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Volumn 72, Issue 11, 2008, Pages 2815-2823

Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance β-cell insulin secretion and viability in min6 cells via PKA-dependent pathways

Author keywords

3T3 L1 adipocytes; Ginsenosides; Insulin secretion; Min6 cells; PKA

Indexed keywords

AMINES; BODY FLUIDS; CELLS; CHEMICAL ACTIVATION; FETAL MONITORING; GLUCOSE; HORMONES; INSULIN; PHYSIOLOGY; SUGAR (SUCROSE);

EID: 56749161352     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.80205     Document Type: Article
Times cited : (94)

References (34)
  • 1
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes
    • Kahn, S. E., The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia, 46, 3-19 (2003).
    • (2003) Diabetologia , vol.46 , pp. 3-19
    • Kahn, S.E.1
  • 2
    • 3142728651 scopus 로고    scopus 로고
    • The role of sulphonylureas in the management of type 2 diabetes mellitus
    • Rendell, M., The role of sulphonylureas in the management of type 2 diabetes mellitus. Drugs, 64, 1339-1358 (2004).
    • (2004) Drugs , vol.64 , pp. 1339-1358
    • Rendell, M.1
  • 3
    • 33744821064 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation
    • Lu, M., and Shyy, J. Y., Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation. Am. J. Physiol. Cell Physiol., 290, C1477-C1486 (2006).
    • (2006) Am. J. Physiol. Cell Physiol , vol.290
    • Lu, M.1    Shyy, J.Y.2
  • 4
    • 0242384915 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis In 3T3-L1 adipocytes
    • Yin, W., Mu, J., and Birnbaum, M. J., Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis In 3T3-L1 adipocytes. J. Biol. Chem., 278, 43074-43080 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 43074-43080
    • Yin, W.1    Mu, J.2    Birnbaum, M.J.3
  • 5
    • 26844582510 scopus 로고    scopus 로고
    • Estrogen and exercise may enhance b-cell function and mass via IRS2 induction in ovariectomized diabetic rats
    • Choi, S. B., Jang, J. S., and Park, S., Estrogen and exercise may enhance b-cell function and mass via IRS2 induction in ovariectomized diabetic rats. Endocrinology, 146, 4786-4794 (2005).
    • (2005) Endocrinology , vol.146 , pp. 4786-4794
    • Choi, S.B.1    Jang, J.S.2    Park, S.3
  • 6
    • 33644850386 scopus 로고    scopus 로고
    • Exendin-4 promotes IRS2 signaling to mediate pancreatic beta-cell growth and function
    • Park, S., Dong, X., Fisher, T. L., Dunn, S. L., Omer, A. K., Weir, G., and White, M. F., Exendin-4 promotes IRS2 signaling to mediate pancreatic beta-cell growth and function. J. Biol. Chem., 281, 1159-1168 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 1159-1168
    • Park, S.1    Dong, X.2    Fisher, T.L.3    Dunn, S.L.4    Omer, A.K.5    Weir, G.6    White, M.F.7
  • 7
    • 0033304603 scopus 로고    scopus 로고
    • The glucagon-like peptides
    • Kieffer, T. J., and Habener, J. F., The glucagon-like peptides. Endocr. Rev., 20, 876-913 (1999).
    • (1999) Endocr. Rev , vol.20 , pp. 876-913
    • Kieffer, T.J.1    Habener, J.F.2
  • 8
    • 56749144007 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptides
    • eds. LeRoith, D, Taylon, S. I, and Olefsky, J. M, Lippincott Williams and Wilkins, Philadelphia, pp
    • Habener, J. F., and Kemp, D. M., Insulinotropic glucagon-like peptides. In "Diabetes Mellitus: A Fundamental and Clinical Text," eds. LeRoith, D., Taylon, S. I., and Olefsky, J. M., Lippincott Williams and Wilkins, Philadelphia, pp. 123-134 (2004).
    • (2004) Diabetes Mellitus: A Fundamental and Clinical Text , pp. 123-134
    • Habener, J.F.1    Kemp, D.M.2
  • 9
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 receptor agonist, reverses hepatic steatosis in ob/ob mice
    • Ding, X., Saxena, N. K., Lin, S., Gupta, N. A., and Anania, F. A., Exendin-4, a glucagon-like protein-1 receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology, 43, 173-181 (2006).
    • (2006) Hepatology , vol.43 , pp. 173-181
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Gupta, N.A.4    Anania, F.A.5
  • 10
  • 11
    • 0019488469 scopus 로고
    • Effects of hypoglycemic components in ginseng radix on blood insulin level in alloxan diabetic mice and on insulin release from perfused rat pancreas
    • Kimura, M., Waki, I., Chujo, T., Kikuchi, T., Hiyama, C., Yamazaki, K., and Tanaka, O., Effects of hypoglycemic components in ginseng radix on blood insulin level in alloxan diabetic mice and on insulin release from perfused rat pancreas. J. Pharmacobiodyn., 4, 410-417 (1981).
    • (1981) J. Pharmacobiodyn , vol.4 , pp. 410-417
    • Kimura, M.1    Waki, I.2    Chujo, T.3    Kikuchi, T.4    Hiyama, C.5    Yamazaki, K.6    Tanaka, O.7
  • 12
    • 0029097005 scopus 로고
    • Ginseng therapy in non-insulin-dependent diabetic patients
    • Sotaniemi, E. A., Haapakoski, E., and Rautio, A., Ginseng therapy in non-insulin-dependent diabetic patients. Diabetes Care, 18, 1373-1375 (1995).
    • (1995) Diabetes Care , vol.18 , pp. 1373-1375
    • Sotaniemi, E.A.1    Haapakoski, E.2    Rautio, A.3
  • 13
    • 0034630423 scopus 로고    scopus 로고
    • American Ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus
    • Vuksan, V., Sievenpiper, J. L., Koo, V. Y., Francis, T., Beljan-Zdravkovic, U., Xu, Z., and Vidgen, E., American Ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch. Intern. Med., 160, 1009-1013 (2000).
    • (2000) Arch. Intern. Med , vol.160 , pp. 1009-1013
    • Vuksan, V.1    Sievenpiper, J.L.2    Koo, V.Y.3    Francis, T.4    Beljan-Zdravkovic, U.5    Xu, Z.6    Vidgen, E.7
  • 14
    • 0344549853 scopus 로고    scopus 로고
    • Multiple pharmacological effects of ginseng
    • Attele, A. S., Wu, J. A., and Yuan, C. S., Multiple pharmacological effects of ginseng. Biochem. Pharmacol., 58, 1685-1693 (1999).
    • (1999) Biochem. Pharmacol , vol.58 , pp. 1685-1693
    • Attele, A.S.1    Wu, J.A.2    Yuan, C.S.3
  • 17
    • 30944468918 scopus 로고    scopus 로고
    • Insulin sensitizing and α-glycoamylase inhibitory action of sennosides, rheins and rhaponticin in Rhei Rhizoma
    • Choi, S. B., Ko, B. S., Park, S. K., Jang, J. S., and Park, S., Insulin sensitizing and α-glycoamylase inhibitory action of sennosides, rheins and rhaponticin in Rhei Rhizoma. Life Sci., 78, 934-942 (2006).
    • (2006) Life Sci , vol.78 , pp. 934-942
    • Choi, S.B.1    Ko, B.S.2    Park, S.K.3    Jang, J.S.4    Park, S.5
  • 18
    • 38049063954 scopus 로고    scopus 로고
    • Ginsenoside Re reduces insulin resistance through inhibition of JNK and NF-kB
    • Zhang, Z., Li, X., Lv, W., Yang, Y., Gao, H., Yang, J., Shen, Y., and Ning, G., Ginsenoside Re reduces insulin resistance through inhibition of JNK and NF-kB. Mol. Endocrinol., 22, 186-195 (2008).
    • (2008) Mol. Endocrinol , vol.22 , pp. 186-195
    • Zhang, Z.1    Li, X.2    Lv, W.3    Yang, Y.4    Gao, H.5    Yang, J.6    Shen, Y.7    Ning, G.8
  • 19
    • 34249947136 scopus 로고    scopus 로고
    • Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats
    • Lee, W. K., Kao, S. T., Liu, I. M., and Cheng, J. T., Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats. Horm. Metab. Res., 39, 347-354 (2007).
    • (2007) Horm. Metab. Res , vol.39 , pp. 347-354
    • Lee, W.K.1    Kao, S.T.2    Liu, I.M.3    Cheng, J.T.4
  • 20
    • 33645083467 scopus 로고    scopus 로고
    • Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats
    • Lee, W. K., Kao, S. T., Liu, I. M., and Cheng, J. T., Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats. Clin. Exp. Pharmacol. Physiol., 33, 27-32 (2006).
    • (2006) Clin. Exp. Pharmacol. Physiol , vol.33 , pp. 27-32
    • Lee, W.K.1    Kao, S.T.2    Liu, I.M.3    Cheng, J.T.4
  • 21
    • 33846064201 scopus 로고    scopus 로고
    • Ginsenoside Rb1 promotes adipogenesis in 3T3-L1 cells by enhancing PPARgamma2 and C/EBPalpha gene expression
    • Shang, W., Yang, Y., Jiang, B., Jin, H., Zhou, L., Liu, S., and Chen, M., Ginsenoside Rb1 promotes adipogenesis in 3T3-L1 cells by enhancing PPARgamma2 and C/EBPalpha gene expression. Life Sci., 80, 618-625 (2007).
    • (2007) Life Sci , vol.80 , pp. 618-625
    • Shang, W.1    Yang, Y.2    Jiang, B.3    Jin, H.4    Zhou, L.5    Liu, S.6    Chen, M.7
  • 22
    • 0033982177 scopus 로고    scopus 로고
    • CREB activation induces adipogenesis in 3T3-L1 cells
    • Reusch, J. E., Colton, L. A., and Klemm, D. J., CREB activation induces adipogenesis in 3T3-L1 cells. Mol. Cell. Biol., 20, 1008-1020 (2000).
    • (2000) Mol. Cell. Biol , vol.20 , pp. 1008-1020
    • Reusch, J.E.1    Colton, L.A.2    Klemm, D.J.3
  • 23
    • 1042289760 scopus 로고    scopus 로고
    • Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein β gene during adipogenesis
    • Zhang, J. W., Klemm, D. J., Vinson, C., and Lane, M. D., Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein β gene during adipogenesis. J. Biol. Chem., 279, 4471-4478 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 4471-4478
    • Zhang, J.W.1    Klemm, D.J.2    Vinson, C.3    Lane, M.D.4
  • 25
    • 33845764280 scopus 로고    scopus 로고
    • Kato, Y., Ozaki, N., Yamada, T., Miura, Y., and Oiso, Y., H-89 potentiates adipogenesis in 3T3-L1 cells by activating insulin signaling independently of protein kinase A. Life Sci., 80, 476-483 (2007).
    • Kato, Y., Ozaki, N., Yamada, T., Miura, Y., and Oiso, Y., H-89 potentiates adipogenesis in 3T3-L1 cells by activating insulin signaling independently of protein kinase A. Life Sci., 80, 476-483 (2007).
  • 26
    • 0242384915 scopus 로고    scopus 로고
    • Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats
    • Yin, W., Mu, J., and Birnbaum, M. J., Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats. J. Biol. Chem., 278, 43074-43080 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 43074-43080
    • Yin, W.1    Mu, J.2    Birnbaum, M.J.3
  • 28
    • 18044386757 scopus 로고    scopus 로고
    • Incretin hormones and insulin sensitivity
    • Hansen, P. A., and Corbett, J. A., Incretin hormones and insulin sensitivity. Trends Endocrinol. Metab., 16, 135-136 (2005).
    • (2005) Trends Endocrinol. Metab , vol.16 , pp. 135-136
    • Hansen, P.A.1    Corbett, J.A.2
  • 29
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • Ding, X., Saxena, N. K., Lin, S., Gupta, N. A., and Anania, F. A., Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology, 43, 173-181 (2006).
    • (2006) Hepatology , vol.43 , pp. 173-181
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Gupta, N.A.4    Anania, F.A.5
  • 30
    • 0030884317 scopus 로고    scopus 로고
    • Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes
    • Montrose-Rafizadeh, C., Yang, H., Wang, Y., Roth, J., Montrose, M. H., and Adams, L. G., Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes. J. Cell. Physiol., 172, 275-283 (1997).
    • (1997) J. Cell. Physiol , vol.172 , pp. 275-283
    • Montrose-Rafizadeh, C.1    Yang, H.2    Wang, Y.3    Roth, J.4    Montrose, M.H.5    Adams, L.G.6
  • 31
    • 0036496551 scopus 로고    scopus 로고
    • Exendin-4 increases insulin sensitivity via a PI-3-kinase-dependent mechanism: Contrasting effects of GLP-1
    • Idris, I., Patiag, D., Gray, S., and Donnelly, R., Exendin-4 increases insulin sensitivity via a PI-3-kinase-dependent mechanism: contrasting effects of GLP-1. Biochem. Pharmacol., 63, 993-996 (2002).
    • (2002) Biochem. Pharmacol , vol.63 , pp. 993-996
    • Idris, I.1    Patiag, D.2    Gray, S.3    Donnelly, R.4
  • 33
    • 0036896635 scopus 로고    scopus 로고
    • Pdx1 restores beta cell function in Irs2 knockout mice
    • Matschinsky, F. M., Pdx1 restores beta cell function in Irs2 knockout mice. Diabetes, 51, S394-S404 (2002).
    • (2002) Diabetes , vol.51
    • Matschinsky, F.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.