Protective effects of American ginseng (Panax quinquefolium) against mitomycin C induced micronuclei in mice

Phytotherapy Research

Volumn 21, Issue 12, 2007, Pages 1221-1227

  Pawar, Amol Ashok ^a   Tripathi, Durga Nand ^a   Ramarao, Poduri ^a   Jena, Gopabandhu ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

American ginseng; Mice; Micronuclei test; Mitomycin C

Indexed keywords

GINSENG EXTRACT; MITOMYCIN C; PANAX QUINQUEFOLIUM EXTRACT; UNCLASSIFIED DRUG;

ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD; BONE MARROW; CELL PROTECTION; CHROMOSOME ABERRATION; CONTROLLED STUDY; ERYTHROCYTE; GENOTOXICITY; GINSENG; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PANAX QUINQUEFOLIUM; PLANT ROOT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CYTOPROTECTION; MALE; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MITOMYCIN; PANAX; PLANT EXTRACTS; PLANT ROOTS;

MUS; PANAX GINSENG; PANAX QUINQUEFOLIUS;

EID: 37849039770     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2245     Document Type: Article

References (30)

1. Bhunya SP, Jena GB. 1992. Genotoxic potential of the organochlorine insecticide lindane (gamma-BHC); an in vivo study in chicks. Mutat Res 272: 175-181.
2. Bradner WT. 2001. Mitomycin C: a clinical update. Cancer Treat Rev 27: 35-50.
3. Carter SK. 1968. Mitomycin C (NSC-26980) - clinical brochure. Cancer Chemother Rep 3 1: 99-114.
4. Games J. 1996. Nursing implications in the management of superficial bladder cancer. Semin Urol Oncol 14: 36-40.
5. Godfrey TE, Wilbur DW. 1972. Clinical experience with mitomycin C in large infrequent doses. Cancer 29: 1647-1652.
6. Gollapudi BB, McFadden LG. 1995. Sample size for the estimation of polychromatic to normochromatic erythrocyte ratio in the bone marrow micronucleus test. Mutat Res 347: 97-99.
7. Guyton KZ, Kensler TW. 1993. Oxidative mechanisms in carcinogenesis. Br Med Bull 49: 523-544.
8. Hayashi M, Sofuni T, Ishidate M Jr. 1983. An application of acridine orange fluorescent staining to the micronucleus test. Mutat Res 120: 241-247.
9. Holden HE, Majeska JB, Studwell D. 1997. A direct comparison of mouse and rat bone marrow and blood as target tissues in the micronucleus assay. Mutat Res 391: 87-89.
10. Jena GB, Bhunya SP. 1995. Use of chick, Gallus domesticus, as an in vivo model for the study of chromosome aberration: a study with mitomycin C and probable location of a 'hot spot'. Mutat Res 334: 167-174.
11. Jena GB, Nemmani KV, Kaul CL, Ramarao P. 2003. Protective effect of a polyherbal formulation (Immu-21) against cyclophosphamide-induced mutagenicity in mice. Phytother Res 17: 306-310.
12. Jena GB, Nemmani VSK, Kaul CL, Ramarao P. 2001. Protective effects of polyherbal compound (Immu-21) against cyclophosphamide induced mutagenicity in mice. Phytother Res 17: 306-310.
13. Keum YS, Han SS, Chun KS et al. 2003. Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion. Mutat Res 523-524: 75-85.
14. Kim YK, Guo Q, Packer L. 2002. Free radical scavenging activity of red ginseng aqueous extracts. Toxicology 172: 149-156.
15. Kitts DD, Wijewickreme AN, Hu C. 2000. Antioxidant properties of a North American ginseng extract. Mol Cell Biochem 203: 1-10.
16. Korkina LG, Deeva IB, Biase AD et al. 2000. Redox-dependent toxicity of diepoxybutane and mitomycin C in sea urchin embryogenesis. Carcinogenesis 21: 213-220.
17. Lee TK, Allison RR, O'Brien KF et al. 2004. Ginseng reduces the micronuclei yield in lymphocytes after irradiation. Mutat Res 557: 75-84.
18. Luo JZ, Luo L. 2006. American ginseng stimulates insulin production and prevents apoptosis through regulation of uncoupling protein-2 in cultured beta cells. Evid Based Complement Alternat Med 3: 365-372.
19. Mavournin KH, Blakey DH, Cimino MC, Salamone MF, Heddle JA. 1990. The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res 239: 29-80.
20. Miller BM, Adler ID. 1990. Application of antikinetochore antibody staining (CREST staining) to micronuclei in erythrocytes induced in vivo. Mutagenesis 5: 411-415.
21. Molyneux G, Gibson FM, Gordon-Smith EC et al. 2005. The haemotoxicity of mitomycin in a repeat dose study in the female CD-1 mouse. Int J Exp Pathol 86: 415-430.
22. Ng TB, Liu F, Wang HX. 2004. The antioxidant effects of aqueous and organic extracts of Panax quinquefolium, Panax notoginseng, Codonopsis pilosula, Pseudostellaria heterophylla and Glehnia littoralis. J Ethnopharmacol 93: 285-288.
23. OECD. 1997. Mammalian erythrocyte micronucleus test. Organization Economic Coperation and Development. OECD Test Guideline 474,
24. Roos WP, Kaina B. 2006. DNA damage-induced cell death by apoptosis. Trends Mol Med 12: 440-450.
25. Russo A, Stocco A, Majone F. 1992. Identification of kinetochore- containing (CREST+) micronuclei in mouse bone marrow erythrocytes. Mutagenesis 7: 195-197.
26. Schmid K, Boettcher MI, Pelz JO et al. 2006. Investigations on safety of hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) with Mitomycin C. Eur J Surg Oncol 32: 1222-1225.
27. Schmid W. 1975. The micronucleus test. Mutat Res 31: 9-15.
28. Schriever-Schwemmer G, Adler ID. 1994. Differentiation of micronuclei in mouse bone marrow cells: a comparison between CREST staining and fluorescent in situ hybridization with centromeric and telomeric DNA probes. Mutagenesis 9: 333-340.
29. Wahnschaffe U, Bitsch A, Kielhorn J, Mangelsdorf I. 2005. Mutagenicity testing with transgenic mice. Part I: Comparison with the mouse bone marrow micronucleus test. J Carcinog 4: 3.
30. Zhang Q, Kang X, Zhao W. 2006. Antiangiogenic effect of low-dose cyclophosphamide combined with ginsenoside Rg3 on Lewis lung carcinoma. Biochem Biophys Res Commun 342: 824-828.