Design and synthesis of substrate analogue inhibitors of peptide deformylase

Biochemistry

Volumn 38, Issue 14, 1999, Pages 4287-4295

  Meinnel, Thierry ^a   Patiny, Luc ^b   Ragusa, Stéphane ^a   Blanquet, Sylvain ^a  

^a LABORATOIRE D OPTIQUE ET BIOSCIENCES   (France)

^b LABORATOIRE DE BIOCHIMIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; ARGININE; ARGININE DERIVATIVE; BACTERIAL ENZYME; CARBONYL DERIVATIVE; ENZYME INHIBITOR; IMINO[(5 METHOXY 5 OXO 4 [[2 (SULFANYLMETHYL)HEXANOYL]AMINO]PENTYLAMINO]METHANAMINE; METHIONINE DERIVATIVE; PEPTIDE DEFORMYLASE; THERMOLYSIN; THIORPHAN; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; HYDROPHOBICITY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DEGRADATION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURFACE CHARGE; SYNTHESIS;

AMIDOHYDROLASES; AMINOPEPTIDASES; BINDING, COMPETITIVE; CAPTOPRIL; ENZYME INHIBITORS; HYDROLYSIS; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; SUBSTRATE SPECIFICITY; THERMOLYSIN; ZINC;

BACTERIA (MICROORGANISMS); FELIS CATUS; NEGIBACTERIA;

EID: 0033528708     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982622r     Document Type: Article

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