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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 19, 2010, Pages 5673-5676

2,3-Disubstituted acrylamides as potent glucokinase activators

(12) Sidduri, Achyutharao a Grimsby, Joseph S b Corbett, Wendy L a Sarabu, Ramakanth a Grippo, Joseph F b Lou, Jianping a Kester, Robert F a Dvorozniak, Mark b Marcus, Linda b Spence, Cheryl b Racha, Jagdish K a Moore, David J a

a HOFFMANN LA ROCHE INC (United States)

b Hoffman La Roche Department of Metabolic Diseases (United States)

Author keywords

Discovery of novel GK activators for the treatment of diabetes

Indexed keywords

ACRYLAMIDE DERIVATIVE; ALKENE DERIVATIVE; ENZYME ACTIVATOR; GLUCOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHIRALITY; DOG; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; MONKEY; NONHUMAN; RAT; SUBSTITUTION REACTION; WISTAR RAT;

ACRYLAMIDES; ANIMALS; BENZENEACETAMIDES; GLUCOKINASE; HYPOGLYCEMIC AGENTS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

RATTUS NORVEGICUS;

EID: 77957566729 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.08.029 Document Type: Article

Times cited : (23)

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