Crucial role of insulin receptor substrate-2 in compensatory β-cell hyperplasia in response to high fat diet-induced insulin resistance

Diabetes, Obesity and Metabolism

Volumn 10, Issue SUPPL. 4, 2008, Pages 147-156

  Takamoto, I ^a,b   Terauchi, Y ^c   Kubota, N ^a,b,d   Ohsugi, M ^a   Ueki, K ^a,d   Kadowaki, Takashi ^a,b,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

cAMP response element binding protein; Forkhead protein FoxO1; Glucokinase; Glucose; High fat diet; Insulin receptor substrate 2; cell hyperplasia

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOKINASE; INSULIN RECEPTOR SUBSTRATE 2; TRANSCRIPTION FACTOR FKHR;

CALCIUM SIGNALING; CELL PROLIFERATION; CELL SPECIFICITY; CONFERENCE PAPER; DOWNSTREAM PROCESSING; ENZYME SUBSTRATE; GENE OVEREXPRESSION; GLUCOSE METABOLISM; HORMONAL REGULATION; INSULIN RELEASE; INSULIN RESISTANCE; KNOCKOUT MOUSE; LIPID DIET; MOLECULAR DYNAMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET CELL HYPERPLASIA; PATHOGENESIS; PROTEIN FUNCTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

EID: 53549098812     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2008.00951.x     Document Type: Conference Paper

References (56)

1. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004; 89: 2548-2556.
2. Kadowaki T, Yamauchi T, Kubota N et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006; 116: 1784-1792.
3. Butler AE, Janson J, Bonner-Weir S et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52: 102-110.
4. Sakuraba H, Mizukami H, Yagihashi N et al. Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia 2002; 45: 85-96.
5. Yoon KH, Ko SH, Cho JH et al. Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab 2003; 88: 2300-2308.
6. Bonner-Weir S. Perspective: Postnatal pancreatic beta cell growth. Endocrinology 2000; 141: 1926-1929.
7. Weir GC, Bonner-Weir S. A dominant role for glucose in beta cell compensation of insulin resistance. J Clin Invest 2007; 117: 81-83.
8. Kulkarni RN, Brüning JC, Winnay JN et al. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 1999; 96: 329-339.
9. Ueki K, Okada T, Hu J et al. Total insulin and IGF-I resistance in pancreatic β cells cause overt diabetes. Nat Genet 2006; 38: 583-588.
10. Kadowaki T Insights into insulin resistance and type 2 diabetes from knockout mouse models. J Clin Invest 2000; 106: 459-465.
11. Terauchi Y, Takamoto I, Kubota N et al. Glucokinase and IRS-2 are required for compensatory β cell hyperplasia in response to high-fat diet-induced insulin resistance. J Clin Invest 2007; 117: 246-257.
12. Jhala US, Canettieri G, Screaton RA et al. cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS-2. Genes Dev 2003; 17: 1575-1580.
13. Kitamura T, Nakae J, Kitamura Y et al. The forkhead transcription factor FoxO1 links insulin signaling to Pdx-1 regulation of pancreatic β cell growth. J Clin Invest 2002; 110: 1839-1847.
14. Brubaker PL, Drucker DJ. Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut and central nervous system. Endocrinology 2004; 145: 2653-2659.
15. Matschinsky FM, Magnuson MA, Zelent D et al. The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes 2006; 55: 1-12.
16. Virkamaki A, Ueki K, Kahn CR. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 1999; 103: 931-943.
17. Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 2000; 106: 171-176.
18. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001; 414: 799-806.
19. Nakae J, Kido Y, Accili D. Distinct and overlapping functions of insulin and IGF-I receptors. Endocr Rev 2001; 22: 813-835.
20. Mauvais-Jarvis F, Kulkarni RN, Kahn CR. Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clin Endocrinol (Oxf) 2002; 57: 1-9.
21. Tamemoto H, Kadowaki T, Tobe K et al. Insulin and growth retardation in mice lacking insulin receptor substrate-1. Nature 1994; 372: 182-186.
22. Araki E, Lipes MA, Patti ME et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 1994; 372: 186-190.
23. Withers DJ, Gutierrez JS, Towery H et al. Disruption of IRS2 causes type 2 diabetes in mice. Nature 1998; 391: 900-904.
24. Withers DJ, Burks DJ, Towery HH et al. Irs2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet 1999; 23: 32-40.
25. Kubota N, Tobe K, Terauchi Y et al. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes 2000; 49: 1880-1889.
26. Tobe K, Suzuki R, Aoyama M et al. Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2-/-mouse liver. J Biol Chem 2001; 276: 38337-38340.
27. Kubota N, Terauchi Y, Tobe K et al. Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest 2004; 114: 917-927.
28. Lin X, Taguchi A, Park S et al. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest 2004; 114: 908-916.
29. Cantley J, Choudhury AI, Asare-Anane H et al. Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice. Diabetologia 2007; 50: 1248-1256.
30. Mohanty S, Spinas GA, Maedler K et al. Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis. Exp Cell Res 2005; 303: 68-78.
31. Lingohr MK, Dickson LM, Wrede CE et al. Decreasing IRS-2 expression in pancreatic - cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression. Mol Cell Endocrinol 2003; 209: 17-31.
32. Miyazaki J, Araki K, Yamato E et al. Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms. Endocrinology 1990; 127: 126-132.
33. Hennige AM, Ozcan U, Okada T et al. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab 2005; 289: E337-E46.
34. Kulkarni RN, Winnay JN, Daniels M et al. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest 1999; 104: R69-R75.
35. Borge PD, Wolf BA. Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells. J Biol Chem 2003; 278: 11359-11368.
36. Bonner-Weir S, Deery D, Leahy JL, Weir GC. Compensatory growth of pancreatic beta - cells in adult rats after short-term glucose infusion. Diabetes 1989; 38: 49-53.
37. Bonner-Weir S, Smith FE. Islet cell growth and the growth factors involved. Trends Endocrinol Metab 1994; 5: 60-64.
38. Terauchi Y, Sakura H, Yasuda K et al. Pancreatic β-cell-specific targeted disruption of glucokinase gene. J Biol Chem 1995; 270: 30253-30256.
39. Velho G, Blanche H, Vaxillaire M et al. Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families. Diabetologia 1997; 40: 217-224.
40. Hennige AM, Burks DJ, Ozcan U et al. Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest 2003; 112: 1521-1532.
41. Ide T, Shimano H, Yahagi N et al. SREBPs suppress IRS-2-mediated insulin signalling in the liver. Nat Cell Biol 2004; 6: 351-357.
42. Lingohr MK, Briaud I, Dickson LM et al. Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells. J Biol Chem 2006; 281: 15884-15892.
43. Amacker-Françoys I, Mohanty S, Niessen M, Spinas GA, Trüb T. The metabolisable hexoses D-glucose and D-mannose enhance the expression of IRS-2 but not of IRS-1 in pancreatic beta-cells. Exp Clin Edocrinal Diabetes 2005; 113: 423-429.
44. During MJ, Cao L, Zuzga DS et al. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med 2003; 9: 1173-1179.
45. Park S, Dong X, Fisher TL et al. Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. J Biol Chem 2006; 281: 1159-1168.
46. Sarkar SA, Gunter J, Bouchard R et al. Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets. Diabetologia 2007; 50: 1649-1659.
47. Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H. Beta-cell-specific inactivation of the mouse Pdx-1/Pdx-1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 1998; 12: 763-768.
48. Lee C, Sund N, Vatamaniuk M et al. Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo. Diabetes 2002; 51: 2546-2551.
49. Nakae J, Biggs III WH, Kitamura T et al. Regulation of insulin action and pancreatic beta cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet 2002; 32: 245-253.
50. Otani K, Kulkarni RN, Baldwin AC et al. Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 2004; 286: E41-E49.
51. Kulkarni RN, Holzenberger M, Shih DQ et al. Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet 2002; 31: 111-115.
52. Xuan S, Kitamura T, Nakae J et al. Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest 2002; 110: 1011-1019.
53. Okada T, Liew CW, Hu J et al. Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A. 2007; 104: 8977-8982.
54. Buteau J, Spatz ML, Accili D. Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. Diabetes 2006; 55: 1190-1196.
55. Kim SJ, Nian C, Widenmaier S, McIntosh CH. Glucose-dependent insulinotropic polypeptide-mediated upregulation of beta-cell anti-apoptotic Bcl-2 gene expression is co-ordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2. Mol Cell Biol 2008; 28: 1644-1656.
56. Screaton RA, Conkright MD, Katoh Y et al. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 2004; 119: 61-74.