Rickettsial evolution in the light of comparative genomics

Biological Reviews

Volumn 86, Issue 2, 2011, Pages 379-405

  Merhej, Vicky ^a   Raoult, Didier ^a  

^a AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

Diversity; DNA repeats; Gene loss; Lateral gene transfer; Non coding DNA; Pathogenicity; Pseudogenes; Rickettsia

Indexed keywords

ANIMAL; BACTERIAL GENOME; EVOLUTION; GENETICS; GENOMICS; HOST PATHOGEN INTERACTION; HUMAN; REVIEW; RICKETTSIA;

ANIMALS; BIOLOGICAL EVOLUTION; GENOME, BACTERIAL; GENOMICS; HOST-PATHOGEN INTERACTIONS; HUMANS; RICKETTSIA;

ANIMALIA; EUKARYOTA; RICKETTSIA; RICKETTSIA CANADENSIS; VERTEBRATA;

EID: 79954532607     PISSN: 14647931     EISSN: 1469185X     Source Type: Journal    
DOI: 10.1111/j.1469-185X.2010.00151.x     Document Type: Review

References (333)

1. Akman, L., Yamashita, A., Watanabe, H., Oshima, K., Shiba, T., Hattori, M. & Aksoy, S. (2002). Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia. Nature Genetics 32, 402-407.
2. Amiri, H., Alsmark, C. M. & Andersson, S. G. (2002). Proliferation and deterioration of Rickettsia palindromic elements. MolecularBiology and Evolution 19, 1234-1243.
3. Amiri, H., Davids, W. & Andersson, S. G. (2003). Birth and death of orphan genes in Rickettsia. MolecularBiology and Evolution 20, 1575-1587.
4. Ammerman, N. C., Gillespie, J. J., Neuwald, A. F., Sobral, B. W. & Azad, A. F. (2009). A typhus group-specific protease defies reductive evolution in rickettsiae. Journal of Bacteriology 191, 7609-7613.
5. Andersson, J. O. & Andersson, S. G. (1997). Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence. Microbiology 143, 2783-2795.
6. Andersson, J. O. & Andersson, S. G. (1999a). Genome degradation is an ongoing process in Rickettsia. Molecular Biology and Evolution 16, 1178-1191.
7. Andersson, J. O. & Andersson, S. G. (1999b). Insights into the evolutionary process of genome degradation. Current Opinion in Genetics & Development 9, 664-671.
8. Andersson, J. O. & Andersson, S. G. (2000). A century of typhus, lice and Rickettsia. Research in Microbiology 151, 143-150.
9. Andersson, S. G. & Kurland, C. G. (1998). Reductive evolution of resident genomes. Trends in Microbiology 6, 263-268.
10. Andersson, S. G., Stothard, D. R., Fuerst, P. & Kurland, C. G. (1999). Molecular phylogeny and rearrangement of rRNA genes in Rickettsia species. Molecular Biology and Evolution 16, 987-995.
11. Andersson, S. G., Zomorodipour, A., Andersson, J. O., Sicheritz-Ponten, T., Alsmark, U. C., Podowski, R. M., Naslund, A. K., Eriksson, A. S., Winkler, H. H. & Kurland, C. G. (1998). The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature 396, 133-140.
12. Andersson, S. G., Zomorodipour, A., Winkler, H. H. & Kurland, C. G. (1995). Unusual organization of the rRNA genes in Rickettsia prowazekii. Journal of Bacteriology 177, 4171-4175.
13. Anigstein, L. & Anigstein, D. (1975). A review of the evidence in retrospect for a rickettsial etiology in Bullis fever. Texas Reports on Biology and Medicine 33, 201-211.
14. Aravind, L., Tatusov, R. L., Wolf, Y. I., Walker, D. R. & Koonin, E. V. (1998). Evidence for massive gene exchange between archaeal and bacterial hyperthermophiles. Trends in Genetics 14, 442-444.
15. Audic, S., Robert, C., Campagna, B., Parinello, H., Claverie, J. M., Raoult, D. & Drancourt, M. (2007). Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria. PLoS Genetics 3, e138.
16. Azad, A. F. (1990). Epidemiology of murine typhus. Annual Review of Entomology 35, 553-569.
17. Azad, A. F., Radulovic, S., Higgins, J. A., Noden, B. H. & Troyer, J. M. (1997). Flea-borne rickettsioses: ecologic considerations. Emerging Infectious Diseases 3, 319-327.
18. Bacellar, F., Regnery, R. L., Nuncio, M. S. & Filipe, A. R. (1995). Genotypic evaluation of rickettsial isolates recovered from various species of ticks in Portugal. Epidemiology and Infection 114, 169-178.
19. Balakirev, E. S. & Ayala, F. J. (2003). Pseudogenes: are they "junk" or functional DNA? Annual Review of Genetics 37, 123-151.
20. Baldridge, G. D., Burkhardt, N., Herron, M. J., Kurtti, T. J. & Munderloh, U. G. (2005). Analysis of fluorescent protein expression in transformants of Rickettsia monacensis, an obligate intracellular tick symbiont. Applied Environmental Microbiology 71, 2095-2105.
21. Baldridge, G. D., Burkhardt, N. Y., Felsheim, R. F., Kurtti, T. J. & Munderloh, U. G. (2007). Transposon insertion reveals pRM, a plasmid of Rickettsia monacensis. Applied Environmental Microbiology 73, 4984-4995.
22. Baldridge, G. D., Burkhardt, N. Y., Felsheim, R. F., Kurtti, T. J. & Munderloh, U. G. (2008). Plasmids of the pRM/pRF family occur in diverse Rickettsia species. Applied Environmental Microbiology 74, 645-652.
23. Baldridge, G. D., Burkhardt, N. Y., Simser, J. A., Kurtti, T. J. & Munderloh, U. G. (2004). Sequence and expression analysis of the ompA gene of Rickettsia peacockii, an endosymbiont of the Rocky Mountain wood tick, Dermacentor andersoni. Applied Environmental Microbiology 70, 6628-6636.
24. Balraj, P., El, K. K., Vestris, G., Espinosa, L., Raoult, D. & Renesto, P. (2008a). Rick A expression is not sufficient to promote actin-based motility of Rickettsia raoultii. PLoS ONE. 3, e2582.
25. Balraj, P., Nappez, C., Raoult, D. & Renesto, P. (2008b). Western-blot detection of RickA within spotted fever group rickettsiae using a specific monoclonal antibody. FEMS Microbiology Letters 286, 257-262.
26. Balraj, P., Renesto, P. & Raoult, D. (2009). Advances in rickettsia pathogenicity. Annals of the New York Academy of Sciences 1166, 94-105.
27. Barker, J. & Brown, M. R. (1994). Trojan horses of the microbial world: protozoa and the survival of bacterial pathogens in the environment. Microbiology 140 (Pt 6), 1253-1259.
28. Beati, L., Kelly, P. J., Matthewman, L. A., Mason, P. R. & Raoult, D. (1995). Prevalence of rickettsia-like organisms and spotted fever group rickettsiae in ticks (Acari: Ixodidae) from Zimbabwe. Journal of Medical Entomology 32, 787-792.
29. Beati, L., Meskini, M., Thiers, B. & Raoult, D. (1997). Rickettsia aeschlimannii sp. nov., a new spotted fever group rickettsia associated with Hyalomma marginatum ticks. International Journal of Systematic Bacteriology 47, 548-554.
30. Beati, L., Peter, O., Burgdorfer, W., Aeschlimann, A. & Raoult, D. (1993). Confirmation that Rickettsia helvetica sp. nov. is a distinct species of the spotted fever group of rickettsiae. International Journal of Systematic Bacteriology 43, 521-526.
31. Beati, L. & Raoult, D. (1993). Rickettsia massiliae sp. nov., a new spotted fever group Rickettsia. International Journal of Systematic Bacteriology 43, 839-840.
32. Beati, L., Roux, V., Ortuno, A., Castella, J., Porta, F. S. & Raoult, D. (1996). Phenotypic and genotypic characterization of spotted fever group Rickettsiae isolated from Catalan Rhipicephalus sanguineus ticks. Journal of Clinical Microbiology 34, 2688-2694.
33. Bell, E. J., Kohls, G. M., Stoenner, H. G. & Lackman, D. B. (1963). Non pathogenic rickettsias related to the Spotted Fever Group isolated from ticks, Dermacentor variabilis and Dermacentor andersoni from Eastern Montana. Journal of Immunology 90, 770-781.
34. Bitam, I., Parola, P., De La Cruz, K. D., Matsumoto, K., Baziz, B., Rolain, J. M., Belkaid, M. & Raoult, D. (2006). First molecular detection of Rickettsia felis in fleas from Algeria. American Journal of Tropical Medicine and Hygiene 74, 532-535.
35. Blair, P. J., Jiang, J., Schoeler, G. B., Moron, C., Anaya, E., Cespedes, M., Cruz, C., Felices, V., Guevara, C., Mendoza, L., Villaseca, P., Sumner, J. W., Richards, A. L. & Olson, J. G. (2004). Characterization of spotted fever group rickettsiae in flea and tick specimens from northern Peru. Journal of Clinical Microbiology 42, 4961-4967.
36. Blanc, G. & Caminopetros, J. (1932). Epidemiological and experimental studies on Boutonneuse fever done at the Pasteur Institute in Athens. Archives de l'Institut Pasteur de Tunis 20, 343-394.
37. Blanc, G., Ngwamidiba, M., Ogata, H., Fournier, P. E., Claverie, J. M. & Raoult, D. (2005a). Molecular evolution of rickettsia surface antigens: evidence of positive selection. Molecular Biology and Evolution 22, 2073-2083.
38. Blanc, G., Ogata, H., Robert, C., Audic, S., Claverie, J. M. & Raoult, D. (2007a). Lateral gene transfer between obligate intracellular bacteria: evidence from the Rickettsia massiliae genome. Genome Research 17, 1657-1664.
39. Blanc, G., Ogata, H., Robert, C., Audic, S., Suhre, K., Vestris, G., Claverie, J. M. & Raoult, D. (2007b). Reductive genome evolution from the mother of Rickettsia. PLoS Genetics 3, e14.
40. Blanc, G., Renesto, P. & Raoult, D. (2005b). Phylogenic analysis of rickettsial patatin-like protein with conserved phospholipase A2 active sites. Annals of the New York Academy of Sciences 1063, 83-86.
41. Blatch, G. L. & Lassle, M. (1999). The tetratricopeptide repeat: a structural motif mediating protein-protein interactions. Bioessays 21, 932-939.
42. Bordenstein, S. R. & Reznikoff, W. S. (2005). Mobile DNA in obligate intracellular bacteria. Nature Review Microbiology 3, 688-699.
43. Bork, P. (1993). Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally? Proteins 17, 363-374.
44. Boussau, B., Karlberg, E. O., Frank, A. C., Legault, B. A. & Andersson, S. G. (2004). Computational inference of scenarios for alpha-proteobacterial genome evolution. Proceedings of the National Academy of Sciences U.S.A. 101, 9722-9727.
45. Bozeman, F. M., Elisberg, B. L., Humphries, J. W., Runcik, K. & Palmer, D. B., Jr. (1970). Serologic evidence of Rickettsia canada infection of man. Journal of Infectious Diseases 121, 367-371.
46. Bozeman, F. M., Masiello, S. A., Williams, M. S. & Elisberg, B. L. (1975). Epidemic typhus rickettsiae isolated from flying squirrels. Nature 255, 545-547.
47. Braeken, L., Van der Bruggen, B. & Vandecasteele, C. (2006). Flux decline in nanofiltration due to adsorption of dissolved organic compounds: model prediction of time dependency. The Journal of Physical Chemistry. B 110, 2957-2962.
48. Burgdorfer, W. (1963). Investigation of transovarial transmission of Rickettsia rickettsii in the wood tick Dermacentor andersoni. Experimental Parasitology 14, 152-159.
49. Burgdorfer, W. (1988). Ecological and epidemiological considerations of Rocky mountain Spotted fever and scrub typhus. In Biology of rickettsial diseases (ed. D. H. Walker), pp. 33-50. Boca Raton: CRC Press.
50. Burgdorfer, W., Aeschlimann, A., Peter, O., Hayes, S. F. & Philip, R. N. (1979). Ixodes ricinus: vector of a hitherto undescribed spotted fever group agent in Switzerland. Acta Tropica 36, 357-367.
51. Burgdorfer, W. & Brinton, L. P. (1970). Intranuclear Growth of Rickettsia canada, a Member of the Typhus Group. Infecion and Immunity 2, 112-114.
52. Campbell, R. W. & Domrow, R. (1974). Rickettsioses in Australia: isolation of Rickettsia tsutsugamushi and R. australis from naturally infected arthropods. Transactions of the Royal Society of Tropical Medicine and Hygiene 68, 397-402.
53. Cardwell, M. M. & Martinez, J. J. (2009). The Sca2 autotransporter protein from Rickettsia conorii is sufficient to mediate adherence to and invasion of cultured mammalian cells. Infection and Immunity. 77, 5272-5280.
54. Carmichael, J. R. & Fuerst, P. A. (2006). A rickettsial mixed infection in a Dermacentor variabilis tick from Ohio. Annals of the New York Academy of Sciences 1078, 334-337.
55. Caturegli, P., Asanovich, K. M., Walls, J. J., Bakken, J. S., Madigan, J. E., Popov, V. L. & Dumler, J. S. (2000). ankA: an Ehrlichia phagocytophila group gene encoding a cytoplasmic protein antigen with ankyrin repeats. Infection and Immunity 68, 5277-5283.
56. Cazalet, C., Rusniok, C., Bruggemann, H., Zidane, N., Magnier, A., Ma, L., Tichit, M., Jarraud, S., Bouchier, C., Vandenesch, F., Kunst, F., Etienne, J., Glaser, P. & Buchrieser, C. (2004). Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity. Nature Genetics 36, 1165-1173.
57. Chan, Y. G., Cardwell, M. M., Hermanas, T. M., Uchiyama, T. & Martinez, J. J. (2009). Rickettsial outer-membrane protein B (rOmpB) mediates bacterial invasion through Ku70 in an actin, c-Cbl, clathrin and caveolin 2-dependent manner. Cellular Microbiology 11, 629-644.
58. Chatterji, D. & Ojha, A. K. (2001). Revisiting the stringent response, ppGpp and starvation signaling. Current Opinion in Microbiology 4, 160-165.
59. Chen, D. Q., Campbell, B. C. & Purcell, A. H. (1996). A new rickettsia from a herbivorous insect, the pea aphid Acyrthosiphon pisum (Harris). Current Microbiology 33, 123-128.
60. Chen, J., de Felipe, K. S., Clarke, M., Lu, H., Anderson, O. R., Segal, G. & Shuman, H. A. (2004). Legionella effectors that promote nonlytic release from protozoa. Science 303, 1358-1361.
61. Childs, J. E. & Paddock, C. D. (2007). Rocky Mountain Spotted Fever. In Rickettsial diseases (eds. D. Raoult & P. Parola), pp. 97-114. Marseille: Informa Healthcare USA.
62. Cho, N. H., Kim, H. R., Lee, J. H., Kim, S. Y., Kim, J., Cha, S., Kim, S. Y., Darby, A. C., Fuxelius, H. H., Yin, J., Kim, J. H., Kim, J., Lee, S. J., Koh, Y. S., Jang, W. J., Park, K. H., Andersson, S. G., Choi, M. S. & Kim, I. S. (2007). The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes. Proceedings of the National Academy of Sciences U.S.A. 104, 7981-7986.
63. Choi, Y. J., Lee, E. M., Park, J. M., Lee, K. M., Han, S. H., Kim, J. K., Lee, S. H., Song, H. J., Choi, M. S., Kim, I. S., Park, K. H. & Jang, W. J. (2007). Molecular detection of various rickettsiae in mites (acari: trombiculidae) in southern Jeolla Province, Korea. Microbiology and Immunology 51, 307-312.
64. Christie, P. J. (2001). Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines. Molecular Microbiology 40, 294-305.
65. Cirillo, S. L., Lum, J. & Cirillo, J. D. (2000). Identification of novel loci involved in entry by Legionella pneumophila. Microbiology 146, 1345-1359.
66. Claverie, J. M. & Ogata, H. (2003). The insertion of palindromic repeats in the evolution of proteins. Trends in Biochemical Sciences 28, 75-80.
67. Czarnetzki, A. B. & Tebbe, C. C. (2004). Diversity of bacteria associated with Collembola-a cultivation-independent survey based on PCR-amplified 16S rRNA genes. Microbial Ecology 49, 217-227.
68. Dagan, T., Blekhman, R. & Graur, D. (2006). The "domino theory" of gene death: gradual and mass gene extinction events in three lineages of obligate symbiotic bacterial pathogens. Molecular Biology and Evolution 23, 310-316.
69. Darby, A. C., Cho, N. H., Fuxelius, H. H., Westberg, J. & Andersson, S. G. (2007). Intracellular pathogens go extreme: genome evolution in the Rickettsiales. Trends in Genetics 23, 511-520.
70. Darling, A. C., Mau, B., Blattner, F. R. & Perna, N. T. (2004). Mauve: multiple alignment of conserved genomic sequence with rearrangements. Genome Research 14, 1394-1403.
71. Davis, M. J., Ying, Z., Brunner, B. R., Pantoja, A. & Ferwerda, F. H. (1998). Rickettsial relative associated with papaya bunchy top disease. Current Microbiology 36, 80-84.
72. Demesure, B., Sodzi, N. & Petit, R. J. (1995). A set of universal primers for amplification of polymorphic non-coding regions of mitochondrial and chloroplast DNA in plants. Molecular Ecology 4, 129-131.
73. Demma, L. J., Traeger, M. S., Nicholson, W. L., Paddock, C. D., Blau, D. M., Eremeeva, M. E., Dasch, G. A., Levin, M. L., Singleton, J., Jr., Zaki, S. R., Cheek, J. E., Swerdlow, D. L. & McQuiston, J. H. (2005). Rocky Mountain spotted fever from an unexpected tick vector in Arizona. The New England Journal of Medicine 353, 587-594.
74. Dermitzakis, E. T., Reymond, A., Scamuffa, N., Ucla, C., Kirkness, E., Rossier, C. & Antonarakis, S. E. (2003). Evolutionary discrimination of mammalian conserved non-genic sequences (CNGs). Science 302, 1033-1035.
75. Doolittle, W. F. & Papke, R. T. (2006). Genomics and the bacterial species problem. Genome Biology 7, 116.
76. Doolittle, W. F. & Sapienza, C. (1980). Selfish genes, the phenotype paradigm and genome evolution. Nature 284, 601-603.
77. Driskell, L. O., Yu, X. J., Zhang, L., Liu, Y., Popov, V. L., Walker, D. H., Tucker, A. M. & Wood, D. O. (2009). Directed mutagenesis of the Rickettsia prowazekii pld gene encoding phospholipase D. Infection and Immunity 77, 3244-3248.
78. Dumler, J. S. & Walker, D. H. (2000). Rickettsia typhi (Murine typhus). In Principles and practice of infectious diseases (eds. G. L. Mandell, J. E. Bennett & R. Dolin), pp. 2053-2055. Philadelphia: Churchill Livingstone.
79. Edgar, R. C. (2004). MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Research 32, 1792-1797.
80. Ellison, D. W., Clark, T. R., Sturdevant, D. E., Virtaneva, K., Porcella, S. F. & Hackstadt, T. (2008). Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa. Infection and Immunity 76, 542-550.
81. Eremeeva, M. E., Beati, L., Makarova, V. A., Fetisova, N. F., Tarasevich, I. V., Balayeva, N. M. & Raoult, D. (1994). Astrakhan fever rickettsiae: antigenic and genotypic analysis of isolates obtained from human and Rhipicephalus pumilio ticks. The American Journal of Tropical Medicine and Hygiene 51, 697-706.
82. Eremeeva, M. E., Bosserman, E., Zambrano, M., Demma, L. & Dasch, G. A. (2006). Molecular typing of novel Rickettsia rickettsii isolates from Arizona. Annals of the New York Academy of Sciences 1078, 573-577.
83. Eremeeva, M. E. & Paddock, C. D. (2007). Rickettsialpox. In Rickettsial diseases (eds. D. Raoult & P. Parola), pp. 62-86. Marseille: Informa healthcare USA.
84. Eremeeva, M. E., Warashina, W. R., Sturgeon, M. M., Buchholz, A. E., Olmsted, G. K., Park, S. Y., Effler, P. V. & Karpathy, S. E. (2008). Rickettsia typhi and R. felis in rat fleas (Xenopsylla cheopis), Oahu, Hawaii. Emerging Infectious Diseases 14, 1613-1615.
85. Farhangazad Azad, A. & Traub, R. (1985). Transmission of murine typhus rickettsiae by Xenopsylla cheopis, with notes on experimental infection and effects of temperature. The American Journal of Tropical Medicine and Hygiene 34, 555-563.
86. Felsenstein, J. (1993). PHYLIP (Phylogeny Inference Package) version 3.5c. Distributed by the author. Department of Genetics, University of Washington, Seattle.
87. Felsheim, R. F., Kurtti, T. J. & Munderloh, U. G. (2009). Genome sequence of the endosymbiont Rickettsia peacockii and comparison with virulent Rickettsia rickettsii: identification of virulence factors. PLoS.ONE 4, e8361.
88. Fenn, K. & Blaxter, M. (2006). Wolbachia genomes: revealing the biology of parasitism and mutualism. Trends in Parasitology 22, 60-65.
89. Fournier, P. E., Allombert, C., Supputamongkol, Y., Caruso, G., Brouqui, P. & Raoult, D. (2004a). Aneruptive fever associated with antibodies to Rickettsia helvetica in Europe and Thailand. Journal of Clinical Microbiology 42, 816-818.
90. Fournier, P. E., Belghazi, L., Robert, C., El Karkouri, K., Richards, A. L., Greub, G., Collyn, F., Ogawa, M., Portillo, A., Oteo, J. A., Psaroulaki, A., Bitam, I. & Raoult, D. (2008). Variations of plasmid content in Rickettsia felis. PLoS ONE 3, e2289.
91. Fournier, P. E., Dumler, J. S., Greub, G., Zhang, J., Wu, Y. & Raoult, D. (2003). Gene sequence-based criteria for identification of new rickettsia isolates and description of Rickettsia heilongjiangensis sp. nov. Journal of Clinical Microbiology 41, 5456-5465.
92. Fournier, P. E., El Karkouri, K., Leroy, Q., Robert, C., Giumelli, B., Renesto, P., Socolovschi, C., Parola, P., Audic, S. & Raoult, D. (2009). Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction. BMC Genomics 10, 166.
93. Fournier, P. E., Fujita, H., Takada, N. & Raoult, D. (2002). Genetic identification of rickettsiae isolated from ticks in Japan. Journal of Clinical Microbiology 40, 2176-2181.
94. Fournier, P. E., Grunnenberger, F., Jaulhac, B., Gastinger, G. & Raoult, D. (2000). Evidence of Rickettsia helvetica infection in humans, eastern France. Emerging Infectious Diseases 6, 389-392.
95. Fournier, P. E. & Raoult, D. (2004). Suicide PCR on skin biopsy specimens for diagnosis of rickettsioses. Journal of Clinical Microbiology 42, 3428-3434.
96. Fournier, P. E. & Raoult, D. (2007). Identification of rickettsial isolates at the species level using multi-spacer typing. BMC Microbiology 7, 72.
97. Fournier, P. E., Roux, V. & Raoult, D. (1998). Phylogenetic analysis of spotted fever group rickettsiae by study of the outer surface protein rOmpA. International Journal of Systematic Bacteriology 48, 839-849.
98. Fournier, P. E., Takada, N., Fujita, H. & Raoult, D. (2006a). Rickettsia tamurae sp. nov., isolated from Amblyomma testudinarium ticks. International Journal of Systematic and Evolutionary Microbiology 56, 1673-1675.
99. Fournier, P. E., Zhu, Y., Ogata, H. & Raoult, D. (2004b). Use of highly variable intergenic spacer sequences for multispacer typing of Rickettsia conorii strains. Journal of Clinical Microbiology 42, 5757-5766.
100. Fournier, P. E., Zhu, Y., Yu, X. & Raoult, D. (2006b). Proposal to create subspecies of Rickettsia sibirica and an emended description of Rickettsia sibirica. Annals of the New York Academy of Sciences 1078, 597-606.
101. Frank, A. C., Alsmark, C. M., Thollesson, M. & Andersson, S. G. (2005). Functional divergence and horizontal transfer of type IV secretion systems. Molecular Biology and Evolution 22, 1325-1336.
102. Frank, A. C., Amiri, H. & Andersson, S. G. (2002). Genome deterioration: loss of repeated sequences and accumulation of junk DNA. Genetica 115, 1-12.
103. Frischknecht, F. & Way, M. (2001). Surfing pathogens and the lessons learned for actin polymerization. Trends in Cell Biology 11, 30-38.
104. Fritsche, T. R., Horn, M., Seyedirashti, S., Gautom, R. K., Schleifer, K. H. & Wagner, M. (1999). In situ detection of novel bacterial endosymbionts of Acanthamoeba spp. phylogenetically related to members of the order Rickettsiales. Applied Environmental Microbiology 65, 206-212.
105. Frost, L. S., Leplae, R., Summers, A. O. & Toussaint, A. (2005). Mobile genetic elements: the agents of open source evolution. Nature Reviews. Microbiology 3, 722-732.
106. Fujita, H., Fournier, P. E., Takada, N., Saito, T. & Raoult, D. (2006). Rickettsia asiatica sp. nov., isolated in Japan. International Journal of Systematic and Evolutionary Microbiology 56, 2365-2368.
107. Fukatsu, T. & Nikoh, N. (2000). Endosymbiotic microbiota of the bamboo pseudococcid Antonina crawii (Insecta, Homoptera).Applied Environmental Microbiology 66, 643-650.
108. Fukatsu, T. & Shimada, M. (1999). Molecular characterization of Rickettsia sp. in a bruchid beetle, Kytorhinus sharpianus (Coleoptera: Bruchidae). Applied Entomology and Zoology 34, 391-397.
109. Fuxelius, H. H., Darby, A. C., Cho, N. H. & Andersson, S. G. (2008). Visualization of pseudogenes in intracellular bacteria reveals the different tracks to gene destruction. Genome Biology 9, R42.
110. Gage, K. L., Schrumpf, M. E., Karstens, R. H., Burgdorfer, W. & Schwan, T. G. (1994). DNA typing of rickettsiae in naturally infected ticks using a polymerase chain reaction/restriction fragment length polymorphism system. The American Journal of Tropical Medicine and Hygiene 50, 247-260.
111. Gerstein, M. & Zheng, D. (2006). The real life of pseudogenes. Scientific American 295, 48-55.
112. Gikas, A., Doukakis, S., Pediaditis, J., Kastanakis, S., Psaroulaki, A. & Tselentis, Y. (2002). Murine typhus in Greece: epidemiological, clinical, and therapeutic data from 83 cases. Transactions of the Royal Society of Tropical Medicine and Hygiene 96, 250-253.
113. Gillespie, J. J., Beier, M. S., Rahman, M. S., Ammerman, N. C., Shallom, J. M., Purkayastha, A., Sobral, B. S. & Azad, A. F. (2007). Plasmids and rickettsial evolution: insight from Rickettsia felis. PLoS.ONE 2, e266.
114. Gillespie, J. J., Williams, K., Shukla, M., Snyder, E. E., Nordberg, E. K., Ceraul, S. M., Dharmanolla, C., Rainey, D., Soneja, J., Shallom, J. M., Vishnubhat, N. D., Wattam, R., Purkayastha, A., Czar, M., Crasta, O., Setubal, J. C., Azad, A. & Sobral, B. S. (2008). Rickettsia phylogenomics: unwinding the intricacies of obligate intracellular life. PLoS.ONE 3, e2018.
115. Goddard, J. (2003). Experimental infection of lone star ticks, Amblyomma americanum (L.), with Rickettsia parkeri and exposure of guinea pigs to the agent. Journal of Medical Entomology 40, 686-689.
116. Gouin, E., Egile, C., Dehoux, P., Villiers, V., Adams, J., Gertler, F., Li, R. & Cossart, P. (2004). The RickA protein of Rickettsia conorii activates the Arp2/3 complex. Nature 427, 457-461.
117. Graves, S. & Stenos, J. (2003). Rickettsia honei: a spotted fever group Rickettsia on three continents. Annals of the New York Academy of Sciences 990, 62-66.
118. Graves, S. R., Stewart, L., Stenos, J., Stewart, R. S., Schmidt, E., Hudson, S., Banks, J., Huang, Z. & Dwyer, B. (1993). Spotted fever group rickettsial infection in south-eastern Australia: isolation of rickettsiae. Comparative Immunology, Microbiology and Infectious Diseases 16, 223-233.
119. Green, C. R., Fishbein, D. & Gleiberman, I. (1990). Brill-Zinsser: still with us. JAMA: the Journal of the American Medical Association 264, 1811-1812.
120. Greub, G. & Raoult, D. (2003). History of the ADP/ATP-translocase-encoding gene, a parasitism gene transferred from a Chlamydiales ancestor to plants 1 billion years ago. Applied Environmental Microbiology 69, 5530-5535.
121. Grimont, P. A. (1988). Use of DNA reassociation in bacterial classification. Canadian Journal of Microbiology 34, 541-546.
122. Guedes, E., Leite, R. C., Prata, M. C., Pacheo, R. C., Walker, D. H. & Labruna, M. B. (2005). Detection of Rickettsia rickettsii in the tick Amblyomma cajennense in a new Brazilian spotted fever-endemic area in the state of Minas Gerais. Memórias do Instituto Oswaldo Cruz 100, 841-845.
123. Hacker, J. & Kaper, J. B. (2000). Pathogenicity islands and the evolution of microbes. Annual Review of Microbiology 54, 641-679.
124. Hagimori, T., Abe, Y., Date, S. & Miura, K. (2006). The first finding of a Rickettsia bacterium associated with parthenogenesis induction among insects. Current Microbiology 52, 97-101.
125. Haldane, J. B. S. (1932). The causes of evolution. London: Longmans, Green and co. pp. 234.
126. Hardison, R. C., Oeltjen, J. & Miller, W. (1997). Long human-mouse sequence alignments reveal novel regulatory elements: a reason to sequence the mouse genome. Genome Research 7, 959-966.
127. Hassan, A. A., Khan, I. U., Abdulmawjood, A. & Lammler, C. (2003). Inter- and intraspecies variations of the 16S-23S rDNA intergenic spacer region of various streptococcal species. Systematic and Applied Microbiology 26, 97-103.
128. Hayes, C. S. & Sauer, R. T. (2003). Toxin-antitoxin pairs in bacteria: killers or stress regulators? Cell 112, 2-4.
129. Hayes, S. F. & Burgdorfer, W. (1979). Ultrastructure of Rickettsia rhipicephali, a new member of the spotted fever group rickettsiae in tissues of the host vector Rhipicephalus sanguineus. Journal of Bacteriology 137, 605-613.
130. Heinzen, R. A., Hayes, S. F., Peacock, M. G. & Hackstadt, T. (1993). Directional actin polymerization associated with spotted fever group Rickettsia infection of Vero cells. Infection and Immunity 61, 1926-1935.
131. Higgins, J. A., Radulovic, S., Schriefer, M. E. & Azad, A. F. (1996). Rickettsia felis: a new species of pathogenic rickettsia isolated from cat fleas. Journal of Clinical Microbiology 34, 671-674.
132. Hill, K. E., Davies, C. E., Wilson, M. J., Stephens, P., Lewis, M. A., Hall, V., Brazier, J. & Thomas, D. W. (2002). Heterogeneity within the gram-positive anaerobic cocci demonstrated by analysis of 16S-23S intergenic ribosomal RNA polymorphisms. Journal of Medical Microbiology 51, 949-957.
133. Hirotsune, S., Yoshida, N., Chen, A., Garrett, L., Sugiyama, F., Takahashi, S., Yagami, K., Wynshaw-Boris, A. & Yoshiki, A. (2003). An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene. Nature 423, 91-96.
134. Hooper, S. D. & Berg, O. G. (2003). On the nature of gene innovation: duplication patterns in microbial genomes. Molecular Biology and Evolution 20, 945-954.
135. Horta, M. C., Pinter, A., Schumaker, T. T. & Labruna, M. B. (2006). Natural infection, transovarial transmission, and transstadial survival of Rickettsia bellii in the Tick Ixodes loricatus (Acari: Ixodidae) from Brazil. Annals of the New York Academy of Sciences 1078, 285-290.
136. Hotopp, J. C., Clark, M. E., Oliveira, D. C., Foster, J. M., Fischer, P., Torres, M. C., Giebel, J. D., Kumar, N., Ishmael, N., Wang, S., Ingram, J., Nene, R. V., Shepard, J., Tomkins, J., Richards, S., Spiro, D. J., Ghedin, E., Slatko, B. E., Tettelin, H. & Werren, J. H. (2007). Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes. Science 317, 1753-1756.
137. Houhamdi, L., Fournier, P. E., Fang, R., Lepidi, H. & Raoult, D. (2002). An experimental model of human body louse infection with Rickettsia prowazekii. Journal of Infectious Diseases 186, 1639-1646.
138. Houhamdi, L., Fournier, P. E., Fang, R. & Raoult, D. (2003). An experimental model of human body louse infection with Rickettsia typhi. Annals of the New York Academy of Sciences 990, 617-627.
139. Houhamdi, L. & Raoult, D. (2006). Experimentally infected human body lice (Pediculus humanus humanus) as vectors of Rickettsia rickettsii and Rickettsia conorii in a rabbit model. American Journal of Tropical Medicine and Hygiene 74, 521-525.
140. Hurst, G. D. & Jiggins, F. M. (2000). Male-killing bacteria in insects: mechanisms, incidence, and implications. Emerging Infectious Diseases 6, 329-336.
141. Ibarra, V., Portillo, A., Santibanez, S., Blanco, J. R., Perez-Martinez, L., Marquez, J. & Oteo, J. A. (2005). DEBONEL/TIBOLA: is Rickettsia slovaca the only etiological agent? Annals of the New York Academy of Sciences 1063, 346-348.
142. Ijdo, J. W., Carlson, A. C. & Kennedy, E. L. (2007). Anaplasma phagocytophilum AnkA is tyrosine-phosphorylated at EPIYA motifs and recruits SHP-1 during early infection. Cellular Microbiology 9, 1284-1296.
143. Ishikura, M., Ando, S., Shinagawa, Y., Matsuura, K., Hasegawa, S., Nakayama, T., Fujita, H. & Watanabe, M. (2003). Phylogenetic analysis of spotted fever group rickettsiae based on gltA, 17-kDa, and rOmpA genes amplified by nested PCR from ticks in Japan. Microbiology and Immunology 47, 823-832.
144. Ishikura, M., Fujita, H., Ando, S., Matsuura, K. & Watanabe, M. (2002). Phylogenetic analysis of spotted fever group Rickettsiae isolated from ticks in Japan. Microbiology and Immunology 46, 241-247.
145. Jado, I., Oteo, J. A., Aldamiz, M., Gil, H., Escudero, R., Ibarra, V., Portu, J., Portillo, A., Lezaun, M. J., Garcia-Amil, C., Rodriguez-Moreno, I. & Anda, P. (2007). Rickettsia monacensis and human disease, Spain. Emerging Infectious Diseases 13, 1405-1407.
146. Jiang, J., Blair, P. J., Felices, V., Moron, C., Cespedes, M., Anaya, E., Schoeler, G. B., Summer, J. W., Olson, J. G. & Richards, A. L. (2005). Phylogenetic analysis of a novel molecular isolate of spotted fever group Rickettsiae from northern Peru: Candidatus Rickettsia andeanae. Annals of the New York Academy of Sciences 1063, 337-342.
147. Jiggins, F. M. (2006). Adaptive evolution and recombination of Rickettsia antigens. Journal of Molecular Evolution 62, 99-110.
148. Jukes, T. H. & Kimura, M. (1984). Evolutionary constraints and the neutral theory. Journal of Molecular Evolution 21, 90-92.
149. Karpathy, S. E., Dasch, G. A. & Eremeeva, M. E. (2007). Molecular typing of isolates of Rickettsia rickettsii by use of DNA sequencing of variable intergenic regions. Journal of Clinical Microbiology 45, 2545-2553.
150. Kellis, M., Patterson, N., Endrizzi, M., Birren, B. & Lander, E. S. (2003). Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423, 241-254.
151. Kelly, P. J., Beati, L., Mason, P. R., Matthewman, L. A., Roux, V. & Raoult, D. (1996). Rickettsia africae sp. nov., the etiological agent of African tick bite fever. International Journal of Systematic Bacteriology 46, 611-614.
152. Kelly, P. J. & Mason, P. R. (1991). Transmission of a spotted fever group rickettsia by Amblyomma hebraeum (Acari: Ixodidae). Journal of Medical Entomology 28, 598-600.
153. Kikuchi, Y. & Fukatsu, T. (2005). Rickettsia infection in natural leech populations. Microbial Ecology 49, 265-271.
154. Kikuchi, Y., Sameshima, S., Kitade, O., Kojima, J. & Fukatsu, T. (2002). Novel clade of Rickettsia spp. from leeches. Applied Environmental Microbiology 68, 999-1004.
155. Kleba, B., Clark, T. R., Lutter, E. I., Ellison, D. W. & Hackstadt, T. (2010). Disruption of the Rickettsia rickettsii Sca2 autotransporter inhibits actin based motility. Infection and Immunity 78, 2240-2247.
156. Kolsto, A. B. (1997). Dynamic bacterial genome organization. MolecularMicrobiology 24, 241-248.
157. Kondo, N., Nikoh, N., Ijichi, N., Shimada, M. & Fukatsu, T. (2002). Genome fragment of Wolbachia endosymbiont transferred to X chromosome of host insect. Proceedings of the National Academy of Sciences U.S.A. 99, 14280-14285.
158. Koonin, E. V. & Wolf, Y. I. (2008). Genomics of bacteria and archaea: the emerging dynamic view of the prokaryotic world. Nucleic Acids Research 36, 6688-6719.
159. Labruna, M. B., McBride, J. W., Bouyer, D. H., Camargo, L. M., Camargo, E. P. & Walker, D. H. (2004a). Molecular evidence for a spotted fever group Rickettsia species in the tick Amblyomma longirostre in Brazil. Journal of Medical Entomology 41, 533-537.
160. Labruna, M. B., Pacheco, R. C., Nava, S., Brandao, P. E., Richtzenhain, L. J. & Guglielmone, A. A. (2007a). Infection by Rickettsia bellii and Candidatus"Rickettsia amblyommii" in Amblyomma neumanni ticks from Argentina. Microbial Ecology 54, 126-133.
161. Labruna, M. B., Pacheco, R. C., Richtzenhain, L. J. & Szabo, M. P. (2007b). Isolation of Rickettsia rhipicephali and Rickettsia bellii from Haemaphysalis juxtakochi ticks in the state of Sao Paulo, Brazil. Applied Environmental Microbiology 73, 869-873.
162. Labruna, M. B., Whitworth, T., Bouyer, D. H., McBride, J., Camargo, L. M., Camargo, E. P., Popov, V. & Walker, D. H. (2004b). Rickettsia bellii and Rickettsia amblyommii in Amblyomma ticks from the State of Rondonia, Western Amazon, Brazil. Journal of Medical Entomology 41, 1073-1081.
163. Labruna, M. B., Whitworth, T., Horta, M. C., Bouyer, D. H., McBride, J. W., Pinter, A., Popov, V., Gennari, S. M. & Walker, D. H. (2004c). Rickettsia species infecting Amblyomma cooperi ticks from an area in the state of Sao Paulo, Brazil, where Brazilian spotted fever is endemic. Journal of Clinical Microbiology 42, 90-98.
164. Lakos, A. (1999). Tick-borne lymphadenopathy (TIBOLA)- a new, probably rickettsial infection. Inf. Dis. Rev. Infectious Diseases Review 1, 114-116.
165. Lawley, T. D., Klimke, W. A., Gubbins, M. J. & Frost, L. S. (2003). F factor conjugation is a true type IV secretion system. FEMS Microbiology Letters 224, 1-15.
166. Lawrence, J. G., Hendrix, R. W. & Casjens, S. (2001). Where are the pseudogenes in bacterial genomes? Trends in Microbiology 9, 535-540.
167. Lawrence, J. G. & Ochman, H. (1998). Molecular archaeology of the Escherichia coli genome. Proceedings of the National Academy of Sciences U.S.A. 95, 9413-9417.
168. Lawson, E. T., Mousseau, T. A., Klaper, R., Hunter, M. D. & Werren, J. H. (2001). Rickettsia associated with male-killing in a buprestid beetle. Heredity 86, 497-505.
169. Li, H. & Walker, D. H. (1998). rOmpA is a critical protein for the adhesion of Rickettsia rickettsii to host cells. Microbial Pathogenesis 24, 289-298.
170. Li, J., Mahajan, A. & Tsai, M. D. (2006). Ankyrin repeat: a unique motif mediating protein-protein interactions. Biochemistry 45, 15168-15178.
171. Liu, Y., Harrison, P. M., Kunin, V. & Gerstein, M. (2004). Comprehensive analysis of pseudogenes in prokaryotes: widespread gene decay and failure of putative horizontally transferred genes. Genome Biology 5, R64.
172. Livesey, H. R. & Pollard, M. (1943). Laboratory report on a clinical syndrome referred to as "Bullis fever". American Journal of Tropical Medicine and Hygiene 23, 475-479.
173. Loots, G. G., Locksley, R. M., Blankespoor, C. M., Wang, Z. E., Miller, W., Rubin, E. M. & Frazer, K. A. (2000). Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science 288, 136-140.
174. Macaluso, K. R., Pornwiroon, W., Popov, V. L. & Foil, L. D. (2008). Identification of Rickettsia felis in the salivary glands of cat fleas. Vector Borne and Zoonotic Diseases 8, 391-396.
175. Maiden, M. C., Bygraves, J. A., Feil, E., Morelli, G., Russell, J. E., Urwin, R., Zhang, Q., Zhou, J., Zurth, K., Caugant, D. A., Feavers, I. M., Achtman, M. & Spratt, B. G. (1998). Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proceedings of the National Academy of Sciences U.S.A. 95, 3140-3145.
176. Maiwald, M., Lepp, P. W. & Relman, D. A. (2003). Analysis of conserved non-rRNA genes of Tropheryma whipplei. Systematic and Applied Microbiology 26, 3-12.
177. Martinez, J. J., Seveau, S., Veiga, E., Matsuyama, S. & Cossart, P. (2005). Ku70, a component of DNA-dependent protein kinase, is a mammalian receptor for Rickettsia conorii. Cell 123, 1013-1023.
178. Matsumoto, K., Ogawa, M., Brouqui, P., Raoult, D. & Parola, P. (2005). Transmission of Rickettsia massiliae in the tick, Rhipicephalus turanicus. Medical and Veterinary Entomology 19, 263-270.
179. Matsumoto, K., Parola, P., Rolain, J. M., Jeffery, K. & Raoult, D. (2007). Detection of "Rickettsia sp. strain Uilenbergi" and "Rickettsia sp. strain Davousti" in Amblyomma tholloni ticks from elephants in Africa. BMC. Microbiology 7, 74.
180. Maurelli, A. T., Fernandez, R. E., Bloch, C. A., Rode, C. K. & Fasano, A. (1998). "Black holes" and bacterial pathogenicity: a large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli. Proceedings of the National Academy of Sciences U.S.A. 95, 3943-3948.
181. Mayr, E. (1942). Systematics and the origin of species from the viewpoint of a zoologist., New York: Columbia University Press. pp. 334.
182. Mayr, E. (1965). Animal species and evolution. Cambridge: Harvard University Press. pp. 797.
183. McBride, W. J. H., Hanson, J. P., Miller, R. & Wenck, D. (2007). Severe Spotted Fever Group rickettsiosis, australia. Emerging Infectious Diseases 13, 1742-1744.
184. McClarty, G. (1994). Chlamydiae and the biochemistry of intracellular parasitism. Trends in Microbiology 2, 157-164.
185. McKiel, J. A., Bell, E. J. & Lackman, D. B. (1967). Rickettsia canada: a new member of the typhus group of rickettsiae isolated from Haemaphysalis leporispalustris ticks in Canada. Canadian Journal of Microbiology 13, 503-510.
186. McLeod, M. P., Qin, X., Karpathy, S. E., Gioia, J., Highlander, S. K., Fox, G. E., McNeill, T. Z., Jiang, H., Muzny, D., Jacob, L. S., Hawes, A. C., Sodergren, E., Gill, R., Hume, J., Morgan, M., Fan, G., Amin, A. G., Gibbs, R. A., Hong, C., Yu, X. J., Walker, D. H. & Weinstock, G. M. (2004). Complete genome sequence of Rickettsia typhi and comparison with sequences of other rickettsiae. Journal of Bacteriology 186, 5842-5855.
187. Mediannikov, O., Parola, P. & Raoult, D. (2007). Other tick-borne rickettsioses. In Rickettsial diseases (eds. D. Raoult & P. Parola), pp. 139-162. Marseille: Informa Healthcare USA.
188. Mediannikov, O., Makarova, V., Tarasevich, I., Sidelnikov, Y. & Raoult, D. (2009). Isolation of Rickettsia heilongjiangensis strains from humans and ticks and its multispacer typing. Clinical Microbiology and Infection 15, 288-289.
189. Mediannikov, O., Matsumoto, K., Samoylenko, I., Drancourt, M., Roux, V., Rydkina, E., Davoust, B., Tarasevich, I., Brouqui, P. & Fournier, P. E. (2008). Rickettsia raoultii sp. nov., a spotted fever group rickettsia associated with Dermacentor ticks in Europe and Russia. International Journal of Systematic and Evolutionary Microbiology 58, 1635-1639.
190. Mediannikov, O., Sidelnikov, Y., Ivanov, L., Fournier, P. E., Tarasevich, I. & Raoult, D. (2006). Far eastern tick-borne rickettsiosis: identification of two new cases and tick vector. Annals of the New York Academy of Sciences 1078, 80-88.
191. Medina-Sanchez, A., Bouyer, D. H., cantara-Rodriguez, V., Mafra, C., Zavala-Castro, J., Whitworth, T., Popov, V. L., Fernandez-Salas, I. & Walker, D. H. (2005). Detection of a typhus group Rickettsia in Amblyomma ticks in the state of Nuevo Leon, Mexico. Annals of the New York Academy of Sciences 1063, 327-332.
192. Merhej, V., Karkouri, El. K. & Raoult, D. (2009a). Whole genome-based phylogenetic analysis of Rickettsiae. Clinical Microbiology and Infection 18, 336-337.
193. Merhej, V., Royer-Carenzi, M., Pontarotti, P. & Raoult, D. (2009b). Massive comparative genomic analysis reveals convergent evolution of specialized bacteria. Biology Direct 4, 13.
194. Mira, A., Ochman, H. & Moran, N. A. (2001). Deletional bias and the evolution of bacterial genomes. Trends in Genetics 17, 589-596.
195. Mohlmann, T., Tjaden, J., Schwoppe, C., Winkler, H. H., Kampfenkel, K. & Neuhaus, H. E. (1998). Occurrence of two plastidic ATP/ADP transporters in Arabidopsis thaliana L.-molecular characterisation and comparative structural analysis of similar ATP/ADP translocators from plastids and Rickettsia prowazekii. European Journal of Biochemistry / FEBS 252, 353-359.
196. Moliner, C., Fournier, P. E. & Raoult, D. (2010). Genome analysis of microorganisms living in amoebae reveals a melting pot of evolution. FEMS Microbiology Review 1, 1-14.
197. Moran, J. V., DeBerardinis, R. J. & Kazazian, H. H., Jr. (1999). Exon shuffling by L1 retrotransposition. Science 283, 1530-1534.
198. Moran, N. A. (1996). Accelerated evolution and Muller's rachet in endosymbiotic bacteria. Proceedings of the National Academy of Sciences U.S.A. 93, 2873-2878.
199. Moran, N. A. & Mira, A. (2001). The process of genome shrinkage in the obligate symbiont Buchnera aphidicola. Genome Biology 2, research0054.1- research0054.12.
200. Mosavi, L. K., Cammett, T. J., Desrosiers, D. C. & Peng, Z. Y. (2004). The ankyrin repeat as molecular architecture for protein recognition. Protein Science 13, 1435-1448.
201. Mura, A., Masala, G., Tola, S., Satta, G., Fois, F., Piras, P., Rolain, J. M., Raoult, D. & Parola, P. (2008). First direct detection of rickettsial pathogens and a new rickettsia, 'Candidatus Rickettsia barbariae', in ticks from Sardinia, Italy. Clinical Microbiology and Infection 14, 1028-1033.
202. Nakabachi, A., Yamashita, A., Toh, H., Ishikawa, H., Dunbar, H. E., Moran, N. A. & Hattori, M. (2006). The 160-kilobase genome of the bacterial endosymbiont Carsonella. Science 314, 267.
203. Neimark, H. & Kocan, K. M. (1997). The cell wall-less rickettsia Eperythrozoon wenyonii is a Mycoplasma. FEMS Microbiology Letters 156, 287-291.
204. Newton, H. J., Sansom, F. M., nett-Wood, V. & Hartland, E. L. (2006). Identification of Legionella pneumophila-specific genes by genomic subtractive hybridization with Legionella micdadei and identification of lpnE, a gene required for efficient host cell entry. Infection and Immunity 74, 1683-1691.
205. Ngwamidiba, M., Blanc, G., Ogata, H., Raoult, D. & Fournier, P. E. (2005). Phylogenetic study of Rickettsia species using sequences of the autotransporter protein-encoding gene sca2. Annals of the New York Academy of Sciences 1063, 94-99.
206. Ngwamidiba, M., Blanc, G., Raoult, D. & Fournier, P. E. (2006). Sca1, a previously undescribed paralog from autotransporter protein-encoding genes in Rickettsia species. BMC Microbiology 6, 12.
207. Niebylski, M. L., Peacock, M. G. & Schwan, T. G. (1999). Lethal effect of Rickettsia rickettsii on its tick vector (Dermacentor andersoni). Applied Environmental Microbiology 65, 773-778.
208. Niebylski, M. L., Schrumpf, M. E., Burgdorfer, W., Fischer, E. R., Gage, K. L. & Schwan, T. G. (1997). Rickettsia peacockii sp. nov., a new species infecting wood ticks, Dermacentor andersoni, in western Montana. International Journal of Systematic Bacteriology 47, 446-452.
209. Nikoh, N., Tanaka, K., Shibata, F., Kondo, N., Hizume, M., Shimada, M. & Fukatsu, T. (2008). Wolbachia genome integrated in an insect chromosome: evolution and fate of laterally transferred endosymbiont genes. Genome Research 18, 272-280.
210. Nilsson, K., Lindquist, O. & Pahlson, C. (1999). Association of Rickettsia helvetica with chronic perimyocarditis in sudden cardiac death. Lancet 354, 1169-1173.
211. Nilsson, K., Pahlson, C., Lukinius, A., Eriksson, L., Nilsson, L. & Lindquist, O. (2002). Presence of Rickettsia helvetica in granulomatous tissue from patients with sarcoidosis. Journal of Infectious Diseases 185, 1128-1138.
212. Ochman, H., Lawrence, J. G. & Groisman, E. A. (2000). Lateral gene transfer and the nature of bacterial innovation. Nature 405, 299-304.
213. Odegaard, F. (2000). How many species of arthropods? Erwin's estimate revised. Biological Journal of the Linnean Society 71, 583-597.
214. Ogata, H., Audic, S., Abergel, C., Fournier, P. E. & Claverie, J. M. (2002). Protein coding palindromes are a unique but recurrent feature in Rickettsia. Genome Research 12, 808-816.
215. Ogata, H., Audic, S., Barbe, V., Artiguenave, F., Fournier, P. E., Raoult, D. & Claverie, J. M. (2000). Selfish DNA in protein-coding genes of Rickettsia. Science 290, 347-350.
216. Ogata, H., Audic, S., Renesto-Audiffren, P., Fournier, P. E., Barbe, V., Samson, D., Roux, V., Cossart, P., Weissenbach, J., Claverie, J. M. & Raoult, D. (2001). Mechanisms of evolution in Rickettsia conorii and R. prowazekii. Science 293, 2093-2098.
217. Ogata, H., La Scola, B., Audic, S., Renesto, P., Blanc, G., Robert, C., Fournier, P. E., Claverie, J. M. & Raoult, D. (2006). Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens. PLoS.Genetics 2, e76.
218. Ogata, H., Renesto, P., Audic, S., Robert, C., Blanc, G., Fournier, P. E., Parinello, H., Claverie, J. M. & Raoult, D. (2005a). The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite. PLoS Biology 3, e248.
219. Ogata, H., Robert, C., Audic, S., Robineau, S., Blanc, G., Fournier, P. E., Renesto, P., Claverie, J. M. & Raoult, D. (2005b). Rickettsia felis, from culture to genome sequencing. Annals of the New York Academy of Sciences 1063, 26-34.
220. Oliveira, K. A., Oliveira, L. S., Dias, C. C., Silva, A., Jr., Almeida, M. R., Almada, G., Bouyer, D. H., Galvao, M. A. & Mafra, C. (2008). Molecular identification of Rickettsia felis in ticks and fleas from an endemic area for Brazilian Spotted Fever. Memórias do Instituto Oswaldo Cruz 103, 191-194.
221. Ophir, R., Itoh, T., Graur, D. & Gojobori, T. (1999). A simple method for estimating the intensity of purifying selection in protein-coding genes. MolecularBiology and Evolution 16, 49-53.
222. Orgel, L. E. & Crick, F. H. (1980). Selfish DNA: the ultimate parasite. Nature 284, 604-607.
223. Oteo, J. A., Ibarra, V., Blanco, J. R., Martinez, D. A., V, Marquez, F. J., Portillo, A., Raoult, D. & Anda, P. (2004). Dermacentor-borne necrosis erythema and lymphadenopathy: clinical and epidemiological features of a new tick-borne disease. Clinical Microbiology and Infection 10, 327-331.
224. Owen, H., Clark, P., Stenos, J., Robertson, I. & Fenwick, S. (2006a). Potentially pathogenic spotted fever group rickettsiae present in Western Australia. The Australian Journal of Rural Health 14, 284-285.
225. Owen, H., Unsworth, N., Stenos, J., Robertson, I., Clark, P. & Fenwick, S. (2006b). Detection and identification of a novel spotted fever group rickettsia in Western Australia. Annals of the New York Academy of Sciences 1078, 197-199.
226. Paddock, C. D., Koss, T., Eremeeva, M. E., Dasch, G. A., Zaki, S. R. & Sumner, J. W. (2006). Isolation of Rickettsia akari from eschars of patients with rickettsialpox. American Journal of Tropical Medicine and Hygiene 75, 732-738.
227. Paddock, C. D., Sumner, J. W., Comer, J. A., Zaki, S. R., Goldsmith, C. S., Goddard, J., McLellan, S. L., Tamminga, C. L. & Ohl, C. A. (2004). Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States. Clinical Infectious Diseases 38, 805-811.
228. Park, J., Kim, K. J., Choi, K. S., Grab, D. J. & Dumler, J. S. (2004). Anaplasma phagocytophilum AnkA binds to granulocyte DNA and nuclear proteins. Cellular Microbiology 6, 743-751.
229. Parker, R. R., Kohls, G. M., Cox, G. W. & Davis, G. E. (1939). Observations on an infectious agent from Amblyomma maculatum. Public Health Reports 54, 1482-1484.
230. Parola, P., Beati, L., Cambon, M. & Raoult, D. (1998). First isolation of Rickettsia helvetica from Ixodes ricinus ticks in France. European Journal of Clinical Microbiology & Infectious Diseases 17, 95-100.
231. Parola, P., Inokuma, H., Camicas, J. L., Brouqui, P. & Raoult, D. (2001). Detection and identification of spotted fever group Rickettsiae and Ehrlichiae in African ticks. Emerging Infectious Diseases 7, 1014-1017.
232. Parola, P. & Raoult, D. (2001). Ticks and tickborne bacterial diseases in humans: an emerging infectious threat. Clinical Infectious Diseases 32, 897-928.
233. Parola, P., Vestris, G., Martinez, D., Brochier, B., Roux, V. & Raoult, D. (1999). Tick-borne rickettiosis in Guadeloupe, the French West Indies: isolation of Rickettsia africae from Amblyomma variegatum ticks and serosurvey in humans, cattle, and goats. The American Journal of Tropical Medicine and Hygiene 60, 888-893.
234. Pennacchio, L. A. & Rubin, E. M. (2001). Genomic strategies to identify mammalian regulatory sequences. Nature Reviews. Genetics 2, 100-109.
235. Perine, P. L., Chandler, B. P., Krause, D. K., McCardle, P., Awoke, S., Habte-Gabr, E., Wisseman, C. L., Jr. & McDade, J. E. (1992). A clinico-epidemiological study of epidemic typhus in Africa. Clinical Infectious Diseases 14, 1149-1158.
236. Perlman, S. J., Hunter, M. S. & Zchori-Fein, E. (2006). The emerging diversity of Rickettsia. Proceedings. Biological Sciences 273, 2097-2106.
237. Perotti, M. A., Clarke, H. K., Turner, B. D. & Braig, H. R. (2006). Rickettsia as obligate and mycetomic bacteria. The FASEB Journal 20, 2372-2374.
238. Philip, C. B. & Hughes, L. E. (1948). The tropical rat mite; Liponyssus bacoti, as an experimental vector of rickettsialpox. American Journal of Tropical Medicine and Hygiene 28, 697-705.
239. Philip, R. N., Casper, E. A., Anacker, R. L., Cory, J., Hayes, S. F., Burgdorfer, W. & Yunker, C. E. (1983). Rickettsia bellii sp. nov.-a tick-borne Rickettsia, widely distributed in the United States, that is distinct from the spotted fever and typhus biogroups. International Journal of Systematic Bacteriology 33, 94-106.
240. Phongmany, S., Rolain, J. M., Phetsouvanh, R., Blacksell, S. D., Soukkhaseum, V., Rasachack, B., Phiasakha, K., Soukkhaseum, S., Frichithavong, K., Chu, V., Keolouangkhot, V., Martinez-Aussel, B., Chang, K., Darasavath, C., Rattanavong, O., Sisouphone, S., Mayxay, M., Vidamaly, S., Parola, P., Thammavong, C., Heuangvongsy, M., Syhavong, B., Raoult, D., White, N. J. & Newton, P. N. (2006). Rickettsial infections and fever, Vientiane, Laos. Emerging Infectious Diseases 12, 256-262.
241. Pinter, A. & Labruna, M. B. (2006). Isolation of Rickettsia rickettsii and Rickettsia bellii in cell culture from the tick Amblyomma aureolatum in Brazil. Annals of the New York Academy of Sciences 1078, 523-529.
242. Pollard, T. D. & Borisy, G. G. (2003). Cellular motility driven by assembly and disassembly of actin filaments. Cell 112, 453-465.
243. Portillo, A., Perez-Martinez, L., Santibanez, S., Blanco, J. R., Ibarra, V. & Oteo, J. A. (2007). Detection of Rickettsia africae in Rhipicephalus (Boophilus) decoloratus ticks from the Republic of Botswana, South Africa. American Journal of Tropical Medicine and Hygiene 77, 376-377.
244. Qin, A., Tucker, A. M., Hines, A. & Wood, D. O. (2004). Transposon mutagenesis of the obligate intracellular pathogen Rickettsia prowazekii. Applied Environmental Microbiology 70, 2816-2822.
245. Rachek, L. I., Tucker, A. M., Winkler, H. H. & Wood, D. O. (1998). Transformation of Rickettsia prowazekii to rifampin resistance. Journal of Bacteriology 180, 2118-2124.
246. Raoult, D., Berbis, P., Roux, V., Xu, W. & Maurin, M. (1997). A new tick-transmitted disease due to Rickettsia slovaca. Lancet 350, 112-113.
247. Raoult, D., Fournier, P. E., Eremeeva, M., Graves, S., Kelly, P. J., Oteo, J. A., Skeyova, S., Tamura, A., Tarasevich, I. & Zhang, L. (2005). Naming of Rickettsiae and rickettsial diseases. Annals of the New York Academy of Sciences 1063, 1-12.
248. Raoult, D., Fournier, P. E., Fenollar, F., Jensenius, M., Prioe, T., de Pina, J. J., Caruso, G., Jones, N., Laferl, H., Rosenblatt, J. E. & Marrie, T. J. (2001). Rickettsia africae, a tick-borne pathogen in travelers to sub-Saharan Africa. The New England Journal of Medicine 344, 1504-1510.
249. Raoult, D., Lakos, A., Fenollar, F., Beytout, J., Brouqui, P. & Fournier, P. E. (2002). Spotless rickettsiosis caused by Rickettsia slovaca and associated with Dermacentor ticks. Clinical Infectious Diseases 34, 1331-1336.
250. Raoult, D., Ndihokubwayo, J. B., Tissot-Dupont, H., Roux, V., Faugere, B., Abegbinni, R. & Birtles, R. J. (1998). Outbreak of epidemic typhus associated with trench fever in Burundi. Lancet 352, 353-358.
251. Raoult, D. & Roux, V. (1997). Rickettsioses as paradigms of new or emerging infectious diseases. Clinical Microbiology Review 10, 694-719.
252. Rehacek, J. (1984). Rickettsia slovaca, the organism and its ecology. Acta Scientifica National Academy Scientifica Bohemoslovacae Brno 18, 1-50.
253. Reif, K. E. & Macaluso, K. R. (2009). Ecology of Rickettsia felis: a review. Journal of Medical Entomology 46, 723-736.
254. Reiss-Gutfreund, R. J. (1966). The isolation of Rickettsia prowazeki and mooseri from unusual sources. American Journal of Tropical Medicine and Hygiene 15, 943-949.
255. Renesto, P., Dehoux, P., Gouin, E., Touqui, L., Cossart, P. & Raoult, D. (2003). Identification and characterization of a phospholipase D-superfamily gene in rickettsiae. Journal of Infectious Diseases 188, 1276-1283.
256. Renesto, P., Ogata, H., Audic, S., Claverie, J. M. & Raoult, D. (2005). Some lessons from Rickettsia genomics. FEMS Microbiology Reviews 29, 99-117.
257. Renesto, P., Samson, L., Ogata, H., Azza, S., Fourquet, P., Gorvel, J. P., Heinzen, R. A. & Raoult, D. (2006). Identification of two putative rickettsial adhesins by proteomic analysis. Research in Microbiology 157, 605-612.
258. Roberts, F. (1960). A systematic study of the Australian species of the genus Ixodes (Acarineae: Ixodidae). Australian Journal of Zoology 8, 392-485.
259. Rocha, E. P. (2003). DNA repeats lead to the accelerated loss of gene order in bacteria. Trends in Genetics 19, 600-603.
260. Rocha, E. P., Danchin, A. & Viari, A. (1999). Functional and evolutionary roles of long repeats in prokaryotes. Research in Microbiology 150, 725-733.
261. Rogozin, I. B., Makarova, K. S., Natale, D. A., Spiridonov, A. N., Tatusov, R. L., Wolf, Y. I., Yin, J. & Koonin, E. V. (2002). Congruent evolution of different classes of non-coding DNA in prokaryotic genomes. Nucleic Acids Research 30, 4264-4271.
262. Rossello-Mora, R. & Amann, R. (2001). The species concept for prokaryotes. FEMS Microbiological Reviews 25, 39-67.
263. Roux, V., Bergoin, M., Lamaze, N. & Raoult, D. (1997a). Reassessment of the taxonomic position of Rickettsiella grylli. International Journal of Systematic Bacteriology 47, 1255-1257.
264. Roux, V. & Raoult, D. (1995a). Inter- and intraspecies identification of Bartonella (Rochalimaea) species. Journal of Clinical Microbiology 33, 1573-1579.
265. Roux, V. & Raoult, D. (1995b). Phylogenetic analysis of the genus Rickettsia by 16S rDNA sequencing. Research in Microbiology 146, 385-396.
266. Roux, V. & Raoult, D. (1999). Phylogenetic analysis and taxonomic relationships among the genus Rickettsia. In Rickettsiae and Rickettsial diseases at the turn of the third millinium. (eds. D. Raoult & P. Brouqui), pp. 52-66. Marseille: Elsevier production.
267. Roux, V. & Raoult, D. (2000). Phylogenetic analysis of members of the genus Rickettsia using the gene encoding the outer-membrane protein rOmpB (ompB). International Journal of Systematic and Evolutionary Microbiology 50 (4), 1449-1455.
268. Roux, V., Rydkina, E., Eremeeva, M. & Raoult, D. (1997b). Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae. International Journal of Systematic Bacteriology 47, 252-261.
269. Rovery, C., Renesto, P., Crapoulet, N., Matsumoto, K., Parola, P., Ogata, H. & Raoult, D. (2005). Transcriptional response of Rickettsia conorii exposed to temperature variation and stress starvation. Research in Microbiology 156, 211-218.
270. Rubtsov, A. M. & Lopina, O. D. (2000). Ankyrins. FEBS Letters 482, 1-5.
271. Rudakov, N., Samoilenko, I., Yakimemko, V., Reshetnikova, A., Shpynov, D., Walker, D. & Tankibaev, M. (1999). The re-emergence of Siberian tick typhus: field and experimental observations. In Ricketsiae and Rickettsial diseases at the Turn of the Third Millenium (eds. D. Raoult & P. Brouqui), pp. 269-273. Paris: Elsevier.
272. Rydkina, E., Roux, V., Rudakov, N., Gafarova, M., Tarasevich, I. & Raoult, D. (1999). New Rickettsiae in ticks collected in territories of the former Soviet Union. Emerging Infectious Diseases 5, 811-814.
273. Saitou, N. & Nei, M. (1987). The neighbor-joining method: a new method for reconstructing phylogenetic trees. MolecularBiology and Evolution 4, 406-425.
274. Sakurai, M., Koga, R., Tsuchida, T., Meng, X. Y. & Fukatsu, T. (2005). Rickettsia symbiont in the pea aphid Acyrthosiphon pisum: novel cellular tropism, effect on host fitness, and interaction with the essential symbiont Buchnera. Applied Environmental Microbiology 71, 4069-4075.
275. Schmitz-Esser, S., Linka, N., Collingro, A., Beier, C. L., Neuhaus, H. E., Wagner, M. & Horn, M. (2004). ATP/ADP translocases: a common feature of obligate intracellular amoebal symbionts related to Chlamydiae and Rickettsiae. Journal of Bacteriology 186, 683-691.
276. Sekeyova, Z., Roux, V. & Raoult, D. (2001). Phylogeny of Rickettsia spp. inferred by comparing sequences of 'gene D', which encodes an intracytoplasmic protein. International Journal of Systematic and Evolutionary Microbiology 51, 1353-1360.
277. Sekeyova, Z., Roux, V., Xu, W., Rehacek, J. & Raoult, D. (1998). Rickettsia slovaca sp. nov., a member of the spotted fever group rickettsiae. International Journal of Systematic Bacteriology 48, 1455-1462.
278. Seshadri, R., Paulsen, I. T., Eisen, J. A., Read, T. D., Nelson, K. E., Nelson, W. C., Ward, N. L., Tettelin, H., Davidsen, T. M., Beanan, M. J., Deboy, R. T., Daugherty, S. C., Brinkac, L. M., Madupu, R., Dodson, R. J., Khouri, H. M., Lee, K. H., Carty, H. A., Scanlan, D., Heinzen, R. A., Thompson, H. A., Samuel, J. E., Fraser, C. M. & Heidelberg, J. F. (2003). Complete genome sequence of the Q-fever pathogen Coxiella burnetii. Proceedings of the National Academy of Sciences U.S.A. 100, 5455-5460.
279. Shpynov, S., Fournier, P. E., Rudakov, N. & Raoult, D. (2003). "Candidatus Rickettsia tarasevichiae" in Ixodes persulcatus ticks collected in Russia. Annals of the New York Academy of Sciences 990, 162-172.
280. Shpynov, S., Parola, P., Rudakov, N., Samoilenko, I., Tankibaev, M., Tarasevich, I. & Raoult, D. (2001). Detection and identification of spotted fever group rickettsiae in Dermacentor ticks from Russia and central Kazakhstan. European Journal of Clinical Microbiology & Infectious Diseases 20, 903-905.
281. Sicheritz-Ponten, T., Kurland, C. G. & Andersson, S. G. (1998). A phylogenetic analysis of the cytochrome b and cytochrome c oxidase I genes supports an origin of mitochondria from within the Rickettsiaceae. Biochimica et Biophysica Acta 1365, 545-551.
282. Simser, J. A., Palmer, A. T., Fingerle, V., Wilske, B., Kurtti, T. J. & Munderloh, U. G. (2002). Rickettsia monacensis sp. nov., a spotted fever group Rickettsia, from ticks (Ixodes ricinus) collected in a European city park. Applied Environmental Microbiology 68, 4559-4566.
283. Sreter-Lancz, Z., Szell, Z., Kovacs, G., Egyed, L., Marialigeti, K. & Sreter, T. (2006). Rickettsiae of the spotted-fever group in ixodid ticks from Hungary: identification of a new genotype ('Candidatus Rickettsia kotlanii'). Annals of Tropical Medicine and Parasitology 100, 229-236.
284. Stackebrandt, E., Frederiksen, W., Garrity, G. M., Grimont, P. A., Kampfer, P., Maiden, M. C., Nesme, X., Rossello-Mora, R., Swings, J., Truper, H. G., Vauterin, L., Ward, A. C. & Whitman, W. B. (2002). Report of the ad hoc committee for the re-evaluation of the species definition in bacteriology. International Journal of Systematic and Evolutionary Microbiology 52, 1043-1047.
285. Stamm, L. V., Bergen, H. L. & Walker, R. L. (2002). Molecular typing of papillomatous digital dermatitis-associated Treponema isolates based on analysis of 16S-23S ribosomal DNA intergenic spacer regions. Journal of Clinical Microbiology 40, 3463-3469.
286. Stenos, J., Graves, S. R. & Unsworth, N. B. (2005). A highly sensitive and specific real-time PCR assay for the detection of spotted fever and typhus group Rickettsiae. American Journal of Tropical Medicine and Hygiene 73, 1083-1085.
287. Stenos, J., Roux, V., Walker, D. & Raoult, D. (1998). Rickettsia honei sp. nov., the aetiological agent of Flinders Island spotted fever in Australia. International Journal of Systematic Bacteriology 48, 1399-1404.
288. Stenos, J. & Walker, D. H. (2000). The rickettsial outer-membrane protein A and B genes of Rickettsia australis, the most divergent rickettsia of the spotted fever group. International Journal of Systematic and Evolutionary Microbiology 50, 1775-1779.
289. Stephens, R. S., Kalman, S., Lammel, C., Fan, J., Marathe, R., Aravind, L., Mitchell, W., Olinger, L., Tatusov, R. L., Zhao, Q., Koonin, E. V. & Davis, R. W. (1998). Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science 282, 754-759.
290. Stevenson, H. L., Labruna, M. B., Montenieri, J. A., Kosoy, M. Y., Gage, K. L. & Walker, D. H. (2005). Detection of Rickettsia felis in a New World flea species, Anomiopsyllus nudata (Siphonaptera: Ctenophthalmidae). Journal of Medical Entomology 42, 163-167.
291. Stothard, D. R., Clark, J. B. & Fuerst, P. A. (1994). Ancestral divergence of Rickettsia bellii from the spotted fever and typhus groups of Rickettsia and antiquity of the genus Rickettsia. International Journal of Systematic Bacteriology 44, 798-804.
292. Sun, Y. C., Hinnebusch, B. J. & Darby, C. (2008). Experimental evidence for negative selection in the evolution of a Yersinia pestis pseudogene. Proceedings of the National Academy of Sciences U.S.A. 105, 8097-8101.
293. Tamas, I., Wernegreen, J. J., Nystedt, B., Kauppinen, S. N., Darby, A. C., Gomez-Valero, L., Lundin, D., Poole, A. M. & Andersson, S. G. (2008). Endosymbiont gene functions impaired and rescued by polymerase infidelity at poly(A) tracts. Proceedings of the National Academy of Sciences U.S.A. 105, 14934-14939.
294. Tamura, A., Ohashi, N., Urakami, H. & Miyamura, S. (1995). Classification of Rickettsia tsutsugamushi in a new genus, Orientia gen. nov., as Orientia tsutsugamushi comb. nov. International Journal of Systematic Bacteriology 45, 589-591.
295. Tautz, D., Arctander, P., Minelli, A., Thomas Richard H & Vogler Alfried P. (2003). A plea for DNA taxonomy. Trends in Ecology & Evolution 18, 70-74.
296. Teysseire, N., Boudier, J. A. & Raoult, D. (1995). Rickettsia conorii entry into Vero cells. Infection and Immunity 63, 366-374.
297. Teysseire, N., Chiche-Portiche, C. & Raoult, D. (1992). Intracellular movements of Rickettsia conorii and R. typhi based on actin polymerization. Research in Microbiology 143, 821-829.
298. Tram, U. & Sullivan, W. (2002). Role of delayed nuclear envelope breakdown and mitosis in Wolbachia-induced cytoplasmic incompatibility. Science 296, 1124-1126.
299. Uchida, T., Uchiyama, T., Kumano, K. & Walker, D. H. (1992). Rickettsia japonica sp. nov., the etiological agent of spotted fever group rickettsiosis in Japan. International Journal of Systematic Bacteriology 42, 303-305.
300. Uchida, T., Yu, X. J., Uchiyama, T. & Walker, D. H. (1989). Identification of a unique spotted fever group rickettsia from humans in Japan. Journal of Infectious Diseases 159, 1122-1126.
301. Uchiyama, T., Kawano, H. & Kusuhara, Y. (2006). The major outer membrane protein rOmpB of spotted fever group rickettsiae functions in the rickettsial adherence to and invasion of Vero cells. Microbes and Infection 8, 801-809.
302. Uchiyama, T. & Uchida, T. (1989). Comparison of antigenic reactivity between intracellular and extracellular rickettsiae of spotted fever group. The Tokushima Journal of Experimental Medicine 36, 25-27.
303. Unsworth, N. B., Stenos, J., Graves, S. R., Faa, A. G., Cox, G. E., Dyer, J. R., Boutlis, C. S., Lane, A. M., Shaw, M. D., Robson, J. & Nissen, M. D. (2007). Flinders Island spotted fever rickettsioses caused by "marmionii" strain of Rickettsia honei, Eastern Australia. Emerging Infectious Diseases 13, 566-573.
304. van Ham, R. C., Kamerbeek, J., Palacios, C., Rausell, C., Abascal, F., Bastolla, U., Fernandez, J. M., Jimenez, L., Postigo, M., Silva, F. J., Tamames, J., Viguera, E., Latorre, A., Valencia, A., Moran, F. & Moya, A. (2003). Reductive genome evolution in Buchnera aphidicola. Proceedings of the National Academy of Sciences U.S.A. 100, 581-586.
305. van Belkum, A., Scherer, S., van Alphen, L. & Verbrugh, H. (1998). Short-sequence DNA repeats in prokaryotic genomes. Microbiology and Molecular Biology Reviews 62, 275-293.
306. Vandamme, P., Pot, B., Gillis, M., De, V. P., Kersters, K. & Swings, J. (1996). Polyphasic taxonomy, a consensus approach to bacterial systematics. Microbiological Reviews 60, 407-438.
307. Venzal, J. M., Perez-Martinez, L., Felix, M. L., Portillo, A., Blanco, J. R. & Oteo, J. A. (2006). Prevalence of Rickettsia felis in Ctenocephalides felis and Ctenocephalides canis from Uruguay. Annals of the New York Academy of Sciences 1078, 305-308.
308. Venzal, J. M., Portillo, A., Estrada-Pena, A., Castro, O., Cabrera, P. A. & Oteo, J. A. (2004). Rickettsia parkeri in Amblyomma triste from Uruguay. Emerging Infectious Diseases 10, 1493-1495.
309. Vitorino, L., Chelo, I. M., Bacellar, F. & Ze-Ze, L. (2007). Rickettsiae phylogeny: a multigenic approach. Microbiology 153, 160-168.
310. von der Schulenburg, J. H., Habig, M., Sloggett, J. J., Webberley, K. M., Bertrand, D., Hurst, G. D. & Majerus, M. E. (2001). Incidence of male-killing Rickettsia spp. (alpha-proteobacteria) in the ten-spot
311. Walker, D. H., Parks, F. M., Betz, T. G., Taylor, J. P. & Muehlberger, J. W. (1989). Histopathology and immunohistologic demonstration of the distribution of Rickettsia typhi in fatal murine typhus. American Journal of Clinical Pathology 91, 720-724.
312. Walker, D. H., Valbuena, G. A. & Olano, J. P. (2003). Pathogenic mechanisms of diseases caused by Rickettsia. Annals of the New York Academy of Sciences 990, 1-11.
313. Walsh, J. B. (1995). How often do duplicated genes evolve new functions? Genetics 139, 421-428.
314. Wayne, L.G., Brenner, D.J., Colwell, R.R., Grimont, P.A.D., Kandler, O., Krichevsky, M.I., Moore, L.H., Moore, W.E.C., Murray, R.G.E., Stackebrandt, E., Starr, M.P., TrYper & H.G. (1987). Report of the ad hoc committee on reconciliation of approaches to bacterial systematics. International Journal of Systematic Bacteriology 37, 463-469.
315. Wedincamp, J., Jr. & Foil, L. D. (2002). Vertical transmission of Rickettsia felis in the cat flea (Ctenocephalides felis Bouche). Journal of Vector Ecology 27, 96-101.
316. Weinert, L. A., Welch, J. J. & Jiggins, F. M. (2009a). Conjugation genes are common throughout the genus Rickettsia and are transmitted horizontally. Proceedings of the royal society B:. Biological Sciences 276, 3619-3627.
317. Weinert, L. A., Werren, J. H., Aebi, A., Stone, G. N. & Jiggins, F. M. (2009b). Evolution and diversity of Rickettsia bacteria. BMC Biology 7, 6.
318. Weisburg, W. G., Dobson, M. E., Samuel, J. E., Dasch, G. A., Mallavia, L. P., Baca, O., Mandelco, L., Sechrest, J. E., Weiss, E. & Woese, C. R. (1989). Phylogenetic diversity of the Rickettsiae. Journal of Bacteriology 171, 4202-4206.
319. Wernegreen, J. J. & Moran, N. A. (1999). Evidence for genetic drift in endosymbionts (Buchnera): analyses of protein-coding genes. Molecular Biology and Evolution 16, 83-97.
320. Werren, J. H., Hurst, G. D., Zhang, W., Breeuwer, J. A., Stouthamer, R. & Majerus, M. E. (1994). Rickettsial relative associated with male killing in the ladybird beetle (Adalia bipunctata). Journal of Bacteriology 176, 388-394.
321. Whitman, W. B., Coleman, D. C. & Wiebe, W. J. (1998). Prokaryotes: the unseen majority. Proceedings of the National Academy of Sciences U.S.A. 95, 6578-6583.
322. Whitworth, T., Popov, V., Han, V., Bouyer, D., Stenos, J., Graves, S., Ndip, L. & Walker, D. (2003). Ultrastructural and genetic evidence of a reptilian tick, Aponomma hydrosauri, as a host of Rickettsia honei in Australia: possible transovarial transmission. Annals of the New York Academy of Sciences 990, 67-74.
323. Whitworth, T., Popov, V. L., Yu, X. J., Walker, D. H. & Bouyer, D. H. (2005). Expression of the Rickettsia prowazekii pld or tlyC gene in Salmonella enterica serovar Typhimurium mediates phagosomal escape. Infection and Immunity 73, 6668-6673.
324. Wolf, Y. I., Aravind, L. & Koonin, E. V. (1999). Rickettsiae and Chlamydiae: evidence of horizontal gene transfer and gene exchange. Trends in Genetics 15, 173-175.
325. Woodland, J. C., McDowell, M. M. & Richards, J. T. (1943). Bullis fever (lone star fever-tick fever). JAMA: the Journal of the American Medical Association 122, 1156-1160.
326. Wu, M., Sun, L. V., Vamathevan, J., Riegler, M., Deboy, R., Brownlie, J. C., McGraw, E. A., Martin, W., Esser, C., Ahmadinejad, N., Wiegand, C., Madupu, R., Beanan, M. J., Brinkac, L. M., Daugherty, S. C., Durkin, A. S., Kolonay, J. F., Nelson, W. C., Mohamoud, Y., Lee, P., Berry, K., Young, M. B., Utterback, T., Weidman, J., Nierman, W. C., Paulsen, I. T., Nelson, K. E., Tettelin, H., O'Neill, S. L. & Eisen, J. A. (2004). Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements. PLoS Biology 2, E69.
327. Yang, Y. W., Tai, P. Y., Chen, Y. & Li, W. H. (2002). A study of the phylogeny of Brassica rapa, B. nigra, Raphanus sativus, and their related genera using noncoding regions of chloroplast DNA. Molecular Phylogenetics and Evolution 23, 268-275.
328. Yu, X., Jin, Y., Fan, M., Xu, G., Liu, Q. & Raoult, D. (1993). Genotypic and antigenic identification of two new strains of spotted fever group rickettsiae isolated from China. Journal of Clinical Microbiology 31, 83-88.
329. Yusuf, M. & Turner, B. (2004). Characterisation of Wolbachia-like bacteria solated from the parthenogenetic stored-product pest psocid Liposcelis bostrychophila (Badonnel) (Psocoptera). Journal of Stored Products Research 40, 207-225.
330. Zhu, Y., Fournier, P. E., Eremeeva, M. & Raoult, D. (2005a). Proposal to create subspecies of Rickettsia conorii based on multi-locus sequence typing and an emended description of Rickettsia conorii. BMC.Microbiology 5, 11.
331. Zhu, Y., Fournier, P. E., Ogata, H. & Raoult, D. (2005b). Multispacer typing of Rickettsia prowazekii enabling epidemiological studies of epidemic typhus. Journal of Clinical Microbiology 43, 4708-4712.
332. Zhu, Y., Medina-Sanchez, A., Bouyer, D., Walker, D. H. & Yu, X. J. (2008). Genotyping Rickettsia prowazekii isolates. Emerging Infectious Diseases 14, 1300-1302.
333. Zomorodipour, A. & Andersson, S. G. (1999). Obligate intracellular parasites: Rickettsia prowazekii and Chlamydia trachomatis. FEBS Letters 452, 11-15.