Translating TCF7L2: From gene to function

Diabetologia

Volumn 52, Issue 7, 2009, Pages 1227-1230

  Pearson, E R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Genetics; Glucagon; Hepatic glucose production; Incretin hormones; Insulin secretion; TCF7L2; Type 2 diabetes

Indexed keywords

INCRETIN; INSULIN; TRANSCRIPTION FACTOR 7 LIKE 2;

GENE; GENE FUNCTION; GENETIC LINKAGE; GENETIC POLYMORPHISM; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; NOTE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TCF7L2 GENE;

DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TCF TRANSCRIPTION FACTORS;

EID: 67349270566     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1356-1     Document Type: Note

References (21)

1. D Altshuler JN Hirschhorn M Klannemark 2000 The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes Nat Genet 26 76 80
2. ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes Diabetes 52 568 572 (Pubitemid 36173218)
3. TM Frayling 2007 Genome-wide association studies provide new insights into type 2 diabetes aetiology Nat Rev 8 657 662 (Pubitemid 47281993)
4. E Zeggini LJ Scott R Saxena 2008 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes Nat Genet 40 638 645
5. SF Grant G Thorleifsson I Reynisdottir 2006 Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nat Genet 38 320 323 (Pubitemid 43315754)
6. F Yi PL Brubaker T Jin 2005 TCF-4 mediates cell type-specific regulation of proglucagon gene expression by β-catenin and glycogen synthase kinase-3β J Biol Chem 280 1457 1464
7. JC Florez KA Jablonski N Bayley 2006 TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program N Engl J Med 355 241 250 (Pubitemid 44079339)
8. R Saxena L Gianniny NP Burtt 2006 Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals Diabetes 55 2890 2895 (Pubitemid 44923692)
9. K Pilgaard CB Jensen JH Schou 2009 The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men Diabetologia 10.1007/s00125-009-1307-x
10. V Lyssenko R Lupi P Marchetti 2007 Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes J Clin Invest 117 2155 2163 (Pubitemid 47219560)
11. SA Schäfer O Tschritter F Machicao 2007 Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms Diabetologia 50 2443 2450 (Pubitemid 350060632)
12. L Shu NS Sauter FT Schulthess AV Matveyenko J Oberholzer K Maedler 2008 Transcription factor 7-like 2 regulates β-cell survival and function in human pancreatic islets Diabetes 57 645 653
13. G da Silva Xavier MK Loder A McDonald 2009 TCF7L2 regulates late events in insulin secretion from pancreatic islet β-cells Diabetes 10.2337/db08-1187
14. R Sladek G Rocheleau J Rung 2007 A genome-wide association study identifies novel risk loci for type 2 diabetes Nature 445 881 885 (Pubitemid 46309843)
15. SH Lee C Demeterco I Geron A Abrahamsson F Levine P Itkin-Ansari 2008 Islet specific Wnt activation in human type II diabetes Exp Diabetes Res 2008 728763
16. ND Palmer AB Lehtinen CD Langefeld 2008 Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans J Clin Endocrinol Metab 93 304 309
17. RJ Loos PW Franks RW Francis 2007 TCF7L2 polymorphisms modulate proinsulin levels and β-cell function in a British Europid population Diabetes 56 1943 1947 (Pubitemid 47025464)
18. RL Prigeon S Quddusi B Paty DA D'Alessio 2003 Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effect Am J Physiol Endocrinol Metab 285 E701 E707
19. D Dardevet MC Moore CA DiCostanzo 2005 Insulin secretion-independent effects of GLP-1 on canine liver glucose metabolism do not involve portal vein GLP-1 receptors Am J Physiol 289 G806 G814
20. S Cauchi D Meyre C Dina 2006 Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes Diabetes 55 2903 2908 (Pubitemid 44923694)
21. A Brackenridge ER Pearson F Shojaee-Moradie AT Hattersley D Russell-Jones AM Umpleby 2006 Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1β and -1α mutations Diabetes 55 405 411 (Pubitemid 43343270)