rOmpA is a critical protein for the adhesion of Rickettsia rickettsii to host cells

Microbial Pathogenesis

Volumn 24, Issue 5, 1998, Pages 289-298

  Li, Han ^a   Walker, David H ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Adhesin; Flow cytometry; Monoclonal antibodies; Rickettsia rickettsii; Surface protein

Indexed keywords

ADHESIN; BACTERIAL PROTEIN; BACTERIUM LIPOPOLYSACCHARIDE; IMMUNOGLOBULIN F(AB) FRAGMENT; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; TRYPSIN;

ANIMAL CELL; ARTICLE; BACTERIUM ADHERENCE; CONTROLLED STUDY; FLOW CYTOMETRY; HOST CELL; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RICKETTSIA RICKETTSII; ROCKY MOUNTAIN SPOTTED FEVER;

ANIMALIA; BACTERIA (MICROORGANISMS); RICKETTSIA; RICKETTSIA RICKETTSII; RICKETTSIALES;

EID: 0031803204     PISSN: 08824010     EISSN: None     Source Type: Journal    
DOI: 10.1006/mpat.1997.0197     Document Type: Article

References (29)

1. Ramm LE, Winkler HH. Rickettsial hemolysis: effect of metabolic inhibitors upon hemolysis and adsorption. Infect Immun 1973; 7: 550-5.
2. Ramm LE, Winkler HH. Identification of cholesterol in the receptor site for rickettsiae on sheep erythrocyte membranes. Infect Immun 1976; 13: 120-6.
3. Walker TS. Rickettsial interactions with human endothelial cell in vitro: adherence and entry. Infect Immun 1984; 44: 205-10.
4. Walker TS, Winkler HH. Penetration of cultured mouse fibroblasts (L cells) by Rickettsia prowazekii. Infect Immun 1978; 22: 200-8.
5. Winkler HH. Inhibitory and restorative effects of adenine nucleotides on rickettsial adsorption and hemolysis. Infect Immun 1974; 9: 119-26.
6. Wisseman, Jr. CL, Waddell AD, Silverman DJ. In vitro studies on rickettsia-host cell interactions: lag phase in intracellular growth cycle as a function of stage of growth of infecting Rickettsia prowazekii, with preliminary observations on inhibition of rickettsial uptake by host cell fragments. Infect Immun 1976; 13: 1749-60.
7. Li H, Walker DH. Characterization of rickettsial attachment to host cells by flow cytometry. Infect Immun 1992; 60: 2030-5.
8. Anderson BE, McDonald GA, Jones DC, Regnery RL. A protective protein antigen of Rickettsia rickettsii has tandemly repeated, near-identical sequences. Infect Immun 1990; 58: 2760-9.
9. Anacker RL, List RH, Mann RE, Hayes S, Thomas LA. Characterization of monoclonal antibodies protecting mice against Rickettsia rickettsii. J Infect Dis 1985; 151: 1052-60.
10. Anacker RL, McDonald GA, List RH, Mann RE. Neutralizing activity of monoclonal antibodies to heat-sensitive and heat-resistant epitopes of Rickettsia rickettsii surface protein. Infect Immun 1987; 55: 825-7.
11. Anacker RL, Mann RE, Gonzales C. Reactivity of monoclonal antibodies to Rickettsia rickettsii with spotted fever and typhus group rickettsiae. J Clin Microbiol 1987; 25: 167-71.
12. Li H, Lenz B, Walker DH. Protective monoclonal antibodies recognize heat-labile epitopes on surface proteins of spotted fever group rickettsiae. Infect Immun 1988; 56: 2587-93.
13. Gilmore, Jr. RD, Joste N, McDonald GA. Cloning, expression and sequence analysis of the gene encoding the 120 kDa surface-exposed protein of Rickettsia rickettsii. Mol Microbiol 1989; 3: 1579-86.
14. Gilmore, Jr. RD, Cieplak, Jr. W, Policastro PF, Hackstadt T. The 120 kilodalton outer membrane protein (rOmpB) of Rickettsia rickettsii is encoded by an unusually long open reading frame: evidence for protein processing from a large precursor. Mol Microbiol 1991; 5: 2361-70.
15. Hackstadt T, Messer R, Cieplak W, Peacock MC. Evidence for proteolytic cleavage of the 120-kilodalton outer membrane protein of rickettsia: identification of an avirulent mutant deficient in processing. Infect Immun 1992; 60: 159-65.
16. Li H, Walker DH. Biological characterization of major polypeptides on the surface of spotted fever group rickettsiae. Ann NY Acad Sci 1990; 590: 389-95.
17. Vishwanath S. Antigenic relationships among the rickettsiae of the spotted fever and typhus groups. FEMS Microbiol Lett 1991; 81: 341-4.
18. Walker DH, Liu QH, Yu X-J, Li H, Taylor C, Feng H-M. Antigenic diversity of Rickettsia conorii. Am J Trop Hyg 1992; 47: 78-86.
19. Dasch GA. Isolation of species-specific protein antigens of Rickettsia typhi and Rickettsia prowazekii for immunodiagnosis and immunoprophylaxis. J Clin Microbiol 1981; 14: 333-41.
20. Gilmore, Jr. RD. Comparison of the rompA gene repeat regions of Rickettsiae reveals species-specific arrangement of individual repeating units. Gene 1993; 125: 97-102.
21. Wallis AE, McMaster WR. Identification of Leishmania genes encoding protein containing tandemly repeated peptides. J Exp Med 1987; 166: 1814-24.
22. Ibanez CF, Affranchinio JL, Macina RA, et al. Multiple Trypanosoma cruzi antigens containing tandemly repeated amino acid sequence motifs. Mol Biochem Parasitol 1988; 30: 27-34.
23. Schneider A, Hemphill A, Wyler T, Seebeck T. Large microtubule-associated protein of Trypanosoma brucei has tandemly repeated near identical sequences. Science 1988; 241: 459-62.
24. Vishwanath S, McDonald GA, Watkins NG. A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. Infect Immun 1990; 58: 646-53.
25. Sumner JW, Sims KG, Jones DC, Anderson BE. Protection of guinea-pigs from experimental Rocky Mountain spotted fever by immunization with baculovirus-expressed Rickettsia rickettsii rOmpA protein. Vaccine 1995; 13: 29-35.
26. McDonald GA, Anacker RL, Garjlan K. Cloned gene of Rickettsia rickettsii surface antigen: candidate vaccine for Rocky Mountain spotted fever. Science 1987; 235: 83-5.
27. McDonald GA, Anacker RL, Mann RE, Milch LJ. Protection of guinea pigs from experimental Rocky Mountain spotted fever with a cloned antigen of Rickettsia rickettsii. J Infect Dis 1988; 158: 228-31.
28. Hanson BA, Wisseman, Jr. CL, Waddell AD, Silverman DJ. Some characteristics of heavy and light bands of Rickettsia prowazekii on renografin gradients. Infect Immun 1981; 34: 596-604.
29. Silverman DJ, Fiset P, Wisseman, Jr. CL. Simple differential staining technique for enumerating rickettsiae in yolk sac, tissue culture extracts, or purified suspensions. J Clin Microbiol 1979; 9: 437-40.