Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 20, 2009, Pages 7301-7312

  Zhang, Lei ^a   Li, Honglin ^b   Zhu, Qingzhang ^a   Liu, Jun ^c   Chen, Ling ^a   Leng, Ying ^a   Jiang, Hualiang ^a,b   Liu, Hong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Dual action; Glucokinase (GK) activators; Glycogen phosphorylase (GP) inhibitors; Type 2 diabetes

Indexed keywords

2 AMINO 4 FLUORO 5 (1 METHYL 1H IMIDAZOL 2 YLSULFANYL) N (3 TRIFLUOROMETHYLPHENYL)BENZAMIDE; 2 AMINO 4 FLUORO N (3 FLUOROPHENYL) 5 (1 METHYL 1H IMIDAZOL 2 YLSULFANYL)BENZAMIDE; 2 AMINO 4 FLUORO N (4 METHOXYPHENYL) 5 (1 METHYL 1H IMIDAZOL 2 YLSULFANYL)BENZAMIDE; 2 AMINO N (3 AMINOPHENYL) 4 FLUORO 5 (1 METHYL 1H IMIDAZOL 2 YLSULFANYL)BENZAMIDE; 2 AMINO N (3 CYANOPHENYL) 4 FLUORO 5 (1 METHYL 1H IMIDAZOL 2 YLSULFANYL)BENZAMIDE; ANTIDIABETIC AGENT; BENZAMIDE DERIVATIVE; GLUCOKINASE; GLYCOGEN PHOSPHORYLASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; MOLECULAR DOCKING; SIMULATION; STRUCTURE ANALYSIS;

BENZAMIDES; ENZYME ACTIVATION; GLUCOKINASE; GLYCOGEN PHOSPHORYLASE; HUMANS; HYPOGLYCEMIC AGENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 71749089240     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.045     Document Type: Article

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