Identification of novel synthetic toll-like receptor 2 agonists by high throughput screening

Journal of Biological Chemistry

Volumn 285, Issue 31, 2010, Pages 23755-23762

  Guan, Yue ^a   Omueti Ayoade, Katherine ^a   Mutha, Sarita K ^a   Hergenrother, Paul J ^a   Tapping, Richard I ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNE RESPONSE; CORECEPTORS; CYTOKINE PRODUCTION; EXTRACELLULAR REGION; HIGH THROUGHPUT; HIGH THROUGHPUT SCREENING; HOST DEFENSE; HOST TISSUES; HUMAN PERIPHERAL BLOOD; HUMAN RECEPTORS; IMMUNOTHERAPEUTICS; IN-CELL; MICROBIAL PRODUCTS; MURINE PERITONEAL MACROPHAGES; MUTATIONAL ANALYSIS; NANOMOLAR RANGE; POTENT COMPOUNDS; SMALL MOLECULES; STRUCTURAL BASIS; SYNERGISTIC ACTIVITY; SYNTHETIC CHEMICALS; SYNTHETIC COMPOUNDS; THERAPEUTIC BENEFITS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTORS;

INTERFERONS; THROUGHPUT;

CHEMICAL COMPOUNDS;

TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 2 AGONIST; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DETERMINATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN STRUCTURE; SPECIES DIFFERENCE;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER SIMULATION; CYTOKINES; DNA MUTATIONAL ANALYSIS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; IMMUNOTHERAPY; INTERLEUKIN-8; MACROPHAGES; MICE; MONOCYTES; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 2;

MURINAE;

EID: 77954904799     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.116046     Document Type: Article

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