The tetratricopeptide repeat: A structural motif mediating protein-protein interactions

BioEssays

Volumn 21, Issue 11, 1999, Pages 932-939

  Blatch, Gregory L ^a   Lässle, Michael ^b  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0344496513     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-1878(199911)21:11<932::AID-BIES5>3.0.CO;2-N     Document Type: Review

References (86)

1. Cyr DM, Langer T, Douglas MG. DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70. Trends Biochem Sci 1994;19:176-181.
2. Noble ME, Endicott JA, Brown NR, Johnson LN. The cyclin box fold: protein recognition in cell-cycle and transcription control. Trends Biochem Sci 1997;22:482-487.
3. Bork P, Sudol M. The WW domain: a signalling site in dystrophin? Trends Biochem Sci 1994;19:531-533.
4. Maleszka R, Lupas A, Hanes SD, Miklos GL. The dodo gene family encodes a novel protein involved in signal transduction and protein folding. Gene 1997;203:89-93.
5. Pawson T, Olivier P, Rozakis-Adcock M, McGlade J, Henkemeyer M. Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways. Philos Trans R Soc Lond B Biol Sci 1993;340:279-285.
6. Hirano T, Kinoshita N, Morikawa K, Yanagida M. Snap helix with knob and hole: essential repeats in Schizosaccharomyces pombe nuclear protein nuc2+. Cell 1990;60:319-328.
7. Sikorski RS, Boguski MS, Goebl M, Hieter P. A repeating amino acid motif in CDC23 defines a family of proteins and a new relationship among genes required for mitosis and RNA synthesis. Cell 1990;60:307-317.
8. Gale M Jr, Tan SL, Wambach M, Katze MG. Interaction of the interferon-induced PKR protein kinase with inhibitory proteins P58IPK and vaccinia virus K3L is mediated by unique domains: implications for kinase regulation. Mol Cell Biol 1996;16:4172-4181.
9. TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains. J Biol Chem 1996;271:6952-6962.
10. Lamb JR, Tugendreich S, Hieter P. Tetratrico peptide repeat interactions: to TPR or not to TPR. Trends Biochem Sci 1995;20:257-259.
11. Das AK, Cohen PTW, Barford D. The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. EMBO J 1998;17:1192-1199.
12. Wang H, Stillman DJ. Transcriptional repression in Saccharomyces cerevisiae by a SIN3LexA fusion protein. Mol Cell Biol 1993;13:1805-1814.
13. Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, Jan YN, Cabrera CV, Buskin JN, Hauschka SD, Lassar AB. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 1989;58:537-544.
14. Park MS, Valdez J, Gurley L, Kim CY. Characterization of a putative helix-loop-helix motif in nucleotide excision repair endonuclease, XPG. J Biol Chem 1997;272:27823-27829.
15. Nicolet CM, Craig EA. Isolation and characterization of STI1, a stress-inducible gene from Saccharomyces cerevisiae. Mol Cell Biol 1989;9:3638-3646.
16. Honoré B, Letters H, Madsen P, Rasmussen HH, Vandeckerckhove J, Celis JE. Molecular cloning and expression of a transformation-sensitive human protein containing the TRP motif and sharing identity to the stress-inducible yeast protein STI1. J Biol Chem 1992;267:8485-8491.
17. Blatch GL, Lässie M, Zetter BR, Kundra V. Isolation of a mouse cDNA encoding mSTI1, a stress-inducible protein containing the TPR motif. Gene 1997;194:277-282.
18. Torres JH, Chatellard P, Stutz E. Isolation and characterization of gmsti, a stress-inducible gene from soybean (Glycine max) coding for a protein belonging to the TPR (tetratricopeptide repeats) family. Plant Mol Biol 1995;27:1221-1226.
19. Joshi M, Dwyer DM, Nakhasi HL. Cloning and characterization of differentially expressed genes from in vitro-grown "amastigotes" of Leishmania donovani. Mol Biochem Parasitol 1993;58:345-354.
20. Smith DF, Sullivan WP, Marion TN, Zaitsu K, Madden B, McCormick DJ, Toft DO. Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70. Mol Cell Biol 1993;13:869-876.
21. Chang H-CJ, Lindquist S. Conservation of Hsp90 macromolecular complexes in Saccharomyces cerevisiae. J Biol Chem 1994;269:24983-24988.
22. Chen S, Prapapanich V, Rimerman RA, Honoré B, Smith DF. Interactions of p60, a mediator of progesterone receptor assembly, with heat shock proteins Hsp90 and Hsp70. Mol Endocrinol 1996;10:682-693.
23. Lassie M, Blatch GL, Takatori T, Kundra V, Zetter BR. Stress-inducible, murine protein mSTI1: characterization of binding domains for heat shock proteins and in vitro phosphorylation by different kinases. J Biol Chem 1997;272:1876-1884.
24. Pratt WB, Toft DO. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr Rev 1997;18:306-360.
25. Ratajczak T, Carrello A. Cyclophilin 40 (cyp-40), mapping of its hsp90 binding domain and evidence that FKBP52 competes with cyp-40 for hsp90 binding. J Biol Chem 1996;271:2961-2965.
26. Irmer H. Hohfeld J. Characterization of functional domains of the eukaryotic co-chaperone Hip J Biol Chem 1997;272:2230-2235.
27. Miyata Y, Chambraud B, Radanyi C, Leclerc J, Lebeau MC, Renoir JM, Shirai R, Catelli MG, Yahara I, Baulieu EE. Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: regulation of HSP90-binding activity of FKBP52. Proc Natl Acad Sci USA 1997;94:14500-14505.
28. Irniger S, Piatti S, Michaelis C, Nasmyth K. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell 1995;81:269-278.
29. King RW, Peters JM, Tugendreich S, Rolfe M, Hieter P, Kirschner MW. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 1995;81:279-288.
30. King RW, Deshaies RJ, Peters JM, Kirschner MW. How proteolysis drives the cell cycle. Science 1996;274:1652-1659.
31. Lamb JR, Michaud WA, Sikorski RS, Hieter PA. Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis. EMBO J 1994;13:4321-4328.
32. cdc23 of Saccharomyces cerevisiae: a nuclear tetratricopeptide repeat protein with two mutable domains. Mol Cell Biol 1993;13:1212-1221.
33. + to initiate anaphase. J Cell Biol 1994;6: 1655-1670.
34. Tzamarias D, Struhl K. Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters. Genes Dev 1995;9:821-831.
35. Smith RL, Redd MJ, Johnson AD. The tetratricopeptide repeats of Ssn6 interact with the homeo domain of alpha 2. Genes Dev 1995;9:290-310.
36. Dodt G, Braverman N, Wong C, Moser A, Moser HW, Watkins P, Valle D, Gould SJ. Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders. Nat Genet 1995;9:115-125.
37. Brocard C, Kragler F, Simon MM, Schuster T, Hartig A. The tetratricopeptide repeat-domain of the PAS10 protein of Saccharomyces cerevisiae is essential for binding the peroxisomal targeting signal-SKL. Biochem Biophys Res Commun 1994;204:1016-1022.
38. Fransen M, Brees C, Baumgart E, Vanhooren JC, Baes M, Mannaerts GP, Van Veldhoven PP. Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor. J Biol Chem 1995;270:7731-7736.
39. van der Leij I, Franse MM, Elgersma Y, Distel B, Tabak HF. PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 1993;90:11782-11786.
40. Lithgow T, Glick BS, Schatz G. The protein import receptor of mitochondria. Trends Biochem Sci 1995;20:98-101.
41. Moczko M, Borner U, Kubrich M, Zufall N, Honlinger A, Pfanner N. The intermembrane space domain of mitochondrial Tom22 functions as a trans binding site for preproteins with N-terminal targeting sequences. Mol Cell Biol 1997;17:6574-6584.
42. Riezman H, Hase T, van Loon AP, Grivell LA, Suda K, Schatz G. Import of proteins into mitochondria: a 70 kilodalton outer membrane protein with a large carboxy-terminal deletion is still transported to the outer membrane. EMBO J 1983;2:2161-2168.
43. Chen MX, McPartlin AE, Brown L, Chen YH, Barker HM, Cohen PTW. A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. EMBO J 1994;13:4278-4290.
44. Radanyi C, Chambraud B, Baulieu E-E. The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain. Proc Natl Acad Sci USA 1994;91: 11197-11201.
45. Kraulis, P. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J Appl Crystallogr 1991;24:946-950.
46. Sikorski RS, Michaud WA, Wootton JC, Boguski MS, Connelly C, Hieter P. TPR proteins as essential components of the yeast cell cycle. Cold Spring Harb Symp Quant Biol 1991;56:663-673.
47. + that encodes a nuclear scaffold-like protein blocks spindle elongation in mitotic anaphase. J Cell Biol 1988;106:1171-1183.
48. O'Donnell KL, Osmani AH, Osmani SA, Morris NR. bimA encodes a member of the tetratricopeptide repeat family of proteins and is required for the completion of mitosis in Aspergillus nidulans. J Cell Sci 1991;99: 711-719.
49. Icho T, Wickner RB. Metal-binding, nucleic acid-binding finger sequences in the CDC16 gene of Saccharomyces cerevisiae. Nucleic Acids Res 1987;15:8439-8450.
50. Schrick JJ, Onuchic LF, Reeders ST, Korenberg J, Chen XN, Moyer JH, Wilkinson JE, Woychik RP. Characterization of the human homologue of the mouse Tg737 candidate polycystic kidney disease gene. Hum Mol Genet 1995;4:559-567.
51. Isfort RJ, Cody DB, Doersen CJ, Richards WG, Yoder BK, Wilkinson JE, Kier LD, Jirtle RL, Isenberg JS, Klounig JE, Woychik RP. The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene. Oncogene 1997;15:1797-1803.
52. Zhang K, Smouse D, Perrimon N. The crooked neck gene of Drosophila contains a motif found in a family of yeast cell cycle genes. Genes Dev 1991;5:1080-1091.
53. Urushiyama S, Tani T, Ohshima Y. The prp1 gene required for pre-mRNA splicing in Schizosaccharomyces pombe encodes a protein that contains TPR motifs and is similar to Prp6p of budding yeast. Genetics 1997;147: 101-115.
54. Legrain P, Choulika A. The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors. EMBO J 1990;9:2775-2781.
55. Schultz J, Marshall-Carlson L, Carlson M. The N-terminal TPR region is the functional domain of SSN6, a nuclear phosphoprotein of Saccharomyces cerevisiae. Mol Cell Biol 1990;10:4744-4756.
56. Rhee SK, Icho T, Wickner RB. Structure and nuclear localization signal of the SKI3 antiviral protein of Saccharomyces cerevisiae. Yeast 1989;5:149-158.
57. 70. Mol Cell Biol 1997;17: 7119-7125.
58. Webb JR, Kaufmann D, Campos-Neto A, Reed SG. Molecular cloning of a novel protein antigen of Leishmania major that elicits a potent immune response in experimental murine Leishmania. J Immunol 1996;157:5034-5041.
59. Duina AA, Marsh JA, Gaber RF. Identification of two CyP-40-like cyclophilins in Saccharomyces cerevisiae, one of which is required for normal growth. Yeast 1996;12:943-952.
60. Lam E, Martin M, Wiederrecht G. Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs. Gene 1995;160:297-302.
61. Blecher O, Erel N, Callebaut I, Aviezer K, Brieman A. A novel plant peptidyl-prolyl-cis-trans-isomerase (PPlase): cDNA cloning, structural analysis, enzymatic activity and expression. Plant Mol Biol 1996;32:493-504.
62. Hase T, Riezman H, Suda K, Schatz G. Import of proteins into mitochondria: nucleotide sequence of the gene for a 70-kd protein of the yeast mitochondrial outer membrane. EMBO J 1983;2:2169-2172.
63. Steger HF, Sollner T, Kiebler M, Dietmeier KA, Pfaller R, Trulzsch KS, Tropschug M, Neupert W, Pfanner N. Import of ADP/ATP carrier into mitochondria: two receptors act in parallel. J Cell Biol 1990;111:2353-2363.
64. McCollum D, Monosov E, Subramani S. The pas8 mutant of Pichia pastoris exhibits the peroxisomal protein import deficiencies of Zellweger syndrome cells: the PAS8 protein binds to the COOH-terminal tripeptide peroxisomal targeting signal, and is a member of the TPR protein family. J Cell Biol 1993;121:761-774.
65. Otera H, Okumoto K, Tateishi K, Ikoma Y, Matsuda E, Nishimura M, Tsukamoto T, Osumi T, Ohashi K, Higuchi O. Fujiki Y. Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: studies with PEX5-defective CHO cell mutants. Mo Cell Biol 1998;18:388-399.
66. Wiemer EA, Nuttley WM, Bertolaet BL, Li X, Francke U, Wheelock MJ, Anne UK, Johnson KR, Subramani S. Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders. J Cell Biol 1995;130:51-65.
67. van der Klei IJ, Hilbrands RE, Swaving GJ, Waterham HR, Vrieling EG, Titorenko VI, Cregg JM, Harder W, Veenhuis M. The Hansenula polymorpha PER3 gene is essential for the import of PTS1 proteins into the peroxisomal matrix. J Biol Chem 1995;270:17229-17236.
68. Nuttley WM, Szilard RK, Smith JJ, Veenhuis M, Rachubinski RA. The PAH2 gene is required for peroxisome assembly in the methylotrophic yeast Hansenula polymorpha and encodes a member of the tetratricopeptide repeat family of proteins. Gene 1995;160:33-39.
69. Iwahashi J, Yamazaki S, Komiya T, Nomura N, Nishikawa S-I, Endo T, Mihara K. Analysis of the functional domain of the rat liver mitochondrial import receptor Tom20. J Biol Chem 1997;272:18467-18472.
70. Gindhart JG Jr, Goldstein LS. Tetratrico peptide repeats are present in the kinesin light chain. Trends Biochem Sci 1996;21:52-53.
71. Ordway RW, Pallanck L, Ganetzky B. A TPR domain in the SNAP secretory proteins. Trends Biochem Sci 1994;19:530-531.
72. Ponting CCP, Phillips C. Rapsyn's knobs and holes: eight tetratrico peptide repeats. Biochem J 1996;314:1053-1054.
73. Lee TG, Tang N, Thompson S, Miller J, Katze MG. The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins. Mol Cell Biol 1994;14:2331-2342.
74. Becker W, Kentrup H, Klump S, Schultz JE, Joost HG. Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. J Biol Chem 1994;269:22586-22592.
75. Yatzkan E, Yarden O. ppt1, a Neurospora crassa PPT/PP5 subfamily serine/threonine protein phosphatase. Biochim Biophys Acta 1997;1353: 18-22.
76. Murthy AE, Bernards A, Church D, Wasmuth J, Gusella JF. Identification and characterization of two novel tetratricopeptide repeat-containing genes. DNA Cell Biol 1996;15:727-735.
77. Ma Q, Whitlock JP Jr. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem 1997;272:8878-8884.
78. Smith JB, Herschman HR. The glucocorticoid attenuated response genes GARG-16, GARG-39, and GARG-49/IRG2 encode inducible proteins containing multiple tetratricopeptide repeat domains. Arch Biochem Biophys 1996;330:290-300.
79. Ohira M, Ootsuyama A, Suzuki E, Ichikawa H, Seki N, Nagase T, Nomura N, Ohki M. Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21. DNA Res 1996;3:9-16.
80. Okuda Y, Denda K, Fukumori Y. Cloning and sequencing of a gene encoding a new member of the tetratricopeptide protein family from magnetosomes of Magnetospirillum magnetotacticum. Gene 1996;171:99-102.
81. Jacobsen SE, Binkowski KA, Olszewski NE. Spindly, a tetratricopeptide repeat protein involved in gibberellin signal transduction in Arabidopsis. Proc Natl Acad Sci USA 1996;93:9292-9296.
82. Lubas WA, Frank DW, Krause M, Hanover JA. O-Linked GIcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. J Biol Chem 1997;272:9316-9324.
83. de Boer M, Hilarius-Stokman PM, Hossle JP, Verhoeven AJ, Graf N, Kenney RT, Seger R, Roos D. Autosomal recessive chronic granulomatous disease with absence of the 67-kD cytosolic NADPH oxidase component, identification of mutation and detection of carriers. Blood 1994;83:531-536.
84. Cziepluch C, Kordes E, Poirey R, Grewenig A, Rommelaere J, Jauniaux JC. Identification of a novel cellular TPR-containing protein, SGT, that interacts with the nonstructural protein NS1 of parvovirus H1. J Virol 1998;72:4149-4156.
85. Russell LC, Whitt SR, Chen M-S, Chinkers M. Identification of conserved residues required for the binding of a tetratricopeptide repeat domain to heat shock protein 90. J Biol Chem 1999;274:20060-20063.
86. Groves MR, Barford D. Topological characteristics of helical repeat proteins. Curr Opin Struct Biol 1999;9:383-389.