A comparative study of the potential antioxidant activities of ginsenosides

Journal of Food Biochemistry

Volumn 34, Issue SUPPL. 1, 2010, Pages 31-43

  Chae, Sungwook ^b   Kang, Kyoung Ah ^a   Youn, Uijoung ^c   Park, Jong Sang ^d   Hyun, Jin Won ^a  

^a Jeju National University   (South Korea)

^b Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^c Chungnam National University   (South Korea)

^d 14 Biomix Co   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

PANAX GINSENG;

EID: 77952557635     PISSN: 01458884     EISSN: 17454514     Source Type: Journal    
DOI: 10.1111/j.1745-4514.2009.00287.x     Document Type: Article

References (43)

1. Ali MB, Yu KW, Hahn EJ, Paek KY. Differential responses of anti-oxidants enzymes, lipoxygenase activity, ascorbate content and the production of saponins in tissue cultured root of mountain Panax ginseng c.a. Mayer and Panax quinquefolium l. In bioreator subjected to methyl jasmonate stress. Plant Sci. 2005, 169:83-92.
2. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: Multiple constituents and multiple actions. Biochem. Pharmacol. 1999, 58:1685-1693.
3. Bindoli A, Valente M, Cavallini L. Inhibitory action of quercetin on xanthine oxidase and xanthine dehydrogenase activity. Pharmacol. Res. Commun. 1985, 17:831-839.
4. Chae S, Kim JS, Kang KA, Bu HD, Lee Y, Seo YR, Hyun JW, Kang SS. Antioxidant activity of isoacteoside from Clerodendron trichotomum. J. Toxicol. Environ. Health A 2005, 68:389-400.
5. Chen XC, Zhu YG, Zhu LA, Huang C, Chen Y, Chen LM, Fang F, Zhou YC, Zhao CH. Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress. Eur. J. Pharmacol. 2003, 473:1-7.
6. Chen XC, Zhou YC, Chen Y, Zhu YG, Fang F, Chen LM. Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress. Acta Pharmacol. Sin. 2005, 26:56-62.
7. Cho WC, Chung WS, Lee SK, Leung AW, Cheng CH, Yue KK. Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 2006, 550:173-179.
8. Cooke MS, Mistry N, Wood C, Herbert KE, Lunec J. Immunogenicity of DNA damaged by reactive oxygen species-implications for anti-DNA antibodies in lupus. Free Radic. Biol. Med. 1997, 22:151-159.
9. Darely-Usmer V, Halliwell B. Blood radicals: Reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharmacol. Res. 1996, 13:649-662.
10. Farinati F, Cardin R, Degan P, Rugge M, Mario FD, Bonvicini P, Naccarato R. Oxidative DNA damage accumulation in gastric carcinogenesis. Gut 1998, 42:351-356.
11. Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine 1998, 22-35. pp., Oxford University Press, New York, NY
12. Huong NT, Matsumoto K, Kasai R, Yamasaki K, Watanabe H. In vitro antioxidant activity of Vietnamese ginseng saponin and its components. Biol. Pharm. Bull. 1998, 21:978-981.
13. Kang KA, Lee KH, Chae S, Koh YS, Yoo BS, Kim JH, Ham YM, Baik JS, Lee NH, Hyun JW. Triphlorethol-A from Ecklonia cava protects V79-4 lung fibroblast against hydrogen peroxide induced cell damage. Free Radic. Res. 2005, 39:883-892.
14. Kang KA, Zhang R, Piao MJ, Ko DO, Wang ZH, Kim BJ, Park JW, Kim HS, Kim DH, Hyun JW. Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect. Bioorg. Med. Chem. 2008, 16:1133-1141.
15. Kang KS, Yokozawa T, Yamabe N, Kim HY, Park JH. ESR study on the structure and hydroxyl radical-scavenging activity relationships of ginsenosides isolated from Panax ginseng C.A. Mayer. Biol. Pharm. Bull. 2007, 30:917-921.
16. Kim YH, Park KH, Rho HM. Transcriptional activation of the Cu, Zn-superoxide dismutase gene through the AP2 site by ginsenoside Rb2 extracted from a medicinal plant, Panax ginseng. J. Biol. Chem. 1996, 271:24539-24543.
17. Kim YS, Hahn EJ, Murthy HN, Paek KY. Adventitious root growth and ginsenoside accumulation in Panax ginseng cultures as affected by methyl jasmonate. Biotechnol. Lett. 2004, 26:1619-1622.
18. Laurindo FR, Luz PLD, Uint L, Rocha TF, Jaeger RG, Lopes EA. Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs. Circulation 1991, 83:1705-1715.
19. Lee LS, Wise SD, Chan C, Parsons TL, Flexner C, Lietman PS. Possible differential induction of phase 2 Enzyme and antioxidant pathways by American ginseng, Panax quinquefolius. J. Clin. Pharmacol. 2008, 48:599-609.
20. Lee TK, Johnke RM, Allison RR, O'brien KF, Dobbs LJ. Radioprotective potential of ginseng. Mutagenesis 2005, 20:237-243.
21. Li QF, Shi SL, Liu QR, Tang J, Song J, Liang Y. Anticancer effects of ginsenoside Rg1, cinnamic acid, and tanshinone IIA in osteosarcoma MG-63 cells: Nuclear matrix downregulation and cytoplasmic trafficking of nucleophosmin. Int. J. Biochem. Cell Biol. 2008, 40:1918-1929.
22. Liu ZQ, Luo XY, Liu GZ, Chen YP, Wang ZC, Sun YX. In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes. J. Agric. Food Chem. 2003, 51:2555-2558.
23. Lo SF, Nalawade SM, Mulabagal V, Matthew S, Chen CL, Kuo CL, Tsay HS. In Vitro propagation by asymbiotic seed germination and 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity studies of tissue culture raised plants of three medicinally important species of Dendrobium. Biol. Pharm. Bull. 2004, 27:731-735.
24. Lopez MV, Cuadrado MP, Ruiz-Poveda OM, Del Fresno AM, Accame ME. Neuroprotective effect of individual ginsenosides on astrocytes primary culture. Biochim. Biophys. Acta 2007, 1770:1308-1316.
25. Ludvigsson J. Intervention at diagnosis of type I diabetes using either antioxidants or photopheresis. Diabetes Metab. Rev. 1993, 9:329-336.
26. Mccord JM, Fridovich I. The reduction of cytochrome c by milk xanthine oxidase. J. Biol. Chem. 1968, 243:5753-5760.
27. Min JK, Kim JH, Cho YL, Maeng YS, Lee SJ, Pyun BJ, Kim YM, Park JH, Kwon YG. 20(S)-Ginsenoside Rg3 prevents endothelial cell apoptosis via inhibition of a mitochondrial caspase pathway. Biochem. Biophys. Res. Commun. 2006, 349:987-994.
28. Naik GH, Priyadarsini KI, Satav JG, Banavalikar MM, Sohoni DP, Biyani MK, Mohan H. Comparative antioxidant activity of individual herbal components used in Ayurvedic medicine. Phytochemistry 2003, 63:97-104.
29. Nakazono K, Matsuno NW, Sasaki K, Sato T, Inoue M. Does superoxide underlie the pathogenesis of hypertension? Proc. Natl. Acad. Sci. U.S.A. 1991, 88:10045-10048.
30. Nishikimi M, Appaji N, Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem. Biophys. Res. Commun. 1972, 46:849-854.
31. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
32. Palinski W, Miller E, Witztum JL. Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis. Proc. Natl. Acad. Sci. USA 1995, 92:821-825.
33. Parthasarathy S, Steinberg D, Witztum JL. The role of oxidized low-density lipoproteins in the pathogenesis of atherosclerosis. Annu. Rev. Med. 1992, 43:219-225.
34. Polidori MC, Stahl W, Eichler O, Niestroj I, Sies H. Profiles of antioxidants in human plasma. Free Radic. Biol. Med. 2001, 30:456-462.
35. Rosenkranz AR, Schmaldienst S, Stuhlmeier KM, Chen W, Knapp W, Zlabinger GJ. A microplate assay for the detection of oxidative products using 2′,7′-dichlorofluorescin-diacetate. J. Immunol. Methods 1992, 156:39-45.
36. Teng CM, Kuo SC, Ko FN, Lee JC, Lee LG, Chen SC, Huang TF. Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. Biochim. Biophys. Acta 1989, 990:315-320.
37. Wang W, Rayburn ER, Hao M, Zhao Y, Hill DL, Zhang R, Wang H. Experimental therapy of prostate cancer with novel natural product anti-cancer ginsenosides. Prostate 2008, 68:809-819.
38. Wu CF, Bi XL, Yang JY, Zhan JY, Dong YX, Wang JH, Wang JM, Zhang R, Li X. Differential effects of ginsenosides on NO and TNF-alpha production by LPS-activated N9 microglia. Int. Immunopharmacol. 2007, 7:313-320.
39. Xie JT, Wang CZ, Wang AB, Wu J, Basila D, Yuan CS. Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng. Acta Pharmacol. Sin. 2005, 26:1104-1110.
40. Xie JT, Shao ZH, Vanden Hoek TL, Chang WT, Li J, Mehendale S, Wang CZ, Hsu CW, Becker LB, Yin JJ, et al Antioxidant effects of ginsenoside Re in cardiomyocytes. Eur. J. Pharmacol. 2006, 532:201-207.
41. Yokozawa T, Fujitsuka N, Oura H, Mori A, Kashiwagi H. Determination of radical species in the kidney of rats with chronic renal failure by the spin trapping method. Nephron 1995, 70:382-384.
42. Yokozawa T, Satoh A, Cho EJ. Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice. J. Pharm. Pharmacol. 2004, 56:107-113.
43. Yu KW, Murthy HN, Jeong CS, Hahn EJ. Organic germanium stimulates the growth of ginseng adventitious roots and ginsenoside production. Process Biochem. 2005, 40:2959-2961.