Anti-diabetic agents from natural products - An update from 2004 to 2009

Current Topics in Medicinal Chemistry

Volumn 10, Issue 4, 2010, Pages 434-457

  Qi, Lian Wen ^a   Liu, E Hu ^a   Chu, Chu ^a   Peng, Yong Bo ^a   Cai, Hai Xia ^a   Li, Ping ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti diabetic agents; Chemical entities; Compound formulae; Diabetes mellitus; Herbal medicines; Hypoglycemic; Medicinal plants; Natural products; Review

Indexed keywords

ALKALOID; ALOE BARBADENSIS EXTRACT; ANTHRAQUINONE; ANTIDIABETIC AGENT; ASTRAGALOSIDE IV; COROSOLIC ACID; COUMARIN; ELEPHANTOPUS SCABER EXTRACT; EPICATECHIN; FLAVONOID; GENSINOSIDE; GLIBENCLAMIDE; GLUCOSE TRANSPORTER 4; HACHIMIJIOGAN; HUANG LIAN JIE DU DECOCTION; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; MOMODRICA CHARANTIA EXTRACT; NATURAL PRODUCT; OLEANOLIC ACID; PHANOSIDE; PHYTOSTEROL; PLANT EXTRACT; POLYSACCHARIDE; QUERCETIN; RUTOSIDE; SAPONIN; TERPENE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XIAOKELING; BIOLOGICAL PRODUCT; HERBACEOUS AGENT;

ANGIOSPERM; ANNONACEAE; ANTIOXIDANT ACTIVITY; ARALIACEAE; CAMPANULOCEAE; CHINESE MEDICINE; CORNACEAE; CUCUMBER; DIABETES MELLITUS; DRUG ACTIVITY; DRUG EFFICACY; DRUG ISOLATION; EUPHORBIA; GINKGOCEAE; GLUCOSE TOLERANCE; GOOSEFOOT; HUMAN; HYPERGLYCEMIA; INSULIN RELEASE; LEGUME; MEDICINAL PLANT; MYRTACEAE; NONHUMAN; POACEAE; REVIEW; RHAMNACEAE; SCROPHULARIACEAE; STERCULIACEAE; CHEMISTRY; ISOLATION AND PURIFICATION;

BIOLOGICAL PRODUCTS; DIABETES MELLITUS; DRUGS, CHINESE HERBAL; HUMANS; HYPOGLYCEMIC AGENTS; PLANTS, MEDICINAL;

EID: 77949452664     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802610790980620     Document Type: Review

References (197)

1. Agarwal, S. K.; Venkatesh, P.; Tandon, N. The kidney and the eye in people with diabetes mellitus. Natl. Med. J. India 2008, 21, 82-89.
2. Qi, L.; Hu, F. B.; Hu, G. Genes, environment, and interactions in prevention of type 2 diabetes: a focus on physical activity and lifestyle changes. Curr. Mol. Med. 2008, 8, 519-532.
3. Wild, S.; Rogic, G.; Green, A.; Sicree, R.; King, H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27, 1047-1053.
4. Roglic, G.; Unwin, N.; Bennett, P. H.; Mathers, C.; Tuomilehto, J.; Nag, S.; Connolly, V.; King, H. The burden of mortality attributable to diabetes: realistic estimates for the year 2000. Diabetes Care 2005, 28, 2130-2135.
5. Halimi, S.; Schweizer, A.; Minic, B.; Foley, J.; Dejager, S. Combination treatment in the management of type 2 diabetes: focus on vildagliptin and metformin as a single tablet. Vasc. Health Risk Manag. 2008, 4, 481-492.
6. Koehn, F. E.; Carter, G. T. The evolving role of natural products in drug discovery. Nat. Rev. Drug Discov. 2005, 4, 206-220.
7. Tan, M. J.; Ye, J. M.; Turner, N.; Hohnen-Behrens, C.; Ke, C. Q.; Tang, C. P.; Chen, T.; Weiss, H. C.; Gesing, E. R.; Rowland, A.; James, D. E.; Ye, Y. Anti-diabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem. Biol. 2008, 15, 263-273.
8. [8] Tanaka, M.; Misawa, E.; Ito, Y.; Habara, N.; Nomaguchi, K.; Yamada, M.; Toida, T.; Hayasawa, H.; Takase, M.; Inagaki, M.; Higuchi, R. Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds. Biol. Pharm. Bull. 2006, 29, 1418-1422.
9. Misawa, E.; Tanaka, M.; Nomaguchi, K.; Yamada, M.; Toida, T.; Takase, M.; Iwatsuki, K.; Kawada, T. Administration of phytosterols isolated from Aloe vera gel reduce visceral fat mass and improve hyperglycemia in Zucker diabetic fatty (ZDF) rats. Obes. Res. Clin. Pract. 2008, 4, 239-245.
10. Norberg, A.; Hoa. N. K.; Liepinsh, E.; Van Phan, D.; Thuan, N. D.; Jörnvall, H.; Sillard, R.; Ostenson, C. G. A novel insulin-releasing substance, phanoside, from the plant Gynostemma pentaphyllum. J. Biol. Chem. 2004, 279, 41361-41367.
11. Hoa, N. K.; Norberg, A.; Sillard, R.; Van, Phan D.; Thuan, N. D.; Dzung, D. T.; Jörnvall, H.; Ostenson, C. G. The possible mechanisms by which phanoside stimulates insulin secretion from rat islets. J. Endocrinol. 2007, 192, 389-394.
12. Miura, T.; Ueda, N.; Yamada, K.; Fukushima, M.; Ishida, T.; Kaneko, T.; Matsuyama, F.; Seino, Y. Anti-diabetic effects of corosolic acid in KK-Ay diabetic mice. Biol. Pharm. Bull. 2006, 29, 585-587.
13. Daisy, P.; Jasmine, R.; Ignacimuthu, S.; Murugan, E. A novel Steroid from Elephantopus scaber L. an Ethnomedicinal plant with anti-diabetic activity. Phytomedicine 2009, 16, 252-257.
14. Zhang, Z.; Li, X.; L, W.; Yang, Y.; Gao, H.; Yang, J.; Shen, Y.; Ning, G. Ginsenoside Re reduces insulin resistance through inhibition of c-Jun NH2-terminal kinase and nuclear factor-kappaB. Mol. Endocrinol. 2008, 22, 186-195.
15. Lai, D. M.; Tu, Y. K.; Liu, I. M.; Chen, P. F.; Cheng, J. T. Mediation of β-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med. 2006, 72, 9-13.
16. Pérez Gutiérrez, R. M.; Vargas Solis, R.; Garcia Baez, E.; Navarro, Y. G. Hypoglycemic activity of constituents from Astianthus viminalis in normal and streptozotocin-induced diabetic mice. Nat. Med. (Tokyo) 2009, 63, 393-401.
17. Gao, D.; Li, Q.; Li, Y.; Liu, Z.; Liu, Z.; Fan, Y.; Han, Z.; Li, J.; Li, K. Anti-diabetic potential of oleanolic acid from Ligustrum lucidum Ait. Can. J. Physiol. Pharmacol. 2007, 85, 1076-1083.
18. Sato, H.; Genet, C.; Strehle, A.; Thomas, C.; Lobstein, A.; Wagner, A.; Mioskowski, C.; Auwerx, J.; Saladin, R. Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea. Biochem. Biophys. Res. Commun. 2007, 362, 793-798.
19. Qi, L. W.; Yu, Q. T.; Li, P.; Li, S. L.; Wang, Y. X.; Sheng, L. H.; Yi, L. Quality evaluation of Radix Astragali through a simultaneous determination of six major active isoflavovoids and four main saponins by high-performance liquid chromatography coupled with diode array and evaporative light scattering detectors. J. Chromatogr. A 2006, 1134, 162-169.
20. Yin, X.; Zhang, Y.; Yu, J.; Zhang, P.; Shen, J.; Qiu, J.; Wu, H.; Zhu, X. The antioxidative effects of Astragalus saponin I protect against development of early diabetic nephropathy. J. Pharmcol. Sci. 2006, 101, 166-173.
21. Coskun, O.; Kanter, M.; Korkmaz, A.; Oter, S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol. Res. 2005, 51, 117-123.
22. Quine, S. D.; Raghu, P. S. Effects of (-)-epicatechin, a flavonoid on lipid peroxidation and antioxidants in streptozotocin-induced diabetic liver, kidney and heart. Pharmacol. Rep. 2005, 57, 610-615.
23. Kamalakkannan, N.; Stanely Mainzen Prince, P. Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues. Mol. Cell Biochem. 2006, 293, 211-219.
24. Estrada. O.; Hasegawa, M.; Gonzalez-Mujíca, F.; Motta, N.; Perdomo, E.; Solorzano, A.; Méndez, J.; Méndez. B.; Zea, E. G. Evaluation of flavonoids from Bauhinia megalandra leaves as inhibitors of glucose-6-phosphatase system. Phytother. Res. 2005, 19, 859-863.
25. Jang, D. S.; Kim, J. M.; Lee, Y. M.; Kim, Y. S.; Kim, J. H.; Kim, J. S. Puerariafuran, a new inhibitor of advanced glycation end products (AGEs) isolated from the roots of Pueraria lobata. Chem. Pharm. Bull. 2006, 54, 1315-1317.
26. Yoo, N. H.; Jang, D. S.; Yoo, J. L.; Lee, Y. M.; Kim, Y. S.; Cho, J. H.; Kim, J. S. Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. J. Nat. Prod. 2008, 71, 713-715.
27. Lee, E. H.; Song, D. G.; Lee, J. Y.; Pan, C. H.; Um, B. H.; Jung, S. H. Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase and advanced glycation endproducts. Biol. Pharm. Bull. 2008, 31, 1626-1630.
28. Wirasathien, L.; Pengsuparp, T.; Suttisri, R.; Ueda, H.; Moriyasu, M.; Kawanishi, K. Inhibitors of aldose reductase and advanced glycation end-products formation from the leaves of Stelechocarpus cauliflorus R.E. Fr. Phytomedicine 2007, 14, 546-550.
29. Enoki, T.; Ohnogi, H.; Nagamine, K.; Kudo, Y.; Sugiyama, K.; Tanabe, M.; Kobayashi, E.; Sagawa, H.; Kato, I. Anti-diabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei. J. Agric. Food Chem. 2007, 55, 6013-6017.
30. Liu, I. M.; Tzeng, T. F.; Liou, S. S.; Lan, T. W. Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus. Planta Med. 2007, 73, 1054-1060.
31. Baluchnejadmojarad, T.; Roghani, M. Chronic administration of genistein improves aortic reactivity of streptozotocin-diabetic rats: mode of action. Vascul. Pharmacol. 2008, 49, 1-5.
32. Jung, U. J.; Lee, M. K.; Jeong, K. S.; Choi, M. S. The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. J. Nutr. 2004, 134, 2499-2503.
33. Luo, P.; Tan, Z. H.; Zhang, Z. F.; Zhang, H.; Liu, X. F.; Mo, Z. J. Scutellarin isolated from Erigeron multiradiatus inhibits high glucose-mediated vascular inflammation. Yakugaku Zasshi 2008. 128, 1293-1299.
34. Kang, Y. J.; Jung, U. J.; Lee, M. K.; Kim, H. J.; Jeon, S. M.; Park, Y. B.; Chung H. G.; Baek, N. I.; Lee, K. T.; Jeong, T. S.; Choi, M. S. Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic beta-cell function in type 2 diabetic mice. Diabetes Res. Clin. Pract. 2008, 82, 25-32.
35. Liu, G.; Grifman, M.; Macdonald, J.; Moller, P.; Wong-Staal, F.; Li, Q. X. Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase. J. Endocrinol. 2007, 194, 569-578.
36. Sengupta, S.; Mukherjee, A.; Goswami, R.; Basu, S. Hypoglycemic activity of the antioxidant saponarin, characterized as alphaglucosidase inhibitor present in Tinospora cordifolia. J. Enzyme Inhib. Med. Chem. 2008, 27, 1.
37. Lee, Y. S.; Kim, W. S.; Kim, K. H.; Yoon, M. J.; Cho, H. J.; Shen, Y.; Ye, J. M.; Lee, C. H.; Oh, W. K.; Kim, C. T., Hohnen-Behrens, C.; Gosby, A.; Kraegen, E. W.; James, D. E.; Kim, J. B. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistance states. Diabetes 2006, 55, 2256-2264.
38. Ko, B. S.; Choi, S. B.; Park, S. K.; Jang, J. S.; Kim, Y. E.; Park, S. Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma. Biol. Pharm. Bull. 2005, 28, 1431-1437.
39. Pan, G. Y.; Huang, Z. J.; Wang, G. J.; Fawcett, J. P.; Liu, X. D.; Zhao, X. C.; Sun, J. G.; Xie, Y. Y. The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption. Planta Med. 2003, 69, 632-636.
40. Zhou. L.; Yang, Y.; Wang, X.; Liu, S.; Shang, W.; Yuan, G.; Li, F.; Tang, J.; Chen, M.; Chen, J. Berberine stimulates glucose transport through a mechanism distinct from insulin. Metabolism 2007, 56, 405-412.
41. Cheng, Z.; Pang T.; Gu, M.; Gao, A. H.; Xie, C. M.; Li, J. Y.; Nan, F. J.; Li, J. Berberine -stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK. Biochim. Biophys. Acta 2006, 1760, 1682 -1689.
42. Zhou, J.; Zhou, S.; Tang, J.; Xu, Y.; Ying Y. Effect of berberine on Cdk9 and cyclin T1 expressions in myocardium of diabetic rats. J. Med. Coll. PLA 2008, 23, 45-51.
43. Zhang, Y.; Li, X.; Zou D.; Liu, W.; Yang, J.; Zhu, N.; Huo, L.; Wang, M.; Hong, J.; Wu, P.; Ren, G.; Ning G. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J. Clin. Endocrin. Metab. 2008, 93, 2559-2565.
44. Jung, H. A.; Yoon, N. Y.; Bae, H. J.; Min, B. S.; Choi, J. S. Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose. Arch. Pharm. Res. 2008, 31, 1405-1412.
45. García López, P. M.; de la Mora, P. G.; Wysocka, W.; Maiztegui, B.; Alzugaray, M. E.; Del Zotto, H.; Borelli, M. I. Quinolizidine alkaloids isolated from Lupinus species enhance insulin secretion. Eur. J. Pharmacol. 2004, 504, 139-142.
46. Bobkiewicz-Kozłowska, T.; Dworacka, M.; Kuczyński, S.; Abramczyk, M.; Kolanoś, R.; Wysocka, W.; Garcia Lopez, P. M.; Winiarska, H. Hypoglycaemic effect of quinolizidine alkaloidslupanine and 2-thionosparteine on non-diabetic and streptozotocininduced diabetic rats. Eur. J. Pharmacol. 2007, 565, 240-244.
47. Kang, Y.; Hu, M.; Zhu, Y.; Gao, X.; Wang, M. W. Antioxidative effect of the herbal remedy Qin Huo Yi Hao and its active component tetramethylpyrazine on high glucose-treated endothelial cells. Life Sci. 2009, 84, 428-436.
48. Kato, A.; Yasuko, H.; Goto, H.; Hollinshead, J.; Nash, R. J.; Adachi, I. Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity. Phytomedicine 2009, 16, 258-261.
49. Choi, S. Z.; Lee, S. O.; Jang, K. U.; Chung, S. H.; Park, S. H.; Kang, H. C.; Yang, E. Y.; Cho, H. J.; Lee, K. R. Anti-diabetic stilbene and anthraquinone derivatives from Rheum undulatum. Arch. Pharm. Res. 2005, 28, 1027-1030.
50. Jang, D. S.; Lee, G. Y.; Kim, Y. S.; Lee, Y. M.; Kim, C. S.; Yoo, J. L.; Kim, J. S. Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase. Biol. Pharm. Bull. 2007, 30, 2207-2210.
51. Kamiya, K.; Hamabe, W.; Harada, S.; Murakami, R.; Tokuyama, S.; Satake, T. Chemical constituents of Morinda citrifolia roots exhibit hypoglycemic effects in xtreptozotocin-Induced diabetic mice. Biol. Pharm. Bull. 2008, 31, 935-938.
52. Chen, J.; Li, W. L.; Wu, J. L.; Ren, B. R.; Zhang, H. Q. Hypoglycemic effects of a sesquiterpene glycoside isolated from leaves of loquat (Eriobotrya japonica (Thunb.) Lindl.). Phytomedicine 2008, 15, 98-102.
53. Eliza, J.; Daisy, P.; Ignacimuthu, S.; Duraipandiyan, V. Normoglycemic, Hypolipidemic effect of costunolide isolated from Costus speciosus (Koen ex.Retz.)Sm. in Streptozotocin induced diabetic rats. Chem. Biol. Interat. 2009, 179, 329-334.
54. Yokozawa, T.; Yamabe, N.; Kim, H. Y.; Kang, K. S.; Hur, J. M. Park, C. H.; Tanaka, T. Protective effects of morroniside isolated from Corni Fructus against renal damage in streptozotocin-induced diabetic rats. Biol. Pharm. Bull. 2008, 31, 1422-1428
55. Lee, S. O.; Choi, S. Z.; Lee, J. H.; Chung, S. H.; Park, S. H.; Kang, H. C.; Yang, E. Y.; Cho, H. J.; Lee, K. R. Anti-diabetic coumarin and cyclitol compounds from Peucedanum japonicum. Arch. Pharm. Res. 2004, 27, 1207-1210.
56. Ogawa, H.; Nakamura, R.; Baba, K. Beneficial effect of laserpitin, a coumarin compound from Angelica keiskei, on lipid metabolism in stroke-prone spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol. 2005, 32, 1104-1109.
57. Ramesh, B.; Viswanathan, P.; Pugalendi, K. V. Protective effect of Umbelliferone on membranous fatty acid composition in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 2007, 566, 231-239.
58. Ramesh, B.; Pugalendi, K. V. Antioxidant role of Umbelliferone in STZ- diabetic rats. Life Sci. 2006, 79, 306-310.
59. Banskota, A. H.; Nguyen, N. T.; Tezuka, Y.; Nobukawa, T.; Kadota, S. Hypoglycemic effects of the wood of Taxus yunnanensis on streptozotocin-induced diabetic rats and its active components. Phytomedicine 2006, 13, 109-114.
60. Schmatz, R.; Mazzanti, C. M.; Spanevello, R.; Stefanello, N;, Gutierres, J; Corrêa, M; da Rosa, M. M.; Rubin, M. A.; Chitolina Schetinger, M. R.; Morsch, V. M. Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 2009, 61, 42-48.
61. Schmatz, R.; Schetinger, M. R.; Spanevello, R. M.; Mazzanti, C. M.; Stefanello, N.; Maldonado, P. A.; Gutierres, J.; Corrêa Mde, C.; Girotto, E.; Moretto, M. B.; Morsch, V. M. Effects of resveratrol on nucleotide degrading enzymes in streptozotocin-induced diabetic rats. Life Sci. 2009, 84, 345-350.
62. Palsamy, P.; Subramanian, S. Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Chem. Biol. Interact. 2009, 179, 356-362.
63. Palsamy, P.; Subramanian, S. Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats. Biomed. Pharmacother. 2008, 62, 598-605.
64. Yamabe, N.; Kang, K. S.; Park, C. H.; Tanaka, T.; Yokozawa, T. 7-O-galloyl-D-sedoheptulose is a novel therapeutic agent against oxidative stress and advanced glycation endproducts in the diabetic kidney. Biol. Pharm. Bull. 2009, 32, 657-664.
65. Heo, S. I.; Jin, Y. S.; Jung, M. J.; Wang, M. H. Anti-diabetic properties of 2,5-dihydroxy-4,3′-di (β-D-glucopyranosyloxy)- transstilbene from mulberry (Morus bombycis Koidzumi) root in streptozotocin-induced diabetic rats. J. Med. Food. 2007, 10, 602-607.
66. Yilmaz, H. R.; Uz, E.; Yucel, N.; Altuntas, I.; Ozcelik, N. Protective effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver. J. Biochem. Mol. Toxicol. 2004, 18, 234-238.
67. Okutan, H.; Ozcelik, N.; Yilmaz, H. R.; Uz, E. Effects of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat heart. Clin. Biochem. 2005, 38, 191-196.
68. Tousch, D.; Lajoix, A. D.; Hosy, E.; Azay-Milhau, J.; Ferrare, K.; Jahannault, C.; Cros, G.; Petit, P. Chicoric acid, a new compound able to enhance insulin release and glucose uptake. Biochem. Biophys. Res. Commun. 2008, 377, 131-135.
69. Tong, H. B.; Liang, Z. Y.; Wang, G. T. Structural characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Physalis alkekengi L. Carbohydr. Polym. 2008, 71, 316-323.
70. Li, S. P.; Zhang, G. H.; Zeng, Q.; Huang, Z. G.; Wang, Y. T.; Dong, T. T.; Tsim, K. W. Hypoglycemic activity of polysaccharide, with antioxidation, isolated from cultured Cordyceps mycelia. Phytomedicine 2006, 13, 428-433.
71. Zhao, Y.; Son, Y. O.; Kim, S. S.; Jang, Y. S; Lee, J. C. Antioxidant and anti-hyperglycemic activity of polysaccharide isolated from Dendrobium chrysotoxum Lindl. J. Biochem. Mol. Biol. 2007, 40, 670-677.
72. Zhang, M.; Cui, S. W.; Cheung, P. C. K.; Wang, Q. Antitumor polysaccharides from mushrooms: a review on their isolation process, structural characteristics and antitumor activity. Trends Food Sci. Technol. 2007, 18, 4-19.
73. Oe, H.; Ozaki, S. Hypoglycemic effect of 13-membered ring thiocyclitol, a novel α-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata). Biosci. Biotechnol. Biochem. 2008, 72, 1962-1964.
74. Tanabe, G.; Yoshikai, K.; Hatanaka, T.; Yamamoto, M.; Shao, Y.; Minematsu, T.; Muraoka, O.; Wang, T.; Matsuda, H.; Yoshikawa, M. Biological evaluation of de-O-sulfonated analogs of salacinol, the role of sulfate anion in the side chain on the α-lucosidase inhibitory activity. Bioorg. Med. Chem. 2007, 15, 3926-3937.
75. Chang, C. L.; Chang, S. L.; Lee, Y. M.; Chuang, D. Y.; Kuo, H. K.; Yang, W. C. Cytopiloyne, a polyacetylenic glucoside, prevents type 1 diabetes in nonobese diabetic mice. J. Immunol. 2007, 178, 6984-6993.
76. Contreras, C.; Román, R.; Pérez, C.; Alarcón, F.; Zavala, M.; Pérez, S. Hypoglycemic activity of a new carbohydrate isolated from the roots of Psacalium peltatum. Chem. Pharm. Bull. 2005, 53, 1408-1410.
77. Noorshahida, A.; Wong, T. W.; Choo, C. Y. Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds. J. Ethnopharmacol. 2009, 124, 586-591.
78. Chen, J.; Li, W. L.; Wu, J. L.; Ren, B. R.; Zhang, H. Q. Euscaphic acid, a new hypoglycemic natural product from Folium eriobotryae. Pharmazie 2008, 63, 765-767.
79. Maurya, R.; Jayendra, A.; Singh, A. B.; Srivastava, A. K. Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity. Bioorg. Med. Chem. Lett. 2008, 18, 6534-6537.
80. Chandramohan, G.; Ignacimuthu, S.; Pugalendi, K. V. A novel compound from Casearia esculenta (Roxb.) root and its effect on carbohydrate metabolism in streptozotocin-diabetic rats. Eur. J. Pharmacol. 2008, 590, 437-443.
81. Donati, D.; Lampariello, L. R.; Pagani, R.; Guerranti, R.; Cinci, G.; Marinello, E. Anti-diabetic oligocyclitols in seeds of Mucuna pruriens. Phytother. Res. 2005, 19, 1057-1060.
82. Subash Babu, P.; Prabuseenivasan, S.; Ignacimuthu, S. Cinnamaldehyde-a potential anti-diabetic agent. Phytomedicine 2007, 14, 15-22.
83. Grover, J. K.; Yadav, S.; Vats, V. Medicinal plants of India with anti-diabetic potential. J. Ethnopharmacol. 2002, 81, 81-100.
84. Babu, P. A.; Suneetha, G.; Boddepalli, R.; Lakshmi, V. V.; Rani, T. S.; Rambabu, Y.; Srinivas, K. A database of 389 medicinal plants for diabetes. Bioinformation 2006, 1, 130-131.
85. Tahraoui, A.; El-Hilaly J.; Israili, Z. H.; Lyoussi, B. Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province). J. Ethnopharmacol. 2007, 110, 105-117.
86. Loizzo, M. R.; Saab, A. M.; Tundis R.; Menichini, F.; Bonesi, M.; Piccolo, V.; Statti, G. A.; de Cindio, B.; Houghton, P. J.; Menichini, F. In vitro inhibitory activities of plants used in Lebanon traditional medicine against angiotensin converting enzyme (ACE) and digestive enzymes related to diabetes. J. Ethnopharmacol. 2008, 119, 109-116.
87. Abo, K. A.; Fred-Jaiyesimi, A. A.; Jaiyesimi, A. E. Ethnobotanical studies of medicinal plants used in the management of diabetes mellitus in South Western Nigeria. J. Ethnopharmacol. 2008, 115, 67-71.
88. Al-Mustafa, A. H., Al-Thunibat, O. Y. Antioxidant activity of some Jordanian medicinal plants used traditionally for treatment of diabetes. Pak. J. Biol. Sci. 2008, 11, 351-358.
89. Andrade-Cetto, A.; Heinrich, M. Mexican plants with hypoglycaemic effect used in the treatment of diabetes. J. Ethnopharmacol. 2005, 99, 325-348.
90. Dièye, A. M.; Sarr, A.; Diop, S. N.; Ndiaye, M.; Sy, G. Y.; Rajraji Gaffary, I.; Ndiaye Sy, A.; Faye, B. Medicinal plants and the treatment of diabetes in Senegal: survey with patients. Fundam. Clin. Pharmacol. 2008, 22, 211-216.
91. Zhang, Y. W.; Wu, C. Y.; Cheng, J. T. Merit of Astragalus polysaccharide in the improvement of early diabetic nephropathy with an effect on mRNA expressions of NF-kappaB and IkappaB in renal cortex of streptozotoxin-induced diabetic rats. J. Ethnopharmacol. 2007, 114, 387-392.
92. Li, R. J.; Qiu, S. D.; Chen, H. X.; Tian, H.; Wang, H. X. The immunotherapeutic effects of Astragalus polysaccharide in type 1 diabetic mice. Biol. Pharm. Bull. 2007, 30, 470-476.
93. Ko, B. S.; Jang, J. S.; Hong, S. M.; Sung, S. R.; Lee, J. E.; Lee, M. Y.; Jeon, W. K.; Park, S. Changes in components, glycyrrhizin and glycyrrhetinic acid, in raw Glycyrrhiza uralensis Fisch, modify insulin sensitizing and insulinotropic actions. Biosci. Biotechnol. Biochem. 2007, 71, 1452-1461.
94. Pavana, P.; Manoharan, S.; Renju, G. L.; Sethupathy, S. Antihyperglycemic and antihyperlipidemic effects of Tephrosia purpurea leaf extract in streptozotocin induced diabetic rats. J. Environ. Biol. 2007, 28, 833-837.
95. Volpato, G. T.; Damasceno, D. C.; Rudge, M. V.; Padovani, C. R.; Calderon, I. M. Effect of Bauhinia forficata aqueous extract on the maternal-fetal outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats. J. Ethnopharmacol. 2008, 116, 131-137.
96. Singh, N.; Gupta, M. Regeneration of β-cells in islets of Langerhans of pancreas of alloxan diabetic rats by acetone extract of Momordica charantia (Linn.) (bitter gourd) fruits. Indian J. Exp. Biol. 2007, 45, 1055-1062.
97. Xiang, L.; Huang, X.; Chen, L.; Rao, P.; Ke, L. The reparative effects of Momordica Charantia Linn. extract on HIT-T15 pancreatic beta-cells. Asia Pac. J. Clin. Nutr. 2007, 16, 249-252.
98. Abd El Sattar El Batran, S.; El-Gengaihi, S. E.; El Shabrawy, O. A. Some toxicological studies of Momordica charantia L. on albino rats in normal and alloxan diabetic rats. J. Ethnopharmacol. 2006, 108, 236-242.
99. Qi, X. Y.; Chen, W. J.; Zhang, L. Q.; Xie, B. J. Mogrosides extract from Siraitia grosvenori scavenges free radicals in vitro and lowers oxidative stress, serum glucose, and lipid levels in alloxan-induced diabetic mice. Nutr. Res. 2008, 28, 278-284.
100. Kuriyan, R.; Rajendran, R.; Bantwal, G.; Kurpad, A. V. Effect of supplementation of Coccinia cordifolia extract on newly detected diabetic patients. Diabetes Care 2008, 31, 216-220.
101. Xia, T.; Wang, Q. Antihyperglycemic effect of Cucurbita ficifolia fruit extract in streptozotocin-induced diabetic rats. Fitoterapia 2006, 77, 530-533.
102. Hernández-Galicia E.; Calzada F.; Roman-Ramos R.; Alarcón-Aguilar F. J. Monoglycerides and fatty acids from Ibervillea sonorae root: isolation and hypoglycemic activity. Planta Med. 2007, 73, 236-240.
103. Lee, K. H.; Choi, H. R.; Kim, C. H. Anti-angiogenic effect of the seed extract of Benincasa hispida Cogniaux. J. Ethnopharmacol. 2005, 97, 509-513.
104. Liu, T. P.; Lee, C. S.; Liou, S. S.; Liu, I. M.; Cheng, J. T. Improvement of insulin resistance by Acanthopanax senticosus root in fructose-rich chow-fed rats. Clin. Exp. Pharmacol. Physiol. 2005, 32, 649-654.
105. Kim, H. Y.; Kim, K. Protective effect of ginseng on cytokine-induced apoptosis in pancreatic beta-cells. J. Agric. Food Chem. 2007, 55, 2816-2823.
106. Kang, K. S.; Kim, H. Y.; Yamabe, N.; Nagai, R.; Yokozawa, T. Protective effect of sun ginseng against diabetic renal damage. Biol. Pharm. Bull. 2006, 29, 1678-1684.
107. Miura, T.; Ichiki, H.; Iwamoto, N.; Kato, M.; Kubo, M.; Sasaki, H.; Okada, M.; Ishida, T.; Seino, Y.; Tanigawa, K. Anti-diabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside. Biol. Pharm. Bull. 2001, 24, 1009-1011.
108. Eidi, A.; Eidi, M.; Esmaeili, E. Anti-diabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine 2006, 13, 624-629.
109. Ashraf, R.; Aamir, K.; Shaikh, A.R.; Ahmed, T. Effects of garlic on dyslipidemia in patients with type 2 diabetes mellitus. J. Ayub. Med. Coll. Abbottabad. 2005, 17, 60-64.
110. Chen, X.; Bai, X.; Liu, Y.; Tian, L.; Zhou, J.; Zhou, Q.; Fang, J.; Chen, J. Anti-diabetic effects of water extract and crude polysaccharides from tuberous root of Liriope spicata var. prolifera in mice. J. Ethnopharmacol. 2009, 122, 205-209.
111. Campos, K. E.; Diniz, Y. S.; Cataneo, A. C.; Faine, L. A.; Alves, M. J.; Novelli, E. L. Hypoglycaemic and antioxidant effects of onion, Allium cepa: dietary onion addition, antioxidant activity and hypoglycaemic effects on diabetic rats. Int. J. Food Sci. Nutr. 2003, 54, 241-246.
112. Mathews, J. N.; Flatt, P. R.; Abdel-Wahab, Y. H. Asparagus adscendens (Shweta musali) stimulates insulin secretion, insulin action and inhibits starch digestion. Br. J. Nutr. 2006, 95, 576-581.
113. Han, L. K.; Nose, R.; Li, W.; Gong, X.J.; Zheng, Y. N.; Yoshikawa, M.; Koike, K.; Nikaido, T.; Okuda, H.; Kimura, Y. Reduction of fat storage in mice fed a high-fat diet long term by treatment with saponins prepared from Kochia scoparia fruit. Phytother. Res. 2006, 20, 877-882.
114. Ozsoy-Sacan, O.; Karabulut-Bulan, O.; Bolkent, S.; Yanardag, R.; Ozgey, Y. Effects of chard (Beta vulgaris L. var cicla) on the liver of the diabetic rats: a morphological and biochemical study. Biosci. Biotechnol. Biochem. 2004, 68, 1640-1648.
115. Li, X. M. Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats. Int. J. Biol. Macromol. 2007, 40, 461-465.
116. Gao, D.; Li, Q.; Liu, Z.; Li, Y.; Liu, Z.; Fan, Y.; Li, K.; Han, Z.; Li, J. Hypoglycemic effects and mechanisms of action of Cortex Lycii Radicis on alloxan-induced diabetic mice. Yakugaku Zasshi 2007, 127, 1715-1721.
117. Islam, M. S.; Choi, H. Dietary red chilli (Capsicum frutescens L.) is insulinotropic rather than hypoglycemic in type 2 diabetes mellitus model of rats. Phytother. Res. 2008, 22, 1025-1029.
118. Kwon, Y. I.; Apostolidis, E.; Shetty, K. In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension. Bioresour. Technol. 2008, 99, 2981-2988.
119. Bose, K. S.; Agrawal, B. K. Effect of long term supplementation of tomatoes (cooked) on levels of antioxidant enzymes, lipid peroxidation rate, lipid profile and glycated haemoglobin in Type 2 diabetes mellitus. West Indian Med. J. 2006, 55, 274-278.
120. Kar, D. M.; Maharana, L.; Pattnaik, S.; Dash, G. K. Studies on hypoglycaemic activity of Solanum xanthocarpum Schrad. & Wendl. fruit extract in rats. J. Ethnopharmacol. 2006, 108, 251-256.
121. Pushparaj, P. N.; Low, H. K.; Manikandan, J.; Tan, B. K.; Tan, C. H. Anti-diabetic effects of Cichorium intybus in streptozotocininduced diabetic rats J. Ethnopharmacol. 2007, 111, 430-434.
122. Huseini, H. F.; Larijani, B.; Heshmat, R.; Fakhrzadeh, H.; Radjabipour, B.; Toliat, T.; Raza, M. The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phytother. Res. 2006, 20, 1036-1039.
123. Xu, Z.; Wang, X.; Zhou, M.; Ma, L.; Deng, Y.; Zhang, H.; Zhao, A.; Zhang, Y.; Jia, W. The anti-diabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats. Phytother Res. 2008, 22, 97-101.
124. Cemek. M.; Kaǧa, S.; Simsek, N.; Büyükokuroǧlu, M.E.; Konuk, M. Antihyperglycemic and antioxidative potential of Matricaria chamomilla L. in streptozotocin-induced diabetic rats. Nat. Med. (Tokyo) 2008, 62, 284-293.
125. Zhang, J.; Huang, Y.; Hou, T.; Wang, Y. Hypoglycaemic effect of Artemisia sphaerocephala Krasch seed polysaccharide in alloxaninduced diabetic rats. Swiss Med. Wkly. 2006, 136, 529-532.
126. Ribnicky, D. M.; Poulev. A.; Watford, M.; Cefalu, W. T.; Raskin, I. Antihyperglycemic activity of Tarralin, an ethanolic extract of Artemisia dracunculus L. Phytomedicine 2006, 13, 550-557.
127. Hsu, Y. J.; Lee, T. H.; Chang, C. L.; Huang, Y. T.; Yang, W. C. Anti-hyperglycemic effects and mechanism of Bidens pilosa water extract. J. Ethnopharmacol. 2009, 122, 379-383.
128. Zeggwagh, N. A.; Ouahidi, M. L.; Lemhadri, A.; Eddouks, M. Study of hypoglycaemic and hypolipidemic effects of Inula viscosa L. aqueous extract in normal and diabetic rats. J. Ethnopharmacol. 2006, 108, 223-227.
129. Zheng, J.; He, J.; Ji, B.; Li, Y.; Zhang, X. Antihyperglycemic effects of Platycodon grandiflorum (Jacq.) A. DC. extract on streptozotocin-induced diabetic mice. Plant Foods Hum. Nutr. 2007, 62, 7-11.
130. Yamabe, N.; Kang, K. S.; Goto, E.; Tanaka, T.; Yokozawa, T. Beneficial effect of Corni Fructus, a constituent of Hachimi-jiogan, on advanced glycation end-product-mediated renal injury in Streptozotocin-treated diabetic rats. Biol. Pharm. Bull. 2007, 30, 520-526.
131. Yamabe, N.; Kang, K. S.; Matsuo, Y.; Tanaka, T.; Yokozawa, T. Identification of anti-diabetic effect of iridoid glycosides and low molecular weight polyphenol fractions of Corni Fructus, a constituent of Hachimi-jio-gan, in streptozotocin-induced diabetic rats. Biol. Pharm. Bull. 2007, 30, 1289-1296.
132. Abdel-Zaher, A. O.; Salim, S. Y.; Assaf, M. H.; Abdel-Hady, R. H. Anti-diabetic activity and toxicity of Zizyphus spina-christi leaves. J. Ethnopharmacol. 2005, 101, 129-138.
133. Zhang, R.; Zhou, J.; Jia, Z.; Zhang, Y.; Gu, G. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J. Ethnopharmacol. 2004, 90, 39-43.
134. Lau, T. W.; Lam, F. F.; Lau, K. M.; Chan, Y. W.; Lee, K. M.; Sahota, D. S.; Ho, Y. Y.; Fung, K. P.; Leung, P. C.; Lau, C. B. Pharmacological investigation on the wound healing effects of Radix Rehmanniae in an animal model of diabetic foot ulcer. J. Ethnopharmacol. 2009, 123, 155-162.
135. Pari, L.; Latha, M. Antihyperlipidemic effect of Scoparia dulcis (sweet broomweed) in streptozotocin diabetic rats. J. Med. Food 2006, 9, 102-107.
136. Pari, L.; Latha, M. Anti-diabetic effect of Scoparia dulcis: effect on lipid peroxidation in streptozotocin diabetes. Gen. Physiol. Biophys. 2005, 24, 13-26.
137. Kumar, S.; Kumar, D.; Deshmukh, R. R.; Lokhande, P. D.; More, S. N.; Rangari, V. D. Anti-diabetic potential of Phyllanthus reticulatus in alloxan-induced diabetic mice. Fitoterapia 2008, 79, 21-23.
138. Suryanarayana, P.; Saraswat, M.; Petrash, J. M.; Reddy, G. B. Emblica officinalis and its enriched tannoids delay streptozotocininduced diabetic cataract in rats. Mol. Vis. 2007, 13, 1291-1297.
139. Rudge, M. V.; Damasceno, D. C.; Volpato, G. T.; Almeida, F. C.; Calderon, I. M.; Lemonica, I. P. Effect of Ginkgo biloba on the reproductive outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats. Braz. J. Med. Biol. Res. 2007, 40, 1095-1099.
140. Fodor, J. I.; Keve, T. New phytotherapical opportunity in the prevention and treatment of 2-type of diabetes mellitus. Acta Pharm. Hung. 2006, 76, 200-207.
141. Blumenthal, M. The effect of the ingestion of Ginkgo biloba extract (EGb 761) on the pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects-a double blind placebo-controlled, crossover study. Clin. Nutr. 2007, 26, 164-165.
142. Suzuki, R.; Okada, Y.; Okuyama, T. The favorable effect of style of Zea mays L. on streptozotocin induced diabetic nephropathy. Biol. Pharm. Bull. 2005, 28, 919-920.
143. Sharma, B.; Balomajumder, C.; Roy, P. Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats. Food Chem. Toxicol. 2008, 46, 2376-2383.
144. Alonso-Castro, A. J.; Salazar-Olivo, L. A. The anti-diabetic properties of Guazuma ulmifolia Lam are mediated by the stimulation of glucose uptake in normal and diabetic adipocytes without inducing adipogenesis. J. Ethnopharmacol. 2008, 118, 252-256.
145. Shirwaikar, A.; Rajendran, K.; Dinesh Kumar, C.; Bodla, R. Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin-nicotinamide type 2 diabetic rats. J. Ethnopharmacol. 2004, 91, 171-175.
146. Gupta, R. K.; Kesari, A. N.; Watal, G.; Murthy, P. S.; Chandra, R.; Tandon, V. Nutritional and hypoglycemic effect of fruit pulp of Annona squamosa in normal healthy and alloxan-induced diabetic rabbits. Ann. Nutr. Metab. 2005, 49, 407-413.
147. Gupta R. K.; Kesari A. N.; Murthy P. S.; Chandra R.; Tandon V.; Watal G. Hypoglycemic and anti-diabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals. J. Ethnopharmacol.
148. Zheng, J.; He, J.; Ji, B.; Li, Y.; Zhang, X. Antihyperglycemic activity of Prunella vulgaris L. in streptozotocin-induced diabetic mice. Asia Pac. J. Clin. Nutr. 2007, 16, 427-431.
149. Waisundara, V. Y.; Hsu, A.; Huang, D.; Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Am. J. Chin. Med. 2008, 36, 517-540.
150. Yang, M.; Xu, Z.; Zhang, R.; Zhang, P.; Weng, Y.; Shen, Y.; Zhang, X. Protection of myocardium in streptozotocin-induced diabetic rats by water extracts of Hsian-tsao (Mesona procumbens Hemsl.). Asia Pac. J. Clin. Nutr. 2008, 17, 23-29.
151. Yoshikawa, M.; Wang, T.; Morikawa, T.; Xie, H.; Matsuda, H. Bioactive constituents from Chinese natural medicines. XXIV. Hypoglycemic effects of Sinocrassula indica in sugar-loaded rats and genetically diabetic KK-Ay mice and structures of new acylated flavonol Glycosides, Sinocrassosides A1, A2, B1, and B2. Chem. Pharm. Bull. 2007, 55, 1308-1315.
152. Suryanarayana, P.; Satyanarayana, A.; Balakrishna, N.; Kumar, P. U.; Reddy, G. B. Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat. Med. Sci. Monit. 2007, 13, 286-292.
153. Islam, M. S.; Choi, H. Comparative effects of dietary ginger (Zingiber officinale) and garlic (Allium sativum) investigated in a type 2 diabetes model of rats. J. Med. Food 2008, 11, 152-159.
154. Nammi, S.; Sreemantula, S.; Roufogalis, B. D. Protective effects of ethanolic extract of Zingiber officinale rhizome on the development of metabolic syndrome in high-fat diet-fed rats. Basic. Clin. Pharmacol. Toxicol. 2009, 104, 366-373.
155. Liou, S. S.; Liu, I. M.; Lai, M. C. The plasma glucose lowering action of Hei-Shug-Pian, the fire-processed product of the root of Aconitum (Aconitum carmichaeli), in streptozotocin-induced diabetic rats. J. Ethnopharmacol. 2006, 106, 256-262.
156. Gao, X.; Li, B.; Jiang, H.; Liu, F.; Xu, D.; Liu, Z. Dioscorea opposita reverses dexamethasone induced insulin resistance. Fitoterapia 2007, 78, 12-15.
157. Lau, C. H.; Chan, C. M.; Chan, Y. W.; Lau, K. M.; Lau, T. W. In vitro anti-diabetic activities of five medicinal herbs used in Chinese medicinal formulae. Phytother. Res. 2008, 22, 1384-1388.
158. Ni, T.; Hu, Y.; Sun, L.; Chen, X.; Zhong, J.; Ma, H.; Lin, Z. Oral route of mini-proinsulin-expressing Ganoderma lucidum decreases blood glucose level in streptozocin-induced diabetic rats. Int. J. Mol. Med. 2007, 20, 45-51.
159. Tanaka, K.; Nishizono, S.; Makino, N.; Tamaru, S.; Terai, O.; Ikeda, I. Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice. Biosci. Biotechnol. Biochem. 2008, 72, 686-693.
160. Li, W. L.; Wu, J. L.; Ren, B. R.; Chen, J.; Lu, C. G. Pharmacological studies on anti-hyperglycemic effect of folium eriobotryae. Am. J. Chin. Med. 2007, 35, 705-711.
161. Lü, H.; Chen, J.; Li, W. L.; Ren, B. R.; Wu, J. L.; Kang, H. Y.; Zhang, H. Q.; Adams, A.; De Kimpe, N. Hypoglycemic and hypolipidemic effects of the total triterpene acid fraction from Folium Eriobotryae. J. Ethnopharmacol. 2009, 122, 486-491.
162. Walker, A. F.; Marakis, G.; Simpson, E.; Hope, J. L.; Robinson, P. A.; Hassanein, M.; Simpson, H. C. Hypotensive effects of hawthorn for patients with diabetes taking prescription drugs: a randomised controlled trial. Br. J. Gen. Pract. 2006, 56, 437-443.
163. Utsunomiya, H.; Yamakawa, T.; Kamei, J.; Kadonosono, K.; Tanaka, S. Anti-hyperglycemic effects of plum in a rat model of obesity and type 2 diabetes, Wistar fatty rat. Biomed. Res. 2005, 26, 193-200.
164. Parmar, H. S.; Kar, A. Anti-diabetic potential of Citrus sinensis and Punica granatum peel extracts in alloxan treated male mice. Biofactors 2007, 31, 17-24.
165. Zhao, Y.; Son, Y. O.; Kim, S. S.; Jang, Y. S.; Lee, J. C. Antioxidant and anti-hyperglycemic activity of polysaccharide isolated from Dendrobium chrysotoxum Lindl. J. Biochem. Mol. Biol. 2007, 40, 670-677.
166. Zhang, Y.; Cai, J.; Ruan, H.; Pi, H.; Wu, J. Antihyperglycemic activity of kinsenoside, a high yielding constituent from Anoectochilus roxburghii in streptozotocin diabetic rats. J. Ethnopharmacol. 2007, 114, 141-145.
167. Sangameswaran, B.; Jayakar, B. Anti-diabetic, anti-hyperlipidemic and spermatogenic effects of Amaranthus spinosus Linn. on streptozotocin-induced diabetic rats. Nat. Med. (Tokyo) 2008, 62, 79-82.
168. Baker, W. L.; Gutierrez-Williams, G.; White, C. M.; Kluger, J.; Coleman, C. I. Effect of cinnamon on glucose control and lipid parameters. Diabetes Care 2008, 31, 41-43.
169. Singh, J.; Kakkar, P. Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats. J. Ethnopharmacol. 2009, 123, 22-26.
170. Leu, Y. L.; Chen, Y. W.; Yang, C. Y.; Huang, C. F.; Lin, G. H.; Tsai, K. S.; Yang, R. S.; Liu, S. H. Extract isolated from Angelica hirsutiflora with insulin secretagogue activity. J. Ethnopharmacol. 2009, 123, 208-212.
171. Oh, K. S.; Ryu, S. Y.; Lee, S.; Seo, H. W.; Oh, B. K.; Kim, Y. S.; Lee, B. H. Melanin-concentrating hormone-1 receptor antagonism and anti-obesity effects of ethanolic extract from Morus alba leaves in diet-induced obese mice. J. Ethnopharmacol. 2009, 122, 216-220.
172. Huang, C. N.; Chan, K. C.; Lin, W. T.; Su, S. L.; Wang, C. J.; Peng, C. H. Hibiscus sabdariffa inhibits vascular smooth muscle cell proliferation and migration induced by high glucose-A mechanism involves connective tissue growth factor signals. J. Agric. Food. Chem. 2009, 57, 3073-3079.
173. Zeng, J. Z.; Dong, K. L.; Li, G. C.; Li, L. M. Effect of xiaokeling concentration fluid on mRNA expression of insulin-like growth factor-1 in sciatic nerve of Streptozotocin-induced diabetic rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2005, 30, 49-52.
174. Yu, Y. L.; Lu, S. S.; Yu, S.; Liu, Y. C.; Wang, P.; Xie, L.; Wang, G. J.; Liu, X. D. Huang-Lian-Jie-Du-Decoction modulates gluca gon-like peptide-1 secretion in diabetic rats. J. Ethnopharmacol. 2009, 124, 444-449.
175. Hirotani Y.; Ikeda, T.; Yamamoto, K.; Kurokawa, N. Effects of Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) on hyperglycemia in streptozotocin-induced diabetic rats. Biol. Pharm. Bull. 2007, 30, 1015-1020.
176. Wong, M. W.; Leung, P. C.; Wong, W. C. Limb salvage in extensive diabetic foot ulceration-a preliminary clinical study using simple debridement and herbal drinks. Hong Kong Med. J. 2001, 7, 403-407.
177. Chan, C. M.; Chan, Y. W.; Lau, C. H.; Lau, T. W.; Lau, K. M.; Lam, F. C.; Che, C. T.; Leung, P. C.; Fung, K. P.; Lau, C. B.; Ho, Y. Y. Influence of an anti-diabetic foot ulcer formula and its component herbs on tissue and systemic glucose homeostasis. J. Ethnopharmacol. 2007, 109, 10-20.
178. Goto, H.; Shimada, Y.; Sekiya, N.; Yang, Q.; Kogure, T.; Mantani, N.; Hikiami, H.; Shibahara, N.; Terasawa, K. Effects of Keishibukuryo-gan on vascular function and hemorheological factors in spontaneously diabetic (WBN/kob) rats. Phytomedicine 2004, 11, 188-195.
179. Wu, Y. C.; Hsu, J. H.; Liu, I. M.; Liou, S. S.; Su, H. C.; Cheng, J. T. Increase of insulin sensitivity in diabetic rats received diehuang-wan, a herbal mixture used in Chinese traditional medicine. Acta Pharmacol. Sin. 2002, 23, 1181-1187.
180. Zhang, H; Chen, S.; Deng, X.; Yang, X.; Huang, X. Danggui-Buxue-Tang decoction has an anti-inflammatory effect in diabetic atherosclerosis rat model. Diabetes Res. Clin. Pract. 2006, 74, 194-196.
181. Tao, X. M.; Wang, X. Y.; Jia, W. Using Chinese natural products for diabetes mellitus drug discovery and development. Expert Opin. Drug Discov. 2007, 2, 977-986.
182. Butler, M. S. The role of natural product chemistry in drug discovery. J. Nat. Prod. 2004, 67, 2141-2153.
183. Newman, D. J.; Cragg, G. M. Natural products as sources of new drugs over the last 25 years. J. Nat. Prod. 2007, 70, 461-477.
184. Lam, K. S. New aspects of natural products in drug discovery. Trends Microbiol. 2007, 15, 279-289.
185. Gurib-Fakim, A. Medicinal plants: Traditions of yesterday and drugs of tomorrow. Mol. Aspects Med. 2006, 27, 1-93.
186. Clardy, J.; Walsh, C. Lessons from natural molecules. Nature 2004, 432, 829-837.
187. Bérdy, J. Bioactive microbial metabolites. J. Antibiot (Tokyo). 2005, 58, 1-26.
188. Feher, M.; Schmidt, J. M. Property distributions: differences between drugs, natural products and molecules from combinatorial chemistry. J. Chem. Inf. Comput. Sci. 2003, 43, 218-227
189. Koehn, F. E.; Carter, G. T. The evolving role of natural products in drug discovery. Nat. Rev. Drug Discov. 2005, 4, 206-220.
190. Qi, L. W.; Wen, X. D.; Cao, J.; Li, C. Y.; Li, P.; Yi, L.; Wang, Y. X.; Cheng, X. L.; Ge, X. X. Rapid and sensitive screening and characterization of phenolic acids, phthalides, saponins and isoflavonoids in Danggui Buxue Tang by rapid resolution liquid chromatography/diode-array detection coupled with time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2008, 22, 2493-2509.
191. Qi, L. W.; Cao, J.; Li, P.; Yu, Q. T.; Wen, X. D.; Wang, Y. X.; Li, C. Y.; Bao, K. D.; Ge, X. X.; Cheng, X. L. Qualitative and quantitative analysis of Radix Astragali Products by fast highperformance liquid chromatography-diode array detection coupled with time-of-flight mass spectrometry through dynamic adjustment of fragmentor voltage, J. Chromatogr. A 2008, 1203, 27-35.
192. Li, H. J.; Jiang, Y.; Li, P.. Chemistry, bioactivity and geographical diversity of steroidal alkaloids from the Liliaceae family. Nat. Prod. Rep. 2006, 23, 735-752.
193. Li, P.; Qi, L. W.; Liu, E. H.; Zhou, J. L.; Wen, X. D. Analysis of Chinese herbal medicines with holistic approaches and integrated evaluation models. Trends Anal. Chem. 2008, 27, 66-77.
194. Su, X.; Kong, L.; Lei, X.; Hu, L.; Ye, M.; Zou, H. Biological fingerprinting analysis of traditional Chinese medicines with targeting ADME/Tox property for screening of bioactive compounds by chromatographic and MS methods. Mini Rev. Med. Chem. 2007, 7, 87-98.
195. Chen, J.; Zhao, X.; Fritsche, J.; Yin, P.; Schmitt-Kopplin, P.; Wang, W.; Lu, X.; Haring, H. U.; Schleicher, E. D.; Lehmann, R.; Xu, G. Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information. Anal. Chem. 2008, 80, 1280-1289.
196. Qiu, J. Traditional medicine: A culture in the balance. Nature 2007, 448, 126-128.
197. Silano, M.; De Vincenzi, M.; De Vincenzi, A.; Silano, V. The new European legislation on traditional herbal medicines: main features and perspectives. Fitoterapia 2004, 75, 107-116.