Conformational transition pathway in the allosteric process of human glucokinase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 36, 2006, Pages 13368-13373

  Zhang, Jian ^a   Li, Chenjing ^a   Chen, Kaixian ^a   Zhu, Weiliang ^a   Shen, Xu ^a   Jiang, Hualiang ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Molecular dynamics; Mutagenesis

Indexed keywords

GLUCOKINASE; GLUCOSE;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; ENERGY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME MECHANISM; GLUCOSE BLOOD LEVEL; HORMONAL REGULATION; HUMAN; HYPERINSULINEMIA; HYPOGLYCEMIA; METABOLIC DISORDER; MOLECULAR DYNAMICS; MUTAGENESIS; MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RELIABILITY; SIMULATION; WILD TYPE;

ALLOSTERIC REGULATION; BINDING SITES; BLOOD GLUCOSE; COMPUTER SIMULATION; DIABETES MELLITUS, TYPE 2; GLUCOKINASE; HUMANS; HYPOGLYCEMIA; KINETICS; MODELS, MOLECULAR; POINT MUTATION; PREDICTIVE VALUE OF TESTS; PROTEIN BINDING; PROTEIN CONFORMATION; REPRODUCIBILITY OF RESULTS; THERMODYNAMICS;

EID: 33748592855     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0605738103     Document Type: Article

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