Combining information from common type 2 diabetes risk polymorphisms improves disease prediction

PLoS Medicine

Volumn 3, Issue 10, 2006, Pages 1877-1882

  Weedon, Michael N ^a   McCarthy, Mark I ^b   Hitman, Graham ^c   Walker, Mark ^d   Groves, Christopher J ^b   Zeggini, Eleftheria ^b   Rayner, N William ^b   Shields, Beverley ^a   Owen, Katharine R ^a   Hattersley, Andrew T ^a   Frayling, Timothy M ^a  

^a PENINSULA MEDICAL SCHOOL   (United Kingdom)

^b CHURCHILL HOSPITAL   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LYSINE; PROLINE; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; T CELL FACTOR PROTEIN; TCF7L2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR 7 LIKE 2;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; POPULATION BASED CASE CONTROL STUDY; PREDICTION; RISK FACTOR; UNITED KINGDOM; CASE CONTROL STUDY; CAUCASIAN; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MIDDLE AGED; PREDICTIVE VALUE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL; STATISTICS;

ADULT; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GREAT BRITAIN; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PPAR GAMMA; PREDICTIVE VALUE OF TESTS; RISK FACTORS; TCF TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN;

EID: 33750876203     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.0030374     Document Type: Article

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