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Volumn 52, Issue 6, 2009, Pages 1003-1012

The beta cell lesion in type 2 diabetes: There has to be a primary functional abnormality

Author keywords

Amyloid; Animal models; Beta cell function; Beta cell mass; Beta cell volume; Genes; Glucagon; Insulin secretion; Islets; Pancreatectomy

Indexed keywords

AMYLOID; C PEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE;

EID: 67349228410     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1321-z     Document Type: Review
Times cited : (233)

References (62)
  • 1
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • GM Reaven 1988 Role of insulin resistance in human disease Diabetes 37 1595 1607 (Pubitemid 19004941)
    • (1988) Diabetes , vol.37 , Issue.12 , pp. 1595-1607
    • Reaven, G.M.1
  • 2
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • SE Kahn 2003 The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes Diabetologia 46 3 19 (Pubitemid 36237741)
    • (2003) Diabetologia , vol.46 , Issue.1 , pp. 3-19
    • Kahn, S.E.1
  • 3
    • 85025386842 scopus 로고
    • The relation of diabetes mellitus to lesions of the pancreas. Hyaline degeneration of the islets of Langerhans
    • E Opie 1901 The relation of diabetes mellitus to lesions of the pancreas. Hyaline degeneration of the islets of Langerhans J Exp Med 5 527 540
    • (1901) J Exp Med , vol.5 , pp. 527-540
    • Opie, E.1
  • 4
    • 0001210612 scopus 로고
    • Quantitative estimation of the pancreatic islet tissue in diabetic subjects
    • N Maclean RF Ogilvie 1955 Quantitative estimation of the pancreatic islet tissue in diabetic subjects Diabetes 4 367 376
    • (1955) Diabetes , vol.4 , pp. 367-376
    • MacLean, N.1    Ogilvie, R.F.2
  • 5
  • 6
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • DOI 10.2337/diabetes.52.1.102
    • AE Butler J Janson S Bonner-Weir R Ritzel RA Rizza PC Butler 2003 ß-cell deficit and increased ß-cell apoptosis in humans with type 2 diabetes Diabetes 52 102 110 (Pubitemid 36042113)
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 8
    • 0020623615 scopus 로고
    • Cellular composition of the human diabetic pancreas
    • J Rahier RM Goebbels JC Henquin 1983 Cellular composition of the human diabetic pancreas Diabetologia 24 366 371
    • (1983) Diabetologia , vol.24 , pp. 366-371
    • Rahier, J.1    Goebbels, R.M.2    Henquin, J.C.3
  • 9
    • 0018641183 scopus 로고
    • Differential volumetry of A, B and D cells in the pancreatic islets of diabetic and nondiabetic subjects
    • K Saito N Yaginuma T Takahashi 1979 Differential volumetry of A, B, and D cells in the pancreatic islets of diabetic and nondiabetic subjects Tohoku J Exp Med 129 273 283 (Pubitemid 10136627)
    • (1979) Tohoku Journal of Experimental Medicine , vol.129 , Issue.3 , pp. 273-283
    • Saito, K.1    Yaginuma, N.2    Takahashi, T.3
  • 10
    • 0036163156 scopus 로고    scopus 로고
    • Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients
    • DOI 10.1007/s125-002-8248-z
    • H Sakuraba H Mizukami N Yagihashi R Wada C Hanyu S Yagihashi 2002 Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients Diabetologia 45 85 96 (Pubitemid 34118546)
    • (2002) Diabetologia , vol.45 , Issue.1 , pp. 85-96
    • Sakuraba, H.1    Mizukami, H.2    Yagihashi, N.3    Wada, R.4    Hanyu, C.5    Yagihashi, S.6
  • 13
    • 0026652507 scopus 로고
    • Effects of hemipancreatectomy on pancreatic alpha and beta cell function in healthy human donors
    • ER Seaquist RP Robertson 1992 Effects of hemipancreatectomy on pancreatic alpha and beta cell function in healthy human donors J Clin Invest 89 1761 1766
    • (1992) J Clin Invest , vol.89 , pp. 1761-1766
    • Seaquist, E.R.1    Robertson, R.P.2
  • 14
    • 58149477520 scopus 로고    scopus 로고
    • Metabolic consequences of a 50% partial pancreatectomy in humans
    • BA Menge H Schrader TG Breuer 2009 Metabolic consequences of a 50% partial pancreatectomy in humans Diabetologia 52 306 317
    • (2009) Diabetologia , vol.52 , pp. 306-317
    • Menge, B.A.1    Schrader, H.2    Breuer, T.G.3
  • 15
    • 0020636495 scopus 로고
    • Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release
    • S Bonner-Weir DF Trent GC Weir 1983 Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release J Clin Invest 71 1544 1553
    • (1983) J Clin Invest , vol.71 , pp. 1544-1553
    • Bonner-Weir, S.1    Trent, D.F.2    Weir, G.C.3
  • 17
    • 0024271685 scopus 로고
    • Reduction of glycemic potentiation. Sensitive indicator of beta-cell loss in partially pancreatectomized dogs
    • WK Ward BJ Wallum JC Beard GJ Taborsky Jr D Porte Jr 1988 Reduction of glycemic potentiation: a sensitive indicator of ß-cell loss in partially pancreatectomized dogs Diabetes 37 723 729 (Pubitemid 19043179)
    • (1988) Diabetes , vol.37 , Issue.6 , pp. 723-729
    • Ward, W.K.1    Wallum, B.J.2    Beard, J.C.3    Taborsky Jr., G.J.4    Porte Jr., D.5
  • 19
    • 0022496637 scopus 로고
    • Longitudinal studies on the development of diabetes in individual Macaca nigra
    • CF Howard Jr 1986 Longitudinal studies on the development of diabetes in individual Macaca nigra Diabetologia 29 301 306 (Pubitemid 16080927)
    • (1986) Diabetologia , vol.29 , Issue.5 , pp. 301-306
    • Howard Jr., C.F.1
  • 20
    • 0033853921 scopus 로고    scopus 로고
    • Beta-Cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy
    • SA Kassem I Ariel PS Thornton I Scheimberg B Glaser 2000 ß-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy Diabetes 49 1325 1333 (Pubitemid 30624233)
    • (2000) Diabetes , vol.49 , Issue.8 , pp. 1325-1333
    • Kassem, S.A.1    Ariel, I.2    Thornton, P.S.3    Scheimberg, I.4    Glaser, B.5
  • 21
    • 0030825432 scopus 로고    scopus 로고
    • Adaptation of islets of Langerhans to pregnancy: Beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones
    • RL Sorenson TC Brelje 1997 Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones Horm Metab Res 29 301 307 (Pubitemid 27293660)
    • (1997) Hormone and Metabolic Research , vol.29 , Issue.6 , pp. 301-307
    • Sorenson, R.L.1    Brelje, T.C.2
  • 23
    • 24144473869 scopus 로고    scopus 로고
    • Very slow turnover of beta-cells in aged adult mice
    • DOI 10.2337/diabetes.54.9.2557
    • M Teta SY Long LM Wartschow MM Rankin JA Kushner 2005 Very slow turnover of beta-cells in aged adult mice Diabetes 54 2557 2567 (Pubitemid 41233576)
    • (2005) Diabetes , vol.54 , Issue.9 , pp. 2557-2567
    • Teta, M.1    Long, S.Y.2    Wartschow, L.M.3    Rankin, M.M.4    Kushner, J.A.5
  • 24
    • 0027449197 scopus 로고
    • A second pathway for regeneration of adult exocrine and endocrine pancreas: A possible recapitulation of embryonic development
    • S Bonner-Weir LA Baxter GT Schuppin FE Smith 1993 A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development Diabetes 42 1715 1220 (Pubitemid 23346407)
    • (1993) Diabetes , vol.42 , Issue.12 , pp. 1715-1720
    • Bonner-Weir, S.1    Baxter, L.A.2    Schuppin, G.T.3    Smith, F.E.4
  • 25
    • 38449086256 scopus 로고    scopus 로고
    • Partial pancreatectomy in adult humans does not provoke ß-cell regeneration
    • BA Menge A Tannapfel O Belyaev 2008 Partial pancreatectomy in adult humans does not provoke ß-cell regeneration Diabetes 57 142 149
    • (2008) Diabetes , vol.57 , pp. 142-149
    • Menge, B.A.1    Tannapfel, A.2    Belyaev, O.3
  • 26
    • 0000380542 scopus 로고
    • Immunoassay of endogenous plasma insulin in man
    • RS Yalow SA Berson 1960 Immunoassay of endogenous plasma insulin in man J Clin Invest 39 1157 1175
    • (1960) J Clin Invest , vol.39 , pp. 1157-1175
    • Yalow, R.S.1    Berson, S.A.2
  • 27
    • 0036306096 scopus 로고    scopus 로고
    • Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S.
    • CC Jensen M Cnop RL Hull WY Fujimoto SE Kahn American Diabetes Association GENNID Study Group 2002 ß-cell function is the major determinant of oral glucose tolerance in four ethnic groups in the United States Diabetes 51 2170 2178 (Pubitemid 34729022)
    • (2002) Diabetes , vol.51 , Issue.7 , pp. 2170-2178
    • Jensen, C.C.1    Cnop, M.2    Hull, R.L.3    Fujimoto, W.Y.4    Kahn, S.E.5
  • 28
    • 0026602267 scopus 로고
    • Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance
    • A Mitrakou D Kelley M Mokan 1992 Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance N Engl J Med 326 22 29
    • (1992) N Engl J Med , vol.326 , pp. 22-29
    • Mitrakou, A.1    Kelley, D.2    Mokan, M.3
  • 30
    • 0017236889 scopus 로고
    • Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests
    • JD Brunzell RP Robertson RL Lerner 1976 Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests J Clin Endocrinol Metab 42 222 229
    • (1976) J Clin Endocrinol Metab , vol.42 , pp. 222-229
    • Brunzell, J.D.1    Robertson, R.P.2    Lerner, R.L.3
  • 31
    • 4143057100 scopus 로고    scopus 로고
    • Loss of beta cell function as fasting glucose increases in the non-diabetic range
    • IF Godsland JA Jeffs DG Johnston 2004 Loss of beta cell function as fasting glucose increases in the non-diabetic range Diabetologia 47 1157 1166 (Pubitemid 39093312)
    • (2004) Diabetologia , vol.47 , Issue.7 , pp. 1157-1166
    • Godsland, I.F.1    Jeffs, J.A.R.2    Johnston, D.G.3
  • 32
    • 0021751981 scopus 로고
    • Diminished B cell secretory capacity in patients with noninsulin dependent diabetes mellitus
    • WK Ward DC Bolgiano B McKnight JB Halter D Porte Jr 1984 Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus J Clin Invest 74 1318 1328 (Pubitemid 15206828)
    • (1984) Journal of Clinical Investigation , vol.74 , Issue.4 , pp. 1318-1328
    • Ward, W.K.1    Bolgiano, D.C.2    McKnight, B.3
  • 35
    • 33644772589 scopus 로고    scopus 로고
    • Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients
    • DOI 10.2337/diabetes.55.02.06.db04-1575
    • CG Ostenson H Gaisano L Sheu A Tibell T Bartfai 2006 Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients Diabetes 55 435 440 (Pubitemid 43343274)
    • (2006) Diabetes , vol.55 , Issue.2 , pp. 435-440
    • Ostenson, C.-G.1    Gaisano, H.2    Sheu, L.3    Tibell, A.4    Bartfai, T.5
  • 37
    • 0023951171 scopus 로고
    • Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes
    • S O'Rahilly RC Turner DR Matthews 1988 Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes N Engl J Med 318 1225 1230 (Pubitemid 18120884)
    • (1988) New England Journal of Medicine , vol.318 , Issue.19 , pp. 1225-1230
    • O'Rahilly, S.1    Turner, R.C.2    Matthews, D.R.3
  • 38
    • 0027296318 scopus 로고
    • Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus
    • NM O'Meara J Sturis E Van Cauter KS Polonsky 1993 Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus J Clin Invest 92 262 271 (Pubitemid 23209005)
    • (1993) Journal of Clinical Investigation , vol.92 , Issue.1 , pp. 262-271
    • O'Meara, N.M.1    Sturis, J.2    Van Cauter, E.3    Polonsky, K.S.4
  • 39
    • 0030662718 scopus 로고    scopus 로고
    • Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM
    • SE Kahn PA Halban 1997 Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM Diabetes 46 1725 1732 (Pubitemid 27456403)
    • (1997) Diabetes , vol.46 , Issue.11 , pp. 1725-1732
    • Kahn, S.E.1    Halban, P.A.2
  • 42
    • 0020514320 scopus 로고
    • Hyperglycemia and ß-cell adaptation during prolonged somatostatin infusion with glucagon replacement in man
    • WK Ward JB Halter JD Best JC Beard D Porte Jr 1983 Hyperglycemia and ß-cell adaptation during prolonged somatostatin infusion with glucagon replacement in man Diabetes 32 943 947
    • (1983) Diabetes , vol.32 , pp. 943-947
    • Ward, W.K.1    Halter, J.B.2    Best, J.D.3    Beard, J.C.4    Porte Jr., D.5
  • 44
    • 85003195436 scopus 로고
    • Cortisol-induced insulin resistance in man: Impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor defect of insulin action
    • RA Rizza LJ Mandarino JE Gerich 1982 Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action J Clin Endocrinol Metab 54 131 138 (Pubitemid 13242146)
    • (1982) Journal of Clinical Endocrinology and Metabolism , vol.54 , Issue.1 , pp. 131-138
    • Rizza, R.A.1    Mandarino, L.J.2    Gerich, J.E.3
  • 45
    • 0023634652 scopus 로고
    • Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance
    • DOI 10.1007/BF00296991
    • WK Ward EC LaCava TL Paquette JC Beard BJ Wallum D Porte Jr 1987 Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and experimental insulin resistance Diabetologia 30 698 702 (Pubitemid 17159895)
    • (1987) Diabetologia , vol.30 , Issue.9 , pp. 698-702
    • Ward, W.K.1    La Cava, E.C.2    Paquette, T.L.3    Beard, J.C.4    Wallum, B.J.5    Porte Jr., D.6
  • 46
    • 0016816209 scopus 로고
    • Inhibitory effect of prednisone on insulin secretion in man: Model for duplication of blood glucose concentration
    • SC Kalhan PAJ Adam 1975 Inhibitory effect of prednisone on insulin secretion in man: model for duplication of blood glucose concentration J Clin Endocrinol Metab 41 600 610
    • (1975) J Clin Endocrinol Metab , vol.41 , pp. 600-610
    • Kalhan, S.C.1    Adam, P.A.J.2
  • 48
    • 0018194884 scopus 로고
    • Abnormal alpha cell function in human diabetes. the response to oral protein
    • P Raskin I Aydin T Yamamoto RH Unger 1978 Abnormal alpha cell function in human diabetes: the response to oral protein Am J Med 64 988 997 (Pubitemid 8358592)
    • (1978) American Journal of Medicine , vol.64 , Issue.6 , pp. 988-997
    • Raskin, P.1    Aydin, I.2    Yamamoto, T.3    Unger, R.H.4
  • 49
    • 0017284855 scopus 로고
    • A role for alpha-adrenergic receptors in abnormal insulin secretion in diabetes mellitus
    • RP Robertson JB Halter D Porte Jr 1976 A role for alpha-adrenergic receptors in abnormal insulin secretion in diabetes mellitus J Clin Invest 57 791 795
    • (1976) J Clin Invest , vol.57 , pp. 791-795
    • Robertson, R.P.1    Halter, J.B.2    Porte Jr., D.3
  • 50
    • 0023940801 scopus 로고
    • Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy
    • JL Leahy S Bonner-Weir GC Weir 1988 Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy J Clin Invest 81 1407 1414 (Pubitemid 18131610)
    • (1988) Journal of Clinical Investigation , vol.81 , Issue.5 , pp. 1407-1414
    • Leahy, J.L.1    Bonner-Weir, S.2    Weir, G.C.3
  • 51
    • 0037300838 scopus 로고    scopus 로고
    • Loss of beta-cell mass leads to a reduction of pulse mass with normal periodicity, regularity and entrainment of pulsatile insulin secretion in Göttingen minipigs
    • DOI 10.1007/s00125-002-1011-6
    • MO Larsen CF Gotfredsen M Wilken RD Carr N Porksen B Rolin 2003 Loss of beta-cell mass leads to a reduction of pulse mass with normal periodicity, regularity and entrainment of pulsatile insulin secretion in Göttingen minipigs Diabetologia 46 195 202 (Pubitemid 36343883)
    • (2003) Diabetologia , vol.46 , Issue.2 , pp. 195-202
    • Larsen, M.O.1    Gotfredsen, C.F.2    Wilken, M.3    Carr, R.D.4    Porksen, N.5    Rolin, B.6
  • 52
    • 0141449123 scopus 로고    scopus 로고
    • Early changes in beta-cell function and insulin pulsatility as predictors for type 2 diabetes
    • N Porksen 2002 Early changes in beta-cell function and insulin pulsatility as predictors for type 2 diabetes Diabetes Nutr Metab 15 Suppl 9 14
    • (2002) Diabetes Nutr Metab , vol.15 , Issue.SUPPL. , pp. 9-14
    • Porksen, N.1
  • 53
    • 0021220641 scopus 로고
    • Abnormal glucose regulation of insulin secretion in models of reduced B-cell mass
    • JL Leahy S Bonner-Weir GC Weir 1984 Abnormal glucose regulation of insulin secretion in models of reduced B cell mass Diabetes 33 667 673 (Pubitemid 14087559)
    • (1984) Diabetes , vol.33 , Issue.7 , pp. 667-673
    • Leahy, J.L.1    Bonner-Weir, S.2    Weir, G.C.3
  • 54
    • 58149347547 scopus 로고    scopus 로고
    • Beta-cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1
    • A Ackermann Misfeldt RH Costa M Gannon 2008 Beta-cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1 Diabetes 57 3069 3077
    • (2008) Diabetes , vol.57 , pp. 3069-3077
    • Ackermann Misfeldt, A.1    Costa, R.H.2    Gannon, M.3
  • 56
    • 0037312829 scopus 로고    scopus 로고
    • Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy
    • DOI 10.2337/diabetes.52.2.365
    • DD De Leon S Deng R Madani RS Ahima DJ Drucker DA Stoffers 2003 Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy Diabetes 52 365 371 (Pubitemid 36173191)
    • (2003) Diabetes , vol.52 , Issue.2 , pp. 365-371
    • De Leon, D.D.1    Deng, S.2    Madani, R.3    Ahima, R.S.4    Drucker, D.J.5    Stoffers, D.A.6
  • 57
    • 43549108142 scopus 로고    scopus 로고
    • Glucolipotoxicity: Fuel excess and ß-cell dysfunction
    • V Poitout RP Robertson 2008 Glucolipotoxicity: fuel excess and ß-cell dysfunction Endocr Rev 29 351 366
    • (2008) Endocr Rev , vol.29 , pp. 351-366
    • Poitout, V.1    Robertson, R.P.2
  • 58
    • 0024508097 scopus 로고
    • Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion
    • S Bonner-Weir D Deery JL Leahy GC Weir 1989 Compensatory growth of pancreatic ß-cells in adult rats after short-term glucose infusion Diabetes 38 49 53 (Pubitemid 19021816)
    • (1989) Diabetes , vol.38 , Issue.1 , pp. 49-53
    • Bonner-Weir, S.1    Deery, D.2    Leahy, J.L.3    Weir, G.C.4
  • 61
    • 0024463227 scopus 로고
    • Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet beta-cell dysfunction?
    • D Porte Jr SE Kahn 1989 Hyperproinsulinemia and amyloid in NIDDM: clues to etiology of islet ß-cell dysfunction? Diabetes 38 1333 1336 (Pubitemid 19271711)
    • (1989) Diabetes , vol.38 , Issue.11 , pp. 1333-1336
    • Porte Jr., D.1    Kahn, S.E.2
  • 62
    • 33749318236 scopus 로고    scopus 로고
    • Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death
    • L Marzban CJ Rhodes DF Steiner L Haataja PA Halban CB Verchere 2006 Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death Diabetes 55 2192 2201
    • (2006) Diabetes , vol.55 , pp. 2192-2201
    • Marzban, L.1    Rhodes, C.J.2    Steiner, D.F.3    Haataja, L.4    Halban, P.A.5    Verchere, C.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.