The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb1 by heat processing

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4515-4520

  Lee, Yong Jae ^a   Kim, Hyun Young ^b   Kang, Ki Sung ^a,c   Lee, Jin Gyun ^a   Yokozawa, Takako ^c   Park, Jeong Hill ^a  

^a Seoul National University   (South Korea)

^b Gyeongsang National University   (South Korea)

^c UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Ginsenoside Rb1; Glycine; Hydroxyl radical; Maillard reaction

Indexed keywords

CARBON; GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RG 3; GINSENOSIDE RG5; GINSENOSIDE RK1; GLYCINE; HYDROXYL RADICAL; UNCLASSIFIED DRUG;

ARTICLE; EPIMERIZATION; GLYCATION; HEAT;

CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICAL SCAVENGERS; GINSENOSIDES; GLUCOSE; GLYCINE; HOT TEMPERATURE; HYDROXYL RADICAL; LIGHT; MAILLARD REACTION; MODELS, CHEMICAL; PANAX; PLANT EXTRACTS; SUPEROXIDES;

EID: 48649105424     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.056     Document Type: Article

References (23)

1. Kitagawa I., Yoshikawa M., Yoshihara M., Hayashi T., and Taniyama T. Yakugaku Zasshi 103 (1983) 612
2. Matsuura H., Hirao Y., Yoshida S., Kunihiro K., Fuwa T., Kasai R., and Tanaka O. Chem. Pharm. Bull. 32 (1984) 4674
3. Park J.H., Kim J.M., Han S.B., Kim N.Y., Surh Y.J., Lee S.K., Kim N.D., and Park M.K. Advances in Ginseng Research (1998), Korean Society of Ginseng, Seoul 146
4. Yun T.K. J. Korean Med. Sci. 16 (2001) 3
5. Kang K.S., Yokozawa T., Yamabe N., Kim H.Y., and Park J.H. Biol. Pharm. Bull. 30 (2007) 917
6. Kang K.S., Lee Y.J., Park J.H., and Yokozawa T. Biol. Pharm. Bull. 30 (2007) 1975
7. Lee H.U., Bae E.A., Han M.J., Kim N.J., and Kim D.H. Liver Int. 25 (2005) 1069
8. Park E.K., Shin Y.W., Lee H.U., Kim S.S., Lee Y.C., Lee B.Y., and Kim D.H. Biol. Pharm. Bull. 28 (2005) 652
9. Ohashi R., Yan S., Mu H., Chai H., Yao Q., Lin P.H., and Chen C. J. Surg. Res. 133 (2006) 89
10. Lim J.H., Wen T.C., Matsuda S., Tanaka J., Maeda N., Peng H., Aburaya J., Ishihara K., and Sakanaka M. Neurosci. Res. 28 (1997) 191
11. Kang K.S., Kim H.Y., Yamabe N., and Yokozawa T. Bioorg. Med. Chem. Lett. 16 (2006) 5028
12. Davidek T., Clety N., Devaud S., Robert F., and Blank I. J. Agric. Food Chem. 51 (2003) 7259
13. Samaras T.S., Camburn P.A., Chandra S.X., Gordon M.H., and Ames J.M. J. Agric. Food Chem. 53 (2005) 8068
14. Park J.D. Korean J. Ginseng Sci. 20 (1996) 389
15. Yoshimura Y., Iijima T., Watanabe T., and Nakazawa H. J. Agric. Food Chem. 45 (1997) 4106
16. Shoji J. In: Shibata S., Ohtsuka Y., and Sato S. (Eds). Recent Advances in Ginseng Studies (1990), Hirokawa Publishing, Tokyo 11
17. 1-glycine mixtures at 120 °C were prepared. The samples were dissolved in distilled water (D.W.)-acetonitrile (1:1, v/v), and the absorbance at 420 nm was measured in a 1 cm glass cuvette using a UV-1200 UV-Vis spectrophotometer (Shimadzu, Kyoto, Japan) to measure the extent of browning. The heat processing and measurement were repeated three times for each sample. The results for each group are expressed as mean ± SE values. Individual differences between groups were evaluated using Student's t-test, and those at p < 0.05 were considered significant.
18. 2+ and compared to the ratio of the control.
19. The changes in constituents by heat processing were analyzed with a Hitachi (Tokyo, Japan) L-7100 liquid chromatograph fitted with a C-18, reversed-phase column (5 μm, 25 cm × 4.6 mm I.D.; Phenomenex Luna) utilizing the solvent gradient system. The mobile phase consisted of water (solvent A) and acetonitrile (solvent B), and the flow rate was 1 mL/min. The detector was a SEDEX 55 evaporative light scattering detector (Sedere, France). The gradient elution was used as follows: 0 min, 15% B; 10 min, 34.5% B; 25 min, 47.5% B; 40 min, 80% B; and 50 min, 100% B.
20. 1H NMR with standard samples.
21. Borrelli R.C., Visconti A., Mennella C., Anese M., and Fogliano V. J. Agric. Food Chem. 50 (2002) 6527
22. Kang K.S., Kim H.Y., Baek S.H., Yoo H.H., Park J.H., and Yokozawa T. Biol. Pharm. Bull. 30 (2007) 724
23. Hatano T., Edamatsu R., Hiramatsu M., Mori A., Fujita Y., Yasuhara T., Yoshida T., and Okuda T. Chem. Pharm. Bull. 37 (1989) 2016