^a   Withers III, George ^a   Gu, Helen ^a   Dunn, Elina ^a   Kulathila, R ^a   Pan, Shi Hao ^a   Porter, Wilma L ^a   Jacobs, Jeff ^a   Trias, Joaquim ^a   Patel, Dinesh V ^a   Weidmann, Beat ^a   White, Richard J ^a   Yuan, Zhengyu ^a   more..

^a Versicor Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; HYDROXAMIC ACID DERIVATIVE; METALLOPROTEIN; PEPTIDE DEFORMYLASE INHIBITOR; UNCLASSIFIED DRUG; UREAHYDROXAMIC ACID DERIVATIVE; VANCOMYCIN; VRC 3324; VRC 4232; VRC 4307;

ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA SEQUENCE; DRUG BIOAVAILABILITY; DRUG METABOLISM; ENZYME INHIBITION; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SEPTICEMIA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

EID: 0036716795     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.9.2752-2764.2002     Document Type: Article

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