Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations

Diabetes

Volumn 58, Issue 6, 2009, Pages 1419-1427

  Sayed, Samir ^a   Langdon, David R ^a   Odili, Stella ^b   Chen, Pan ^a   Buettger, Carol ^b   Schiffman, Alisa B ^a   Suchi, Mariko ^c,d   Taub, Rebecca ^e   Grimsby, Joseph ^e   Matschinsky, Franz M ^b   Stanley, Charles A ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d CHILDREN S HOSPITAL OF WISCONSIN   (United States)

^e Hoffman La Roche Department of Metabolic Diseases   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIAZOXIDE; ENZYME ACTIVATOR; GLUCOKINASE; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; MUTANT PROTEIN; RO 0281675; UNCLASSIFIED DRUG;

ADOLESCENT; ALLOSTERISM; ARTICLE; CASE REPORT; CHILD; CLINICAL FEATURE; DRUG MEGADOSE; ENZYME ACTIVITY; ENZYME STABILITY; GENE MUTATION; HUMAN; HYPERINSULINISM; MALE; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL;

ADOLESCENT; AMINO ACID SUBSTITUTION; BIRTH WEIGHT; BLOOD GLUCOSE; CHILD; CIRCADIAN RHYTHM; DIAZOXIDE; DNA TRANSPOSABLE ELEMENTS; GLUCOKINASE; HUMANS; HYPERINSULINISM; INSULIN; KINETICS; MALE; MUTATION; PHENOTYPE; RECOMBINANT PROTEINS;

EID: 66649108506     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-1792     Document Type: Article

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