Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes

Journal of Endocrinology

Volumn 198, Issue 3, 2008, Pages 561-569

  Shang, Wenbin ^a,b   Yang, Ying ^a   Zhou, Libin ^a   Jiang, Boren ^a   Jin, Hua ^a   Chen, Mingdao ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GINSENOSIDE RB 1; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; ANDROSTANE DERIVATIVE; GINSENOSIDE; GLUCOSE; GREEN FLUORESCENT PROTEIN; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, MOUSE; SLC2A1 PROTEIN, MOUSE; SLC2A4 PROTEIN, MOUSE; WORTMANNIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENETIC TRANSFECTION; GLUCOSE TRANSPORT; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CELL STRAIN 3T3; CRICETULUS; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HAMSTER; IMMUNOPRECIPITATION; METABOLISM; MOUSE; PHOSPHORYLATION; TRANSPORT AT THE CELLULAR LEVEL; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3-L1 CELLS; ANDROSTADIENES; ANIMALS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; GINSENOSIDES; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; GLUCOSE TRANSPORTER TYPE 4; GREEN FLUORESCENT PROTEINS; IMMUNOPRECIPITATION; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MICE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 53349141483     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-08-0104     Document Type: Article

References (38)

1. Argetsinger LS, Hsu GW, Myers MG Jr, Billestrup N, White MF & Carter-Su C 1995 Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. Journal of Biological Chemistry 270 14685-14692.
2. Attele AS, Wu JA & Yuan CS 1999 Ginseng pharmacology: multiple constituents and multiple actions. Biochemical Pharmacology 58 1685-1693.
3. Attele AS, Zhou YP, Xie JT, Wa JA, Zhang L, Dey L, Pugh W Rue PA, Polonsky KS & Yuan CS 2002 Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 51 1851-1858.
4. Clarke JF, Young PW, Yonezawa K, Kasuga M & Holman GD 1994 Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphaticlylinositol 3-kinase inhibitor, wortmannin. Biochemical Journal 300 631-635.
5. Edens NK, Reaves LA & Henry DE 2001 Extract of ginseng (Panax ginseng) stimulates glucose transport and inhibits lipolysis in vitro. Diabetes 50 A413.
6. Esposito DL, Li Y, Carna A & Quon MJ 2001 Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and cranslocation of GLUT4 in adipose cells. Endocrinology 142 2833-2840.
7. Gillis CN 1997 Panax ginseng pharmacology: a nitric oxide link? Biochemical Pharmacology 54 1-8.
8. Heart E & Sung CK 2003 Insuhn-like and non-insulin-like selenium actions in 3T3-L1 adipocytes. Journal of Cellular Biochemistry 88 719-731.
9. Herman MA & Kahn BB 2006 Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. Journal of Clinical Investigation 116 1767-1775.
10. Imamura T, Ishibashi K, Dalle S, Ugi S & Olefsky JM 1999 Endothelin-1-induced GLUT4 translocation is mediated via Galpha(q/11) protein and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. Journal of Biological Chemistry 274 33691-33695.
11. Inoue M, Chang L, Hwang J, Chiang SH & Saltiel AR 2003 The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. Nature 422 629-633.
12. Kausch C, Krutzfeldt J, Witke A, Rettig A, Bachmann O, Rett K, Matthaei S, Machicao, E Haring HU & Stumvoll M 2001 Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochemical and Biophysical Research Communications 280 664-674.
13. Khan AH & Pessin JE 2002 Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia 45 1475-1483.
14. Li Y, Kim J, Li J, Liu F, Liu X, Himmeldirk K, Ren Y, Wagner TE & Chen X 2005 Natural anti-diabetic compound 1,2,3,4,6-penta-O-galloy1-D-glucopyranose binds to insulin receptor and activates insulin-mediated glucose transport signaling pathway. Biochemical and Biophysical Research Communications 336 430-437.
15. Liao W, Nguyen MT, Imamura T, Singer O, Verma IM & Olefsky JM 2006 Lentiviral short hairpin ribonucleic, acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes. Endocrinology 147 2245-2252.
16. Lim W, Mudge KW & Vermeylen F 2005 Effects of population, age, and cultivation methods on ginsenoside content of wild American ginseng (Panax quinquefolium). Journal of Agricultural and Food Chemistry 53 8498-8505.
17. Liu TP, Liu IM & Cheng JT 2005 Improvement of insulin resistance by Panax ginseng in fructose-rich chow-fed rats. Hormone and Metabolic Research 37 146-151.
18. Perrini S, Natalicchio A, Laviola L, Belsanti G, Montrone C, Cignarelli A, Minielli V, Grano M, De Pergola G, Giorgino R et al. 2004 Dehydroepiandrosterone stimulates glucose uptake in human and murine adipocytes by inducing GLUT1 and GLUT4 translocation to the plasma membrane. Diabetes 53 41-52.
19. Piper RC, Hess LJ & James DE 1991 Differential sorting of two glucose transporters expressed in insulin-sensitive cells. American Journal of Physiology 260 C570-C580.
20. Reay JL, Kennedy DO & Scholey AB 2006 The glycaemic effects of single doses of Panax ginseng in young healthy volunteers. British Journal of Nutrition 96 639-642.
21. Shang W, Yang Y, Jiang B, Jin H, Zhou L, Liu S & Chen M 2007a Ginsenoside Rb(1) promotes adipogenesis in 3T3-L1 cells by enhancing PPAR(2) and C/EBPα gene expression. Life Sciences 80 618-625.
22. 1 facilitates adipocyte differentiation and inhibits lipolysis in 3T3-L1 cells. Chinese Journal of Endocrinology and Metabolism 23 258-262.
23. Shintani M, Nishimura H, Yonemitsu S, Ogawa Y, Hayashi T, Hosoda K, Inoue G & Nakao K 2001 Troglitazone not only increases GLUT4 but also induces its translocation in rat adipocytes. Diabetes 50 2296-2300.
24. Sievenpiper JL, Sung MK, Di Buono M, Seung-Lee K, Nam KY, Armason JT, Leiter LA & Vuksan V 2006 Korean red ginseng rootlets decrease acute postprandial glycemia: results from sequential preparation- and dose-finding studies. Journal of the American College of Nutrition 25 100-107.
25. Vuksan V, Sievenpiper JL, Koo VYY, Francis T, Beljan-Zdravkovic U, Xu Z & Vidgen E 2000a American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Archives of Internal Medicine 160 1009-1013.
26. Vuksan V, Stavro MP, Sievenpiper JL, Beljan-Zdravkovic U, Leiter LA, Josse RG & Xu Z 2000b Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care 23 1221-1226.
27. Vuksan V, Sung MK, Sievenpiper JL, Stavro PM, Jenkins AL, Di Buono M, Lee KS, Leiter LA, Nam KY, Arnason JT et al. 2008 Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety. Nutrition, Metabolism, and Cardiovascular Diseases 18 46-56.
28. Wang H, Reaves LA & Edens NK 2006 Ginseng extract inhibits lipolysis in rat adipocytes in vitro by activating phosphodiesterase 4. Journal of Nutrition 136 337-342.
29. Washida D & Kitanaka S 2003 Determination of polyacetylenes and ginsenosides in Panax species using high performance liquid chromatography. Chemical and Pharmaceutical Bulletin 51 1314-1317.
30. Watson RT, Kanzaki M & Pessin JE 2004 Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes. Endocrine Reviews 25 177-204.
31. Weiland M, Schurmann A, Schmidt WF. & Joost HG 1990 Development of the hormone-sensitive glucose transport activity in differentiating 3T3-L1 murine fibroblasts. Role of the two transporter species and their subcellular localization. Biochemical Journal 270 331-336.
32. Xie JT, McHendale S & Yuan CS 2005a Ginseng and diabetes. American Journal of Chinese Medicine 33 397-404.
33. Xie JT, Mehendale Sk, Li X, Quigg R, Wang X, Wang CZ, Wu JA, Aung HH, Rue P A, Bell GI et al. 2005b Anti-diabetic effect of ginsenoside Re in ob/ob mice. Biochimica et Biophysica Acta 1740 319-325.
34. Xie JT, Wang CZ, Wang AB, Win J, Basila D & Yuan CS 2005c Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng. Acta Pharmacologica Sinica 26 1104-1110.
35. Yonemitsu S, Nishimura H, Shintani M, Inoue R, Yamamoto Y, Masuzaki H, Ogawa Y, Hosoda K, Inoue G, Hayashi T et al. 2001 Troglitazone induces GLUT4 translocation in L6 myotubes. Diabetes 50 1093-1101.
36. Yun SN, Moon SJ, Ko SK, Im BO & Chung SH 2004 Wild ginseng prevents the onset of high-fat diet induced hyperglycemia and obesity in ICR mice. Archives of Pharmacological Research 27 790-796.
37. Zhang Z, Li X, Lv W, Yang Y, Gao H, Yang J, Shen Y & Ning G 2008 Ginsenoside Re reduces insulin resistance through inhibition of c-Jun NH2-terminal kinase and nuclear factor-kappaB. Molecular Endocrinology 22 186-195.
38. Zorzano A, Palacin M & Guma A 2005 Mechanisms regulating GLUT4 glucose transporter expression and glucose transport in skeletal muscle. Acta Physiologica Scandinavica 183 43-58.