The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: A platform for the structure-based design of antibacterial agents

Journal of Molecular Biology

Volumn 320, Issue 5, 2002, Pages 951-962

  Guilloteau, Jean Pierre ^a   Mathieu, Magali ^a   Giglione, Carmela ^b   Blanc, Véronique ^a   Dupuy, Alain ^a   Chevrier, Miline ^a   Gil, Patricia ^a   Famechon, Alain ^a   Meinnel, Thierry ^b   Mikol, Vincent ^a  

^a SANOFI   (France)

^b INSTITUT DES SCIENCES DU VÉGÉTAL   (France)

Author keywords

Actinonin; Antibiotic; Crystal structure; Inhibitor; Metalloprotease

Indexed keywords

ACTINONIN; ANTIINFECTIVE AGENT; PEPTIDE DEFORMYLASE; PEPTIDE DEFORMYLASE INHIBITOR;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; GEOMETRY; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); PROKARYOTA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 0036077847     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00549-1     Document Type: Article

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