메뉴 건너뛰기




Volumn 11, Issue 2, 2009, Pages 133-145

Therapeutic applications of nucleic acids as ligands for toll-like receptors

Author keywords

Adjuvant; Autoimmune disease; Cancer; Infectious disease; Nucleic acid; SiRNA; TLR

Indexed keywords

AGATOLIMOD; AMPLIGEN; AMPLIVAX; ANTHRAX VACCINE; ANTIALLERGIC AGENT; ANTIVIRUS AGENT; AVE 0675; BCG VACCINE; CANCER VACCINE; CARBOXYMETHYLCELLULOSE POLYCYTIDYLIC POLYINOSINIC ACID POLYLYSINE; CPG 10101; CPG 52364; CPG 9328; CYT 004; DV 1079; HEPATITIS B VACCINE; HSP E7; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; HYB 2125; IC 31; IMMUNOLOGICAL ADJUVANT; IMMUNOSTIMULATING AGENT; IMO 2055; IMO 2125; IMO 3100; INFLUENZA VACCINE; IR 103; ISS 1018; NUCLEIC ACID; PEGINTERFERON ALPHA; PF 676; QAX 935; RIBAVIRIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG; WART VIRUS VACCINE; YELLOW FEVER VACCINE; YF 17D;

EID: 63849285296     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (40)

References (96)
  • 1
    • 56549116047 scopus 로고    scopus 로고
    • Toll-like receptor and RIG-I-like receptor signaling
    • Kawai T, Akira S: Toll-like receptor and RIG-I-like receptor signaling. Ann NY Acad Sci (2008) 1143:1-20.
    • (2008) Ann NY Acad Sci , vol.1143 , pp. 1-20
    • Kawai, T.1    Akira, S.2
  • 2
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K: Toll-like receptor signalling. Nat Rev Immunol (2004) 4(7):499-511.
    • (2004) Nat Rev Immunol , vol.4 , Issue.7 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 3
    • 48749085127 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases
    • Gilliet M, Cao W, Liu YJ: Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases. Nat Rev Immunol (2008) 8(8):594-606.
    • (2008) Nat Rev Immunol , vol.8 , Issue.8 , pp. 594-606
    • Gilliet, M.1    Cao, W.2    Liu, Y.J.3
  • 5
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-αB by toll-like receptor 3
    • Alexopoulou L, Holt AC, Medzhitov R, Flavell RA: Recognition of double-stranded RNA and activation of NF-αB by toll-like receptor 3. Nature (2001) 413(6857):732-738.
    • (2001) Nature , vol.413 , Issue.6857 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 6
    • 1542317550 scopus 로고    scopus 로고
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C: Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 303(5663):1529-1531.
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C: Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 303(5663):1529-1531.
  • 10
    • 42349090335 scopus 로고    scopus 로고
    • Structural basis of toll-like receptor 3 signaling with double-stranded RNA
    • Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM, Davies DR: Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science (2008) 320(5874):379-381.
    • (2008) Science , vol.320 , Issue.5874 , pp. 379-381
    • Liu, L.1    Botos, I.2    Wang, Y.3    Leonard, J.N.4    Shiloach, J.5    Segal, D.M.6    Davies, D.R.7
  • 11
    • 46449095170 scopus 로고    scopus 로고
    • A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation
    • Pirher N, Ivicak K, Pohar J, Bencina M, Jerala R: A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation. Nat Struct Mol Biol (2008) 15(7):761-763.
    • (2008) Nat Struct Mol Biol , vol.15 , Issue.7 , pp. 761-763
    • Pirher, N.1    Ivicak, K.2    Pohar, J.3    Bencina, M.4    Jerala, R.5
  • 12
    • 56349114913 scopus 로고    scopus 로고
    • Proteolytic cleavage in an endolysosomal compartment is required for activation of toll-like receptor 9
    • Park B, Brinkmann MM, Spooner E, Lee CC, Kim YM, Ploegh HL: Proteolytic cleavage in an endolysosomal compartment is required for activation of toll-like receptor 9. Nat Immunol (2008) 9(12):1407-1414.
    • (2008) Nat Immunol , vol.9 , Issue.12 , pp. 1407-1414
    • Park, B.1    Brinkmann, M.M.2    Spooner, E.3    Lee, C.C.4    Kim, Y.M.5    Ploegh, H.L.6
  • 13
    • 40249088259 scopus 로고    scopus 로고
    • The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation
    • Haas T, Metzger J, Schmitz F, Heit A, Müller T, Latz E, Wagner H: The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation. Immunity (2008) 28(3):315-323.
    • (2008) Immunity , vol.28 , Issue.3 , pp. 315-323
    • Haas, T.1    Metzger, J.2    Schmitz, F.3    Heit, A.4    Müller, T.5    Latz, E.6    Wagner, H.7
  • 15
    • 0038639795 scopus 로고    scopus 로고
    • Systemic lupus erythematosus and the type I interferon system
    • R̈nnblom L, Alm GV: Systemic lupus erythematosus and the type I interferon system. Arthritis Res Ther (2003) 5(2):68-75.
    • (2003) Arthritis Res Ther , vol.5 , Issue.2 , pp. 68-75
    • R̈nnblom, L.1    Alm, G.V.2
  • 17
    • 33750369226 scopus 로고    scopus 로고
    • Toll-like receptors in systemic autoimmune disease
    • Marshak-Rothstein A: Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol (2006) 6(11):823-835.
    • (2006) Nat Rev Immunol , vol.6 , Issue.11 , pp. 823-835
    • Marshak-Rothstein, A.1
  • 22
    • 25444443335 scopus 로고    scopus 로고
    • RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via toll-like receptor 3
    • Brentano F, Schorr O, Gay RE, Gay S, Kyburz D: RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via toll-like receptor 3. Arthritis Rheum (2005) 52(9):2656-2665.
    • (2005) Arthritis Rheum , vol.52 , Issue.9 , pp. 2656-2665
    • Brentano, F.1    Schorr, O.2    Gay, R.E.3    Gay, S.4    Kyburz, D.5
  • 24
    • 26644447379 scopus 로고    scopus 로고
    • TLR agonists as vaccine adjuvants: Comparison of CpG ODN and Resiquimod (R-848)
    • Weeratna RD, Makinen SR, McCluskie MJ, Davis HL: TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848). Vaccine (2005) 23(45):5263-5270.
    • (2005) Vaccine , vol.23 , Issue.45 , pp. 5263-5270
    • Weeratna, R.D.1    Makinen, S.R.2    McCluskie, M.J.3    Davis, H.L.4
  • 25
    • 33748848754 scopus 로고    scopus 로고
    • On regulation of phagosome maturation and antigen presentation
    • Blander JM, Medzhitov R: On regulation of phagosome maturation and antigen presentation. Nat Immunol (2006) 7(10):1029-1035.
    • (2006) Nat Immunol , vol.7 , Issue.10 , pp. 1029-1035
    • Blander, J.M.1    Medzhitov, R.2
  • 26
    • 32944455665 scopus 로고    scopus 로고
    • Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity
    • Querec T, Bennouna S, Alkan S, Laouar Y, Gorden K, Flavell R, Akira S, Ahmed R, Pulendran B: Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J Exp Med (2006) 203(2):413-424.
    • (2006) J Exp Med , vol.203 , Issue.2 , pp. 413-424
    • Querec, T.1    Bennouna, S.2    Alkan, S.3    Laouar, Y.4    Gorden, K.5    Flavell, R.6    Akira, S.7    Ahmed, R.8    Pulendran, B.9
  • 27
    • 63849274799 scopus 로고    scopus 로고
    • Novartis' Agrippal plus IC-31 safe in phase I influenza trial
    • February 27
    • Intercell AG: Novartis' Agrippal plus IC-31 safe in phase I influenza trial. Press Release (2008): February 27.
    • (2008) Press Release
    • Intercell, A.G.1
  • 28
    • 63849203757 scopus 로고    scopus 로고
    • Modern vaccines/adjuvants formulation - second international conference (Part II), Dublin, Ireland
    • November 12-14
    • Hannaman D: Modern vaccines/adjuvants formulation - second international conference (Part II), Dublin, Ireland. IDDB Meeting Report (2007): November 12-14.
    • (2007) IDDB Meeting Report
    • Hannaman, D.1
  • 29
    • 46749144280 scopus 로고    scopus 로고
    • Hemispherx Biopharma Inc: Hemispherx Biopharma, Inc. completes enrollment in phase II study of Ampligen as seasonal flu vaccine enhancer, June 02
    • Hemispherx Biopharma Inc: Hemispherx Biopharma, Inc. completes enrollment in phase II study of Ampligen as seasonal flu vaccine enhancer. Press Release (2008): June 02.
    • (2008) Press Release
  • 30
    • 33947174540 scopus 로고    scopus 로고
    • Hemispherx Biopharma Inc: Esteve starts Spanish phase II Ampligen trial for HCV/HIV infection, :January 04
    • Hemispherx Biopharma Inc: Esteve starts Spanish phase II Ampligen trial for HCV/HIV infection. Press Release (2005):January 04.
    • (2005) Press Release
  • 31
    • 63849256893 scopus 로고    scopus 로고
    • TM) met its primary endpoint. Press Release (2008): August 05.
    • TM) met its primary endpoint. Press Release (2008): August 05.
  • 32
    • 63849185328 scopus 로고    scopus 로고
    • Dynavax Technologies Corp: Dynavax and Merck & Co., Inc. report clinical hold of investigational vaccine HEPLISAV. Press Release (2008): March 17.
    • Dynavax Technologies Corp: Dynavax and Merck & Co., Inc. report clinical hold of investigational vaccine HEPLISAV. Press Release (2008): March 17.
  • 33
    • 63849159559 scopus 로고    scopus 로고
    • TM hepatitis B vaccine. Press Release (2009): February 09.
    • TM hepatitis B vaccine. Press Release (2009): February 09.
  • 34
    • 33947174540 scopus 로고    scopus 로고
    • Orchestra Therapeutics Inc: Orchestra discontinues development of IR-103 and Remune HIV infection vaccines, July 18
    • Orchestra Therapeutics Inc: Orchestra discontinues development of IR-103 and Remune HIV infection vaccines. Press Release (2007): July 18.
    • (2007) Press Release
  • 35
    • 34249677845 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with toll-like receptor agonists and antagonists
    • Kanzler H, Barrat FJ, Hessel EM, Coffman RL: Therapeutic targeting of innate immunity with toll-like receptor agonists and antagonists. Nat Med (2007) 13(5):552-559.
    • (2007) Nat Med , vol.13 , Issue.5 , pp. 552-559
    • Kanzler, H.1    Barrat, F.J.2    Hessel, E.M.3    Coffman, R.L.4
  • 36
    • 19644362276 scopus 로고    scopus 로고
    • Tissue-specific mRNA expression profiles of human toll-like receptors and related genes
    • Nishimura M, Naito S: Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol Pharm Bull (2005) 28(5):886-892.
    • (2005) Biol Pharm Bull , vol.28 , Issue.5 , pp. 886-892
    • Nishimura, M.1    Naito, S.2
  • 37
    • 33845542139 scopus 로고    scopus 로고
    • Toll-like receptor agonists in in the treatment of chronic lymphocytic leukemia
    • Spaner DE, Masellis A: Toll-like receptor agonists in in the treatment of chronic lymphocytic leukemia. Leukemia (2007) 21(1):53-60.
    • (2007) Leukemia , vol.21 , Issue.1 , pp. 53-60
    • Spaner, D.E.1    Masellis, A.2
  • 42
    • 34547665101 scopus 로고    scopus 로고
    • Toll-like receptor 3 expressed by melanoma cells as a target for therapy?
    • Salaun B, Lebecque S, Matikainen S, Rimoldi D, Romero P: Toll-like receptor 3 expressed by melanoma cells as a target for therapy? Clin Cancer Res (2007) 13(15 Pt 1):4565-4574.
    • (2007) Clin Cancer Res , vol.13 , Issue.15 PART 1 , pp. 4565-4574
    • Salaun, B.1    Lebecque, S.2    Matikainen, S.3    Rimoldi, D.4    Romero, P.5
  • 43
    • 33645755382 scopus 로고    scopus 로고
    • TLR3 can directly trigger apoptosis in human cancer cells
    • Salaun B, Coste I, Rissoan MC, Lebecque SJ, Renno T: TLR3 can directly trigger apoptosis in human cancer cells. J Immunol (2006) 176(8):4894-4901.
    • (2006) J Immunol , vol.176 , Issue.8 , pp. 4894-4901
    • Salaun, B.1    Coste, I.2    Rissoan, M.C.3    Lebecque, S.J.4    Renno, T.5
  • 44
    • 19644362276 scopus 로고    scopus 로고
    • Tissue-specific mRNA expression profiles of human toll-like receptors and related genes
    • Nishimura M, Naito S: Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol Pharm Bull (2005) 28(5):886-892.
    • (2005) Biol Pharm Bull , vol.28 , Issue.5 , pp. 886-892
    • Nishimura, M.1    Naito, S.2
  • 47
    • 63849100567 scopus 로고    scopus 로고
    • Innate Pharma licenses TLR assets from Schering-Plough
    • Innate Pharma SAS:, June 19
    • Innate Pharma SAS: Innate Pharma licenses TLR assets from Schering-Plough. Press Release (2006): June 19.
    • (2006) Press Release
  • 48
    • 33947174540 scopus 로고    scopus 로고
    • Coley Pharmaceutical Group Inc: Pfizer abandons PF-3512676 development for NSCLC, June 20
    • Coley Pharmaceutical Group Inc: Pfizer abandons PF-3512676 development for NSCLC. Press Release (2007): June 20.
    • (2007) Press Release
  • 49
    • 63849099171 scopus 로고    scopus 로고
    • Manegold C, Thatcher N, Benner RJ, Readett D, van Zandwijk N: Randomized phase III trial of gemcitabine/cisplatin with or without PF-3512676 as first line treatment of advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol (2008) 26:Abs-8017.
    • Manegold C, Thatcher N, Benner RJ, Readett D, van Zandwijk N: Randomized phase III trial of gemcitabine/cisplatin with or without PF-3512676 as first line treatment of advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol (2008) 26:Abs-8017.
  • 50
    • 63849134231 scopus 로고    scopus 로고
    • American Society of Clinical Oncology - 41st Annual Meeting (Part III) - overnight report, Orlando, FL, USA
    • May 13-17
    • Shah S: American Society of Clinical Oncology - 41st Annual Meeting (Part III) - overnight report, Orlando, FL, USA. IDDB Meeting Report (2005): May 13-17.
    • (2005) IDDB Meeting Report
    • Shah, S.1
  • 51
    • 36348996017 scopus 로고    scopus 로고
    • Autologous tumor cell vaccination with PF-3512676 (CPG 7909) and GM-CSF followed by subcutaneous PF-3512676 and IFN-α for patients with metastatic renal cell carcinoma
    • Abs 2530
    • Van Den Eertwegh AJM: Autologous tumor cell vaccination with PF-3512676 (CPG 7909) and GM-CSF followed by subcutaneous PF-3512676 and IFN-α for patients with metastatic renal cell carcinoma. Proc Am Soc Clin Oncol (2006) 24(18 Suppl):Abs 2530.
    • (2006) Proc Am Soc Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Van Den Eertwegh, A.J.M.1
  • 52
    • 54049138316 scopus 로고    scopus 로고
    • A phase I trial of CpG-7909, rituximab immunotherapy, and Y90 zevalin radioimmunotherapy for patients (pts) with previously treated CD20+ non-Hodgkin lymphoma (NHL)
    • Abs
    • Witzig TE, Wiseman GA, Weiner G, Ansell SM: A phase I trial of CpG-7909, rituximab immunotherapy, and Y90 zevalin radioimmunotherapy for patients (pts) with previously treated CD20+ non-Hodgkin lymphoma (NHL). Am Soc Hematol Ann Meet Exposition (2007) 49:Abs 124.
    • (2007) Am Soc Hematol Ann Meet Exposition , vol.49 , pp. 124
    • Witzig, T.E.1    Wiseman, G.A.2    Weiner, G.3    Ansell, S.M.4
  • 53
    • 46749144280 scopus 로고    scopus 로고
    • Idera Pharmaceuticals Inc: Idera Pharma's IMO-2055 fails to meet primary endpoint in phase II renal carcinoma trial, October 01
    • Idera Pharmaceuticals Inc: Idera Pharma's IMO-2055 fails to meet primary endpoint in phase II renal carcinoma trial. Press Release (2008): October 01.
    • (2008) Press Release
  • 54
    • 63849330617 scopus 로고    scopus 로고
    • NV Organon: Drug development pipeline: Org-30659, Org-6370, Org-4428, rFSH, Organon, ganirelex, tibolone, mirtazapine, Trimiron, desogestrel, etonogestrel contraceptive implant, Organon, vaginal ring (contraceptive), Organon, Gracial, Org-33408, Org-32818, estradiol implant, Organon, dinoprostone, Organon, pipecuronium, BCG vaccine, Organon, danapariod sodium, SR-90107, rimexolone, Org-5222, Tri-Desogen, estradiol valerate, Orion, Org-12962, rapacuronium bromide. Company Communication (1996): October 10.
    • NV Organon: Drug development pipeline: Org-30659, Org-6370, Org-4428, rFSH, Organon, ganirelex, tibolone, mirtazapine, Trimiron, desogestrel, etonogestrel contraceptive implant, Organon, vaginal ring (contraceptive), Organon, Gracial, Org-33408, Org-32818, estradiol implant, Organon, dinoprostone, Organon, pipecuronium, BCG vaccine, Organon, danapariod sodium, SR-90107, rimexolone, Org-5222, Tri-Desogen, estradiol valerate, Orion, Org-12962, rapacuronium bromide. Company Communication (1996): October 10.
  • 55
    • 34447128388 scopus 로고    scopus 로고
    • Antiinfective applications of toll-like receptor 9 agonists
    • Krieg AM: Antiinfective applications of toll-like receptor 9 agonists. Proc Am Thorac Soc (2007) 4(3):289-294.
    • (2007) Proc Am Thorac Soc , vol.4 , Issue.3 , pp. 289-294
    • Krieg, A.M.1
  • 56
    • 18744399291 scopus 로고    scopus 로고
    • Toll-like receptor signaling inhibits hepatitis B virus replication in vivo
    • Isogawa M, Robek MD, Furuichi Y, Chisari FV: Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J Virol (2005) 79(11):7269-7272.
    • (2005) J Virol , vol.79 , Issue.11 , pp. 7269-7272
    • Isogawa, M.1    Robek, M.D.2    Furuichi, Y.3    Chisari, F.V.4
  • 57
    • 63849132870 scopus 로고    scopus 로고
    • Sullivan T, Bhagat L, Trombino A, Cabral D, Agrawal S: IMO-2125, a TLR9 agonist that induces high interferon-a production, as a candidate for hepatitis C therapy. ICAAC (2007) 47:Abs F1-308.
    • Sullivan T, Bhagat L, Trombino A, Cabral D, Agrawal S: IMO-2125, a TLR9 agonist that induces high interferon-a production, as a candidate for hepatitis C therapy. ICAAC (2007) 47:Abs F1-308.
  • 58
    • 33947174540 scopus 로고    scopus 로고
    • Coley Pharmaceutical Group Inc: Coley suspends Actilon HCV infection development, January 22
    • Coley Pharmaceutical Group Inc: Coley suspends Actilon HCV infection development. Press Release (2007): January 22.
    • (2007) Press Release
  • 59
    • 36749081174 scopus 로고    scopus 로고
    • Structural requirement for uptake and recognition of CpG
    • Heeg K, Dalpke A, Peter M, Zimmermann S: Structural requirement for uptake and recognition of CpG. Int J Med Micro (2008) 298(1-2):33-38.
    • (2008) Int J Med Micro , vol.298 , Issue.1-2 , pp. 33-38
    • Heeg, K.1    Dalpke, A.2    Peter, M.3    Zimmermann, S.4
  • 60
    • 37149024435 scopus 로고    scopus 로고
    • Characterization of suppressive oligodeoxynucleotides that inhibit toll-like receptor-9-mediated activation of innate immunity
    • Peter M, Bode K, Lipford GB, Eberle F, Heeg K, Dalpke AH: Characterization of suppressive oligodeoxynucleotides that inhibit toll-like receptor-9-mediated activation of innate immunity. Immunology (2008) 123(1):118-128.
    • (2008) Immunology , vol.123 , Issue.1 , pp. 118-128
    • Peter, M.1    Bode, K.2    Lipford, G.B.3    Eberle, F.4    Heeg, K.5    Dalpke, A.H.6
  • 61
    • 48849089879 scopus 로고    scopus 로고
    • Synthetic oligonucleotides as modulators of inflammation
    • Klinman D, Shirota H, Tross D, Sato T, Klaschik S: Synthetic oligonucleotides as modulators of inflammation. J Leukoc Biol (2008) 84(4):958-964.
    • (2008) J Leukoc Biol , vol.84 , Issue.4 , pp. 958-964
    • Klinman, D.1    Shirota, H.2    Tross, D.3    Sato, T.4    Klaschik, S.5
  • 62
    • 17644405409 scopus 로고    scopus 로고
    • Sequence requirements for oligodeoxyribonucleotide inhibitory activity
    • Ashman RF, Goeken JA, Drahos J, Lenert P: Sequence requirements for oligodeoxyribonucleotide inhibitory activity. Int Immunol (2005) 17(4):411-420.
    • (2005) Int Immunol , vol.17 , Issue.4 , pp. 411-420
    • Ashman, R.F.1    Goeken, J.A.2    Drahos, J.3    Lenert, P.4
  • 63
    • 0242288068 scopus 로고    scopus 로고
    • Structural characterization of the inhibitory DNA motif for the type A (D)-CpG-induced cytokine secretion and NK-cell lytic activity in mouse spleen cells
    • Lenert P, Rasmussen W, Ashman RF, Ballas ZK: Structural characterization of the inhibitory DNA motif for the type A (D)-CpG-induced cytokine secretion and NK-cell lytic activity in mouse spleen cells. DNA Cell Biol (2003) 22(10):621-631.
    • (2003) DNA Cell Biol , vol.22 , Issue.10 , pp. 621-631
    • Lenert, P.1    Rasmussen, W.2    Ashman, R.F.3    Ballas, Z.K.4
  • 66
    • 33144467291 scopus 로고    scopus 로고
    • Targeting toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus
    • Lenert PS: Targeting toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus. Arthritis Res Ther (2006) 8(1):203.
    • (2006) Arthritis Res Ther , vol.8 , Issue.1 , pp. 203
    • Lenert, P.S.1
  • 67
    • 17844383756 scopus 로고    scopus 로고
    • Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation
    • Duramad O, Fearon KL, Chang B, Chan JH, Gregorio J, Coffman RL, Barrat FJ: Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation. J Immunol (2005) 174(9):5193-5200.
    • (2005) J Immunol , vol.174 , Issue.9 , pp. 5193-5200
    • Duramad, O.1    Fearon, K.L.2    Chang, B.3    Chan, J.H.4    Gregorio, J.5    Coffman, R.L.6    Barrat, F.J.7
  • 68
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus
    • Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL: Nucleic acids of mammalian origin can act as endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus. J Exp Med (2005) 202(8):1131-1139.
    • (2005) J Exp Med , vol.202 , Issue.8 , pp. 1131-1139
    • Barrat, F.J.1    Meeker, T.2    Gregorio, J.3    Chan, J.H.4    Uematsu, S.5    Akira, S.6    Chang, B.7    Duramad, O.8    Coffman, R.L.9
  • 69
    • 47249092785 scopus 로고    scopus 로고
    • Development of TLR inhibitors for the treatment of autoimmune diseases
    • Barrat FJ, Coffman RL: Development of TLR inhibitors for the treatment of autoimmune diseases. Immunol Rev (2008) 223:271-283.
    • (2008) Immunol Rev , vol.223 , pp. 271-283
    • Barrat, F.J.1    Coffman, R.L.2
  • 70
    • 37549066665 scopus 로고    scopus 로고
    • Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms
    • Barrat FJ, Meeker T, Chan JH, Guiducci C, Coffman RL: Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. Eur J Immunol (2007) 37(12):3582-3586.
    • (2007) Eur J Immunol , vol.37 , Issue.12 , pp. 3582-3586
    • Barrat, F.J.1    Meeker, T.2    Chan, J.H.3    Guiducci, C.4    Coffman, R.L.5
  • 72
    • 33947174540 scopus 로고    scopus 로고
    • Coley Pharmaceutical Group Inc: Coley's CPG-52364 enters phase I trial for SLE, October 29
    • Coley Pharmaceutical Group Inc: Coley's CPG-52364 enters phase I trial for SLE. Press Release (2008): October 29.
    • (2008) Press Release
  • 73
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge AD, Sood V, Shaw JR, Fang D, McClintock K, MacLachlan I: Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol (2005) 23(4):457-462.
    • (2005) Nat Biotechnol , vol.23 , Issue.4 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 74
    • 48549105152 scopus 로고    scopus 로고
    • Modifications in small interfering RNA that separate immunostimulation from RNA interference
    • Eberle F, Giessler K, Deck C, Heeg K, Peter M, Richert C, Dalpke AH: Modifications in small interfering RNA that separate immunostimulation from RNA interference. J Immunol (2008) 180(5):3229-3237.
    • (2008) J Immunol , vol.180 , Issue.5 , pp. 3229-3237
    • Eberle, F.1    Giessler, K.2    Deck, C.3    Heeg, K.4    Peter, M.5    Richert, C.6    Dalpke, A.H.7
  • 75
    • 34547134721 scopus 로고    scopus 로고
    • Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs
    • Sioud M, Furset G, Cekaite L: Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs. Biochem Biophys Res Commun (2007) 361(1):122-126.
    • (2007) Biochem Biophys Res Commun , vol.361 , Issue.1 , pp. 122-126
    • Sioud, M.1    Furset, G.2    Cekaite, L.3
  • 76
    • 39449097277 scopus 로고    scopus 로고
    • Overcoming the innate immune response to small interfering RNA
    • Judge A, MacLachlan I: Overcoming the innate immune response to small interfering RNA. Hum Gene Ther (2008) 19(2):111-124.
    • (2008) Hum Gene Ther , vol.19 , Issue.2 , pp. 111-124
    • Judge, A.1    MacLachlan, I.2
  • 80
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
    • Kariḱ K, Buckstein M, Ni H, Weissman D: Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity (2005) 23(2):165-175.
    • (2005) Immunity , vol.23 , Issue.2 , pp. 165-175
    • Kariḱ, K.1    Buckstein, M.2    Ni, H.3    Weissman, D.4
  • 81
    • 37749044421 scopus 로고    scopus 로고
    • Synthetic agonists of toll-like receptors 7, 8 and 9
    • Agrawal S, Kandimalla ER: Synthetic agonists of toll-like receptors 7, 8 and 9. Biochem Soc Trans (2007) 35(Pt 6): 1461-1467.
    • (2007) Biochem Soc Trans , vol.35 , Issue.PART 6 , pp. 1461-1467
    • Agrawal, S.1    Kandimalla, E.R.2
  • 83
    • 63849119607 scopus 로고    scopus 로고
    • Statens Serum Institut: SSI and Aeras start phase I TB trial of HyVac4-IC-31. Press Release (2007): December 05.
    • Statens Serum Institut: SSI and Aeras start phase I TB trial of HyVac4-IC-31. Press Release (2007): December 05.
  • 84
    • 33947174540 scopus 로고    scopus 로고
    • Emergent Biosolutions Inc: Emergent BioSolutions gains rights to VaxImmuneTM from Coley Pharmaceutical Group to expand its anthrax franchise, March 15
    • TM from Coley Pharmaceutical Group to expand its anthrax franchise. Press Release (2007): March 15.
    • (2007) Press Release
  • 86
    • 33947174540 scopus 로고    scopus 로고
    • Orchestra Therapeutics Inc: Orchestra discontinues development of IR-103 and Remune HIV infection vaccines, July 18
    • Orchestra Therapeutics Inc: Orchestra discontinues development of IR-103 and Remune HIV infection vaccines. Press Release (2007): July 18.
    • (2007) Press Release
  • 87
    • 63849297854 scopus 로고    scopus 로고
    • Cytos Biotechnology AG: Cytos's CYT004-MelQbG10 induces immune response in phase IIa melanoma trials. Press Release (2007): November 21.
    • Cytos Biotechnology AG: Cytos's CYT004-MelQbG10 induces immune response in phase IIa melanoma trials. Press Release (2007): November 21.
  • 88
    • 33747342457 scopus 로고    scopus 로고
    • Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guerin by Flt3-ligand generated dendritic cells
    • von Meyenn F, Schaefer M, Weighardt H, Bauer S, Kirschning CJ, Wagner H, Sparwasser T: Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guerin by Flt3-ligand generated dendritic cells. Immunobiology (2006) 211(6-8):557-565.
    • (2006) Immunobiology , vol.211 , Issue.6-8 , pp. 557-565
    • von Meyenn, F.1    Schaefer, M.2    Weighardt, H.3    Bauer, S.4    Kirschning, C.J.5    Wagner, H.6    Sparwasser, T.7
  • 89
    • 63849217690 scopus 로고    scopus 로고
    • Rosenfeld MR, Chamberlain MC, Grossman SA, Peereboom DM, Lesser GJ, Batchelor TT, Desideri S, Salazar AM, Ye X: A phase II trial of radiation plus temozolomide followed by adjuvant temozolomide and poly-ICLC in patients with newly diagnosed glioblastoma multiforme (NABTT #0501). Proc Am Soc Clin Oncol (2008) 26:Abs-2055.
    • Rosenfeld MR, Chamberlain MC, Grossman SA, Peereboom DM, Lesser GJ, Batchelor TT, Desideri S, Salazar AM, Ye X: A phase II trial of radiation plus temozolomide followed by adjuvant temozolomide and poly-ICLC in patients with newly diagnosed glioblastoma multiforme (NABTT #0501). Proc Am Soc Clin Oncol (2008) 26:Abs-2055.
  • 91
    • 33947174540 scopus 로고    scopus 로고
    • Idera Pharmaceuticals Inc: Idera receives milestone from Novartis for phase I studies of QAX-935, September 02
    • Idera Pharmaceuticals Inc: Idera receives milestone from Novartis for phase I studies of QAX-935. Press Release (2008): September 02.
    • (2008) Press Release
  • 92
    • 63849299960 scopus 로고    scopus 로고
    • Cytos Biotechnology AG: CYT003-QbG10 monotherapy for the treatment of allergic diseases is safe and efficacious in placebo-controlled phase II study. Press Release (2008): July 09.
    • Cytos Biotechnology AG: CYT003-QbG10 monotherapy for the treatment of allergic diseases is safe and efficacious in placebo-controlled phase II study. Press Release (2008): July 09.
  • 93
    • 63849110771 scopus 로고    scopus 로고
    • Cytos Biotechnology AG: Cytos's dust mite vaccine shows long-term efficacy. Press Release (2006): April 26.
    • Cytos Biotechnology AG: Cytos's dust mite vaccine shows long-term efficacy. Press Release (2006): April 26.
  • 94
    • 63849271480 scopus 로고    scopus 로고
    • Cytos Biotechnology AG: Cytos Biotechnology presents analysis of patient diaries including six month follow-up data from phase II study with CYT003-QbG10 monotherapy for the treatment of allergic diseases. Press Release (2009): January 13.
    • Cytos Biotechnology AG: Cytos Biotechnology presents analysis of patient diaries including six month follow-up data from phase II study with CYT003-QbG10 monotherapy for the treatment of allergic diseases. Press Release (2009): January 13.
  • 95
    • 63849285966 scopus 로고    scopus 로고
    • Cytos Biotechnology AG: Cytos starts phase IIb trial of dust mite allergy vaccine. Press Release (2008): December 10.
    • Cytos Biotechnology AG: Cytos starts phase IIb trial of dust mite allergy vaccine. Press Release (2008): December 10.
  • 96
    • 33947174540 scopus 로고    scopus 로고
    • Idera Pharmaceuticals Inc: Idera's TLR-7 and TLR-9 antagonists effective in preclinical RA studies, July 17
    • Idera Pharmaceuticals Inc: Idera's TLR-7 and TLR-9 antagonists effective in preclinical RA studies. Press Release (2007): July 17.
    • (2007) Press Release


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.