메뉴 건너뛰기




Volumn 10, Issue 1, 2008, Pages 21-31

The future of toll-like receptor therapeutics

Author keywords

Allergy; Asthma; Cancer; Infectious disease; Therapy; TLR; Vaccine

Indexed keywords

6 [N (2 CHLORO 4 FLUOROPHENYL)SULFAMOYL] 1 CYCLOHEXENE 1 CARBOXYLIC ACID ETHYL ESTER; 852A; ADJUVANT; AIC; AMPLIGEN; ANA 975; AVE 0675; BCG VACCINE; CADI 05; CPG 10101; CPG 52364; CPG 7909; CPG 9328; CRX 675; ERITORAN; FLAGELLIN; HYB 2125; IC 31; IMIQUIMOD; IMO 2055; IMO 2125; IMOXINE; ISS 1018; LIPOPEPTIDE; OM 174; OM 174 DP; PF 35126; PF 676; PHOSPHORYL LIPID A; RC 529; RESATORVID; RESIQUIMOD; TOLAMBA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 38649123396     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (48)

References (130)
  • 1
    • 20444439979 scopus 로고    scopus 로고
    • Mechanisms of innate immune responses mediated by toll-like receptors
    • An excellent review of TLRs and their role in the innate immune system, ••
    • Yamamoto M, Akira S: Mechanisms of innate immune responses mediated by toll-like receptors. Clin Appl Immunol Rev (2005) 5:167-183. •• An excellent review of TLRs and their role in the innate immune system.
    • (2005) Clin Appl Immunol Rev , vol.5 , pp. 167-183
    • Yamamoto, M.1    Akira, S.2
  • 2
    • 16644366474 scopus 로고    scopus 로고
    • Toll-like receptors: Linking innate and adaptive immunity
    • Pasare C, Medzhitov R: Toll-like receptors: Linking innate and adaptive immunity. Microb Infect (2004) 6(14):1382-1387.
    • (2004) Microb Infect , vol.6 , Issue.14 , pp. 1382-1387
    • Pasare, C.1    Medzhitov, R.2
  • 3
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre B, Nicolas E, Michaut L, Reichhart J, Hoffmann J: The dorsoventral regulatory gene cassette spatzle/toll/cactus controls the potent antifungal response in Drosophila adults. Cell (1996) 86(6):973-983.
    • (1996) Cell , vol.86 , Issue.6 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.4    Hoffmann, J.5
  • 4
    • 20544474210 scopus 로고    scopus 로고
    • Pathogen recognition with toll-like receptors
    • Kawai T, Akira S: Pathogen recognition with toll-like receptors. Curr Opin Immunol (2005) 17(4):338-344.
    • (2005) Curr Opin Immunol , vol.17 , Issue.4 , pp. 338-344
    • Kawai, T.1    Akira, S.2
  • 5
    • 38649133261 scopus 로고    scopus 로고
    • 1st launch for 3M's genital warts cream. SCRIP World Pharmaceutical News (1997) 2232:18.
    • 1st launch for 3M's genital warts cream. SCRIP World Pharmaceutical News (1997) 2232:18.
  • 6
    • 38649132522 scopus 로고    scopus 로고
    • Mandal TK: American Academy of Dermatology - 57th Annual Meeting New Orleans, LA, USA. IDDB MEETING REPORT (1999): March 19-24.
    • Mandal TK: American Academy of Dermatology - 57th Annual Meeting New Orleans, LA, USA. IDDB MEETING REPORT (1999): March 19-24.
  • 7
    • 38649084642 scopus 로고    scopus 로고
    • Meda AB (publ): Year-end report for 2006
    • February 20
    • Meda AB: Meda AB (publ): Year-end report for 2006. Press Release (2007): February 20.
    • (2007) Press Release
    • Meda, A.B.1
  • 9
    • 17444378895 scopus 로고    scopus 로고
    • Treatment of lentigo melanoma (melanoma in situ) with the immune response modifier imiquimod
    • Wolf IH, Cerroni L, Kodama K, Kerl H: Treatment of lentigo melanoma (melanoma in situ) with the immune response modifier imiquimod. Arch Dermatol (2005) 141(4):510-514.
    • (2005) Arch Dermatol , vol.141 , Issue.4 , pp. 510-514
    • Wolf, I.H.1    Cerroni, L.2    Kodama, K.3    Kerl, H.4
  • 10
    • 18844457392 scopus 로고    scopus 로고
    • Ray CM, Kluk 10. M, Grin CM, Grant-Kels JM: Successful treatment of malignant melanoma in situ with topical 5% imiquimod cream. Int J Dermatol (2005) 44(5):428-434.
    • Ray CM, Kluk 10. M, Grin CM, Grant-Kels JM: Successful treatment of malignant melanoma in situ with topical 5% imiquimod cream. Int J Dermatol (2005) 44(5):428-434.
  • 11
    • 0027420347 scopus 로고    scopus 로고
    • Witt PL, Ritch PS, Reding D, McAuliffe TL, Westrick L, Grossberg 11. SE, Borden EC: Phase I trial of an oral immunomodulator and interferon inducer in cancer patients. Cancer Res (1993) 53(21):5176-5180.
    • Witt PL, Ritch PS, Reding D, McAuliffe TL, Westrick L, Grossberg 11. SE, Borden EC: Phase I trial of an oral immunomodulator and interferon inducer in cancer patients. Cancer Res (1993) 53(21):5176-5180.
  • 12
    • 0029824158 scopus 로고    scopus 로고
    • A phase I clinical trial of imiquimod, an oral interferon inducer, administered daily
    • Savage P, Horton V, Moore J, Owens M, Witt P, Gore ME: A phase I clinical trial of imiquimod, an oral interferon inducer, administered daily. Br J Cancer (1996) 74(9):1482-1486.
    • (1996) Br J Cancer , vol.74 , Issue.9 , pp. 1482-1486
    • Savage, P.1    Horton, V.2    Moore, J.3    Owens, M.4    Witt, P.5    Gore, M.E.6
  • 13
    • 0034903460 scopus 로고    scopus 로고
    • Imiquimodelicited emesis is mediated by the area postrema, but not by direct neuronal activation
    • Strominger NL, Brady R, Gullikson G, Carpenter DO: Imiquimodelicited emesis is mediated by the area postrema, but not by direct neuronal activation. Brain Res Bull (2001) 55(3):445-451.
    • (2001) Brain Res Bull , vol.55 , Issue.3 , pp. 445-451
    • Strominger, N.L.1    Brady, R.2    Gullikson, G.3    Carpenter, D.O.4
  • 14
    • 22944433876 scopus 로고    scopus 로고
    • Opinion: The success and failure of BCG - implications for a novel tuberculosis vaccine
    • Andersen P, Doherty T: Opinion: The success and failure of BCG - implications for a novel tuberculosis vaccine. Nature Rev Microbiol (2005) 3(8):656-662.
    • (2005) Nature Rev Microbiol , vol.3 , Issue.8 , pp. 656-662
    • Andersen, P.1    Doherty, T.2
  • 15
    • 0034443265 scopus 로고    scopus 로고
    • Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis Bacillus Calmette-Guérin: Involvement of toll-like receptors
    • This study demonstrated that BCG acts via TLR2 and TLR4, •
    • Tsuji S, Matsumoto M, Takeuchi O, Akira S, Azuma I, Hayashi A, Toyoshima K, Seya T: Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis Bacillus Calmette-Guérin: Involvement of toll-like receptors. Infect Immun (2000) 68(12):6883-6890. • This study demonstrated that BCG acts via TLR2 and TLR4.
    • (2000) Infect Immun , vol.68 , Issue.12 , pp. 6883-6890
    • Tsuji, S.1    Matsumoto, M.2    Takeuchi, O.3    Akira, S.4    Azuma, I.5    Hayashi, A.6    Toyoshima, K.7    Seya, T.8
  • 16
    • 33747342457 scopus 로고    scopus 로고
    • Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guérin by Flt3-ligand generated dendritic cells
    • von Meyenn F, Schaefer M, Weighardt H, Bauer S, Kirschning CJ, Wagner H, Sparwasser T: Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guérin by Flt3-ligand generated dendritic cells. Immunobiology (2006) 211(6-8):557- 565.
    • (2006) Immunobiology , vol.211 , Issue.6-8 , pp. 557-565
    • von Meyenn, F.1    Schaefer, M.2    Weighardt, H.3    Bauer, S.4    Kirschning, C.J.5    Wagner, H.6    Sparwasser, T.7
  • 17
    • 38649120020 scopus 로고    scopus 로고
    • NV Organon: Drug development pipeline: Org-30659, Org-6370, Org-4428, rFSH, Organon, ganirelex, tibolone, mirtazapine, Trimiron, desogestrel, etonogestrel contraceptive implant, Organon, vaginal ring (contraceptive), Organon, Gracial, Org-33408, Org-32818, estradiol implant, Organon, dinoprostone, Organon, pipecuronium, BCG vaccine, Organon, danapariod sodium, SR-90107, rimexolone, Org-5222, Tri-Desogen, estradiol valerate, Orion, Org-12962, rapacuronium bromide. Company Communication (1996): October 10.
    • NV Organon: Drug development pipeline: Org-30659, Org-6370, Org-4428, rFSH, Organon, ganirelex, tibolone, mirtazapine, Trimiron, desogestrel, etonogestrel contraceptive implant, Organon, vaginal ring (contraceptive), Organon, Gracial, Org-33408, Org-32818, estradiol implant, Organon, dinoprostone, Organon, pipecuronium, BCG vaccine, Organon, danapariod sodium, SR-90107, rimexolone, Org-5222, Tri-Desogen, estradiol valerate, Orion, Org-12962, rapacuronium bromide. Company Communication (1996): October 10.
  • 18
    • 38649117844 scopus 로고    scopus 로고
    • NCT00525408: A study of Mycobacterium w plus docetaxel for hormone refractory metastatic prostate cancer (HRPC). National Institutes of Health, Bethesda, MD, USA (2007). http://clinicaltrials.gov/ ct2/show/NCT00525408?term=NCT00525408 &rank=1
    • NCT00525408: A study of Mycobacterium w plus docetaxel for hormone refractory metastatic prostate cancer (HRPC). National Institutes of Health, Bethesda, MD, USA (2007). http://clinicaltrials.gov/ ct2/show/NCT00525408?term=NCT00525408 &rank=1
  • 19
    • 38649115945 scopus 로고    scopus 로고
    • Products in research & development, Geneva, Switzerland
    • Products in research & development. OM Pharma, Geneva, Switzerland (2007). http://www.ompharma.com/biotech-research/products- research.html
    • (2007) OM Pharma
  • 21
    • 2442561499 scopus 로고    scopus 로고
    • Pink JR, Kieny MP: 4th meeting on novel adjuvants currently in/ close to human clinical testing World Health Organization - organisation Mondiale de la Santé Fondation Mérieux, Annecy, France, 23-25, June 2003. Vaccine (2003) 22(17-18):2097-2102.
    • Pink JR, Kieny MP: 4th meeting on novel adjuvants currently in/ close to human clinical testing World Health Organization - organisation Mondiale de la Santé Fondation Mérieux, Annecy, France, 23-25, June 2003. Vaccine (2003) 22(17-18):2097-2102.
  • 24
    • 7444242674 scopus 로고    scopus 로고
    • Induction of systemic Th1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist
    • Krieg AM, Efler SM, Wittpoth M, Al Adhami MJ, Davis HL: Induction of systemic Th1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist. J Immunother (2004) 27(6):460-471.
    • (2004) J Immunother , vol.27 , Issue.6 , pp. 460-471
    • Krieg, A.M.1    Efler, S.M.2    Wittpoth, M.3    Al Adhami, M.J.4    Davis, H.L.5
  • 25
    • 33947174540 scopus 로고    scopus 로고
    • Pfizer Inc: Pfizer to acquire Coley Pharmaceutical Group, November 16
    • Pfizer Inc: Pfizer to acquire Coley Pharmaceutical Group. Press Release (2007): November 16.
    • (2007) Press Release
  • 26
    • 34248169629 scopus 로고    scopus 로고
    • Development of TLR9 agonists for cancer therapy
    • A comprehensive review on the use of TLR9 agonists for the treatment of cancer, •
    • Krieg AM: Development of TLR9 agonists for cancer therapy. J Clin Invest (2007) 117(5):1184-1194. • A comprehensive review on the use of TLR9 agonists for the treatment of cancer.
    • (2007) J Clin Invest , vol.117 , Issue.5 , pp. 1184-1194
    • Krieg, A.M.1
  • 28
    • 33947174540 scopus 로고    scopus 로고
    • Coley Pharmaceutical Group Inc: Coley Pharmaceutical Group announces Pfizer's discontinuation of clinical trials for PF-3512676 combined with cytotoxic chemotherapy in advanced non small cell lung cancer, June 20
    • Coley Pharmaceutical Group Inc: Coley Pharmaceutical Group announces Pfizer's discontinuation of clinical trials for PF-3512676 combined with cytotoxic chemotherapy in advanced non small cell lung cancer. Press Release (2007): June 20.
    • (2007) Press Release
  • 35
    • 38649140119 scopus 로고    scopus 로고
    • Friedberg JW, Kelly J, Kutok JL, Salloum R, Fisher DC, Ronan E, Dalton V, Rich L, Marquis D, Rothberg Liesveld J et al: Combination immunotherapy with a CpG oligonucleotide and rituximab (R) augments the immunological response and favorably alters the malignant microenvironment of follicular lymphoma (FL). Annual Meeting of the American Society of Hematology, Orlando, Fl, USA (2006) 48:891-II.
    • Friedberg JW, Kelly J, Kutok JL, Salloum R, Fisher DC, Ronan E, Dalton V, Rich L, Marquis D, Rothberg PG, Liesveld J et al: Combination immunotherapy with a CpG oligonucleotide and rituximab (R) augments the immunological response and favorably alters the malignant microenvironment of follicular lymphoma (FL). Annual Meeting of the American Society of Hematology, Orlando, Fl, USA (2006) 48:891-II.
  • 36
    • 38649096867 scopus 로고    scopus 로고
    • Dynavax Technologies Corp, Berkeley, CA, USA
    • Clinical development programs: Cancer. Dynavax Technologies Corp, Berkeley, CA, USA (2007). http://www.dynavax.com/cancer.htm
    • (2007) Clinical development programs: Cancer
  • 37
    • 18944366459 scopus 로고    scopus 로고
    • Hybridon Inc: Hybridon begins phase II trial of anticancer drug, October 26
    • Hybridon Inc: Hybridon begins phase II trial of anticancer drug. Press Release (2004): October 26.
    • (2004) Press Release
  • 38
    • 20444381342 scopus 로고    scopus 로고
    • Idera Pharmaceuticals Inc: Idera begins phase I/II cancer trial of TLR-9 agonist, October 26
    • Idera Pharmaceuticals Inc: Idera begins phase I/II cancer trial of TLR-9 agonist. Press Release (2005): October 26.
    • (2005) Press Release
  • 39
    • 38649120449 scopus 로고    scopus 로고
    • Initial phase 1 results of gemcitabine, carboplatin and IMO-2055, a toll like receptor 9 (TLR9) agonist, in patients (pts) with advanced solid tumors: P3-112
    • Shakun M, Hwang J, Cotarla I, Sullivan T, Karr R, Marshall J: Initial phase 1 results of gemcitabine, carboplatin and IMO-2055, a toll like receptor 9 (TLR9) agonist, in patients (pts) with advanced solid tumors: P3-112. J Thorac Oncol (2007) 2(8 Suppl 4):S726.
    • (2007) J Thorac Oncol , vol.2 , Issue.8 SUPPL. 4
    • Shakun, M.1    Hwang, J.2    Cotarla, I.3    Sullivan, T.4    Karr, R.5    Marshall, J.6
  • 40
    • 38649085904 scopus 로고    scopus 로고
    • Idera Pharmaceuticals Inc: Idera Pharmaceuticals reports financial results for the three months ended March 31, May 15
    • Idera Pharmaceuticals Inc: Idera Pharmaceuticals reports financial results for the three months ended March 31, 2007. Press Release (2007): May 15.
    • (2007) Press Release (2007)
  • 41
    • 38649125514 scopus 로고    scopus 로고
    • Idera Pharmaceuticals Inc, Cambridge, MA, USA
    • Pipeline: Oncology. Idera Pharmaceuticals Inc, Cambridge, MA, USA (2007). http://www.iderapharma.com/programs/oncology.php
    • (2007) Pipeline: Oncology
  • 42
    • 34447632621 scopus 로고    scopus 로고
    • Pharmacokinetics of 852A, an imidazoquinoline toll-like receptor 7-specific agonist, following intravenous, subcutaneous, and oral administrations in humans
    • Harrison LI, Astry C, Kumar S, Yunis C: Pharmacokinetics of 852A, an imidazoquinoline toll-like receptor 7-specific agonist, following intravenous, subcutaneous, and oral administrations in humans. J Clin Pharm (2007) 47(8):962-969.
    • (2007) J Clin Pharm , vol.47 , Issue.8 , pp. 962-969
    • Harrison, L.I.1    Astry, C.2    Kumar, S.3    Yunis, C.4
  • 43
    • 38649140423 scopus 로고    scopus 로고
    • platform through strategic acquisition of 3M company's TLR therapeutic research and development programs
    • Coley Pharmaceutical Group Inc: Coley Pharmaceutical Group broadens leading toll-like receptor TLR, June 11
    • Coley Pharmaceutical Group Inc: Coley Pharmaceutical Group broadens leading toll-like receptor (TLR) platform through strategic acquisition of 3M company's TLR therapeutic research and development programs. Press Release (2007): June 11.
    • (2007) Press Release
  • 46
    • 33947668943 scopus 로고    scopus 로고
    • Viral recognition by toll-like receptors
    • Barton GM: Viral recognition by toll-like receptors. Semin Immunol (2007) 19(1):33-40.
    • (2007) Semin Immunol , vol.19 , Issue.1 , pp. 33-40
    • Barton, G.M.1
  • 47
    • 38649135664 scopus 로고    scopus 로고
    • Pharmaceuticals: 3M initiates phase III trials for resiquimod
    • November 03
    • 3M Pharmaceuticals: 3M initiates phase III trials for resiquimod. Press Release (2000): November 03.
    • (2000) Press Release
  • 48
    • 38649140424 scopus 로고    scopus 로고
    • Eli Lilly & Co; 3M Pharmaceuticals: Preliminary data from recently completed clinical trials of resiquimod suggest dosing used in studies will not achieve adequate efficacy. Press Release (2003): February 24.
    • Eli Lilly & Co; 3M Pharmaceuticals: Preliminary data from recently completed clinical trials of resiquimod suggest dosing used in studies will not achieve adequate efficacy. Press Release (2003): February 24.
  • 49
    • 34347399259 scopus 로고    scopus 로고
    • Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies
    • Pockros PJ, Guyader D, Patton H, Tong MJ, Wright T, McHutchison JG, Meng T-M: Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies. J Hepatol (2007) 47(2):174-182.
    • (2007) J Hepatol , vol.47 , Issue.2 , pp. 174-182
    • Pockros, P.J.1    Guyader, D.2    Patton, H.3    Tong, M.J.4    Wright, T.5    McHutchison, J.G.6    Meng, T.-M.7
  • 52
    • 33947174540 scopus 로고    scopus 로고
    • Anadys Pharmaceuticals Inc: Anadys suspend ANA-975 dosing in phase I HCV trial, June 26
    • Anadys Pharmaceuticals Inc: Anadys suspend ANA-975 dosing in phase I HCV trial. Press Release (2006): June 26.
    • (2006) Press Release
  • 53
    • 38649088184 scopus 로고    scopus 로고
    • Development discontinued for ANA975, an early stage compound for treatment of hepatitis C virus infection
    • Anadys Pharmaceuticals Inc:, July 26
    • Anadys Pharmaceuticals Inc: Development discontinued for ANA975, an early stage compound for treatment of hepatitis C virus infection. Press Release (2007): July 26.
    • (2007) Press Release
  • 55
    • 33947174540 scopus 로고    scopus 로고
    • Coley Pharmaceutical Group Inc: Coley Pharmaceutical Group updates hepatitis C drug development strategy, January 22
    • Coley Pharmaceutical Group Inc: Coley Pharmaceutical Group updates hepatitis C drug development strategy. Press Release (2007): January 22.
    • (2007) Press Release
  • 56
    • 33947174540 scopus 로고    scopus 로고
    • Idera Pharmaceuticals Inc: Idera Pharmaceuticals presents preclinical data on IMO-2125 and other TLR9 agonists, September 17
    • Idera Pharmaceuticals Inc: Idera Pharmaceuticals presents preclinical data on IMO-2125 and other TLR9 agonists. Press Release (2007): September 17.
    • (2007) Press Release
  • 57
    • 34447128388 scopus 로고    scopus 로고
    • Antiinfective applications of toll-like receptor 9 agonists
    • Krieg AM: Antiinfective applications of toll-like receptor 9 agonists. Proc Am Thorac Soc (2007) 4(3):289-294.
    • (2007) Proc Am Thorac Soc , vol.4 , Issue.3 , pp. 289-294
    • Krieg, A.M.1
  • 60
    • 38649087596 scopus 로고    scopus 로고
    • Development programs:, Dynavax Technologies Corp
    • Development programs: Asthma/COPD. Dynavax Technologies Corp (2007). http://www.dynavax.com/asthmacopd.htm.
    • (2007) Asthma/COPD
  • 61
    • 38649099660 scopus 로고    scopus 로고
    • Coley Pharmaceutical Group Inc, Wellesley, MA, USA
    • Product pipeline: TLR therapeutics™ for asthma and allergy. Coley Pharmaceutical Group Inc, Wellesley, MA, USA (2007). http://www. coleypharma.com/product-pipeline/asthma-allergy.cfm
    • (2007) Product pipeline: TLR therapeutics™ for asthma and allergy
  • 63
    • 0036312668 scopus 로고    scopus 로고
    • Endotoxin can induce MyD88-deficient dendritic cells to support Th2 cell differentiation
    • Kaisho T, Hoshino K, Iwabe T, Takeuchi O, Yasui T, Akira S: Endotoxin can induce MyD88-deficient dendritic cells to support Th2 cell differentiation. Int Immunol (2002) 14(7):695-700.
    • (2002) Int Immunol , vol.14 , Issue.7 , pp. 695-700
    • Kaisho, T.1    Hoshino, K.2    Iwabe, T.3    Takeuchi, O.4    Yasui, T.5    Akira, S.6
  • 64
    • 33750141913 scopus 로고    scopus 로고
    • Safety of the intranasal toll-like receptor 4 agonist CRX-675 in allergic rhinitis
    • Casale TB, Kessler J, Romero FA: Safety of the intranasal toll-like receptor 4 agonist CRX-675 in allergic rhinitis. Ann Allergy Asthma Immunol (2006) 97(4):454-456.
    • (2006) Ann Allergy Asthma Immunol , vol.97 , Issue.4 , pp. 454-456
    • Casale, T.B.1    Kessler, J.2    Romero, F.A.3
  • 65
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki A, Medzhitov R: Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 5(10):987-995.
    • (2004) Nat Immunol , vol.5 , Issue.10 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 66
    • 0035134439 scopus 로고    scopus 로고
    • Type 1/type 2 immunity in infectious diseases
    • Spellberg B, Edwards JE Jr: Type 1/type 2 immunity in infectious diseases. Clin Infect Dis (2001) 32(1):76-102.
    • (2001) Clin Infect Dis , vol.32 , Issue.1 , pp. 76-102
    • Spellberg, B.1    Edwards Jr, J.E.2
  • 67
    • 33746096523 scopus 로고    scopus 로고
    • Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only
    • A clinical demonstration that the addition of TLR4 agonist improved the immune response to vaccine, •
    • Giannini SL, Hanon E, Moris P, Van Mechelen M, Morel S, Dessy F, Fourneau MA, Colau B, Suzich J, Losonksy G, Martin MT et al: Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only. Vaccine (2006) 24(33-34):5937-5949. • A clinical demonstration that the addition of TLR4 agonist improved the immune response to vaccine.
    • (2006) Vaccine , vol.24 , Issue.33-34 , pp. 5937-5949
    • Giannini, S.L.1    Hanon, E.2    Moris, P.3    Van Mechelen, M.4    Morel, S.5    Dessy, F.6    Fourneau, M.A.7    Colau, B.8    Suzich, J.9    Losonksy, G.10    Martin, M.T.11
  • 68
    • 38649132836 scopus 로고    scopus 로고
    • GSK's HBV vaccine receives European approval
    • Corixa Corp:, February 08
    • Corixa Corp: GSK's HBV vaccine receives European approval. Press Release (2005): February 08.
    • (2005) Press Release
  • 72
    • 38649119072 scopus 로고    scopus 로고
    • GlaxoSmithKline Biologicals and Aeras Global TB Vaccine Foundation partner to develop new TB vaccine
    • October 20
    • GlaxoSmithKline plc: GlaxoSmithKline Biologicals and Aeras Global TB Vaccine Foundation partner to develop new TB vaccine. Press Release (2005): October 20.
    • (2005) Press Release
    • GlaxoSmithKline plc1
  • 75
    • 0037435939 scopus 로고    scopus 로고
    • The adjuvant OM-174 induces both the migration and maturation of murine dendritic cells in vivo
    • Pajak B, Garze V, Davies G, Bauer J, Moser M, Chiavaroli C: The adjuvant OM-174 induces both the migration and maturation of murine dendritic cells in vivo. Vaccine (2003) 21(9-10):836-842.
    • (2003) Vaccine , vol.21 , Issue.9-10 , pp. 836-842
    • Pajak, B.1    Garze, V.2    Davies, G.3    Bauer, J.4    Moser, M.5    Chiavaroli, C.6
  • 76
    • 0037726802 scopus 로고    scopus 로고
    • OM-174, a new adjuvant with a potential for human use, induces a protective response when administered with the synthetic C-terminal fragment 242-310 from the circumsporozoite protein of Plasmodium berghei
    • Meraldi V, Audran R, Romero JF, Brossard V, Bauer J, López JA, Corradin G: OM-174, a new adjuvant with a potential for human use, induces a protective response when administered with the synthetic C-terminal fragment 242-310 from the circumsporozoite protein of Plasmodium berghei. Vaccine (2003) 21(19-20):2485-2491.
    • (2003) Vaccine , vol.21 , Issue.19-20 , pp. 2485-2491
    • Meraldi, V.1    Audran, R.2    Romero, J.F.3    Brossard, V.4    Bauer, J.5    López, J.A.6    Corradin, G.7
  • 78
    • 38649140628 scopus 로고    scopus 로고
    • National Institutes of Health, Bethesda, MD, USA
    • NCT00344539: AMA1-C1/Alhydrogel + CpG 7909 for malaria. National Institutes of Health, Bethesda, MD, USA (2007). http://clinicaltrials.gov/ ct2/show/NCT00344539?term=NCT00344539 &rank=1
    • (2007) NCT00344539: AMA1-C1/Alhydrogel + CpG 7909 for malaria
  • 79
    • 11344257404 scopus 로고    scopus 로고
    • CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase I/II study
    • A clinical demonstration that addition of a TLR9 agonist improved immunogenicity of the HBV vaccine, •
    • Cooper CL, Davis HL, Morris ML, Efler SM, Adhami MA, Krieg AM, Cameron DW, Heathcote J: CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase I/II study. J Clin Immunol (2004) 24(6):693-701. • A clinical demonstration that addition of a TLR9 agonist improved immunogenicity of the HBV vaccine.
    • (2004) J Clin Immunol , vol.24 , Issue.6 , pp. 693-701
    • Cooper, C.L.1    Davis, H.L.2    Morris, M.L.3    Efler, S.M.4    Adhami, M.A.5    Krieg, A.M.6    Cameron, D.W.7    Heathcote, J.8
  • 81
    • 28344457315 scopus 로고    scopus 로고
    • Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adults
    • Halperin SA, Dobson S, McNeil S, Langley JM, Smith B, McCall-Sani R, Levitt D, Nest GV, Gennevois D, Eiden JJ: Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adults. Vaccine (2006) 24(1):20-26.
    • (2006) Vaccine , vol.24 , Issue.1 , pp. 20-26
    • Halperin, S.A.1    Dobson, S.2    McNeil, S.3    Langley, J.M.4    Smith, B.5    McCall-Sani, R.6    Levitt, D.7    Nest, G.V.8    Gennevois, D.9    Eiden, J.J.10
  • 83
    • 33947174540 scopus 로고    scopus 로고
    • Orchestra Therapeutics Inc: Orchestra Therapeutics discontinues its HIV vaccine development program, July 17
    • Orchestra Therapeutics Inc: Orchestra Therapeutics discontinues its HIV vaccine development program. Press Release (2007): July 17.
    • (2007) Press Release
  • 84
    • 35348988624 scopus 로고    scopus 로고
    • IC31 and IC30, novel types of vaccine adjuvant based on peptide delivery systems
    • Lingnau K, Riedl K, von Gabain A: IC31 and IC30, novel types of vaccine adjuvant based on peptide delivery systems. Expert Rev Vaccines (2007) 6(5):741-746.
    • (2007) Expert Rev Vaccines , vol.6 , Issue.5 , pp. 741-746
    • Lingnau, K.1    Riedl, K.2    von Gabain, A.3
  • 88
    • 27244443079 scopus 로고    scopus 로고
    • HIV Gag protein conjugated to a tolllike receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates
    • Wille-Reece U, Flynn BJ, Loré K, Koup RA, Kedl RM, Mattapallil JJ, Weiss WR, Roederer M, Seder RA: HIV Gag protein conjugated to a tolllike receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates. Proc Natl Acad Sci USA (2005) 102(42):15190-15194.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.42 , pp. 15190-15194
    • Wille-Reece, U.1    Flynn, B.J.2    Loré, K.3    Koup, R.A.4    Kedl, R.M.5    Mattapallil, J.J.6    Weiss, W.R.7    Roederer, M.8    Seder, R.A.9
  • 89
    • 20444430129 scopus 로고    scopus 로고
    • Immunization with HIV-1 gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 gag-specific Th1 and CD8+ T cell responses
    • Wille-Reece U, Wu CY, Flynn BJ, Kedl RM, Seder RA: Immunization with HIV-1 gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 gag-specific Th1 and CD8+ T cell responses. J Immunol (2005) 174(12):7676-7683.
    • (2005) J Immunol , vol.174 , Issue.12 , pp. 7676-7683
    • Wille-Reece, U.1    Wu, C.Y.2    Flynn, B.J.3    Kedl, R.M.4    Seder, R.A.5
  • 92
    • 33947174540 scopus 로고    scopus 로고
    • VaxInnate Inc: VaxInnate initiates phase I clinical study of M2e universal influenza vaccine, September 25
    • VaxInnate Inc: VaxInnate initiates phase I clinical study of M2e universal influenza vaccine. Press Release (2007): September 25.
    • (2007) Press Release
  • 93
    • 17144383586 scopus 로고    scopus 로고
    • Novel conjugates of epitope fusion peptides with CpG-ODN display enhanced immunogenicity and HIV recognition
    • Daftarian P, Sharan R, Haq W, Ali S, Longmate J, Termini J, Diamond DJ: Novel conjugates of epitope fusion peptides with CpG-ODN display enhanced immunogenicity and HIV recognition. Vaccine (2005) 23(26):3453-3468.
    • (2005) Vaccine , vol.23 , Issue.26 , pp. 3453-3468
    • Daftarian, P.1    Sharan, R.2    Haq, W.3    Ali, S.4    Longmate, J.5    Termini, J.6    Diamond, D.J.7
  • 94
    • 0031569601 scopus 로고    scopus 로고
    • Contribution of CpG motifs to the immunogenicity of DNA vaccines
    • This study demonstrated that adding CpG motifs to DNA vaccines improved immunogenicity, ••
    • Klinman DM, Yamshchikov G, Ishigatsubo Y: Contribution of CpG motifs to the immunogenicity of DNA vaccines. J Immunol (1997) 158(8):3635-3639. •• This study demonstrated that adding CpG motifs to DNA vaccines improved immunogenicity.
    • (1997) J Immunol , vol.158 , Issue.8 , pp. 3635-3639
    • Klinman, D.M.1    Yamshchikov, G.2    Ishigatsubo, Y.3
  • 96
    • 33646884783 scopus 로고    scopus 로고
    • Intramuscular immunization with a DNA vaccine encoding a 26-amino acid CETP epitope displayed by HBc protein and containing CpG DNA inhibits atherosclerosis in a rabbit model of atherosclerosis
    • Mao D, Kai G, Gaofu Q, Zheng Z, Li Z, Jie W, Jingjing L, Rongyue C: Intramuscular immunization with a DNA vaccine encoding a 26-amino acid CETP epitope displayed by HBc protein and containing CpG DNA inhibits atherosclerosis in a rabbit model of atherosclerosis. Vaccine (2006) 24(23):4942-4950.
    • (2006) Vaccine , vol.24 , Issue.23 , pp. 4942-4950
    • Mao, D.1    Kai, G.2    Gaofu, Q.3    Zheng, Z.4    Li, Z.5    Jie, W.6    Jingjing, L.7    Rongyue, C.8
  • 97
    • 33846943992 scopus 로고    scopus 로고
    • Immunological analysis of a Lactobacillus lactis-based DNA vaccine expressing HIV gp120
    • Gram GJ, Fomsgaard A, Thorn M, Madsen SM, Glenting J: Immunological analysis of a Lactobacillus lactis-based DNA vaccine expressing HIV gp120. Genet Vaccines Ther (2007) 5:3.
    • (2007) Genet Vaccines Ther , vol.5 , pp. 3
    • Gram, G.J.1    Fomsgaard, A.2    Thorn, M.3    Madsen, S.M.4    Glenting, J.5
  • 99
    • 33745620179 scopus 로고    scopus 로고
    • Sepsis under siege: A new understanding of sepsis might lead to the development of therapies to treat septic shock
    • Hunter P: Sepsis under siege: A new understanding of sepsis might lead to the development of therapies to treat septic shock. EMBO Rep (2006) 7(7):667-669.
    • (2006) EMBO Rep , vol.7 , Issue.7 , pp. 667-669
    • Hunter, P.1
  • 100
    • 38649102112 scopus 로고    scopus 로고
    • Eritoran [E5564] reduces 28-day mortality in patients with severe sepsis
    • No author listed: Eritoran [E5564] reduces 28-day mortality in patients with severe sepsis. Inpharma Weekly (2005) 1503:8.
    • (2005) Inpharma Weekly , vol.1503 , pp. 8
  • 101
    • 20444381342 scopus 로고    scopus 로고
    • Takeda Pharmaceutical Co Ltd: Takeda's investigational compound (TAK-242) for severe sepsis designated as fast track drugs from the U.S. FDA, July 27
    • Takeda Pharmaceutical Co Ltd: Takeda's investigational compound (TAK-242) for severe sepsis designated as fast track drugs from the U.S. FDA. Press Release (2005): July 27.
    • (2005) Press Release
  • 103
    • 0033038486 scopus 로고    scopus 로고
    • Intraarticularly localized bacterial DNA containing CpG motifs induces arthritis
    • Deng GM, Nilsson IM, Verdrengh M, Collins LV, Tarkowski A: Intraarticularly localized bacterial DNA containing CpG motifs induces arthritis. Nat Med (1999) 5(6):702-705.
    • (1999) Nat Med , vol.5 , Issue.6 , pp. 702-705
    • Deng, G.M.1    Nilsson, I.M.2    Verdrengh, M.3    Collins, L.V.4    Tarkowski, A.5
  • 106
    • 33750369226 scopus 로고    scopus 로고
    • Toll-like receptors in systemic autoimmune disease
    • Marshak-Rothstein A: Toll-like receptors in systemic autoimmune disease. Nat Rev Immuol (2006) 6(11):823-835.
    • (2006) Nat Rev Immuol , vol.6 , Issue.11 , pp. 823-835
    • Marshak-Rothstein, A.1
  • 107
    • 4644330955 scopus 로고    scopus 로고
    • Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner
    • Rutz M, Metzger J, Gellert T, Luppa P, Lipford GB, Wagner H, Bauer S: Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur J Immunol (2004) 34(9):2541-2550.
    • (2004) Eur J Immunol , vol.34 , Issue.9 , pp. 2541-2550
    • Rutz, M.1    Metzger, J.2    Gellert, T.3    Luppa, P.4    Lipford, G.B.5    Wagner, H.6    Bauer, S.7
  • 108
    • 33748414196 scopus 로고    scopus 로고
    • Mode of action of hydroxychloroquine in RA - evidence of an inhibitory effect on toll-like receptor signaling
    • Kyburz D, Brentano F, Gay S: Mode of action of hydroxychloroquine in RA - evidence of an inhibitory effect on toll-like receptor signaling. Nat Clin Pract Rheumatol (2006) 2(9):458-459.
    • (2006) Nat Clin Pract Rheumatol , vol.2 , Issue.9 , pp. 458-459
    • Kyburz, D.1    Brentano, F.2    Gay, S.3
  • 110
    • 38649090636 scopus 로고    scopus 로고
    • Idera Pharmaceuticals Inc, Cambridge, MA, USA
    • Pipeline: Autoimmune diseases. Idera Pharmaceuticals Inc, Cambridge, MA, USA (2007). http://www.iderapharma.com/programs/autoimmune. php
    • (2007) Pipeline: Autoimmune diseases
  • 111
    • 17044385039 scopus 로고    scopus 로고
    • TLR signalling in the gut in health and disease
    • Abreu MT, Fukata M, Arditi M: TLR signalling in the gut in health and disease. J Immunol (2005) 174(8):4453-4460.
    • (2005) J Immunol , vol.174 , Issue.8 , pp. 4453-4460
    • Abreu, M.T.1    Fukata, M.2    Arditi, M.3
  • 112
    • 33846207958 scopus 로고    scopus 로고
    • MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists
    • Bagchi A, Herrup EA, Warren HS, Trigilio J, Shin HS, Valentine C, Hellman J: MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. J Immunol (2007) 178(2):1164- 1171.
    • (2007) J Immunol , vol.178 , Issue.2 , pp. 1164-1171
    • Bagchi, A.1    Herrup, E.A.2    Warren, H.S.3    Trigilio, J.4    Shin, H.S.5    Valentine, C.6    Hellman, J.7
  • 114
    • 33750823681 scopus 로고    scopus 로고
    • Activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides
    • Gorden KK, Qiu XX, Binsfeld CC, Vasilakos JP, Alkan SS: Activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides. J Immunol (2006) 177(10):6584- 6587.
    • (2006) J Immunol , vol.177 , Issue.10 , pp. 6584-6587
    • Gorden, K.K.1    Qiu, X.X.2    Binsfeld, C.C.3    Vasilakos, J.P.4    Alkan, S.S.5
  • 115
    • 0035218374 scopus 로고    scopus 로고
    • CpG DNA functions as an effective adjuvant for the induction of immune responses in aged mice
    • This study demonstrated that CpG DNA improved vaccine efficacy in the elderly population, ••
    • Manning BM, Enioutina EY, Visic DM, Knudson AD, Daynes RA: CpG DNA functions as an effective adjuvant for the induction of immune responses in aged mice. Exp Gerontol (2001) 37(1): 107-126. •• This study demonstrated that CpG DNA improved vaccine efficacy in the elderly population.
    • (2001) Exp Gerontol , vol.37 , Issue.1 , pp. 107-126
    • Manning, B.M.1    Enioutina, E.Y.2    Visic, D.M.3    Knudson, A.D.4    Daynes, R.A.5
  • 116
    • 0036746072 scopus 로고    scopus 로고
    • CpG-DNA stimulates cellular and humoral immunity and promotes Th1 differentiation in aged BALB/c mice
    • Maletto B, Rópolo A, Morón V, Pistoresi-Palencia MC: CpG-DNA stimulates cellular and humoral immunity and promotes Th1 differentiation in aged BALB/c mice. J Leukoc Biol (2002) 72(3):447-454.
    • (2002) J Leukoc Biol , vol.72 , Issue.3 , pp. 447-454
    • Maletto, B.1    Rópolo, A.2    Morón, V.3    Pistoresi-Palencia, M.C.4
  • 117
    • 20044379241 scopus 로고    scopus 로고
    • Orally administered OVA/CpG-ODN induces specific mucosal and systemic immune response in young and aged mice
    • Alignani D, Maletto B, Liscovsky M, Rópolo A, Morón G, Pistoresi-Palencia MC: Orally administered OVA/CpG-ODN induces specific mucosal and systemic immune response in young and aged mice. J Leukocyte Biol (2005) 77(6):898-905.
    • (2005) J Leukocyte Biol , vol.77 , Issue.6 , pp. 898-905
    • Alignani, D.1    Maletto, B.2    Liscovsky, M.3    Rópolo, A.4    Morón, G.5    Pistoresi-Palencia, M.C.6
  • 118
    • 33645530404 scopus 로고    scopus 로고
    • Immunization of aged mice with a Pneumococcal conjugate vaccine combined with an unmethylated CpG-containing oligodeoxynucleotide restores defective immunoglobulin G antipolysaccharide responses and specific CD4+-T-cell priming to young adult levels
    • Sen G, Chen Q, Snapper CM: Immunization of aged mice with a Pneumococcal conjugate vaccine combined with an unmethylated CpG-containing oligodeoxynucleotide restores defective immunoglobulin G antipolysaccharide responses and specific CD4+-T-cell priming to young adult levels. Infect Immun (2006) 74(4):2177-2186.
    • (2006) Infect Immun , vol.74 , Issue.4 , pp. 2177-2186
    • Sen, G.1    Chen, Q.2    Snapper, C.M.3
  • 119
    • 0030613651 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
    • Chu RS, Targoni OS, Krieg AM, Lehmann PV, Harding CV: CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med (1997) 186(10):1623-1631.
    • (1997) J Exp Med , vol.186 , Issue.10 , pp. 1623-1631
    • Chu, R.S.1    Targoni, O.S.2    Krieg, A.M.3    Lehmann, P.V.4    Harding, C.V.5
  • 120
    • 0004582004 scopus 로고    scopus 로고
    • CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice
    • This study demonstrated that CpG DNA improved vaccine efficacy in neonates, ••
    • Brazolot Millan CL, Weeratna R, Krieg AM, Siegrist CA, Davis HL: CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice. Proc Natl Acad Sci USA (1998) 95(26):15553-15558. •• This study demonstrated that CpG DNA improved vaccine efficacy in neonates.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.26 , pp. 15553-15558
    • Brazolot Millan, C.L.1    Weeratna, R.2    Krieg, A.M.3    Siegrist, C.A.4    Davis, H.L.5
  • 121
    • 0033082499 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming
    • Kovarik J, Bozzotti P, Love-Homan L, Pihlgren M, Davis HL, Lambert PH, Krieg AM, Siegrist CA: CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming. J Immunol (1999) 162(3)1611-1617.
    • (1999) J Immunol , vol.162 , Issue.3 , pp. 1611-1617
    • Kovarik, J.1    Bozzotti, P.2    Love-Homan, L.3    Pihlgren, M.4    Davis, H.L.5    Lambert, P.H.6    Krieg, A.M.7    Siegrist, C.A.8
  • 122
    • 25844484501 scopus 로고    scopus 로고
    • CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV infected adults
    • Cooper CL, Davis HL, Angel JB, Morris ML, Elfer SM, Seguin I, Krieg AM, Cameron DW: CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV infected adults. AIDS (2005) 19(14):1473-1479.
    • (2005) AIDS , vol.19 , Issue.14 , pp. 1473-1479
    • Cooper, C.L.1    Davis, H.L.2    Angel, J.B.3    Morris, M.L.4    Elfer, S.M.5    Seguin, I.6    Krieg, A.M.7    Cameron, D.W.8
  • 123
    • 35748944306 scopus 로고    scopus 로고
    • McCluskie MJ, Weeratna RD: CpG oligodeoxynucleotides as vaccine adjuvants. In: Immunopotentiators in Modern Vaccines. Schijns V, O'Hagan D (Eds), Elsevier Academic Press, San Diego, CA, USA (2006):73-92. • A comprehensive review of the use of CpGs in vaccines.
    • McCluskie MJ, Weeratna RD: CpG oligodeoxynucleotides as vaccine adjuvants. In: Immunopotentiators in Modern Vaccines. Schijns V, O'Hagan D (Eds), Elsevier Academic Press, San Diego, CA, USA (2006):73-92. • A comprehensive review of the use of CpGs in vaccines.
  • 124
    • 2442655250 scopus 로고    scopus 로고
    • Persistent toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance
    • Yang Y, Huang CT, Huang X, Pardoll DM: Persistent toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat Immunol (2004) 5(5):508-515.
    • (2004) Nat Immunol , vol.5 , Issue.5 , pp. 508-515
    • Yang, Y.1    Huang, C.T.2    Huang, X.3    Pardoll, D.M.4
  • 126
    • 34547533793 scopus 로고    scopus 로고
    • Additive effects of CpG ODN and R-848 as adjuvants on augmenting immune responses to HbsAg vaccination
    • Ma R, Du JL, Huang J, Wu CY: Additive effects of CpG ODN and R-848 as adjuvants on augmenting immune responses to HbsAg vaccination. Biochem Biophys Res Comm (2007) 361(2):537-542.
    • (2007) Biochem Biophys Res Comm , vol.361 , Issue.2 , pp. 537-542
    • Ma, R.1    Du, J.L.2    Huang, J.3    Wu, C.Y.4
  • 127
    • 38649119401 scopus 로고    scopus 로고
    • Pharmaceuticals: 3M to partner with Vanguard Medica in evaluating potential treatment of hepatitis C
    • December 11
    • 3M Pharmaceuticals: 3M to partner with Vanguard Medica in evaluating potential treatment of hepatitis C. Press Release (1998): December 11.
    • (1998) Press Release
  • 128
    • 38649116876 scopus 로고    scopus 로고
    • NCT00537355: An evaluation of the efficacy and safety of Tolamba for ragweed-allergic rhinitis in an environmental exposure chamber. National Institutes of Health, Bethesda, MD, USA (2007). http://clinicaltrials.gov/ ct2/show/NCT00537355?term=NCT00537355 &rank=1
    • NCT00537355: An evaluation of the efficacy and safety of Tolamba for ragweed-allergic rhinitis in an environmental exposure chamber. National Institutes of Health, Bethesda, MD, USA (2007). http://clinicaltrials.gov/ ct2/show/NCT00537355?term=NCT00537355 &rank=1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.