Use of ginseng in medicine with emphasis on neurodegenerative disorders

Journal of Pharmacological Sciences

Volumn 100, Issue 3, 2006, Pages 175-186

  Radad, Khaled ^a   Gille, Gabriele ^b   Liu, Linlin ^c   Rausch, Wolf Dieter ^d  

^a Assiut University Faculty of Medicine   (Egypt)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c JILIN UNIVERSITY   (China)

^d UNIVERSITY OF VETERINARY MEDICINE   (Austria)

Author keywords

Central nervous system; Chinese herb; Ginseng; Ginsenoside; Herbal medicine

Indexed keywords

ALCOHOL; ANTINEOPLASTIC AGENT; GINSENG EXTRACT; GINSENG POLYSACCHARIDE; GINSENG SAPONIN; GINSENOSIDE; PHENELZINE; WARFARIN;

ANTIHYPERTENSIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; CANCER RECURRENCE; CARDIOVASCULAR EFFECT; CLINICAL TRIAL; COGNITION; CONFUSION; DEGENERATIVE DISEASE; DEPERSONALIZATION; DEPRESSION; DIARRHEA; DRUG ALCOHOL INTERACTION; DRUG ERUPTION; DRUG MECHANISM; DRUG RESEARCH; HUMAN; HYPERTENSION; HYPOGLYCEMIA; IMMUNOSTIMULATION; IMPOTENCE; INSOMNIA; MASTALGIA; NASOPHARYNX CARCINOMA; NERVOUSNESS; NEUROMODULATION; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; PARKINSON DISEASE; RADIATION INJURY; REVIEW; STOMACH TUMOR; UNSPECIFIED SIDE EFFECT; VAGINA BLEEDING;

EID: 33645058893     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.CRJ05010X     Document Type: Review

References (149)

1. Nocerino E, Amato M, Izzo AA. The aphrodisiac and adaptogenic properties of ginseng. Fitoterapia. 2000;71:1-5.
2. Yun TK. Brief introduction of Panax ginseng C.A. Meyer. J Korean Med Sci. 2001;16:53-55.
3. 2+ channel currents in rat sensory neurons. Eur J Pharmacol. 2002;463:151-158.
4. Himi T, Saito H, Nishiyama N. Effects of ginseng saponins on the survival of cerebral cortex neurons in cell cultures. Chem Pharm Bull (Tokyo). 1989;37:481-484.
5. Wen TC, Yoshimura H, Matsuda S, Lim JH, Sakanaka M. Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischaemia. Acta Neuropathol. 1996;91:15-22.
6. Blumenthal M. Asian ginseng: potential therapeutic uses. Adv Nurse Pract. 2001;2:26-28.
7. Smolinski AT, Pestka JJ. Modulation of lipopolysacchride-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb1 (ginseng) and parthenolide. Food Chem Toxicol. 2003;41:1381-1390.
8. Liu CX, Xiao PG. Recent advances on ginseng research in China. J Ethnopharmacol. 1992;36:27-38.
9. Back NI, Kim DS, Lee YH, Park JD, Lee CB, Kim SI. Ginsenoside Rh4, a genuine dammarane glycoside from korean red ginseng. Planta Med. 1996;62:86-87.
10. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pahrmacol. 1999;58:1685-1693.
11. Fleming T. Physician desk references for herbal medicine. 1st ed. Montvale, NJ: Medical Economics Company; 1998.
12. Tyler VE. The honest herbal-A sensible guide to the use of herbs and related remedies. 3rd ed. New York: Haworth Press; 1993.
13. Wakabayashi C, Hasegawa H, Murata J, Saiki I. In vivo anti-metastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolism after oral administration. Oncol Res. 1997;9:411-417.
14. Murphy LL, Lee TJ. Ginseng, sex behavior and nitric oxide. Ann NY Acad Sci. 2002;962:372-377.
15. Byun BH, Shin I, Yoon YS, Kim SI, Joe CO. Modulation of protein kinase C activity in NIH 3T3 cells by plant glycosides from Panax ginseng. Planta Med. 1997;63:389-392.
16. Tackikawa E, Kudo K, Harada K, Kashimoto T, Miyate M, Kakizaki A. Effects of ginseng saponins on responses induced by various receptor stimuli. Eur J Pharmacol. 1999;369:23-32.
17. Liberti LE, Der Mardersian A. Evaluation of commercial ginseng products. J Pharm Sci. 1978;10:1487-1489.
18. Phillipson JD, Anderson LA. Ginseng-quality safety and efficacy? Pharm J. 1984;232:161-165.
19. Brekhman I, Dardymov I. New substances of plant origin which increase non specific resistance. Ann Rev Pharmacol. 1969;9:419-430.
20. O'Hara M, Kiefer D, Farrell K, Kemper K. A review of 12 commonly used medicinal herbs. Arch Fam Med. 1998;7:523-536.
21. Van Kampen J, Robertson H, Hagg T, Drobitch R. Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson's disease. Exp Neurol. 2003;184:21-29.
22. Sugaya A, Yuzurihara M, Tsuda T, Yasuda K, Kajiwara K, Sugaya AE. Proliferative effect of ginseng saponin on neurite extension of primary cultured neurons of the rat cerebral cortex. J Ethnopharmacol. 1988;22:173-181.
23. Mizumaki Y, Kurimoto M, Hirashima Y, Nishijima M, Kamiyama H, Nagai S, et al. Lipophilic fraction of Panax ginseng induces neuronal differentiation of PC12 cells and promotes neuronal survival of rat cortical neurons by protein kinase C dependent manner. Brain Res. 2002;20:254-260.
24. Kim YC, Kim SR, Markelonis GJ, Oh TH. Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration. J Neurosci Res. 1998;4:426-432.
25. Lim JH, Wen TC, Matsuda S, Tanaka J, Maeda N, Peng H, et al. Protection of ischaemic hippocampal neurons by ginsenosides Rb1, a main ingredient of ginseng root. Neurosci Res. 1997;28:191-200.
26. Liao B, Newmark H, Zhou R. Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. Exp Neurol. 2002;173:224-234.
27. Tohda C, Matsumoto N, Zou K, Meselhy MR, Komatsu K. Axonal and dendritic extension by protopanaxadiol-type saponins from ginseng drugs in SK-N-SH cells. Jpn J Pharmacol. 2002;90:254-262.
28. Radad K, Gille G, Moldzio R, Saito H, Rausch WD. Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate. Brain Res. 2004;17:41-53.
29. +-affected mesencephalic dopaminergic cells. J Neural Transm. 2004;111:37-45.
30. Tanner CM, Ben-Schlomo Y. Epidemiology of Parkinson's disease. Adv Neurol. 1999;80:153-159.
31. Tsang D, Yeung HW, Tso WW, Peck H. Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes. Planta Med. 1985;3:221-224.
32. Chun CX, Gui ZY, An ZL, Chun H, Ying C, Min CL, et al. Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress. Eur J Pharmacol. 2003;473:1-7.
33. Kim EH, Jang MH, Shin MC, Shin MS, Kim CJ. Protective effect of aqueous extract of Ginseng radix against 1-methyl-4-phenylpyridinium-induced apoptosis in PC12 cells. Biol Pharm Bull. 2003;26:1668-1673.
34. Chen XC, Chen Y, Zhu YG, Fang F, Chen LM. Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons. Acta Pharmacol Sin. 2002;23:829-834.
35. Salim KN, McEven BS, Choa HM. Ginsenoside Rb1 regulates ChAT, NGF and trkA mRNA expression in the rat brain. Brain Res Mol Brain Res. 1997;47:177-182.
36. Rudakewich M, Ba F, Benishin CG. Neurotrophic and neuroprotective actions of ginsenosides Rb1 and Rg1. Planta Med. 2001;67:533-537.
37. Kim HS, Zhang YH, Fang LH, Lee MK. Effects of ginsenosides on bovine adrenal tyrosine hydroxylase. J Ethnopharmacol. 1999;66:107-111.
38. Jiang F, DeSilva S, Turnbull J. Beneficial effect of ginseng root in SOD-1 (G93A) transgenic mice. J Neurol Sci. 2000;180:52-54.
39. Lee TF, Shiao YJ, Chen CF, Wang LC. Effect of ginseng saponins on beta-amyloid-suppressed acetylcholine release from rat hippocampal slices. Planta Med. 2001;67:634-637.
40. Nishiyama N, Cho SI, Kitagawa I, Saito H. Malonylginsenoside Rb1 potentiates nerve growth factor (NGF)-induced neurite outgrowth of cultured chick embryonic dorsal root ganglia. Biol Pharm Bull. 1994;17:509-513.
41. Braughler JM, Chase RL, Neff GL, Yonkers PA, Day JS, Hall ED, et al. A new 21-aminosteroid antioxidant lacking glucocorticoid activity stimulates adrenocorticotropin secretion and blocks arachidonic acid release from mouse pituitary tumor (AtT-20) cells. J Pharmacol Exp Ther. 1988;244:423-427.
42. Chu GX, Chen X. Anti-lipid peroxidation and protection of ginsenosides against cerebral ischemia-reperfusion injuries in rats. Zhongguo Yao Li Xue Bao. 1990;11:119-123.
43. Chang MS, Lee SG, Rho HM. Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng. Phytother Res. 1999;13:641-644.
44. Kim S, Ahn K, Oh TH, Nah SY, Rhim H. Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons. Biochem Biophys Res Commun. 2002;296:247-254.
45. Kim S, Rhim H. Ginsenosides inhibit NMDA receptor-mediated epileptic discharges in cultured hippocampal neurons. Arch Pharm Res. 2004;27:524-530.
46. Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science. 1993;262:689-695.
47. Choi DW, Rothman SM. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci. 1990;13:171-182.
48. Sattler R, Tymianski M. Molecular mechanisms of calcium-dependent excitotoxicity. J Mol Med. 2000;78:3-13.
49. Liu M, Zhang J. Effects of ginsenoside Rb1 and Rg1 on synaptosomal free calcium level, ATPase and calmodulin in rat hippocampus. Chin Med J. 1995;108:544-547.
50. Liu D, Li B, Liu Y, Attele AS, Kyle JW, Yuan CS. Voltage-dependent inhibition of brain Na+ channels by American ginseng. Eur J Pharmacol. 2001;413:47-54.
51. Jiang KY, Qian ZN. Effects of Panax notoginseng saponins on posthypoxic cell damage of neurons in vitro. Zhongguo Yao Li Xue Bao. 1995;16:399-402.
52. Seong YH, Shin CS, Kim HS, Baba A. Inhibitory effect of ginseng total saponins on glutamate-induced swelling of cultured astrocytes. Biol Pharm Bull. 1995;18:1776-1778.
53. Gong YS, Zhang JT. Effect of 17-beta-estradiol and ginsenoside Rg1 on reactive microglia induced by beta-amyloid peptides. J Asian Nat Prod Res. 1999;1:153-161.
54. Benishin CG. Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings. Neurochem Int. 1992;21:1-5.
55. Zhang JT, Qu ZW, Liu Y, Deng HL. Preliminary study on antiamnestic mechanism of ginsenosides Rb1 and Rg1. Chin Med J. 1990;103:932-938.
56. Itoh T, Zang YF, Murai S, Saito H. Effects of Panax ginseng root on the vertical and horizontal motor activities and on brain monoamine-related substances in mice. Planta Med. 1989;55:429-433.
57. D'Angelo L, Grimaldi R, Caravaggi M, Marcoli M, Perucca E, Lecchini S, et al. A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. J Ethnopharmacol. 1986;16:15-22.
58. Kim HS, Kang JG, Seong YH, Nam KY, Oh KW. Blockade by ginseng total saponins of the development of cocaine induced reverse tolerance and dopamine receptor supersensitivity in mice. Pharmacol Biochem Behav. 1995;50:23-27.
59. Kim HS, Kang JG, Oh KW. Inhibition by ginseng total saponins of the development of morphine reverse tolerance and dopamine receptor supersensitivity in mice. Gen Pharmacol. 1995;26:1071-1076.
60. Kim HS, Hong YT, Oh KW, Seong YH, Rheu HM, Cho DH. Inhibition by ginsenosides Rb1 and Rg1 of methamphetamine-induced hypersensitivity, conditioned place preference and postsynaptic dopamine receptor supersensitivity on mice. Gen Pharmacol. 1998;30:783-789.
61. Kim HS, Kim K, Oh K. Ginseng total saponins inhibits nicotine induced hyperactivity and conditioned place preference in mice. J Ethnopharmacol. 1999;66:83-90.
62. + channels. Eur J Pharmacol. 1999;367:41-49.
63. Shim I, Won J, Song J, Kim SE, Huh S. Modulatory effect of ginseng total saponins on dopamine release and tyrosine hydroxylase gene expression induced by nicotine in the mouse. J Ethnopharmacol. 2000;70:161-169.
64. Petkov V. Effect of ginseng on the brain biogenic monoamines and 3′,5′-AMP system. Experiments on rats. Arzneimittelforschung. 1978;28:388-393.
65. Wang A, Cao Y, Wang Y, Zhao R, Liu C. [Effects of Chinese ginseng root and stem-leaf saponins on learning, memory and biogenic monoamines of brain in rats]. Zhongguo Zhong Yao Za Zhi 1995;20:493-495. (text in Chinese with English abstract)
66. Sala F, Mulet J, Choi S, Jung SY, Nah SY, Rhim H, et al. Effects of ginsenoside Rg2 on human neuronal nicotinic acetylcholine receptors. J Pharmacol Exp Ther. 2002;301:1052-1059.
67. Kimura T, Saunders PA, Kim HS, Rheu HM, Oh KW, Ho IK. Interactions of ginsenosides with ligand-bindings of GABA(A) and GABA(B) receptors. Gen Pharmacol. 1994;25:193-199.
68. Choi SE, Choi S, Lee JH, Whiting PJ, Lee SM, Nah SY. Effects of ginsenosides on GABA(A) receptor channels expressed in Xenopus oocytes. Arch Pharm Res. 2003;26:28-33.
69. Yamaguchi Y, Higashi M, Kobayashi H. Effects of ginsenosides on impaired performance caused by scopolamine in rats. Eur J Pharmacol. 1996;312:149-151.
70. Mook-Jung I, Hong HS, Boo JH, Lee KH, Yun SH, Cheong MY, et al. Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice. J Neurosci Res. 2001;63:509-515.
71. Zhao R, McDaniel WF. Ginseng improves strategic learning by normal and brain-damaged rats. Neuroreport. 1998;11:1619-1624.
72. Zhong YM, Nishijo H, Uwano T, Tamura R, Kawanishi K, Ono T. Red ginseng ameliorated place navigation deficits in young rats with hippocampal lesions and aged rats. Physiol Behav. 2000;69:511-525.
73. Kennedy DO, Scholey AB. Ginseng: potential for the enhancement of cognitive performance and mood. Pharmacol Biochem Behav. 2003;75:687-700.
74. Terasawa K, Shimada Y, Kita T. Choto-san in the treatment of vascular dementia: a double blind, placeb-controlled study. Phytomedicine. 1997;4:15-22.
75. Kurimoto H, Nishijo H, Uwano T, Yamaguchi H, Zhong YM, Kawanishi K, et al. Effects of nonsaponin fraction of red ginseng on learning deficits in aged rats. Physiol Behav. 2004;82:345-355.
76. Shen L, Zhang J. Ginsenoside Rg1 increases ischemia-induced cell proliferation and survival in the dentate gyrus of adult gerbils. Neurosci Lett. 2003;344:1-4.
77. Persson J, Bringlov E, Nilsson LG, Nyberg L. The memory-enhancing effects of Ginseng and Ginkgo biloba in healthy volunteers. Psychopharmacology. 2004;172:430-434.
78. Sorensen H, Sonne J. A double-masked study of the effect of ginseng on memory functions. Curr Ther Res. 1996;57:959-968.
79. Wood WB, Roh BL, White RP. Cardiovascular actions of Panax ginseng in dogs. Jpn J Pharmacol. 1964;14:284-294.
80. Lei XL, Chiou GC. Cardiovascular pharmacology of Panax notoginseng. Am J Chin Med. 1986;14:145-152.
81. Kim ND, Kang SY, Schini VB. Ginsenosides evoke endothelium-dependent vascular relaxation in rat aorta. Gen Pharmacol. 1995;25:1071-1077.
82. Kang SY, Kim SH, Schini VB, Kim ND. Dietary ginsenosides improve endothelium-dependent relaxation in the thoracic aorta of hypercholesterolemic rabbit. Gen Pharmacol. 1995;26:483-487.
83. Scott GI, Colligan PB, Ren BH, Ren J. Ginsenosides Rb1 and Re decrease cardiac contraction in adult rat ventricular myocytes: role of nitric oxide. Br J Pharmacol. 2001;134:1159-1165.
84. Sung J, Han KH, Zo JH, Park HJ, Kim CH, Oh BH. Effects of red ginseng upon vascular endothelial function in patients with essential hypertension. Am J Chin Med. 2000;28:205-216.
85. + channels in ginsenosides-induced aortic relaxation in rats. J Cardiovasc Pharmacol. 2001;37:41-47.
86. Kim CS, Park JB, Kim KJ, Chang SJ, Ryoo SW, Jeon BH. Effect of Korea red ginseng on cerebral blood flow and superoxide production. Acta Pharmacol Sin. 2002;23:1152-1156.
87. Shi L, Fan PS, Wu L, Fang JX, Han ZX. Effects of total saponins of Panax notoginseng on increasing PGI2 in carotid artery and decreasing TXA2 in blood platelets. Zhongguo Yao Li Xue Bao. 1990;11:29-32.
88. Kimura Y, Okuda H, Arichi S. Effects of various ginseng saponins on 5-hydroxytryptamine release and aggregation in human platelets. J Pharm Pharmacol. 1988;40:838-843.
89. Park HJ, Lee JH, Song YB, Park KH. Effects of dietary supplementation of lipophilic fraction from Panax ginseng on cGMP and cAMP in rat platelets and on blood coagulation. Biol Pharm Bull. 1996;19:1434-1439.
90. Jung KY, Kim DS, Oh SR, Lee IS, Lee JJ, Park JD, et al. Platelet activating factor antagonist activity of ginsenosides. Biol Pharm Bull. 1998;21:79-80.
91. Nakajima S, Uchiyama Y, Yoshida K, Mizukawa H, Haruki E. The effect of ginseng radius rubra on human vascular endothelial cells. Am J Chin Med. 1998;26:365-373.
92. Yuan CS, Attele AS, Wu JA, Lowell TK, Gu Z, Lin Y. Panax quinquefolium L. Inhibits thrombin-induced endothelin release in vitro. Am J Chin Med. 1999;27:331-338.
93. Sengupta S, Toh SA, Sellers LA, Skepper JN, Koolwijk P, Leung HW, et al. Modulating angiogenesis: the yin and the yang in ginseng. Circulation. 2004;7:1219-1225.
94. Yu SC, Li XY. Effect of ginsenoside on IL-1 beta and IL-6 mRNA expression in hippocampal neurons in chronic inflammation model of aged rats. Acta Pharmacol Sin. 2000;21:915-918.
95. Cho JY, Park J, Yoo ES, Baik KU, Park MH. Effect of ginseng saponin on tumor necrosis factor-α production and T cell proliferation. Yakhak Hoeji. 1998;43:296-301.
96. Keum YS, Han SS, Chun KS, Park KK, Park JH, Lee SK, et al. Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion. Mutat Res. 2003;523-524:75-85.
97. Ro JY, Ahn YS, Kim KH. Inhibitory effect of ginsenoside on the mediator release in the guinea pig lung mast cells activated by specific antigen-antibody reactions. Int J Immunopharmacol. 1998;20:625-641.
98. Li X, Li SH. Effect of total saponins of Sanchi (Panax pseudoginseng notoginseng) on TNF, No and its mechanisms. Zhong cao yao: Chin Tradit Herbal Drugs. 1999;30:514-517.
99. Kim TH, Lee YS, Cho CK, Park S, Choi SY, Yool SY. Protective effect of ginseng on radiation-induced DNA double strand breaks and repair in murine lymphocytes. Cancer Biother Radiopharm. 1996;11:267-272.
100. Zhang GQ, Ye RG, Kong QY, Yang NS, Zhang JL, Guan WM, et al. Panax notoginseng saponins induced of human renal interstitial fibroblast and its mechanisms. Chin J Nephrology. 1998;14:93-95.
101. Matsuda H, Kubo M, Tani T, Kitagawa I, Mizuno M. [Pharmacological study of Panax ginseng C. A. Meyer (IX). Protective effect of red ginseng on interferon (2) on phagocytic activity of mouse reticuloendothelial cells system]. Shoyakugaku Zasshi. 1987;41:135-141. (text in Japanese with English abstract)
102. Ahn YK, Kim YK, Chang JG, Kim JH, Goo JD. The effect of Korean ginseng on the immunotoxicity of mitomycin C. Yakhak Hoe Chi. 1987;31:355-360.
103. Park HW, Kim SC, Jung NP. The effect of ginseng saponin fractions on humoral immunity of mice. Korean J Ginseng Sci. 1988;12:63-67.
104. Ohtani K, Mizutani K, Kasai R, Hirose K, Kishi K, Tanaka O, et al. Reticuloendothelial system activating polysaccharides from Panax spp - Panax-notoginseng, Panax-ginseng and Panax-japonicus. J Pharmacobiodyn. 1987;10:S63.
105. Hu S, Concha C, Johannisson A, Meglia G, Waller KP. Effect of subcutaneous injection of ginseng on cows with subclinical Staphylococcus aureus mastitis. J Vet Med B Infect Dis Vet Public Health. 2001;48:519-528.
106. Yun TK. Experimental and epidemiologic evidence of cancer preventive effects of Panax ginseng C.A. Meyer. Nutr Rev. 1996;54:71-81.
107. Yun TK. Panax ginseng- a non-organ-specific cancer preventive? Lancet Oncol. 2001;2:49-54.
108. Lee YN, Lee HY, Chung HY, Kim SI, Lee SK, Park BC, et al. In vitro induction of differentiation by ginsenoides in F9 teratocarcinoma cells. Eur J Cancer. 1996;32:1420-1428.
109. Park J, Lee KY, Oh YJ, Kim KW, Lee SK. Activation of caspase-3 protease via a Bcl-2-insensitive pathway during the process of ginsenoside Rh2-induced apoptosis. Cancer Lett. 1997;121:73-81.
110. Oh M, Choi YH, Choi S, Chung H, Kim K, Kim SI, et al. Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells. Int J Oncol. 1999;14:869-875.
111. Kim HE, Oh JH, Lee SK, Oh YJ. Ginsenoside Rh2 induces apoptotic cell death in rat C6 glioma via a reactive oxygen- and caspase-dependent but Bcl-X(L)-independent pathway. Life Sci. 1999;65:33-40.
112. Mochizuki M, Yoo YC, Matsuzawa K, Sato K, Saiki I, Tonooka S, et al. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng. Biol Pharm Bull. 1995;18:1197-1202.
113. Byun BH, Shin I, Yoon YS, Kim SI, Joe CO. Modulation of protein kinase C activity in NIH 3T3 cells by plant glycosides from Panax ginseng. Planta Med. 1997;63:389-392.
114. Surh YJ, Na HK, Lee JY, Keum YS. Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer. J Korean Med Sci. 2001;16:38-41.
115. Keum YS, Park KK, Lee JM, Chun KS, Park JH, Lee SK, et al. Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng. Cancer Lett. 2000;150:41-48.
116. Subbaramaiah K, Telang N, Ramonetti JT, Araki R, DeVito B, Weksler BB, et al. Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells. Cancer Res. 1996;6:4424-4429.
117. O'Brien TG. The induction of ornithine decarboxylase as an early, possibly obligatory event in mouse skin carcinogenesis. Cancer Res. 1976;36:2644-2653.
118. Mayo MW, Wang CY, Congswell PC, Rogers-Graham KS, Lowe SW, Der CJ, et al. Requirement of NF-κB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science. 1997;278:1812-1915.
119. Murphy LL, Cadena RS, Chavez D, Ferraro JS. Effect of American ginseng (Panax quinquefolium) on male copulatory behaviour in the rat. Physiol Behav. 1998;64:445-450.
120. Kim C, Choi H, Kim CC, Kim JK, Kim MS, Ahn BT, et al. Influence of ginseng on mating behaviour of male rats. Am J Chin Med. 1976;4:163-168.
121. Choi HK, Seong DH, Rha KH. Clinical efficacy of Korean red ginseng for erectile dysfunction. Int J Impot Res. 1995;7:181-186.
122. Chen X, Lee TJ. Ginsenosides-induced a nitric oxide-mediated relaxation of the rabbit corpus cavernosum. Br J Pharmacol. 1995;115:15-18.
123. Fahim MS, Fahim Z, Harman JM. Effect of Panax ginseng on testosterone level and prostate in male rats. Arch Androl. 1982;8:261-263.
124. Bahrke MS, Morgan WP. Evaluation of the ergogenic properties of ginseng. Sports Med. 1994;18:229-248.
125. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen CJ. Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease. Med Sci Monit. 2004;10:187-192.
126. Long MZ, Wang DB, Yang JM. [Clinical study on effect of Shenmai injection in treating congestive heart failure]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003;23:808-810. (text in Chinese with English abstract)
127. Suh SO, Kroh M, Kim NR, Joh YG, Cho MY. Effects of red ginseng upon postoperative immunity and survival in patients with stage III gastric cancer. Am J Chin Med. 2002;30:483-494.
128. Li NQ. [Clinical and experimental study on shen-qi injection with chemotherapy in the treatment of malignant tumor of digestive tract]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992;12:588-592. (text in Chinese with English abstract)
129. Xie FY, Zeng ZF, Huang HY. [Clinical observation on nasopharyngeal carcinoma treated with combined therapy of radiotherapy and ginseng polysaccharide injection]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21:332-334. (text in Chinese with English abstract)
130. Kim JH, Lee JH, Jeong SM, Lee BH, Yoon IS, Lee JH, et al. Effect of ginseng saponins on a rat visceral hypersensitivity model. Biol Pharm Bull. 2005;28:2120-2124.
131. Kaneko H, Nakanishi K. Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, korean red ginseng: specifically, its anti-stress action for prevention of disease. J Pharmacol Sci. 2004;95:158-162.
132. Tode T, Kikuchi Y, Hirata J, Kita T, Nakata H, Nagata I. Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes. Int J Gynaecol Obstet. 1999;67:169-174.
133. Suzuki Y, Hikino H. Mechanisms of hypoglycaemic activity of panaxans A and B, glycans of Panax ginseng roots: effects on plasma level, secretion, sensitivity and binding of insulin in mice. Phytother Res. 1989;3:20-24.
134. Ng TB, Yeung HW. Hypoglycemic constituents of Panax ginseng. Gen Pharmacol. 1985;16:549-552.
135. Tchilian EZ, Zhelezarov IE, Hadjiivanova CI. Effect of ginsenoside Rg1 on insulin binding in mice liver and membranes. Phytother Res. 1991;5:46-48.
136. Wang LC, Lee TF. Effect of ginseng saponins on cold tolerance in young and elderly rats. Planta Med. 2000;66:144-147.
137. Park DL. Effect of Panax ginseng on x-ray irradiation and synergetic study on nitromin. Insam Munhun Teukjip. 1964;2:55-65.
138. Pande S, Dumar M, Kumar A. Evaluation of radimodyfing effect of root extract of Panax ginseng. Phytother Res. 1998;12:13-17.
139. Yonezawa M, Takeda A, katoh N. Restoration of radiation injury by ginseng extract. Proceeding of the Third International Ginseng Symposium, Soul, Republic of Korea. 1980:17-20.
140. Kim C, Choi JE. Effect of radioprotective ginseng protein on UV-induced sister chromatid exchanges. Arch Pharm Res. 1988;11:93-98.
141. Wang B, Cui J, Liu A. Effect of saponins isolated from stems and leaves of ginseng (SSLG) on experimental liver injury. Acta Pharm Sin. 1983;18:726-731.
142. Hikino H, Kiso Y, Kinouchi J, Sanada S, Shoji J. Validity of the oriental medicines. 73 Liver-protective drugs. 18 Anti-hepatotoxic actions of ginsenosides from Panax ginseng roots. Planta Med. 1985;1:62-64.
143. Wang BX, Cui JC, Liu AJ. The effect of ginseng on immune responses. In: Chang HM, Yeung HW, Tso W-W, Koo A, editors. Advance in Chinese medicinal materials research. Singapore/Philadelphia: World Scientific Publishing; 1985. p. 62-64.
144. Chang PH. The effect of ginseng (Panax ginseng C.A. Meyer) on organism activity. Acta Pharm Sin. 1966;13:106-111.
145. Jeong CS, Hyun JE, Kim YS. Ginsenoside Rb1: the anti-ulcer constituent from the head of Panax ginseng. Arch Pharm Res. 2003;26:906-911.
146. Wang BX, Cui JC, Liu AJ. [The action of ginsenosides extracted from the stems and leaves of Panax ginseng in promoting animal growth]. Yao Xue Xue Bao. 1982;17:899-904. (in Chinese)
147. Hess FG Jr, Parent RA, Stevens KR, Cox GE, Becci PJ. Effects of subchronic feeding of ginseng extract G115 in beagle dogs. Food Chem Toxicol. 1983;21:95-97.
148. Coon JT, Ernst E. Panax ginseng: a systematic review of adverse effects and drug interactions. Drug Saf. 2002;25:323-344.
149. Siegel RK. Ginseng abuse syndrome-problems with the panacea. JAMA. 1979;241:1614-1615.