Synthetic agonists of Toll-like receptors 7, 8 and 9

Biochemical Society Transactions

Volumn 35, Issue 6, 2007, Pages 1461-1467

  Agrawal, S ^a   Kandimalla, E R ^a  

^a HYBRIDON INC   (United States)

Author keywords

Agonist; Immune stimulation; Interferon (IFN ); Intracellular Toll like receptor; Pathogen associated molecular pattern; Unmethylated CpG motif

Indexed keywords

1 (2 DEOXY BETA RIBOFURANOSYL) 2 OXO 7 DEAZA 8 METHYL PURINE; CYTOSINE; DNA BASE; GUANINE; IMIDAZOQUINOLINE DERIVATIVE; IMMUNOSTIMULATING AGENT; IMO 2055; IMO 2125; INTERFERON; LOXORIBINE; NUCLEOSIDE ANALOG; NUCLEOTIDE; OLIGONUCLEOTIDE; PYRIMIDINE DERIVATIVE; RNA; SINGLE STRANDED RNA; STABILIZED IMMUNE MODULATORY RNA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

AGONIST; ALLERGY; ASTHMA; CLINICAL EVALUATION; CONFERENCE PAPER; DNA FLANKING REGION; GENE TARGETING; HUMAN; IMMUNE RESPONSE; IMMUNOSTIMULATION; INFECTION; NEOPLASM; NONHUMAN; NUCLEIC ACID STRUCTURE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; CPG ISLANDS; DNA, BACTERIAL; HUMANS; INTERFERONS; LIGANDS; RNA, VIRAL; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8; TOLL-LIKE RECEPTOR 9;

BACTERIA (MICROORGANISMS); PRIMATES;

EID: 37749044421     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0351461     Document Type: Conference Paper

References (61)

1. Janeway, Jr, C.A. and Medzhitov, R. (2002) Annu. Rev Immunol. 20, 197-216
2. Kawai, T. and Akira, S. (2007) Semin. Immunol. 19, 24-32
3. Lasker, M.V. and Nair, S.K. (2006) J. Immunol. 177, 11-16
4. O'Neill, L.A. and Bowie, A.G. (2007) Nat. Rev. Immunol. 7, 353-364
5. O'Neill, L.A. (2006) Curr. Opin. Immunol. 18, 3-9
6. Miyake, K. (2007) Semin. Immunol. 19, 3-10
7. Alexopoulou, L., Holt, A.C. and Medzhitov, R. (2001) Nature 413, 732-738
8. Lee, J., Chuang, I.H., Redecke, V., She, L., Pitha, P.M., Carson, D.A., Raz, E. and Cottam, H.B. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 6646-6651
9. Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H. and Bauer, S. (2004) Science 303, 1526-1529
10. Diebold, S.S., Kaisho, T., Hemmi, H., Akira, S. and Reis e Sousa, C. (2004) Science 303, 1529-1531
11. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K. and Akira, S. (2000) Nature 408, 740-745
12. Schon, M.P., Schon, M. and Klotz, K.N. (2006) J. Invest. Dermatol. 126, 1338-1347
13. Kariko, K., Bhuyan, P., Capodici, J. and Weissman, D. (2004) J. Immunol. 172, 6545-6549
14. Judge, A.D., Sood, V., Shaw, J.R., Fang, D., McClintock, K. and MacLachlan, I. (2005) Nat. Biotechnol. 23, 457-462
15. Sioud, M. (2005) J. Mol. Biol. 348, 1079-1090
16. Marques, J.T. and Williams, B.R. (2005) Nat. Biotechnol. 23, 1399-1405
17. Agrawal, S. and Kandimalla, E.R. (2004) Nat. Biotechnol. 22, 1533-1537
18. Lan, T., Kandimalla, E.R., Yu, D., Bhagat, L., Li, Y., Wang, D., Zhu, F.-G., Tang, J.X., Putta, M.R., Cong, Y.-P. et al. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 13750-13755
19. Colonna, M., Krug, A. and Cella, M. (2002) Curr. Opin. Immunol. 14, 373-379
20. Krieg, A.M. (2006) Nat. Rev. Drug Discov. 5, 471-484
21. Kandimalla, E.R. and Agrawal, S. (2005) in Toll and Toll Receptors: An Immunologic Perspective (Rich, T., ed.), pp. 181-212, Kluwer Academic/Plenum Publishers, New York
22. Yu, D., Kandimalla, E.R., Roskey, A., Zhao, Q., Chen, L., Chen, J. and Agrawal, S. (2000) Bioorg. Med. Chem. 8, 275-284
23. Zhao, Q., Temsamani, J., Iadarola, P.L., Jiang, Z. and Agrawal, S. (1996) Biochem. Pharmacol. 51, 173-182
24. Yu, D., Kandimalla, E.R., Zhao, Q., Cong, Y. and Agrawal, S. (2001) Bioorg. Med. Chem. 9, 2803-2808
25. Agrawal, S. and Kandimalla, E.R. (2001) Curr. Cancer Drug Targets 1, 197-209
26. Agrawal, S. and Kandimalla, E.R. (2003) Ann. N.Y. Acad. Sci. 1002, 30-42
27. Kandimalla, E.R., Zhu, F.-G., Bhagat, L., Yu, D. and Agrawal, S. (2003) Biochem. Soc. Trans. 31, 654-658
28. Zhao, Q., Yu, D. and Agrawal, S. (1999) Bioorg. Med. Chem. Lett. 9, 3453-3458
29. Zhao, Q., Yu, D. and Agrawal, S. (2000) Bioorg. Med. Chem. Lett. 10, 1051-1054
30. Yu, D., Kandimalla, E.R., Zhao, Q., Cong, Y. and Agrawal, S. (2002) Nucleic Acids Res. 30, 1613-1619
31. Yu, D., Kandimalla, E.R., Cong, Y.-P., Tang, J., Tang, J.Y., Zhao, Q. and Agrawal, S. (2002) J. Med. Chem. 45, 4540-4548
32. Yu, D., Kandimalla, E.R., Zhao, Q., Cong, Y. and Agrawal, S. (2001) Bioorg. Med. Chem. Lett. 11, 2263-2267
33. Yu, D., Kandimalla, E.R., Zhao, Q., Bhagat, L., Cong, Y.-P. and Agrawal, S. (2003) Bioorg. Med. Chem. 11, 459-464
34. Yu, D., Zhao, Q., Kandimalla, E.R. and Agrawal, S. (2000) Bioorg. Med. Chem. Lett. 10, 2585-2588
35. Kandimalla, E.R., Bhagat, L., Yu, D., Cong, Y.-P., Tang, J. and Agrawal, S. (2002) BioConjug. Chem. 13, 966-974
36. Yu, D., Kandimalla, E.R., Bhagat, L., Tang, J.Y., Cong, J.Y., Tang, J. and Agrawal, S. (2002) Nucleic Acids Res. 30, 4460-4469
37. Latz, E., Verma, A., Visintin, A., Gong, M., Sirois, C.M., Klein, D.C., Monks, B.G., McKnight, C.J., Lamphier, M.S., Duprex, W.P. et al. (2007) Nat. Immunol. 8, 772-779
38. Yu, D., Zhu, F.-G., Bhagat, L., Wang, H., Kandimalla, E.R., Zhang, R. and Agrawal, S. (2002) Biochem. Biophys. Res. Commun. 297, 83-90
39. Bhagat, L., Zhu, F.-G., Yu, D., Tang, J., Wang, H., Kandimalla, E.R., Zhang, R. and Agrawal, S. (2003) Biochem. Biophys. Res. Commun. 300, 853-861
40. Wang, D., Kandimalla, E.R., Yu, D., Tang, J.X. and Agrawal, S. (2005) Vaccine 23, 2614-2622
41. Zhu, F.-G., Kandimalla, E.R., Yu, D. and Agrawal, S. (2007) J. Allergy Clin. Immunol. 120, 631-637
42. Kandimalla, E.R., Yu, D., Zhao, Q. and Agrawal, S. (2001) Bioorg. Med. Chem. 9, 807-813
43. Kandimalla, E.R., Bhagat, L., Zhu, F.-G., Yu, D., Cong, Y.-P., Wang, D., Tang, J., Tang, J.Y., Knetter, C., Lien, E. and Agrawal, S. (2003) Proc. Nat., Acad. Sci. U.S.A. 100, 14303-14308
44. Putta, M.R., Zhu, F., Li, Y., Bhagat, L., Cong, Y., Kandimalla, E.R. and Agrawal, S. (2006) Nucleic Acids Res. 34, 3231-3238
45. Kandimalla, E.R., Bhagat, L., Wang, D., Yu, D., Zhu, F.-G., Tang, J., Wang, H., Huang, P., Zhang, R. and Agrawal, S. (2003) Nucleic Acids Res. 31, 2393-2400
46. Kandimalla, E.R., Bhagat, L., Li, Y., Yu, D., Wang, D., Cong, Y.P., Song, S.S., Tang, J.X., Sullivan, T. and Agrawal, S. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 6925-6930
47. Mbow, M.L. and Sarisky, R.T. (2005) Drug News Perspect. 18, 179-184
48. Daubenberger, C.A. (2007) Curr. Opin. Mol. Ther. 9, 45-52
49. Li, Y., Kandimalla, E.R., Yu, D. and Agrawal, S. (2005) Int. Immunopharmacol. 5, 981-991
50. Trabattoni, D., Clivio, A., Bray, D.H., Bhagat, L., Beltrami, S., Maffeis, G., Cesana, E., Lowry, P., Lissoni, F., Kandimall, E.R. et al. (2006) Vaccine 24, 1470-1477
51. Duez, C., Gosset, P. and Tonnel, A.B. (2006) Eur. J. Dermatol. 16, 12-16
52. Horner, A.A. (2006) Curr. Allergy Asthma Rep. 6, 395-401
53. Agrawal, D.K., Edwan, J., Kandimalla, E.R., Yu, D., Bhagat, L., Wang, D. and Agrawal, S. (2004) Int. Immunopharmacol. 4, 127-138
54. Zhu, F.-G., Kandimalla, E.R., Yu, Y., Tang, J.X. and Agrawal, S. (2004) Int. Immunopharmacol. 4, 851-862
55. Ebert, Jr, C.S., Rose, A.S., Patel, M.R., Hardy, S.M., Kandimalla, E.R., Agrawal, S., Prazma, J. and Pillsbury, III, H.C. (2006) Int. J. Pediatr. Otorhinolaryngol. 70, 2019-2026
56. Ebert, Jr, C.S., Rose, A.S., Blanks, D.A., Eapen, R.P., Kandimalla, E.R., Agrawal, S., Prazma, J. and Pillsbury, III, H.C. (2007) Otolaryngol. Head Neck Surg. 137, 250-255
57. Blanks, D.A., Ebert, Jr, C.S., Eapen, R.P., Zdanski, C., Kandimalla, E.R., Agrawal, S. and Prazma, J. (2007) Otolaryngol. Head Neck Surg. 137, 321-326
58. Wang, D., Li, Y., Yu, D., Song, S.S., Kandimalla, E.R. and Agrawal, S. (2004) Int. J. Oncol. 24, 901-908
59. Krieg, A.M. (2007) J. Clin. Invest. 117, 1184-1194
60. Damiano, V., Caputo, R., Bianco, R., D'Armiento, F.P., Leonardi, A., De Placido, S., Bianco, A.R., Agrawal, S., Ciardiello, F. and Tortora, G. (2006) Clin. Cancer Res. 12, 577-583
61. Damiano, V., Caputo, R., Garofalo, S., Bianco, R., Rosa, R., Merola, G., Gelardi, T., Racioppi, L., Fontanini, G., DePlacido, S. et al. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 12468-12473