Red notoginseng: Higher ginsenoside content and stronger anticancer potential than Asian and American ginseng

Food Chemistry

Volumn 125, Issue 4, 2011, Pages 1299-1305

  Sun, Shi ^a   Qi, Lian Wen ^a   Du, Guang Jian ^a   Mehendale, Sangeeta R ^a   Wang, Chong Zhi ^a   Yuan, Chun Su ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

American ginseng; Anticancer; Asian ginseng; Ginsenosides; Notoginseng; Steaming

Indexed keywords

AMERICAN GINSENG; ANTICANCER; ASIAN GINSENG; GINSENOSIDES; NOTOGINSENG; STEAMING;

CHEMICAL ANALYSIS; DISEASES; FLOW CYTOMETRY;

PHARMACODYNAMICS;

GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RB 3; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RF; GINSENOSIDE RG 1; GINSENOSIDE RG 2; GINSENOSIDE RG 3; GINSENOSIDE RG 5; GINSENOSIDE RH 2; GINSENOSIDE RH 4; GINSENOSIDE RK 1; GINSENOSIDE RK 3; NOTOGINSENOSIDE R1; PANAX NOTOGINSENG EXTRACT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CHEMICAL ANALYSIS; CHEMOPROPHYLAXIS; COLORECTAL CANCER; CONTROLLED STUDY; DRUG DEGRADATION; DRUG MECHANISM; DRUG STRUCTURE; FLOW CYTOMETRY; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; HUMAN; HUMAN CELL; PANAX NOTOGINSENG; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET RADIATION;

PANAX GINSENG; PANAX NOTOGINSENG; PANAX QUINQUEFOLIUS;

EID: 78649327499     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodchem.2010.10.049     Document Type: Article

References (20)

1. Assinewe V.A., Arnason J.T., Aubry A., Mullin J., Lemaire I. Extractable polysaccharides of Panax quinquefolius L. (North American ginseng) root stimulate TNF alpha production by alveolar macrophages. Phytomedicine 2002, 9(5):398-404.
2. Chan T.W.D., But P.P.H., Cheng S.W., Kwok I.M.Y., Lau F.W., Xu H.X. Differentiation and authentication of Panax ginseng, Panax quinquefolius, and ginseng products by using HPLC/MS. Analytical Chemistry 2000, 72(6):1281-1287.
3. Chen C.Y.O., Ribaya-Mercado J.D., McKay D.L., Croom E., Blumberg J.B. Differential antioxidant and quinone reductase inducing activity of American, Asian, and Siberian ginseng. Food Chemistry 2010, 119(2):445-451.
4. Dong S.J., Kiyama R. Characterisation of oestrogenic activity of ginsenosides in MCF-7 cells using a customised DNA microarray. Food Chemistry 2009, 113(2):672-678.
5. Du X.W., Wills R.B.H., Stuart D.L. Changes in neutral and malonyl ginsenosides in American ginseng (Panax quinquefolium) during drying, storage and ethanolic extraction. Food Chemistry 2004, 86(2):155-159.
6. Kang K.S., Yamabe N., Kim H.Y., Okamoto T., Sei Y., Yokozawa T. Increase in the free radical scavenging activities of American ginseng by heat processing and its safety evaluation. Journal of Ethnopharmacology 2007, 113(2):225-232.
7. Kim S.N., Ha Y.W., Shin H., Son S.H., Wu S.J., Kim Y.S. Simultaneous quantification of 14 ginsenosides in Panax ginseng C. A. Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control. Journal of Pharmaceutical and Biomedical Analysis 2007, 45(1):164-170.
8. Kite G.C., Howes M.J.R., Leon C.J., Simmonds M.S.J. Liquid chromatography/mass spectrometry of malonyl-ginsenosides in the authentication of ginseng. Rapid Communications in Mass Spectrometry 2003, 17(3):238-244.
9. Kwon S.W., Han S.B., Park I.H., Kim J.M., Park M.K., Park J.H. Liquid chromatographic determination of less polar ginsenosides in processed ginseng. Journal of Chromatography A 2001, 921(2):335-339.
10. Lee Y.J., Kim H.Y., Kang K.S., Lee J.G., Yokozawa T., Park J.H. The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb-1 by heat processing. Bioorganic & Medicinal Chemistry Letters 2008, 18(16):4515-4520.
11. Lee S.M., Shon H.J., Choi C.S., Hung T.M., Min B.S., Bae K. Ginsenosides from heat processed Ginseng. Chemical & Pharmaceutical Bulletin 2009, 57(1):92-94.
12. Li W.K., Gu C.G., Zhang H.J., Awang D.V.C., Fitzloff J.F., Fong H.H.S., et al. Use of high performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C. A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng). Analytical Chemistry 2000, 72(21):5417-5422.
13. Li L., Luo G.A., Liang Q.L., Hu P., Wang Y.M. Rapid qualitative and quantitative analyses of Asian ginseng in adulterated American ginseng preparations by UPLC/Q-TOF-MS. Journal of Pharmaceutical and Biomedical Analysis 2010, 52(1):66-72.
14. Lu G.H., Zhou Q., Sun S.Q., Leung K.S.Y., Zhang H., Zhao Z.Z. Differentiation of Asian ginseng, American ginseng and notoginseng by Fourier transform infrared spectroscopy combined with two-dimensional correlation infrared spectroscopy. Journal of Molecular Structure 2008, 883:91-98.
15. Qi L.W., Wang C.Z., Yuan C.S. American ginseng: Potential structure-function relationship in cancer chemoprevention. Biochemical Pharmacology 2010, 80(7):947-954.
16. Sun B.S., Gu L.J., Fang Z.M., Wang C.Y., Wang Z., Lee M.R., et al. Simultaneous quantification of 19 ginsenosides in black ginseng developed from Panax ginseng by HPLC-ELSD. Journal of Pharmaceutical and Biomedical Analysis 2009, 50(1):15-22.
17. Sun S., Wang C.Z., Tong R., Li X.L., Fishbein A., Wang Q., et al. Effects of steaming the root of Panax notoginseng on chemical composition and anticancer activities. Food Chemistry 2010, 118(2):307-314.
18. Wang C.Z., Aung H.H., Ni M., Wu J.A., Tong R.B., Wicks S., et al. Red American ginseng: Ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots. Planta Medica 2007, 73(7):669-674.
19. Wang C.Z., Zhang B., Song W.X., Wang A.B., Ni M., Luo X.J., et al. Steamed American ginseng berry: Ginsenoside analyses and anticancer activities. Journal of Agricultural and Food Chemistry 2006, 54(26):9936-9942.
20. Yue P.Y.K., Wong D.Y.L., Wu P.K., Leung P.Y., Mak N.K., Yeung H.W., et al. The angiosuppressive effects of 20(R)-ginsenoside Rg(3). Biochemical Pharmacology 2006, 72(4):437-445.