메뉴 건너뛰기




Volumn , Issue , 2008, Pages 1-85

Evolving Role of Mass Spectrometry in Drug Discovery and Development

Author keywords

Drug discovery and development mass spectrometry; Quantitative analysis mass spectrometry; Sample preparation cleanup and column technology

Indexed keywords


EID: 79953668060     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470409817.ch1     Document Type: Chapter
Times cited : (5)

References (322)
  • 1
    • 0035810332 scopus 로고    scopus 로고
    • Liquid chromatographic-mass spectrometric determination of celecoxib in plasma using single-ion monitoring and its use in clinical pharmacokinetics
    • Abdel-Hamid, M., Novotny, L., and Hamza, H. (2001). Liquid chromatographic-mass spectrometric determination of celecoxib in plasma using single-ion monitoring and its use in clinical pharmacokinetics. J. Chromatogr. B: Biomed. Sci. Appl. 753:401-408.
    • (2001) J. Chromatogr. B: Biomed. Sci. Appl. , vol.753 , pp. 401-408
    • Abdel-Hamid, M.1    Novotny, L.2    Hamza, H.3
  • 2
    • 2142728539 scopus 로고    scopus 로고
    • Solid-state characterization of rifampicin samples and its biopharmaceutic relevance
    • Agrawal, S., Ashokraj, Y., Bharatam, P. V., Pillai, O., and Panchagnula, R. (2004). Solid-state characterization of rifampicin samples and its biopharmaceutic relevance. Eur. J. Pharm. Sci. 22:127-144.
    • (2004) Eur. J. Pharm. Sci. , vol.22 , pp. 127-144
    • Agrawal, S.1    Ashokraj, Y.2    Bharatam, P.V.3    Pillai, O.4    Panchagnula, R.5
  • 3
    • 20444481663 scopus 로고    scopus 로고
    • Development and application of a new on-line SPE system combined with LC-MS/MS detection for high throughput direct analysis of pharmaceutical compounds in plasma
    • Alnouti, Y., Srinivasan, K., Waddell, D., Bi, H., Kavetskaia, O., and Gusev, A. I. (2005). Development and application of a new on-line SPE system combined with LC-MS/MS detection for high throughput direct analysis of pharmaceutical compounds in plasma. J. Chromatogr. A 1080:99-106.
    • (2005) J. Chromatogr. A , vol.1080 , pp. 99-106
    • Alnouti, Y.1    Srinivasan, K.2    Waddell, D.3    Bi, H.4    Kavetskaia, O.5    Gusev, A.I.6
  • 4
    • 19444367378 scopus 로고    scopus 로고
    • Bridging cheminformatic metabolite prediction and tandem mass spectrometry
    • Anari, M. R., and Baillie, T. A. (2005). Bridging cheminformatic metabolite prediction and tandem mass spectrometry. Drug Discov. Today 10:711-717.
    • (2005) Drug Discov. Today , vol.10 , pp. 711-717
    • Anari, M.R.1    Baillie, T.A.2
  • 5
    • 0842327199 scopus 로고    scopus 로고
    • Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: Application to studies on the biotransformation of indinavir
    • Anari, M. R., Sanchez, R. I., Bakhtiar, R., Franklin, R. B., and Baillie, T. A. (2004). Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: Application to studies on the biotransformation of indinavir. Anal. Chem. 76:823-832.
    • (2004) Anal. Chem. , vol.76 , pp. 823-832
    • Anari, M.R.1    Sanchez, R.I.2    Bakhtiar, R.3    Franklin, R.B.4    Baillie, T.A.5
  • 6
    • 0037254307 scopus 로고    scopus 로고
    • Quantitative characterization of differential ion suppression on liquid chromatography/atmospheric pressure ionization mass spectrometric bioanalytical methods
    • Avery, M. J. (2003). Quantitative characterization of differential ion suppression on liquid chromatography/atmospheric pressure ionization mass spectrometric bioanalytical methods. Rapid Commun. Mass Spectrom. 17:197-201.
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 197-201
    • Avery, M.J.1
  • 7
    • 0031453346 scopus 로고    scopus 로고
    • The use of turbulent flow chromatography/mass spectrometry for the rapid, direct analysis of a novel pharmaceutical compound in plasma
    • Ayrton, J., Dear, G. J., Leavens, W. J., Mallett, D. N., and Plumb, R. S. (1997). The use of turbulent flow chromatography/mass spectrometry for the rapid, direct analysis of a novel pharmaceutical compound in plasma. Rapid Commun. Mass Spectrom. 11:1953-1958.
    • (1997) Rapid Commun. Mass Spectrom. , vol.11 , pp. 1953-1958
    • Ayrton, J.1    Dear, G.J.2    Leavens, W.J.3    Mallett, D.N.4    Plumb, R.S.5
  • 10
    • 33947256444 scopus 로고    scopus 로고
    • Tracking problems and possible solutions in the quantitative determination of small molecule drugs and metabolites in biological fluids using liquid chromatography-mass spectrometry
    • Bakhtiar, R., and Majumdar, T. K. (2007). Tracking problems and possible solutions in the quantitative determination of small molecule drugs and metabolites in biological fluids using liquid chromatography-mass spectrometry. J. Pharmacol. Toxicol. Methods 55:227-243.
    • (2007) J. Pharmacol. Toxicol. Methods , vol.55 , pp. 227-243
    • Bakhtiar, R.1    Majumdar, T.K.2
  • 12
    • 84889455240 scopus 로고    scopus 로고
    • Rapid Metabolite Identification Using Advanced Algorithms for Mass Spectral Interpretation
    • In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN
    • Bayliss, M. A., Antler, M., McGibbon, G., and Lashin, V. (2007). Rapid Metabolite Identification Using Advanced Algorithms for Mass Spectral Interpretation. In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN.
    • (2007)
    • Bayliss, M.A.1    Antler, M.2    McGibbon, G.3    Lashin, V.4
  • 13
    • 0034924482 scopus 로고    scopus 로고
    • A new technique for unbiased external ion accumulation in a quadrupole two-dimensional ion trap for electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
    • Belov, M. E., Nikolaev, E. N., Alving, K., and Smith, R. D. (2001). A new technique for unbiased external ion accumulation in a quadrupole two-dimensional ion trap for electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun. Mass Spectrom. 15:1172-1180.
    • (2001) Rapid Commun. Mass Spectrom. , vol.15 , pp. 1172-1180
    • Belov, M.E.1    Nikolaev, E.N.2    Alving, K.3    Smith, R.D.4
  • 14
    • 20644463474 scopus 로고    scopus 로고
    • Electrospray ionization mass spectrometry as a tool for determination of drug binding sites to human serum albumin by noncovalent interaction
    • Benkestock, K., Edlund, P. O., and Roeraade, J. (2005). Electrospray ionization mass spectrometry as a tool for determination of drug binding sites to human serum albumin by noncovalent interaction. Rapid Commun. Mass Spectrom. 19:1637-1643.
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , pp. 1637-1643
    • Benkestock, K.1    Edlund, P.O.2    Roeraade, J.3
  • 15
    • 0032986050 scopus 로고    scopus 로고
    • The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds
    • Bonfiglio, R., King, R. C., Olah, T. V., and Merkle, K. (1999). The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds. Rapid Commun. Mass Spectrom. 13:1175-1185.
    • (1999) Rapid Commun. Mass Spectrom. , vol.13 , pp. 1175-1185
    • Bonfiglio, R.1    King, R.C.2    Olah, T.V.3    Merkle, K.4
  • 16
    • 34347250503 scopus 로고    scopus 로고
    • Combined approach for highthroughput preparation and analysis of plasma samples from exposure studies
    • Briem, S., Martinsson, S., Bueters, T., and Skoglund, E. (2007). Combined approach for highthroughput preparation and analysis of plasma samples from exposure studies. Rapid Commun. Mass Spectrom. 21:1965-1972.
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , pp. 1965-1972
    • Briem, S.1    Martinsson, S.2    Bueters, T.3    Skoglund, E.4
  • 18
    • 0025866208 scopus 로고
    • Liquid chromatography-mass spectrometry with ionspray and electrospray interfaces in pharmaceutical and biomedical research
    • Bruins, A. P. (1991). Liquid chromatography-mass spectrometry with ionspray and electrospray interfaces in pharmaceutical and biomedical research. J. Chromatogr. 554:39-46.
    • (1991) J. Chromatogr. , vol.554 , pp. 39-46
    • Bruins, A.P.1
  • 19
    • 0035108902 scopus 로고    scopus 로고
    • High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. V. Validation of a direct injection/on-line guard cartridge extraction-tandem mass spectrometry method for CYP1A2 inhibition assessment
    • Bu, H. Z., Knuth, K., Magis, L., and Teitelbaum, P. (2001a). High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. V. Validation of a direct injection/on-line guard cartridge extraction-tandem mass spectrometry method for CYP1A2 inhibition assessment. Eur. J. Pharm. Sci. 12:447-452.
    • (2001) Eur. J. Pharm. Sci. , vol.12 , pp. 447-452
    • Bu, H.Z.1    Knuth, K.2    Magis, L.3    Teitelbaum, P.4
  • 21
    • 0033811314 scopus 로고    scopus 로고
    • High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and their metabolites
    • Bu, H. Z., Magis, L., Knuth, K., and Teitelbaum, P. (2000a). High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and their metabolites. Rapid Commun. Mass Spectrom. 14:1619-1624.
    • (2000) Rapid Commun. Mass Spectrom. , vol.14 , pp. 1619-1624
    • Bu, H.Z.1    Magis, L.2    Knuth, K.3    Teitelbaum, P.4
  • 22
    • 0035015324 scopus 로고    scopus 로고
    • High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing stra. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1
    • Bu, H. Z., Magis, L., Knuth, K., and Teitelbaum, P. (2001c). High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing stra. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1. Rapid Commun. Mass Spectrom. 15:741-748.
    • (2001) Rapid Commun. Mass Spectrom. , vol.15 , pp. 741-748
    • Bu, H.Z.1    Magis, L.2    Knuth, K.3    Teitelbaum, P.4
  • 23
    • 0035810338 scopus 로고    scopus 로고
    • High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy II. Validation of a direct injection/on-line guard cartridge extraction-tandem mass spectrometry method for CYP2D6 inhibition assessment
    • Bu, H. Z., Magis, L., Knuth, K., and Teitelbaum, P. (2001d). High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy II. Validation of a direct injection/on-line guard cartridge extraction-tandem mass spectrometry method for CYP2D6 inhibition assessment. J. Chromatogr. B: Biomed. Sci. Appl. 753:321-326.
    • (2001) J. Chromatogr. B: Biomed. Sci. Appl. , vol.753 , pp. 321-326
    • Bu, H.Z.1    Magis, L.2    Knuth, K.3    Teitelbaum, P.4
  • 24
    • 0034100505 scopus 로고    scopus 로고
    • High-throughput Caco-2 cell permeability screening by cassette dosing and sample pooling approaches using direct injection/on-line guard cartridge extraction/tandem mass spectrometry
    • Bu, H. Z., Poglod, M., Micetich, R. G., and Khan, J. K. (2000b). High-throughput Caco-2 cell permeability screening by cassette dosing and sample pooling approaches using direct injection/on-line guard cartridge extraction/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 14:523-528.
    • (2000) Rapid Commun. Mass Spectrom. , vol.14 , pp. 523-528
    • Bu, H.Z.1    Poglod, M.2    Micetich, R.G.3    Khan, J.K.4
  • 25
    • 20644438228 scopus 로고    scopus 로고
    • Advantages of atmospheric pressure photoionization mass spectrometry in support of drug discovery
    • Cai, Y., Kingery, D., McConnell, O., and Bach, A. C. 2nd (2005). Advantages of atmospheric pressure photoionization mass spectrometry in support of drug discovery. Rapid Commun. Mass Spectrom. 19:1717-1724.
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , pp. 1717-1724
    • Cai, Y.1    Kingery, D.2    McConnell, O.3    Bach, A.C.4
  • 26
    • 0035032944 scopus 로고    scopus 로고
    • High-throughput analysis in drug discovery: Application of liquid chromatography/ion-trap mass spectrometry for simultaneous cassette analysis of alpha-1a antagonists and their metabolites in mouse plasma
    • Cai, Z., Han, C., Harrelson, S., Fung, E., and Sinhababu, A. K. (2001). High-throughput analysis in drug discovery: Application of liquid chromatography/ion-trap mass spectrometry for simultaneous cassette analysis of alpha-1a antagonists and their metabolites in mouse plasma. Rapid Commun. Mass Spectrom. 15:546-550.
    • (2001) Rapid Commun. Mass Spectrom. , vol.15 , pp. 546-550
    • Cai, Z.1    Han, C.2    Harrelson, S.3    Fung, E.4    Sinhababu, A.K.5
  • 27
    • 0033827627 scopus 로고    scopus 로고
    • Simultaneous quantitative cassette analysis of drugs and detection of their metabolites by high performance liquid chromatography/ion trap mass spectrometry
    • Cai, Z., Sinhababu, A. K., and Harrelson, S. (2000). Simultaneous quantitative cassette analysis of drugs and detection of their metabolites by high performance liquid chromatography/ion trap mass spectrometry. Rapid Commun. Mass Spectrom. 14:1637-1643.
    • (2000) Rapid Commun. Mass Spectrom. , vol.14 , pp. 1637-1643
    • Cai, Z.1    Sinhababu, A.K.2    Harrelson, S.3
  • 28
    • 34047127580 scopus 로고    scopus 로고
    • The drug development crisis: Efficiency and safety
    • Caskey, C. T. (2007). The drug development crisis: Efficiency and safety. Annu. Rev. Med. 58:1-16.
    • (2007) Annu. Rev. Med. , vol.58 , pp. 1-16
    • Caskey, C.T.1
  • 29
    • 14844293921 scopus 로고    scopus 로고
    • Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer
    • Castro-Perez, J., Plumb, R., Granger, J. H., Beattie, I., Joncour, K., and Wright, A. (2005). Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom. 19:843-848.
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , pp. 843-848
    • Castro-Perez, J.1    Plumb, R.2    Granger, J.H.3    Beattie, I.4    Joncour, K.5    Wright, A.6
  • 30
    • 0034669615 scopus 로고    scopus 로고
    • An interface with a linear quadrupole ion guide for an electrospray-ion trap mass spectrometer system
    • Cha, B., Blades, M. W., and Douglas, D. J. (2000). An interface with a linear quadrupole ion guide for an electrospray-ion trap mass spectrometer system. Anal. Chem. 72:5647-5654.
    • (2000) Anal. Chem. , vol.72 , pp. 5647-5654
    • Cha, B.1    Blades, M.W.2    Douglas, D.J.3
  • 31
    • 34848919555 scopus 로고    scopus 로고
    • Historical review of sample preparation for chromatographic bioanalysis: Pros and cons
    • Chang, M. S., Ji, Q., Zhang, J., and El-Shourbagy, T. A. (2007a). Historical review of sample preparation for chromatographic bioanalysis: Pros and cons. Drug Dev. Res. 68:107-133.
    • (2007) Drug Dev. Res. , vol.68 , pp. 107-133
    • Chang, M.S.1    Ji, Q.2    Zhang, J.3    El-Shourbagy, T.A.4
  • 32
    • 33846312100 scopus 로고    scopus 로고
    • Evaluation of 384-well formatted sample preparation technologies for regulated bioanalysis
    • Chang, M. S., Kim, E. J., and El-Shourbagy, T. A. (2007b). Evaluation of 384-well formatted sample preparation technologies for regulated bioanalysis. Rapid Commun. Mass Spectrom. 21:64-72.
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , pp. 64-72
    • Chang, M.S.1    Kim, E.J.2    El-Shourbagy, T.A.3
  • 33
    • 0034306765 scopus 로고    scopus 로고
    • Determination of rofecoxib (MK-0966), a cyclooxygenase-2 inhibitor, in human plasma by high-performance liquid chromatography with tandem mass spectrometric detection
    • Chavez-Eng, C. M., Constanzer, M. L., and Matuszewski, B. K. (2000). Determination of rofecoxib (MK-0966), a cyclooxygenase-2 inhibitor, in human plasma by high-performance liquid chromatography with tandem mass spectrometric detection. J. Chromatogr. B Biomed. Sci. Appl. 748:31-39.
    • (2000) J. Chromatogr. B Biomed. Sci. Appl. , vol.748 , pp. 31-39
    • Chavez-Eng, C.M.1    Constanzer, M.L.2    Matuszewski, B.K.3
  • 34
    • 33947249054 scopus 로고    scopus 로고
    • Applications of LC/MS in structure identifications of small molecules and proteins in drug discovery
    • Chen, G., Pramanik, B. N., Liu, Y. H., and Mirza, U. A. (2007). Applications of LC/MS in structure identifications of small molecules and proteins in drug discovery. J. Mass Spectrom. 42:279-287.
    • (2007) J. Mass Spectrom. , vol.42 , pp. 279-287
    • Chen, G.1    Pramanik, B.N.2    Liu, Y.H.3    Mirza, U.A.4
  • 35
    • 0034852208 scopus 로고    scopus 로고
    • An introduction to quadrupole-time-of-flight mass spectrometry
    • Chernushevich, I. V., Loboda, A. V., and Thomson, B. A. (2001). An introduction to quadrupole-time-of-flight mass spectrometry. J. Mass Spectrom. 36:849-865.
    • (2001) J. Mass Spectrom. , vol.36 , pp. 849-865
    • Chernushevich, I.V.1    Loboda, A.V.2    Thomson, B.A.3
  • 36
    • 84889437180 scopus 로고    scopus 로고
    • Early Assessment of human metabolism: Why, how, challenges and opportunities
    • In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN
    • Chowdhury, S. K. (2007). Early Assessment of human metabolism: Why, how, challenges and opportunities. In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN.
    • (2007)
    • Chowdhury, S.K.1
  • 37
    • 26444507780 scopus 로고    scopus 로고
    • Improving LC-MS sensitivity through increases in chromatographic performance: Comparisons of UPLC-ES/MS/MS to HPLC-ES/MS/MS
    • Churchwell, M. I., Twaddle, N. C., Meeker, L. R., and Doerge, D. R. (2005). Improving LC-MS sensitivity through increases in chromatographic performance: Comparisons of UPLC-ES/MS/MS to HPLC-ES/MS/MS. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 825:134-143.
    • (2005) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.825 , pp. 134-143
    • Churchwell, M.I.1    Twaddle, N.C.2    Meeker, L.R.3    Doerge, D.R.4
  • 38
    • 17644408113 scopus 로고    scopus 로고
    • Versatile new ion source for the analysis of materials in open air under ambient conditions
    • Cody, R. B., Laramee, J. A., and Durst, H. D. (2005). Versatile new ion source for the analysis of materials in open air under ambient conditions. Anal. Chem. 77:2297-2302.
    • (2005) Anal. Chem. , vol.77 , pp. 2297-2302
    • Cody, R.B.1    Laramee, J.A.2    Durst, H.D.3
  • 39
    • 0036041749 scopus 로고    scopus 로고
    • Small molecule analysis by MALDI mass spectrometry
    • Cohen, L. H., and Gusev, A. I. (2002). Small molecule analysis by MALDI mass spectrometry. Anal. Bioanal. Chem. 373:571-586.
    • (2002) Anal. Bioanal. Chem. , vol.373 , pp. 571-586
    • Cohen, L.H.1    Gusev, A.I.2
  • 41
    • 14744283130 scopus 로고    scopus 로고
    • Automated nanospray using chip-based emitters for the quantitative analysis of pharmaceutical compounds
    • Corkery, L. J., Pang, H., Schneider, B. B., Covey, T. R., and Siu, K. W. (2005). Automated nanospray using chip-based emitters for the quantitative analysis of pharmaceutical compounds. J. Am. Soc. Mass Spectrom. 16:363-369.
    • (2005) J. Am. Soc. Mass Spectrom. , vol.16 , pp. 363-369
    • Corkery, L.J.1    Pang, H.2    Schneider, B.B.3    Covey, T.R.4    Siu, K.W.5
  • 42
    • 84889499618 scopus 로고    scopus 로고
    • Imaging drugs and metabolites in tissue using Fourier transform mass spectrometry
    • In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO
    • Cornett, D. S., Frappier, S. L., and Caprioli, R. M. (2008). Imaging drugs and metabolites in tissue using Fourier transform mass spectrometry. In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO.
    • (2008)
    • Cornett, D.S.1    Frappier, S.L.2    Caprioli, R.M.3
  • 43
    • 84889484234 scopus 로고    scopus 로고
    • Peaks of Interest
    • Cudiamat, G. (2005). Peaks of Interest. LCGC N. Am. 23:984.
    • (2005) LCGC N. Am. , vol.23 , pp. 984
    • Cudiamat, G.1
  • 44
    • 84889466010 scopus 로고    scopus 로고
    • Extracting relevant data out of the MS background
    • In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO
    • Cuyckens, F., Hurkmans, R., Leclercq, L., and Mortishire-Smith, R. (2008). Extracting relevant data out of the MS background. In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO.
    • (2008)
    • Cuyckens, F.1    Hurkmans, R.2    Leclercq, L.3    Mortishire-Smith, R.4
  • 45
    • 84994986424 scopus 로고
    • Quadrupole mass analyzers: Performance, design and some recent applications
    • Dawson, P. H. (1986). Quadrupole mass analyzers: Performance, design and some recent applications. Mass Spectrom. Rev. 5:1-37.
    • (1986) Mass Spectrom. Rev. , vol.5 , pp. 1-37
    • Dawson, P.H.1
  • 46
    • 34047157087 scopus 로고    scopus 로고
    • The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools
    • De Buck, S. S., Sinha, V. K., Fenu, L. A., Gilissen, R. A., Mackie, C. E., and Nijsen, M. J. (2007). The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools. Drug Metab. Dispos. 35:649-659.
    • (2007) Drug Metab. Dispos. , vol.35 , pp. 649-659
    • De Buck, S.S.1    Sinha, V.K.2    Fenu, L.A.3    Gilissen, R.A.4    Mackie, C.E.5    Nijsen, M.J.6
  • 47
    • 0033799309 scopus 로고    scopus 로고
    • Evaluation of automated single mass spectrometry to tandem mass spectrometry function switching for comprehensive drug profiling analysis using a quadrupole time-of-flight mass spectrometer
    • Decaestecker, T. N., Clauwaert, K. M., Van Bocxlaer, J. F., Lambert,W. E., Van den Eeckhout, E. G., Van Peteghem, C. H., and De Leenheer, A. P. (2000). Evaluation of automated single mass spectrometry to tandem mass spectrometry function switching for comprehensive drug profiling analysis using a quadrupole time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom. 14:1787-1792.
    • (2000) Rapid Commun. Mass Spectrom. , vol.14 , pp. 1787-1792
    • Decaestecker, T.N.1    Clauwaert, K.M.2    Van Bocxlaer, J.F.3    Lambert, W.E.4    Van Den Eeckhout, E.G.5    Van Peteghem, C.H.6    De Leenheer, A.P.7
  • 48
    • 84889432827 scopus 로고    scopus 로고
    • Identification of drug metabolites by UPLC-MS with isotope pattern directed mass chromatograms and UPLC with radioactivity flow detection
    • In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO
    • De Maio, W., Hoffmann, M., Carbonara, M., Moore, R., Mutlib, A., and Talaat, R. E. (2008). Identification of drug metabolites by UPLC-MS with isotope pattern directed mass chromatograms and UPLC with radioactivity flow detection. In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO.
    • (2008)
    • De Maio, W.1    Hoffmann, M.2    Carbonara, M.3    Moore, R.4    Mutlib, A.5    Talaat, R.E.6
  • 49
    • 32444451730 scopus 로고    scopus 로고
    • Applications of mass spectrometry in early stages of target based drug discovery
    • Deng, G., and Sanyal, G. (2006). Applications of mass spectrometry in early stages of target based drug discovery. J. Pharm. Biomed. Anal. 40:528-538.
    • (2006) J. Pharm. Biomed. Anal. , vol.40 , pp. 528-538
    • Deng, G.1    Sanyal, G.2
  • 50
    • 0036001224 scopus 로고    scopus 로고
    • High-speed gradient parallel liquid chromatography/tandem mass spectrometry with fully automated sample preparation for bioanalysis: 30 seconds per sample from plasma
    • Deng, Y., Wu, J. T., Lloyd, T. L., Chi, C. L., Olah, T. V., and Unger, S. E. (2002). High-speed gradient parallel liquid chromatography/tandem mass spectrometry with fully automated sample preparation for bioanalysis: 30 seconds per sample from plasma. Rapid Commun. Mass Spectrom. 16:1116-1123.
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , pp. 1116-1123
    • Deng, Y.1    Wu, J.T.2    Lloyd, T.L.3    Chi, C.L.4    Olah, T.V.5    Unger, S.E.6
  • 51
    • 0034839055 scopus 로고    scopus 로고
    • Multiple-sprayer tandem mass spectrometry with parallel high flow extraction and parallel separation for high-throughput quantitation in biological fluids
    • Deng, Y., Zeng, H., Unger, S. E., and Wu, J. T. (2001). Multiple-sprayer tandem mass spectrometry with parallel high flow extraction and parallel separation for high-throughput quantitation in biological fluids. Rapid Commun. Mass Spectrom. 15:1634-1640.
    • (2001) Rapid Commun. Mass Spectrom. , vol.15 , pp. 1634-1640
    • Deng, Y.1    Zeng, H.2    Unger, S.E.3    Wu, J.T.4
  • 52
    • 0032974197 scopus 로고    scopus 로고
    • Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: Concepts and perspectives
    • Derendorf, H., and Meibohm, B. (1999). Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: Concepts and perspectives. Pharm. Res. 16:176-185.
    • (1999) Pharm. Res. , vol.16 , pp. 176-185
    • Derendorf, H.1    Meibohm, B.2
  • 53
    • 33645804584 scopus 로고    scopus 로고
    • Follow-on biologics: Competition in the biopharmaceutical marketplace
    • Devine, J. W., Cline, R. R., and Farley, J. F. (2006). Follow-on biologics: Competition in the biopharmaceutical marketplace. J. Am. Pharm. Assoc. 46:213-221.
    • (2006) J. Am. Pharm. Assoc. , vol.46 , pp. 213-221
    • Devine, J.W.1    Cline, R.R.2    Farley, J.F.3
  • 54
    • 84889356826 scopus 로고    scopus 로고
    • Characterisation of metabolites generated by mutant cytochromes P450 enzymes using a 3D ion trap-time of flight mass spectrometer
    • In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN
    • De vlieger, J., Krabbe, J. G., Commandeur, J. N. M., Vermeulen, N. P. E., Niessen, W. M. A., and Loftus, N. (2007). Characterisation of metabolites generated by mutant cytochromes P450 enzymes using a 3D ion trap-time of flight mass spectrometer. In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN.
    • (2007)
    • De Vlieger, J.1    Krabbe, J.G.2    Commandeur, J.N.M.3    Vermeulen, N.P.E.4    Niessen, W.M.A.5    Loftus, N.6
  • 55
    • 0035336557 scopus 로고    scopus 로고
    • New drug development in the United States from 1963 to 1999
    • DiMasi, J. A. (2001a). New drug development in the United States from 1963 to 1999. Clin. Pharmacol. Ther. 69:286-296.
    • (2001) Clin. Pharmacol. Ther. , vol.69 , pp. 286-296
    • DiMasi, J.A.1
  • 56
    • 0035336557 scopus 로고    scopus 로고
    • New drug development in the United States from 1963 to 1999
    • DiMasi, J. A. (2001b). New drug development in the United States from 1963 to 1999. Clin. Pharmacol. Ther. 69:286-296.
    • (2001) Clin. Pharmacol. Ther. , vol.69 , pp. 286-296
    • DiMasi, J.A.1
  • 57
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • DiMasi, J. A., Hansen, R.W., and Grabowski, H. G. (2003). The price of innovation: New estimates of drug development costs. J. Health Econ. 22:151-185.
    • (2003) J. Health Econ. , vol.22 , pp. 151-185
    • DiMasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3
  • 58
    • 37249084346 scopus 로고    scopus 로고
    • The perfect method, Part V: Changing column selectivity
    • Dolan, J. W. (2007). The perfect method, Part V: Changing column selectivity. LCGC N. Am. 25:1014-1020.
    • (2007) LCGC N. Am. , vol.25 , pp. 1014-1020
    • Dolan, J.W.1
  • 60
    • 35148857181 scopus 로고    scopus 로고
    • Ultrahigh-pressure LC in pharmaceutical analysis: Performance and practical issues
    • Dong, M.W. (2007). Ultrahigh-pressure LC in pharmaceutical analysis: Performance and practical issues. LCGC N. Am. 25:656-666.
    • (2007) LCGC N. Am. , vol.25 , pp. 656-666
    • Dong, M.W.1
  • 61
    • 0034677966 scopus 로고    scopus 로고
    • Drug discovery: A historical perspective
    • Drews, J. (2000). Drug discovery: A historical perspective. Science 287:1960-1964.
    • (2000) Science , vol.287 , pp. 1960-1964
    • Drews, J.1
  • 62
    • 0002523133 scopus 로고
    • Atmospheric pressure ion-sampling system for liquid chromatography/mass spectrometry analyses on a benchtop mass spectrometer
    • Duffin, K. L., Wachs, T., and Henion, J. D. (1992). Atmospheric pressure ion-sampling system for liquid chromatography/mass spectrometry analyses on a benchtop mass spectrometer. Anal. Chem. 64:61-68.
    • (1992) Anal. Chem. , vol.64 , pp. 61-68
    • Duffin, K.L.1    Wachs, T.2    Henion, J.D.3
  • 63
    • 84889416286 scopus 로고    scopus 로고
    • Comparison of laser diode thermal desorption (LDTD) source vs LC-MS for the analysis of a theraputic drug in biological extracts
    • In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO
    • Edge, T., Smith, C., Hill, S., Picard, P., Letarte, S., Wilson, I. D., and Vince, P. (2008). Comparison of laser diode thermal desorption (LDTD) source vs LC-MS for the analysis of a theraputic drug in biological extracts. In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO.
    • (2008)
    • Edge, T.1    Smith, C.2    Hill, S.3    Picard, P.4    Letarte, S.5    Wilson, I.D.6    Vince, P.7
  • 64
    • 0033867668 scopus 로고    scopus 로고
    • Detection of microcystins using electrospray ionization high-field asymmetric waveform ion mobility mass spectrometry/mass spectrometry
    • Ells, B., Froese, K., Hrudey, S. E., Purves, R. W., Guevremont, R., and Barnett, D. A. (2000). Detection of microcystins using electrospray ionization high-field asymmetric waveform ion mobility mass spectrometry/mass spectrometry. Rapid Commun. Mass Spectrom. 14:1538-1542.
    • (2000) Rapid Commun. Mass Spectrom. , vol.14 , pp. 1538-1542
    • Ells, B.1    Froese, K.2    Hrudey, S.E.3    Purves, R.W.4    Guevremont, R.5    Barnett, D.A.6
  • 65
    • 33749505275 scopus 로고    scopus 로고
    • Responding rapidly to FDA drug withdrawals: Design and application of a new approach for a consumer health website
    • Embi, P. J., Acharya, P., McCuistion, M., Kishman, C. P., Haag, D., and Marine, S. (2006). Responding rapidly to FDA drug withdrawals: Design and application of a new approach for a consumer health website. J. Med. Internet Res. 8:e16.
    • (2006) J. Med. Internet Res. , vol.8
    • Embi, P.J.1    Acharya, P.2    McCuistion, M.3    Kishman, C.P.4    Haag, D.5    Marine, S.6
  • 66
    • 0034607382 scopus 로고    scopus 로고
    • Salt form selection and characterization of LY333531 mesylate monohydrate
    • Engel, G. L., Farid, N. A., Faul, M. M., Richardson, L. A., and Winneroski, L. L. (2000). Salt form selection and characterization of LY333531 mesylate monohydrate. Int. J. Pharm. 198:239-247.
    • (2000) Int. J. Pharm. , vol.198 , pp. 239-247
    • Engel, G.L.1    Farid, N.A.2    Faul, M.M.3    Richardson, L.A.4    Winneroski, L.L.5
  • 67
    • 56149091565 scopus 로고    scopus 로고
    • Rapid metabolite identification with sub parts-per million mass accuracy from biological matrices by direct infusion nanoelectrospray ionization after clean-up on a ZipTip and LTQ/Orbitrap mass spectrometry
    • Erve, J. C. L., DeMaio, W., and Talaat, R. E. (2008). Rapid metabolite identification with sub parts-per million mass accuracy from biological matrices by direct infusion nanoelectrospray ionization after clean-up on a ZipTip and LTQ/Orbitrap mass spectrometry. Rapid Commun. Mass Spectrom. 22:3015-3026.
    • (2008) Rapid Commun. Mass Spectrom. , vol.22 , pp. 3015-3026
    • Erve, J.C.L.1    DeMaio, W.2    Talaat, R.E.3
  • 68
    • 0021707968 scopus 로고
    • Properties of acyl glucuronides. Implications for studies of the pharmacokinetics and metabolism of acidic drugs
    • Faed, E. M. (1984). Properties of acyl glucuronides. Implications for studies of the pharmacokinetics and metabolism of acidic drugs. Drug Metab. Rev. 15:1213-1249.
    • (1984) Drug Metab. Rev. , vol.15 , pp. 1213-1249
    • Faed, E.M.1
  • 69
    • 0036318786 scopus 로고    scopus 로고
    • Highthroughput liquid chromatography ultraviolet/mass spectrometric analysis of combinatorial libraries using an eight-channel multiplexed electrospray time-of-flight mass spectrometer
    • Fang, L., Cournoyer, J., Demee, M., Zhao, J., Tokushige, D., and Yan, B. (2002). Highthroughput liquid chromatography ultraviolet/mass spectrometric analysis of combinatorial libraries using an eight-channel multiplexed electrospray time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom. 16:1440-1447.
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , pp. 1440-1447
    • Fang, L.1    Cournoyer, J.2    Demee, M.3    Zhao, J.4    Tokushige, D.5    Yan, B.6
  • 70
    • 0037774451 scopus 로고    scopus 로고
    • Parallel highthroughput accurate mass measurement using a nine-channel multiplexed electrospray liquid chromatography ultraviolet time-of-flight mass spectrometry system
    • Fang, L., Demee, M., Cournoyer, J., Sierra, T., Young, C., and Yan, B. (2003). Parallel highthroughput accurate mass measurement using a nine-channel multiplexed electrospray liquid chromatography ultraviolet time-of-flight mass spectrometry system. Rapid Commun. Mass Spectrom. 17:1425-1432.
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 1425-1432
    • Fang, L.1    Demee, M.2    Cournoyer, J.3    Sierra, T.4    Young, C.5    Yan, B.6
  • 71
    • 33645088717 scopus 로고    scopus 로고
    • Mass spectrometry in drug discovery: A current review
    • Feng, W. Y. (2004). Mass spectrometry in drug discovery: A current review. Curr. Drug Discov. Technol. 1:295-312.
    • (2004) Curr. Drug Discov. Technol. , vol.1 , pp. 295-312
    • Feng, W.Y.1
  • 72
    • 0041918439 scopus 로고    scopus 로고
    • Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates
    • Fernandez-Metzler, C. L., Owens, K. G., Baillie, T. A., and King, R. C. (1999). Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates. Drug Metab. Dispos. 27:32-40.
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 32-40
    • Fernandez-Metzler, C.L.1    Owens, K.G.2    Baillie, T.A.3    King, R.C.4
  • 73
    • 34547639694 scopus 로고    scopus 로고
    • Importance of the electron mass in the calculations of exact mass by time-of-flight mass spectrometry
    • Ferrer, I., and Thurman, E. M. (2007). Importance of the electron mass in the calculations of exact mass by time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 21:2538-2539.
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , pp. 2538-2539
    • Ferrer, I.1    Thurman, E.M.2
  • 74
    • 33748678161 scopus 로고    scopus 로고
    • Integration of a rapid automated solubility classification into early validation of hits obtained by high throughput screening
    • Fligge, T. A., and Schuler, A. (2006). Integration of a rapid automated solubility classification into early validation of hits obtained by high throughput screening. J. Pharm. Biomed. Anal. 42:449-454.
    • (2006) J. Pharm. Biomed. Anal. , vol.42 , pp. 449-454
    • Fligge, T.A.1    Schuler, A.2
  • 75
    • 53549097600 scopus 로고    scopus 로고
    • Draft Guidance for Industry: Safety Testing of Drug Metabolites
    • Food and Administration D., June 2005
    • Food and Drug Administration (2005). Draft Guidance for Industry: Safety Testing of Drug Metabolites. http://www.fda.gov/ohrms/dockets/98fr/2005d-0203-gdl0001.pdf (June, 2005).
    • (2005)
  • 76
    • 53549097600 scopus 로고    scopus 로고
    • Guidance for Industry: Safety Testing of Drug Metabolites
    • Food and Drug Administration, February 2008
    • Food and Drug Administration (2008). Guidance for Industry: Safety Testing of Drug Metabolites. http://www.fda.gov/cder/guidance/6897fnl.pdf (February, 2008).
    • (2008)
  • 77
    • 34548363291 scopus 로고    scopus 로고
    • Regulation of follow-on biologics
    • Frank, R. G. (2007). Regulation of follow-on biologics. N. Engl. J. Med. 357:841-843.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 841-843
    • Frank, R.G.1
  • 78
    • 0042836926 scopus 로고    scopus 로고
    • Higher-throughput screening for Caco-2 permeability utilizing a multiple sprayer liquid chromatography/tandem mass spectrometry system
    • Fung, E. N., Chu, I., Li, C., Liu, T., Soares, A., Morrison, R., and Nomeir, A. A. (2003). Higher-throughput screening for Caco-2 permeability utilizing a multiple sprayer liquid chromatography/tandem mass spectrometry system. Rapid Commun. Mass Spectrom. 17:2147-2152.
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 2147-2152
    • Fung, E.N.1    Chu, I.2    Li, C.3    Liu, T.4    Soares, A.5    Morrison, R.6    Nomeir, A.A.7
  • 79
    • 4544230043 scopus 로고    scopus 로고
    • A computer program for automated data evaluation to support in vitro higher-throughput screening for drug metabolism and pharmacokinetics attributes
    • Fung, E. N., Chu, I., and Nomeir, A. A. (2004). A computer program for automated data evaluation to support in vitro higher-throughput screening for drug metabolism and pharmacokinetics attributes. Rapid Commun. Mass Spectrom. 18:2046-2052.
    • (2004) Rapid Commun. Mass Spectrom. , vol.18 , pp. 2046-2052
    • Fung, E.N.1    Chu, I.2    Nomeir, A.A.3
  • 81
    • 84889279239 scopus 로고    scopus 로고
    • New approach for identification of metabolites of a model drug: Partial isotope-enrichment combined with novel mass spectral modeling software
    • In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO
    • Gallagher, R. T., Wilson, I. D., and Hobby, K. (2008). New approach for identification of metabolites of a model drug: Partial isotope-enrichment combined with novel mass spectral modeling software. In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO.
    • (2008)
    • Gallagher, R.T.1    Wilson, I.D.2    Hobby, K.3
  • 82
    • 33847391115 scopus 로고    scopus 로고
    • New drug development: Science, business, regulatory, and intellectual property issues cited as hampering drug development Efforts
    • General Accountability Office (GAO) Report GAO-07-49. GAO, Washington, DC, November 2006
    • General Accountability Office (GAO) (2006). New drug development: Science, business, regulatory, and intellectual property issues cited as hampering drug development Efforts, Report GAO-07-49. GAO, Washington, DC, November 2006.
    • (2006)
  • 83
    • 84889337728 scopus 로고    scopus 로고
    • Cytochrome P450 (CYP) and UDP-glucuronosyltranferase (UGT) enzymes: Role in drug metabolism, polymorphism, and identification of their involvement in drug metabolism
    • In Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS (Chowdhury S. K., Ed.). Elsevier, San Diego, CA
    • Ghosal, A., Ramanathan, R., Kishnani, N., Chowdhury, S. K., and Alton, K. B. (2005). Cytochrome P450 (CYP) and UDP-glucuronosyltranferase (UGT) enzymes: Role in drug metabolism, polymorphism, and identification of their involvement in drug metabolism. In Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS (Chowdhury S. K., Ed.). Elsevier, San Diego, CA, pp. 277-336.
    • (2005) , pp. 277-336
    • Ghosal, A.1    Ramanathan, R.2    Kishnani, N.3    Chowdhury, S.K.4    Alton, K.B.5
  • 84
    • 34347402421 scopus 로고    scopus 로고
    • Evaluation of ultra-performance liquid chromatography in the bioanalysis of small molecule drug candidates in plasma
    • Goodwin, L., White, S. A., and Spooner, N. (2007). Evaluation of ultra-performance liquid chromatography in the bioanalysis of small molecule drug candidates in plasma. J. Chromatogr. Sci. 45:298-304.
    • (2007) J. Chromatogr. Sci. , vol.45 , pp. 298-304
    • Goodwin, L.1    White, S.A.2    Spooner, N.3
  • 85
    • 49149102936 scopus 로고    scopus 로고
    • Automated determination of precursor ion, product ion, and neutral loss compositions and deconvolution of composite mass spectra using ion correlation based on exact masses and relative isotopic abundances
    • Grange, A. H., and Sovocool, G. W. (2008). Automated determination of precursor ion, product ion, and neutral loss compositions and deconvolution of composite mass spectra using ion correlation based on exact masses and relative isotopic abundances. Rapid Commun. Mass Spectrom. 22:2375-2390.
    • (2008) Rapid Commun. Mass Spectrom. , vol.22 , pp. 2375-2390
    • Grange, A.H.1    Sovocool, G.W.2
  • 86
    • 2242478738 scopus 로고    scopus 로고
    • Measuring Mass: From Positive Rays to Proteins
    • Chemical Heritage Press, Philadelphia, PA
    • Grayson, M. A. (2002). Measuring Mass: From Positive Rays to Proteins. Chemical Heritage Press, Philadelphia, PA.
    • (2002)
    • Grayson, M.A.1
  • 87
    • 15744393178 scopus 로고    scopus 로고
    • Influence of pressure on the properties of chromatographic columns. II. The column hold-up volume
    • Gritti, F., Martin, M., and Guiochon, G. (2005). Influence of pressure on the properties of chromatographic columns. II. The column hold-up volume. J. Chromatogr. A 1070:13-22.
    • (2005) J. Chromatogr. A , vol.1070 , pp. 13-22
    • Gritti, F.1    Martin, M.2    Guiochon, G.3
  • 88
    • 15544377096 scopus 로고    scopus 로고
    • Mass Spectrometry: A Textbook
    • Springer-Verlag, Berlin
    • Gross, J. H. (2004). Mass Spectrometry: A Textbook. Springer-Verlag, Berlin.
    • (2004)
    • Gross, J.H.1
  • 89
    • 33644652820 scopus 로고    scopus 로고
    • Accurate mass filtering of ion chromatograms for metabolite identification using a unit mass resolution liquid chromatography/mass spectrometry system
    • Gu, M., Wang, Y., Zhao, X. G., and Gu, Z. M. (2006). Accurate mass filtering of ion chromatograms for metabolite identification using a unit mass resolution liquid chromatography/mass spectrometry system. Rapid Commun. Mass Spectrom. 20:764-770.
    • (2006) Rapid Commun. Mass Spectrom. , vol.20 , pp. 764-770
    • Gu, M.1    Wang, Y.2    Zhao, X.G.3    Gu, Z.M.4
  • 90
    • 33645050104 scopus 로고    scopus 로고
    • Cytochrome P450s and other enzymes in drug metabolism and toxicity
    • Guengerich, F. P. (2006). Cytochrome P450s and other enzymes in drug metabolism and toxicity. AAPS J. 8:E101-E111.
    • (2006) AAPS J. , vol.8
    • Guengerich, F.P.1
  • 91
    • 8444223860 scopus 로고    scopus 로고
    • High-field asymmetric waveform ion mobility spectrometry: A new tool for mass spectrometry
    • Guevremont, R. (2004). High-field asymmetric waveform ion mobility spectrometry: A new tool for mass spectrometry. J. Chromatogr. A. 1058:3-19.
    • (2004) J. Chromatogr. A. , vol.1058 , pp. 3-19
    • Guevremont, R.1
  • 92
    • 34247230154 scopus 로고    scopus 로고
    • Recent developments in liquid chromatography: Impact on qualitative and quantitative performance
    • Guillarme, D., Nguyen, D. T. T., Rudaz, S., and Veuthey, J. L. (2007). Recent developments in liquid chromatography: Impact on qualitative and quantitative performance. J. Chromatogr. A 1149:20-29.
    • (2007) J. Chromatogr. A , vol.1149 , pp. 20-29
    • Guillarme, D.1    Nguyen, D.T.T.2    Rudaz, S.3    Veuthey, J.L.4
  • 93
    • 0036199431 scopus 로고    scopus 로고
    • A new linear ion trap mass spectrometer
    • Hager, J.W. (2002). A new linear ion trap mass spectrometer. Rapid Commun. Mass Spectrom. 16:512-526.
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , pp. 512-526
    • Hager, J.W.1
  • 95
    • 0037398266 scopus 로고    scopus 로고
    • Interfacing the orbitrap mass analyzer to an electrospray ion source
    • Hardman, M., and Makarov, A. A. (2003). Interfacing the orbitrap mass analyzer to an electrospray ion source. Anal. Chem. 75:1699-1705.
    • (2003) Anal. Chem. , vol.75 , pp. 1699-1705
    • Hardman, M.1    Makarov, A.A.2
  • 96
    • 12944317156 scopus 로고    scopus 로고
    • Orthogonal trap time-of-flight mass spectrometer using a collisional damping chamber
    • Hashimoto, Y., Waki, I., Yoshinari, K., Shishika, T., and Terui, Y. (2005). Orthogonal trap time-of-flight mass spectrometer using a collisional damping chamber. Rapid Commun. Mass Spectrom. 19:221-226.
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , pp. 221-226
    • Hashimoto, Y.1    Waki, I.2    Yoshinari, K.3    Shishika, T.4    Terui, Y.5
  • 98
    • 34547164394 scopus 로고    scopus 로고
    • Evaluation of high-field asymmetric waveform ion mobility spectrometry coupled to nanoelectrospray ionization for bioanalysis in drug discovery
    • Hatsis, P., Brockman, A. H., and Wu, J. T. (2007). Evaluation of high-field asymmetric waveform ion mobility spectrometry coupled to nanoelectrospray ionization for bioanalysis in drug discovery. Rapid Commun. Mass Spectrom. 21:2295-2300.
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , pp. 2295-2300
    • Hatsis, P.1    Brockman, A.H.2    Wu, J.T.3
  • 100
    • 10844231839 scopus 로고    scopus 로고
    • Improved precision and accuracy for high-performance liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometric exact mass measurement of small molecules from the simultaneous and controlled introduction of internal calibrants via a second electrospray nebuliser
    • Herniman, J. M., Bristow, T. W. T., O'Connor, G., Jarvis, J., and Langley, G. J. (2004). Improved precision and accuracy for high-performance liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometric exact mass measurement of small molecules from the simultaneous and controlled introduction of internal calibrants via a second electrospray nebuliser. Rapid Commun. Mass Spectrom. 18:3035-3040.
    • (2004) Rapid Commun. Mass Spectrom. , vol.18 , pp. 3035-3040
    • Herniman, J.M.1    Bristow, T.W.T.2    O'Connor, G.3    Jarvis, J.4    Langley, G.J.5
  • 101
    • 33847409678 scopus 로고    scopus 로고
    • Phase 0 trials: Are they ethically challenged? Clin
    • Hill, T. P. (2007). Phase 0 trials: Are they ethically challenged? Clin. Cancer Res. 13:783-784.
    • (2007) Cancer Res. , vol.13 , pp. 783-784
    • Hill, T.P.1
  • 103
    • 33745652264 scopus 로고    scopus 로고
    • Applications of ESI-MS in drug discovery:Interrogation of noncovalent complexes
    • Hofstadler, S. A., and Sannes-Lowery, K. A. (2006). Applications of ESI-MS in drug discovery:Interrogation of noncovalent complexes. Nat. Rev. Drug Discov. 5:585-595.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 585-595
    • Hofstadler, S.A.1    Sannes-Lowery, K.A.2
  • 104
    • 0036007823 scopus 로고    scopus 로고
    • In vitro metabolite identification using fast gradient high performance liquid chromatography combined with tandem mass spectrometry
    • Hop, C. E., Tiller, P. R., and Romanyshyn, L. (2002). In vitro metabolite identification using fast gradient high performance liquid chromatography combined with tandem mass spectrometry. Rapid Commun. Mass Spectrom. 16:212-219.
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , pp. 212-219
    • Hop, C.E.1    Tiller, P.R.2    Romanyshyn, L.3
  • 105
    • 52649120591 scopus 로고    scopus 로고
    • Metabolite identification by LC-MS: Applications in drug discovery and development
    • In Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS (Chowdhury, S. K., Ed.). Elsevier, Amsterdam, The Netherlands
    • Hop, C. E. C. A., and Prakash, C. (2005). Metabolite identification by LC-MS: Applications in drug discovery and development. In Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS (Chowdhury, S. K., Ed.). Elsevier, Amsterdam, The Netherlands, pp. 123-158.
    • (2005) , pp. 123-158
    • Hop, C.E.C.A.1    Prakash, C.2
  • 106
    • 85056512155 scopus 로고    scopus 로고
    • Q Trap MS: A New Tool for Metabolite Identification
    • (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, FL
    • Hopfgartner, G., and Zell, M. (2005). Q Trap MS: A New Tool for Metabolite Identification. (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, FL, pp. 277-304.
    • (2005) , pp. 277-304
    • Hopfgartner, G.1    Zell, M.2
  • 107
    • 84889498247 scopus 로고    scopus 로고
    • A statistical based approach in metabolite identification by high mass accuracy MSn analysis
    • In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN
    • Hopfgartner, G., Sleno, L., Loftus, N.,Warrander, J., and Ashton, S. (2007). A statistical based approach in metabolite identification by high mass accuracy MSn analysis. In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN.
    • (2007)
    • Hopfgartner, G.1    Sleno, L.2    Loftus, N.3    Warrander, J.4    Ashton, S.5
  • 108
    • 0034446117 scopus 로고    scopus 로고
    • The impact of accurate mass measurements using quadrupole/time-of-flight mass spectrometry on the characterisation and screening of drug metabolites: Structure elucidation by LC-MS
    • Hopfgartner, G., and Vilbois, F. (2000). The impact of accurate mass measurements using quadrupole/time-of-flight mass spectrometry on the characterisation and screening of drug metabolites: Structure elucidation by LC-MS. Analusis 28:906-914.
    • (2000) Analusis , vol.28 , pp. 906-914
    • Hopfgartner, G.1    Vilbois, F.2
  • 110
    • 75249091983 scopus 로고    scopus 로고
    • APPI: A New Ionization Source for LC-MS/MS Assays
    • (Korfmacher, W. A., Ed.) CRC Press, Boca Raton, FL
    • Hsieh, Y. (2005). APPI: A New Ionization Source for LC-MS/MS Assays. (Korfmacher, W. A., Ed.) CRC Press, Boca Raton, FL, pp. 253-276.
    • (2005) , pp. 253-276
    • Hsieh, Y.1
  • 111
    • 27544432708 scopus 로고    scopus 로고
    • Simultaneous determination of nicotinic acid and its metabolites using hydrophilic interaction chromatography with tandem mass spectrometry
    • Hsieh, Y., and Chen, J. (2005). Simultaneous determination of nicotinic acid and its metabolites using hydrophilic interaction chromatography with tandem mass spectrometry. Rapid Commun. Mass Spectrom. 19:3031-3036.
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , pp. 3031-3036
    • Hsieh, Y.1    Chen, J.2
  • 113
    • 33745752978 scopus 로고    scopus 로고
    • Increasing speed and throughput when using HPLCMS/MS systems for drug metabolism and pharmacokinetic screening
    • Hsieh, Y., and Korfmacher,W. A. (2006). Increasing speed and throughput when using HPLCMS/MS systems for drug metabolism and pharmacokinetic screening. Curr. Drug Metab. 7:479-489.
    • (2006) Curr. Drug Metab. , vol.7 , pp. 479-489
    • Hsieh, Y.1    Korfmacher, W.A.2
  • 114
    • 0036012891 scopus 로고    scopus 로고
    • Simultaneous determination of a drug candidate and its metabolite in rat plasma samples using ultrafast monolithic column high-performance liquid chromatography/tandem mass spectrometry
    • Hsieh, Y., Wang, G., Wang, Y., Chackalamannil, S., Brisson, J. M., Ng, K., and Korfmacher, W. A. (2002). Simultaneous determination of a drug candidate and its metabolite in rat plasma samples using ultrafast monolithic column high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 16:944-950.
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , pp. 944-950
    • Hsieh, Y.1    Wang, G.2    Wang, Y.3    Chackalamannil, S.4    Brisson, J.M.5    Ng, K.6    Korfmacher, W.A.7
  • 115
    • 0037446554 scopus 로고    scopus 로고
    • Direct plasma analysis of drug compounds using monolithic column liquid chromatography and tandem mass spectrometry
    • Hsieh, Y., Wang, G., Wang, Y., Chackalamannil, S., and Korfmacher, W. A. (2003). Direct plasma analysis of drug compounds using monolithic column liquid chromatography and tandem mass spectrometry. Anal. Chem. 75:1812-1818.
    • (2003) Anal. Chem. , vol.75 , pp. 1812-1818
    • Hsieh, Y.1    Wang, G.2    Wang, Y.3    Chackalamannil, S.4    Korfmacher, W.A.5
  • 117
    • 1042264121 scopus 로고    scopus 로고
    • Impact of solid state properties on developability assessment of drug candidates
    • Huang, L. F., and Tong,W. Q. (2004). Impact of solid state properties on developability assessment of drug candidates. Adv. Drug Deliv. Rev. 56:321-334.
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 321-334
    • Huang, L.F.1    Tong, W.Q.2
  • 118
    • 33646913874 scopus 로고    scopus 로고
    • Increased productivity in quantitative bioanalysis using a monolithic column coupled with high-flow direct-injection liquid chromatography/tandem mass spectrometry
    • Huang, M. Q., Mao, Y., Jemal, M., and Arnold, M. (2006). Increased productivity in quantitative bioanalysis using a monolithic column coupled with high-flow direct-injection liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 20:1709-1714.
    • (2006) Rapid Commun. Mass Spectrom. , vol.20 , pp. 1709-1714
    • Huang, M.Q.1    Mao, Y.2    Jemal, M.3    Arnold, M.4
  • 119
    • 0041698335 scopus 로고    scopus 로고
    • Highsensitivity quantitation of cabergoline and pergolide using a triple-quadrupole mass spectrometer with enhanced mass-resolution capabilities
    • Hughes, N., Winnik, W., Dunyach, J. J., Amad, M., Splendore, M., and Paul, G. (2003). Highsensitivity quantitation of cabergoline and pergolide using a triple-quadrupole mass spectrometer with enhanced mass-resolution capabilities. J. Mass Spectrom. 38:743-751.
    • (2003) J. Mass Spectrom. , vol.38 , pp. 743-751
    • Hughes, N.1    Winnik, W.2    Dunyach, J.J.3    Amad, M.4    Splendore, M.5    Paul, G.6
  • 120
    • 84889329030 scopus 로고    scopus 로고
    • Structure elucidation of Sildanafil analogues by MSn and accurate mass measurement
    • In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN
    • Inohana, Y., Hirano, I., Yamaguchi, S., Arakawa, K., Ashton, S., Loftus, N., and Warrander, J. (2007). Structure elucidation of Sildanafil analogues by MSn and accurate mass measurement. In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN.
    • (2007)
    • Inohana, Y.1    Hirano, I.2    Yamaguchi, S.3    Arakawa, K.4    Ashton, S.5    Loftus, N.6    Warrander, J.7
  • 121
    • 0031037573 scopus 로고    scopus 로고
    • Induction of two UDP-glucuronosyltransferase isoforms sensitive to phenobarbital that are involved in morphine glucuronidation. Production of isoform-selective antipeptide antibodies toward UGT1.1r and UGT2B1
    • Ishii, Y., Takami, A., Tsuruda, K., Kurogi, A., Yamada, H., and Oguri, K. (1997). Induction of two UDP-glucuronosyltransferase isoforms sensitive to phenobarbital that are involved in morphine glucuronidation. Production of isoform-selective antipeptide antibodies toward UGT1.1r and UGT2B1. Drug Metab. Dispos. 25:163-167.
    • (1997) Drug Metab. Dispos. , vol.25 , pp. 163-167
    • Ishii, Y.1    Takami, A.2    Tsuruda, K.3    Kurogi, A.4    Yamada, H.5    Oguri, K.6
  • 122
    • 0034654137 scopus 로고    scopus 로고
    • Performance of a monolithic silica column in a capillary under pressure-driven and electrodriven conditions
    • Ishizuka, N., Minakuchi, H., Nakanishi, K., Soga, N., Nagayama, H., Hosoya, K., and Tanaka, N. (2000). Performance of a monolithic silica column in a capillary under pressure-driven and electrodriven conditions. Anal. Chem. 72:1275-1280.
    • (2000) Anal. Chem. , vol.72 , pp. 1275-1280
    • Ishizuka, N.1    Minakuchi, H.2    Nakanishi, K.3    Soga, N.4    Nagayama, H.5    Hosoya, K.6    Tanaka, N.7
  • 123
    • 84889443795 scopus 로고    scopus 로고
    • Speed up of the identification of the metabolites of Citalopram using LC/MS/MS and in silico prediction
    • In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN
    • Ives, S., Gjervig-Jensen, K., and McSweeney, N. (2007). Speed up of the identification of the metabolites of Citalopram using LC/MS/MS and in silico prediction. In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN.
    • (2007)
    • Ives, S.1    Gjervig-Jensen, K.2    McSweeney, N.3
  • 124
    • 0034880597 scopus 로고    scopus 로고
    • Pharmacokinetics and its role in small molecule drug discovery research
    • Jang, G. R., Harris, R. Z., and Lau, D. T. (2001). Pharmacokinetics and its role in small molecule drug discovery research. Med. Res. Rev. 21:382-396.
    • (2001) Med. Res. Rev. , vol.21 , pp. 382-396
    • Jang, G.R.1    Harris, R.Z.2    Lau, D.T.3
  • 125
    • 0034962065 scopus 로고    scopus 로고
    • Increased throughput in quantitative bioanalysis using parallel-column liquid chromatography with mass spectrometric detection
    • Jemal, M., Huang, M., Mao, Y., Whigan, D., and Powell, M. L. (2001). Increased throughput in quantitative bioanalysis using parallel-column liquid chromatography with mass spectrometric detection. Rapid Commun. Mass Spectrom. 15:994-999.
    • (2001) Rapid Commun. Mass Spectrom. , vol.15 , pp. 994-999
    • Jemal, M.1    Huang, M.2    Mao, Y.3    Whigan, D.4    Powell, M.L.5
  • 126
    • 0037216382 scopus 로고    scopus 로고
    • Enhanced resolution triple-quadrupole mass spectrometry for fast quantitative bioanalysis using liquid chromatography/tandem mass spectrometry:Investigations of parameters that affect ruggedness
    • Jemal, M., and Ouyang, Z. (2003). Enhanced resolution triple-quadrupole mass spectrometry for fast quantitative bioanalysis using liquid chromatography/tandem mass spectrometry:Investigations of parameters that affect ruggedness. Rapid Commun. Mass Spectrom. 17:24-38.
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 24-38
    • Jemal, M.1    Ouyang, Z.2
  • 127
    • 0043270582 scopus 로고    scopus 로고
    • Liquid chromatography/tandem mass spectrometry methods for quantitation of mevalonic acid in human plasma and urine:Method validation, demonstration of using a surrogate analyte, and demonstration of unacceptable matrix effect in spite of use of a stable isotope analog internal standard
    • Jemal, M., Schuster, A., and Whigan, D. B. (2003). Liquid chromatography/tandem mass spectrometry methods for quantitation of mevalonic acid in human plasma and urine:Method validation, demonstration of using a surrogate analyte, and demonstration of unacceptable matrix effect in spite of use of a stable isotope analog internal standard. Rapid Commun. Mass Spectrom. 17:1723-1734.
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 1723-1734
    • Jemal, M.1    Schuster, A.2    Whigan, D.B.3
  • 128
    • 33745744213 scopus 로고    scopus 로고
    • LC-MS development strategies for quantitative bioanalysis
    • Jemal, M., and Xia, Y. Q. (2006). LC-MS development strategies for quantitative bioanalysis. Curr. Drug. Metab. 7:491-502.
    • (2006) Curr. Drug. Metab. , vol.7 , pp. 491-502
    • Jemal, M.1    Xia, Y.Q.2
  • 129
    • 20044374914 scopus 로고    scopus 로고
    • The use of ACQUITY UPLC in pharmaceutical development
    • Jerkovich, A. D., LoBrutto, R., and Vivilecchia, R. V. (2005). The use of ACQUITY UPLC in pharmaceutical development. LCGC N. Am.15-21.
    • (2005) LCGC N. Am. , pp. 15-21
    • Jerkovich, A.D.1    LoBrutto, R.2    Vivilecchia, R.V.3
  • 130
    • 33847375985 scopus 로고    scopus 로고
    • Mitochondrial DNA mutation detection by electrospray mass spectrometry
    • Jiang, Y., Hall, T. A., Hofstadler, S. A., and Naviaux, R. K. (2007). Mitochondrial DNA mutation detection by electrospray mass spectrometry. Clin. Chem. 53:195-203.
    • (2007) Clin. Chem. , vol.53 , pp. 195-203
    • Jiang, Y.1    Hall, T.A.2    Hofstadler, S.A.3    Naviaux, R.K.4
  • 131
    • 33745741783 scopus 로고    scopus 로고
    • Bioanalytical quality assurance: Concepts and concerns
    • Jones, A. B. (2006). Bioanalytical quality assurance: Concepts and concerns. Quality Assur. J. 10:101-106.
    • (2006) Quality Assur. J. , vol.10 , pp. 101-106
    • Jones, A.B.1
  • 132
    • 38949100528 scopus 로고    scopus 로고
    • Cytochrome P450 inactivation by pharmaceuticals and phytochemicals:Therapeutic relevance
    • Johnson, W. W. (2008a). Cytochrome P450 inactivation by pharmaceuticals and phytochemicals:Therapeutic relevance. Drug Metab. Rev. 40:101-147.
    • (2008) Drug Metab. Rev. , vol.40 , pp. 101-147
    • Johnson, W.W.1
  • 133
    • 45249088967 scopus 로고    scopus 로고
    • Many drugs and phytochemicals can be activated to biological reactive intermediates
    • Johnson, W. W. (2008b). Many drugs and phytochemicals can be activated to biological reactive intermediates. Curr. Drug Metab. 9:344-351.
    • (2008) Curr. Drug Metab. , vol.9 , pp. 344-351
    • Johnson, W.W.1
  • 134
    • 17244375700 scopus 로고    scopus 로고
    • The use of liquid chromatography-atmospheric pressure chemical ionization mass spectrometry to explore the in vitro metabolism of cyanoalkyl piperidine derivatives
    • Kantharaj, E., Ehmer, P. B., De Wagter, K., Tuytelaars, A., Proost, P. E., Mackie, C., and Gilissen, R. A. (2005a). The use of liquid chromatography-atmospheric pressure chemical ionization mass spectrometry to explore the in vitro metabolism of cyanoalkyl piperidine derivatives. Biomed. Chromatogr. 19:245-249.
    • (2005) Biomed. Chromatogr. , vol.19 , pp. 245-249
    • Kantharaj, E.1    Ehmer, P.B.2    De Wagter, K.3    Tuytelaars, A.4    Proost, P.E.5    Mackie, C.6    Gilissen, R.A.7
  • 135
    • 17844373870 scopus 로고    scopus 로고
    • Simultaneous measurement of metabolic stability and metabolite identification of 7-methoxymethylthiazolo[3,2-a]pyrimidin-5-one derivatives in human liver microsomes using liquid chromatography/ion-trap mass spectrometry
    • Kantharaj, E., Ehmer, P. B., Tuytelaars, A., Van Vlaslaer, A., Mackie, C., and Gilissen, R. A. (2005b). Simultaneous measurement of metabolic stability and metabolite identification of 7-methoxymethylthiazolo[3,2-a]pyrimidin-5-one derivatives in human liver microsomes using liquid chromatography/ion-trap mass spectrometry. Rapid Commun. Mass Spectrom. 19:1069-1074.
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , pp. 1069-1074
    • Kantharaj, E.1    Ehmer, P.B.2    Tuytelaars, A.3    Van Vlaslaer, A.4    Mackie, C.5    Gilissen, R.A.6
  • 136
    • 0344233243 scopus 로고    scopus 로고
    • Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry
    • Kantharaj, E., Tuytelaars, A., Proost, P. E., Ongel, Z., Van Assouw, H. P., and Gilissen, R. A. (2003). Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry. Rapid Commun. Mass Spectrom. 17:2661-2668.
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 2661-2668
    • Kantharaj, E.1    Tuytelaars, A.2    Proost, P.E.3    Ongel, Z.4    Van Assouw, H.P.5    Gilissen, R.A.6
  • 137
    • 22744437139 scopus 로고    scopus 로고
    • Removal of metabolite interference during liquid chromatography/tandem mass spectrometry using high-field asymmetric waveform ion mobility spectrometry
    • Kapron, J. T., Jemal, M., Duncan, G. F., Kolakowski, B. M., and Purves, R. (2005). Removal of metabolite interference during liquid chromatography/tandem mass spectrometry using high-field asymmetric waveform ion mobility spectrometry. Rapid Commun. Mass Spectrom. 19:1979-1983.
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , pp. 1979-1983
    • Kapron, J.T.1    Jemal, M.2    Duncan, G.F.3    Kolakowski, B.M.4    Purves, R.5
  • 138
    • 2942525302 scopus 로고    scopus 로고
    • Applications of high-throughput ADME in drug discovery
    • Kassel, D. B. (2004). Applications of high-throughput ADME in drug discovery. Curr. Opin. Chem. Biol. 8:339-345.
    • (2004) Curr. Opin. Chem. Biol. , vol.8 , pp. 339-345
    • Kassel, D.B.1
  • 139
    • 85056533764 scopus 로고    scopus 로고
    • High throughput strategies for in vitro ADME assays: How fast we go?
    • In Using Mass Spectrometry for Drug Metabolism Studies (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, FL
    • Kassel, D. B. (2005). High throughput strategies for in vitro ADME assays: How fast we go?. In Using Mass Spectrometry for Drug Metabolism Studies (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, FL, pp. 83-102.
    • (2005) , pp. 83-102
    • Kassel, D.B.1
  • 141
    • 0033926938 scopus 로고    scopus 로고
    • A brief overview of the present status of the mechanisms involved in electrospray mass spectrometry
    • Kebarle, P. (2000). A brief overview of the present status of the mechanisms involved in electrospray mass spectrometry. J. Mass Spectrom. 35:804-817.
    • (2000) J. Mass Spectrom. , vol.35 , pp. 804-817
    • Kebarle, P.1
  • 142
    • 0035150465 scopus 로고    scopus 로고
    • High throughput physicochemical profiling for drug discovery
    • Kerns, E. H. (2001). High throughput physicochemical profiling for drug discovery. J. Pharm. Sci. 90:1838-1858.
    • (2001) J. Pharm. Sci. , vol.90 , pp. 1838-1858
    • Kerns, E.H.1
  • 143
    • 84889489384 scopus 로고    scopus 로고
    • Quadrupole mass analyzers: Theoretical and practical considerations
    • In Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, Part 3: Proteomics. Wiley, Hoboken, NJ
    • Kero, F. H., Pedder, R. E., and Yost, R. A. (2005). Quadrupole mass analyzers: Theoretical and practical considerations. In Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, Part 3: Proteomics. Wiley, Hoboken, NJ.
    • (2005)
    • Kero, F.H.1    Pedder, R.E.2    Yost, R.A.3
  • 144
    • 50649109649 scopus 로고    scopus 로고
    • Improved imaging resolution in desorption electrospray ionization mass spectrometry
    • Kertesz, V., and Van Berkel, G. J. (2008). Improved imaging resolution in desorption electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrom. 22:2639-2644.
    • (2008) Rapid Commun. Mass Spectrom. , vol.22 , pp. 2639-2644
    • Kertesz, V.1    Van Berkel, G.J.2
  • 145
    • 33646754900 scopus 로고    scopus 로고
    • Metabolomic database annotations via query of elemental compositions:Mass accuracy is insufficient even at less than 1 ppm
    • Kind, T., and Fiehn, O. (2006). Metabolomic database annotations via query of elemental compositions:Mass accuracy is insufficient even at less than 1 ppm. BMC Bioinformatics 7.
    • (2006) BMC Bioinformatics , pp. 7
    • Kind, T.1    Fiehn, O.2
  • 146
    • 33947216093 scopus 로고    scopus 로고
    • A comprehensive urinary metabolomic approach for identifying kidney cancerr
    • Kind, T., Tolstikov, V., Fiehn, O., and Weiss, R. H. (2007). A comprehensive urinary metabolomic approach for identifying kidney cancerr. Anal. Biochem. 363:185-195.
    • (2007) Anal. Biochem. , vol.363 , pp. 185-195
    • Kind, T.1    Tolstikov, V.2    Fiehn, O.3    Weiss, R.H.4
  • 147
    • 0036006588 scopus 로고    scopus 로고
    • Description and validation of a staggered parallel high performance liquid chromatography system for good laboratory practice level quantitative analysis by liquid chromatography/tandem mass spectrometry
    • King, R. C., Miller-Stein, C., Magiera, D. J., and Brann, J. (2002). Description and validation of a staggered parallel high performance liquid chromatography system for good laboratory practice level quantitative analysis by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 16:43-52.
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , pp. 43-52
    • King, R.C.1    Miller-Stein, C.2    Magiera, D.J.3    Brann, J.4
  • 149
    • 0242354924 scopus 로고    scopus 로고
    • Collection of selected reaction monitoring and full scan data on a time scale suitable for target compound quantitative analysis by liquid chromatography/tandem mass spectrometry
    • King, R. C., Gundersdorf, R., and Fernandez-Metzler, C. L. (2003). Collection of selected reaction monitoring and full scan data on a time scale suitable for target compound quantitative analysis by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 17:2413-2422.
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 2413-2422
    • King, R.C.1    Gundersdorf, R.2    Fernandez-Metzler, C.L.3
  • 150
    • 33644826088 scopus 로고    scopus 로고
    • Direct and fast determination of antiretroviral drugs by automated online solid-phase extraction-liquid chromatography-tandem mass spectrometry in human plasma
    • Koal, T., Sibum, M., Koster, E., Resch, K., and Kaever, V. (2006). Direct and fast determination of antiretroviral drugs by automated online solid-phase extraction-liquid chromatography-tandem mass spectrometry in human plasma. Clin. Chem. Lab. Med. 44:299-305.
    • (2006) Clin. Chem. Lab. Med. , vol.44 , pp. 299-305
    • Koal, T.1    Sibum, M.2    Koster, E.3    Resch, K.4    Kaever, V.5
  • 151
    • 0033988596 scopus 로고    scopus 로고
    • Physicochemical properties and bioavailability of carbamazepine polymorphs and dihydrate
    • Kobayashi, Y., Ito, S., Itai, S., and Yamamoto, K. (2000). Physicochemical properties and bioavailability of carbamazepine polymorphs and dihydrate. Int. J. Pharm. 193:137-146.
    • (2000) Int. J. Pharm. , vol.193 , pp. 137-146
    • Kobayashi, Y.1    Ito, S.2    Itai, S.3    Yamamoto, K.4
  • 152
    • 84889319138 scopus 로고    scopus 로고
    • Selected ion monitoring (SIM) mode data collection using the laser diode thermal desorption (LDTD) source to increase sensitivity
    • In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO
    • Koers, J. M. (2008). Selected ion monitoring (SIM) mode data collection using the laser diode thermal desorption (LDTD) source to increase sensitivity. In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO.
    • (2008)
    • Koers, J.M.1
  • 153
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola, I., and Landis, J. (2004). Can the pharmaceutical industry reduce attrition rates? Nature Rev. 3:711-715.
    • (2004) Nature Rev. , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 154
    • 84889334163 scopus 로고    scopus 로고
    • Separation and quantitation of caffeine metabolites by high-field asymmetric waveform ion mobility spectrometry (FAIMS)
    • In Proceedings of the 52nd ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Nashville, TN
    • Kolakowski, B. M., Lustig, D., and Purves, R. W. (2004). Separation and quantitation of caffeine metabolites by high-field asymmetric waveform ion mobility spectrometry (FAIMS). In Proceedings of the 52nd ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Nashville, TN.
    • (2004)
    • Kolakowski, B.M.1    Lustig, D.2    Purves, R.W.3
  • 155
    • 15744388954 scopus 로고    scopus 로고
    • Target identification and validation in drug discovery: The role of proteomics
    • Kopec, K. K., Bozyczko-Coyne, D., and Williams, M. (2005). Target identification and validation in drug discovery: The role of proteomics. Biochem. Pharmacol. 69:1133-1139.
    • (2005) Biochem. Pharmacol. , vol.69 , pp. 1133-1139
    • Kopec, K.K.1    Bozyczko-Coyne, D.2    Williams, M.3
  • 156
    • 84889321838 scopus 로고    scopus 로고
    • The proteomics toolbox-A review of the newest drug discovery methods
    • Business Briefing: Future Drug Discovery. Touch Briefings, London, UK
    • Köpke, A. (2006). The proteomics toolbox-A review of the newest drug discovery methods. Business Briefing: Future Drug Discovery. Touch Briefings, London, UK.
    • (2006)
    • Köpke, A.1
  • 157
    • 85056517731 scopus 로고    scopus 로고
    • Bioanalytical assays in a drug discovery environment
    • In Using Mass Spectrometry for Drug Metabolism Studies (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, FL
    • Korfmacher, W. A. (2005). Bioanalytical assays in a drug discovery environment. In Using Mass Spectrometry for Drug Metabolism Studies (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, FL, pp. 1-34.
    • (2005) , pp. 1-34
    • Korfmacher, W.A.1
  • 158
    • 0035100437 scopus 로고    scopus 로고
    • Cassette-accelerated rapid rat screen:A systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery
    • Korfmacher, W. A., Cox, K. A., Ng, K. J., Veals, J., Hsieh, Y., Wainhaus, S., Broske, L., Prelusky, D., Nomeir, A., and White, R. E. (2001). Cassette-accelerated rapid rat screen:A systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery. Rapid Commun. Mass Spectrom. 15:335-340.
    • (2001) Rapid Commun. Mass Spectrom. , vol.15 , pp. 335-340
    • Korfmacher, W.A.1    Cox, K.A.2    Ng, K.J.3    Veals, J.4    Hsieh, Y.5    Wainhaus, S.6    Broske, L.7    Prelusky, D.8    Nomeir, A.9    White, R.E.10
  • 160
    • 24144479453 scopus 로고    scopus 로고
    • On-line solid phase extraction using the Prospekt-2 coupled with a liquid chromatography/tandem mass spectrometer for the determination of dextromethorphan, dextrorphan and guaifenesin in human plasma
    • Kuhlenbeck, D. L., Eichold, T. H., Hoke, S. H., 2nd, Baker, T. R., Mensen, R., andWehmeyer, K. R. (2005). On-line solid phase extraction using the Prospekt-2 coupled with a liquid chromatography/tandem mass spectrometer for the determination of dextromethorphan, dextrorphan and guaifenesin in human plasma. Eur. J. Mass Spectrom. (Chichester, Engl.) 11:199-208.
    • (2005) Eur. J. Mass Spectrom. (Chichester, Engl.) , vol.11 , pp. 199-208
    • Kuhlenbeck, D.L.1    Eichold, T.H.2    Hoke, S.H.3    Baker, T.R.4    Mensen, R.5    Wehmeyer, K.R.6
  • 161
    • 41149135497 scopus 로고    scopus 로고
    • Inhibition of poly (ADP-ribose) polymerase (PARP) by ABT-888 in patients with advanced malignancies: Results of a phase 0 trial
    • In American Society of Clinical Oncology Meeting. Chicago, IL
    • Kummar, S., Kinder, R., Gutierrez, M., Rubinstein, L., Parchment, R., Phillips, L., Low, J., Murgo, A., Tomaszewski, J., and Doroshow, J. (2007). Inhibition of poly (ADP-ribose) polymerase (PARP) by ABT-888 in patients with advanced malignancies: Results of a phase 0 trial. In American Society of Clinical Oncology Meeting. Chicago, IL.
    • (2007)
    • Kummar, S.1    Kinder, R.2    Gutierrez, M.3    Rubinstein, L.4    Parchment, R.5    Phillips, L.6    Low, J.7    Murgo, A.8    Tomaszewski, J.9    Doroshow, J.10
  • 162
    • 84889442792 scopus 로고
    • Method and apparatus for the mass spectrometric analysis of solutions
    • Labowsky, M. J., Fenn, J. B., and Yamashita, M. (1984). Method and apparatus for the mass spectrometric analysis of solutions. US patent 84-302751.
    • (1984) US patent , pp. 84-302751
    • Labowsky, M.J.1    Fenn, J.B.2    Yamashita, M.3
  • 163
    • 33748361948 scopus 로고    scopus 로고
    • The use of accelerator mass spectrometry to obtain early human ADME/PK data
    • Lappin, G., and Garner, R. C. (2005). The use of accelerator mass spectrometry to obtain early human ADME/PK data. Expert Opin. Drug Metab. Toxicol. 1:23-31.
    • (2005) Expert Opin. Drug Metab. Toxicol. , vol.1 , pp. 23-31
    • Lappin, G.1    Garner, R.C.2
  • 164
    • 0036570099 scopus 로고    scopus 로고
    • Timing of new black box warnings and withdrawals for prescription medications
    • Lasser, K. E., Allen, P. D., Woolhandler, S. J., Himmelstein, D. U., Wolfe, S. M., and Bor, D. H. (2002). Timing of new black box warnings and withdrawals for prescription medications. JAMA 287:2215-2220.
    • (2002) JAMA , vol.287 , pp. 2215-2220
    • Lasser, K.E.1    Allen, P.D.2    Woolhandler, S.J.3    Himmelstein, D.U.4    Wolfe, S.M.5    Bor, D.H.6
  • 165
    • 84889396660 scopus 로고    scopus 로고
    • Microdosing study in rat plasma using high sensitive LC-ESI/MS/MS technique
    • In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN
    • Lebre, D. T., Aiello, M., Impey, G., and Bonelli, F. (2007). Microdosing study in rat plasma using high sensitive LC-ESI/MS/MS technique. In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN.
    • (2007)
    • Lebre, D.T.1    Aiello, M.2    Impey, G.3    Bonelli, F.4
  • 166
    • 84889388344 scopus 로고    scopus 로고
    • Integrated Strategies for Drug Discovery Using Mass Spectrometry
    • Wiley, Hoboken, NJ
    • Lee, M. S. (2005). Integrated Strategies for Drug Discovery Using Mass Spectrometry. Wiley, Hoboken, NJ.
    • (2005)
    • Lee, M.S.1
  • 167
    • 0036009118 scopus 로고    scopus 로고
    • Ion dispersion near parallel wire grids in orthogonal acceleration time-of-flight mass spectrometry:Predicting the effect of the approach angle on resolution
    • Lewin, M., Guilhaus, M., Wildgoose, J., Hoyes, J., and Bateman, B. (2002). Ion dispersion near parallel wire grids in orthogonal acceleration time-of-flight mass spectrometry:Predicting the effect of the approach angle on resolution. Rapid Commun. Mass Spectrom. 16:609-615.
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , pp. 609-615
    • Lewin, M.1    Guilhaus, M.2    Wildgoose, J.3    Hoyes, J.4    Bateman, B.5
  • 168
    • 26444437824 scopus 로고    scopus 로고
    • Increase of the LC-MS/MS sensitivity and detection limits using on-line sample preparation with large volume plasma injection
    • Li, M., Alnouti, Y., Leverence, R., Bi, H., and Gusev, A. I. (2005a). Increase of the LC-MS/MS sensitivity and detection limits using on-line sample preparation with large volume plasma injection. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 825:152-160.
    • (2005) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.825 , pp. 152-160
    • Li, M.1    Alnouti, Y.2    Leverence, R.3    Bi, H.4    Gusev, A.I.5
  • 169
    • 22744441263 scopus 로고    scopus 로고
    • Rapid Commun. Mass Spectrom.
    • Li, et al. (2005b). Rapid Commun. Mass Spectrom. 19:1943-1950.
    • (2005) , vol.19 , pp. 1943-1950
    • Li1
  • 170
    • 0033051101 scopus 로고    scopus 로고
    • Direct analysis of protein complexes using mass spectrometry
    • Link, A. J. (1999). Direct analysis of protein complexes using mass spectrometry. Nat. Biotechnol. 17:676-682.
    • (1999) Nat. Biotechnol. , vol.17 , pp. 676-682
    • Link, A.J.1
  • 171
    • 0002720633 scopus 로고    scopus 로고
    • How can we optimize selection of drug development candidates from many compounds at the discovery stage?
    • Lipper, R. A. (1999). How can we optimize selection of drug development candidates from many compounds at the discovery stage? Modern Drug Discov. 2:55.
    • (1999) Modern Drug Discov. , vol.2 , pp. 55
    • Lipper, R.A.1
  • 172
    • 84889442782 scopus 로고    scopus 로고
    • Optimized high resolution SRM quantitative analysis using a calibration correction method on triple quadrupole system
    • In Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Seattle, WA
    • Liu, Y. M., Akervik, K., and Maljers, L. (2006). Optimized high resolution SRM quantitative analysis using a calibration correction method on triple quadrupole system. In Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Seattle, WA.
    • (2006)
    • Liu, Y.M.1    Akervik, K.2    Maljers, L.3
  • 173
    • 33745758232 scopus 로고    scopus 로고
    • Application of mass spectrometry for metabolite identification
    • Ma, S., Chowdhury, S. K., and Alton, K. B. (2006). Application of mass spectrometry for metabolite identification. Curr. Drug. Metab. 7:503-523.
    • (2006) Curr. Drug. Metab. , vol.7 , pp. 503-523
    • Ma, S.1    Chowdhury, S.K.2    Alton, K.B.3
  • 174
    • 33749009806 scopus 로고    scopus 로고
    • Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry
    • Ma, S., and Subramanian, R. (2006). Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry. J. Mass Spectrom. 41:1121-1139.
    • (2006) J. Mass Spectrom. , vol.41 , pp. 1121-1139
    • Ma, S.1    Subramanian, R.2
  • 175
    • 0037122748 scopus 로고    scopus 로고
    • Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates
    • Mandagere, A. K., Thompson, T. N., and Hwang, K. K. (2002). Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates. J. Med. Chem. 45:304-311.
    • (2002) J. Med. Chem. , vol.45 , pp. 304-311
    • Mandagere, A.K.1    Thompson, T.N.2    Hwang, K.K.3
  • 176
    • 0030999705 scopus 로고    scopus 로고
    • An introduction to quadrupole ion trap mass spectrometery
    • March, R. E. (1997). An introduction to quadrupole ion trap mass spectrometery. J. Mass Spectrom. 32:351-369.
    • (1997) J. Mass Spectrom. , vol.32 , pp. 351-369
    • March, R.E.1
  • 177
    • 0031623267 scopus 로고    scopus 로고
    • Fourier transform ion cyclotron resonance mass spectrometry: A primer
    • Marshall, A. G., Hendrickson, C. L., and Jackson, G. S. (1998). Fourier transform ion cyclotron resonance mass spectrometry: A primer. Mass Spectrom. Rev. 17:1-35.
    • (1998) Mass Spectrom. Rev. , vol.17 , pp. 1-35
    • Marshall, A.G.1    Hendrickson, C.L.2    Jackson, G.S.3
  • 178
    • 23944464010 scopus 로고    scopus 로고
    • Effects of high pressure in liquid chromatography
    • Martin, M., and Guiochon, G. (2005). Effects of high pressure in liquid chromatography. J. Chromatogr. A 1090:16-38.
    • (2005) J. Chromatogr. A , vol.1090 , pp. 16-38
    • Martin, M.1    Guiochon, G.2
  • 179
    • 0036000312 scopus 로고    scopus 로고
    • A mechanistic approach to understanding the factors affecting drug absorption: A review of fundamentals
    • Martinez, M. N., and Amidon, G. L. (2002). A mechanistic approach to understanding the factors affecting drug absorption: A review of fundamentals. J. Clin. Pharmacol. 42:620-643.
    • (2002) J. Clin. Pharmacol. , vol.42 , pp. 620-643
    • Martinez, M.N.1    Amidon, G.L.2
  • 180
    • 30444448196 scopus 로고    scopus 로고
    • Standard line slopes as a measure of a relative matrix effect in quantitative HPLC-MS bioanalysis
    • Matuszewski, B. K. (2006). Standard line slopes as a measure of a relative matrix effect in quantitative HPLC-MS bioanalysis. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 830:293-300.
    • (2006) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.830 , pp. 293-300
    • Matuszewski, B.K.1
  • 181
    • 0032011562 scopus 로고    scopus 로고
    • Matrix effect in quantitative LC/MS/MS analyses of biological fluids: A method for determination of finasteride in human plasma at picogram per milliliter concentrations
    • Matuszewski, B. K., Constanzer, M. L., and Chavez-Eng, C. M. (1998). Matrix effect in quantitative LC/MS/MS analyses of biological fluids: A method for determination of finasteride in human plasma at picogram per milliliter concentrations. Anal. Chem. 70:882-889.
    • (1998) Anal. Chem. , vol.70 , pp. 882-889
    • Matuszewski, B.K.1    Constanzer, M.L.2    Chavez-Eng, C.M.3
  • 182
    • 0037663202 scopus 로고    scopus 로고
    • Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS
    • Matuszewski, B. K., Constanzer, M. L., and Chavez-Eng, C. M. (2003). Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal. Chem. 75:3019-3030.
    • (2003) Anal. Chem. , vol.75 , pp. 3019-3030
    • Matuszewski, B.K.1    Constanzer, M.L.2    Chavez-Eng, C.M.3
  • 183
    • 34547294263 scopus 로고    scopus 로고
    • Current role of liquid chromatography-mass spectrometry in clinical and forensic toxicology
    • Maurer, H. H. (2007). Current role of liquid chromatography-mass spectrometry in clinical and forensic toxicology. Anal. Bioanal. Chem. 388:1315-1325.
    • (2007) Anal. Bioanal. Chem. , vol.388 , pp. 1315-1325
    • Maurer, H.H.1
  • 184
    • 0037602130 scopus 로고    scopus 로고
    • Separation and quantitation of the stereoisomers of ephedra alkaloids in natural health products using flow injection-electrospray ionization-high field asymmetric waveform ion mobility spectrometry-mass spectrometry
    • McCooeye, M., Ding, L., Gardner, G. J., Fraser, C. A., Lam, J., Sturgeon, R. E., and Mester, Z. (2003). Separation and quantitation of the stereoisomers of ephedra alkaloids in natural health products using flow injection-electrospray ionization-high field asymmetric waveform ion mobility spectrometry-mass spectrometry. Anal. Chem. 75:2538-2542.
    • (2003) Anal. Chem. , vol.75 , pp. 2538-2542
    • McCooeye, M.1    Ding, L.2    Gardner, G.J.3    Fraser, C.A.4    Lam, J.5    Sturgeon, R.E.6    Mester, Z.7
  • 185
    • 33646927291 scopus 로고    scopus 로고
    • Comparison of flow injection analysis electrospray mass spectrometry and tandem mass spectrometry and electrospray high-field asymmetric waveform ion mobility mass spectrometry and tandem mass spectrometry for the determination of underivatized amino acids
    • McCooeye, M., and Mester, Z. (2006). Comparison of flow injection analysis electrospray mass spectrometry and tandem mass spectrometry and electrospray high-field asymmetric waveform ion mobility mass spectrometry and tandem mass spectrometry for the determination of underivatized amino acids. Rapid Commun. Mass Spectrom. 20:1801-1808.
    • (2006) Rapid Commun. Mass Spectrom. , vol.20 , pp. 1801-1808
    • McCooeye, M.1    Mester, Z.2
  • 186
    • 0035096864 scopus 로고    scopus 로고
    • Quantitation of morphine and codeine in human urine using high-field asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection
    • McCooeye, M. A., Ells, B., Barnett, D. A., Purves, R. W., and Guevremont, R. (2001). Quantitation of morphine and codeine in human urine using high-field asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection. J. Anal. Toxicol. 25:81-87.
    • (2001) J. Anal. Toxicol. , vol.25 , pp. 81-87
    • McCooeye, M.A.1    Ells, B.2    Barnett, D.A.3    Purves, R.W.4    Guevremont, R.5
  • 187
    • 0036646082 scopus 로고    scopus 로고
    • Quantitation of amphetamine, methamphetamine, and their methylenedioxy derivatives in urine by solid-phase microextraction coupled with electrospray ionization-high-field asymmetric waveform ion mobility spectrometry-mass spectrometry
    • McCooeye, M. A., Mester, Z., Ells, B., Barnett, D. A., Purves, R. W., and Guevremont, R. (2002). Quantitation of amphetamine, methamphetamine, and their methylenedioxy derivatives in urine by solid-phase microextraction coupled with electrospray ionization-high-field asymmetric waveform ion mobility spectrometry-mass spectrometry. Anal. Chem. 74:3071-3075.
    • (2002) Anal. Chem. , vol.74 , pp. 3071-3075
    • McCooeye, M.A.1    Mester, Z.2    Ells, B.3    Barnett, D.A.4    Purves, R.W.5    Guevremont, R.6
  • 188
    • 28544448597 scopus 로고    scopus 로고
    • Analysis of solids, liquids, and biological tissues using solids probe introduction at atmospheric pressure on commercial LC/MS instruments
    • McEwen, C. N., McKay, R. G., and Larsen, B. S. (2005). Analysis of solids, liquids, and biological tissues using solids probe introduction at atmospheric pressure on commercial LC/MS instruments. Anal. Chem. 77:7826-7831.
    • (2005) Anal. Chem. , vol.77 , pp. 7826-7831
    • McEwen, C.N.1    McKay, R.G.2    Larsen, B.S.3
  • 189
    • 84889417505 scopus 로고    scopus 로고
    • Automated software analysis of isotpe cluster mass differences for components in LC-MS datasets
    • In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO
    • McGibbon, G. A., Bayliss, M. A., Antler, M., and Lashin, V. (2008). Automated software analysis of isotpe cluster mass differences for components in LC-MS datasets. In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO.
    • (2008)
    • McGibbon, G.A.1    Bayliss, M.A.2    Antler, M.3    Lashin, V.4
  • 190
    • 34547881888 scopus 로고    scopus 로고
    • Profiling and imaging of tissues by imaging ion mobility-mass spectrometry
    • McLean, J. A., Ridenour, W. B., and Caprioli, R. M. (2007). Profiling and imaging of tissues by imaging ion mobility-mass spectrometry. J. Mass Spectrom. 42:1099-1105.
    • (2007) J. Mass Spectrom. , vol.42 , pp. 1099-1105
    • McLean, J.A.1    Ridenour, W.B.2    Caprioli, R.M.3
  • 191
    • 75249102235 scopus 로고    scopus 로고
    • Matrix effects: Causes and solutions
    • In Using Mass Spectrometry for Drug Metabolism Studies (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, FL
    • Mei, H. (2005). Matrix effects: Causes and solutions. In Using Mass Spectrometry for Drug Metabolism Studies (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, FL, pp. 103-150.
    • (2005) , pp. 103-150
    • Mei, H.1
  • 192
    • 0037214121 scopus 로고    scopus 로고
    • Investigation of matrix effects in bioanalytical high-performance liquid chromatography/tandem mass spectrometric assays: Application to drug discovery
    • Mei, H., Hsieh, Y., Nardo, C., Xu, X., Wang, S., Ng, K., and Korfmacher, W. A. (2003). Investigation of matrix effects in bioanalytical high-performance liquid chromatography/tandem mass spectrometric assays: Application to drug discovery. Rapid Commun. Mass Spectrom. 17:97-103.
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 97-103
    • Mei, H.1    Hsieh, Y.2    Nardo, C.3    Xu, X.4    Wang, S.5    Ng, K.6    Korfmacher, W.A.7
  • 194
    • 54049093210 scopus 로고    scopus 로고
    • Development and validation of a UHPLC method for paroxetine hydrochloride
    • Messina, C. J., Grumbach, E. S., and Diehl, D. M. (2007). Development and validation of a UHPLC method for paroxetine hydrochloride. LCGC N. A. 25:1042-1049.
    • (2007) LCGC N. A. , vol.25 , pp. 1042-1049
    • Messina, C.J.1    Grumbach, E.S.2    Diehl, D.M.3
  • 195
    • 33646832904 scopus 로고
    • An ion trap storage/time-of-flight mass spectrometer
    • Michael, S. M., Chien, M., and Lubman, D. M. (1992). An ion trap storage/time-of-flight mass spectrometer. Rev. Sci. Instrum. 63:4277-4284.
    • (1992) Rev. Sci. Instrum. , vol.63 , pp. 4277-4284
    • Michael, S.M.1    Chien, M.2    Lubman, D.M.3
  • 196
    • 1642401467 scopus 로고    scopus 로고
    • Pharmaceutical productivity: The imperative for a new paradigm
    • In Annual Reports in Medicinal Chemistry (Doherty, A. M., Ed.). Elsevier, Amsterdam
    • Milne, G. M. (2003). Pharmaceutical productivity: The imperative for a new paradigm. In Annual Reports in Medicinal Chemistry (Doherty, A. M., Ed.). Elsevier, Amsterdam, pp. 383-396.
    • (2003) , pp. 383-396
    • Milne, G.M.1
  • 197
    • 0029717657 scopus 로고    scopus 로고
    • High sensitivity collisionally-activated decomposition tandem mass spectrometry on a novel quadrupole/orthogonal-acceleration time-of-flight mass spectrometer
    • Morris, H. R., Paxton, T., Dell, A., Langhorne, J., Berg, M., Bordoli, R. S., Hoyes, J., and Bateman, R. H. (1996). High sensitivity collisionally-activated decomposition tandem mass spectrometry on a novel quadrupole/orthogonal-acceleration time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom. 10:889-896.
    • (1996) Rapid Commun. Mass Spectrom. , vol.10 , pp. 889-896
    • Morris, H.R.1    Paxton, T.2    Dell, A.3    Langhorne, J.4    Berg, M.5    Bordoli, R.S.6    Hoyes, J.7    Bateman, R.H.8
  • 198
    • 0030796836 scopus 로고    scopus 로고
    • A novel geometry mass spectrometer, the Q-TOF, for low-femtomole/attomole-range biopolymer sequencing
    • Morris, H. R., Paxton, T., Panico, M., McDowell, R., and Dell, A. (1997). A novel geometry mass spectrometer, the Q-TOF, for low-femtomole/attomole-range biopolymer sequencing. J. Protein Chem. 16:469-479.
    • (1997) J. Protein Chem. , vol.16 , pp. 469-479
    • Morris, H.R.1    Paxton, T.2    Panico, M.3    McDowell, R.4    Dell, A.5
  • 199
    • 0037090352 scopus 로고    scopus 로고
    • An evaluation of a four-channel multiplexed electrospray tandem mass spectrometry for higher throughput quantitative analysis
    • Morrison, D., Davies, A. E., and Watt, A. P. (2002). An evaluation of a four-channel multiplexed electrospray tandem mass spectrometry for higher throughput quantitative analysis. Anal. Chem. 74:1896-1902.
    • (2002) Anal. Chem. , vol.74 , pp. 1896-1902
    • Morrison, D.1    Davies, A.E.2    Watt, A.P.3
  • 200
    • 0037097063 scopus 로고    scopus 로고
    • Ion suppression effects in liquid chromatography-electrospray-ionisation transport-region collision induced dissociation mass spectrometry with different serum extraction methods for systematic toxicological analysis with mass spectra libraries
    • Muller, C., Schafer, P., Stortzel, M., Vogt, S., and Weinmann, W. (2002). Ion suppression effects in liquid chromatography-electrospray-ionisation transport-region collision induced dissociation mass spectrometry with different serum extraction methods for systematic toxicological analysis with mass spectra libraries. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 773:47-52.
    • (2002) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.773 , pp. 47-52
    • Muller, C.1    Schafer, P.2    Stortzel, M.3    Vogt, S.4    Weinmann, W.5
  • 201
    • 0042626030 scopus 로고    scopus 로고
    • A sensitive LC/MS/MS method using silica column and aqueous-organic mobile phase for the analysis of loratadine and descarboethoxy-loratadine in human plasma
    • Naidong, W., Addison, T., Schneider, T., Jiang, X., and Halls, T. D. (2003). A sensitive LC/MS/MS method using silica column and aqueous-organic mobile phase for the analysis of loratadine and descarboethoxy-loratadine in human plasma. J. Pharm. Biomed. Anal. 32:609-617.
    • (2003) J. Pharm. Biomed. Anal. , vol.32 , pp. 609-617
    • Naidong, W.1    Addison, T.2    Schneider, T.3    Jiang, X.4    Halls, T.D.5
  • 202
    • 0037097559 scopus 로고    scopus 로고
    • Simultaneous development of six LC-MS-MS methods for the determination of multiple analytes in human plasma
    • Naidong, W., Bu, H., Chen, Y. L., Shou, W. Z., Jiang, X., and Halls, T. D. (2002a). Simultaneous development of six LC-MS-MS methods for the determination of multiple analytes in human plasma. J. Pharm. Biomed. Anal. 28:1115-1126.
    • (2002) J. Pharm. Biomed. Anal. , vol.28 , pp. 1115-1126
    • Naidong, W.1    Bu, H.2    Chen, Y.L.3    Shou, W.Z.4    Jiang, X.5    Halls, T.D.6
  • 203
    • 0036393151 scopus 로고    scopus 로고
    • Liquid chromatography/tandem mass spectrometric bioanalysis using normal-phase columns with aqueous/organic mobile phases: A novel approach of eliminating evaporation and reconstitution steps in 96-well SPE
    • Naidong, W., Shou, W. Z., Addison, T., Maleki, S., and Jiang, X. (2002b). Liquid chromatography/tandem mass spectrometric bioanalysis using normal-phase columns with aqueous/organic mobile phases: A novel approach of eliminating evaporation and reconstitution steps in 96-well SPE. Rapid Commun. Mass Spectrom. 16:1965-1975.
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , pp. 1965-1975
    • Naidong, W.1    Shou, W.Z.2    Addison, T.3    Maleki, S.4    Jiang, X.5
  • 204
    • 33947274081 scopus 로고    scopus 로고
    • Pharmacokinetic study of intraperitoneally administered troglitazone in mice using ultraperformance liquid chromatography/tandem mass spectrometry
    • New, L. S., Saha, S., Ong, M. M. K., Boelsterli, U. A., and Chan, E. C. Y. (2007). Pharmacokinetic study of intraperitoneally administered troglitazone in mice using ultraperformance liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 21:982-988.
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , pp. 982-988
    • New, L.S.1    Saha, S.2    Ong, M.M.K.3    Boelsterli, U.A.4    Chan, E.C.Y.5
  • 205
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newman, D. J., and Cragg, G. M. (2007). Natural products as sources of new drugs over the last 25 years. J. Nat. Prod. 70:461-477.
    • (2007) J. Nat. Prod. , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 206
    • 0042844744 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the period 1981-2002
    • Newman, D. J., Cragg, G. M., and Snader, K. M. (2003). Natural products as sources of new drugs over the period 1981-2002. J. Nat. Prod. 66:1022-1037.
    • (2003) J. Nat. Prod. , vol.66 , pp. 1022-1037
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 208
    • 53549100467 scopus 로고    scopus 로고
    • Can in vitro metabolismdependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose
    • Obach, R. S., Kalgutkar, A. S., Soglia, J. R., and Zhao, S. X. (2008). Can in vitro metabolismdependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose. Chem. Res. Toxicol. 21:1814-1822.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 1814-1822
    • Obach, R.S.1    Kalgutkar, A.S.2    Soglia, J.R.3    Zhao, S.X.4
  • 209
    • 33646201478 scopus 로고    scopus 로고
    • High-throughput bioanalysis with simultaneous acquisition of metabolic route data using ultra performance liquid chromatography coupled with time-of-flight mass spectrometry
    • O'Connor, D., and Mortishire-Smith, R. (2006). High-throughput bioanalysis with simultaneous acquisition of metabolic route data using ultra performance liquid chromatography coupled with time-of-flight mass spectrometry. Anal. Bioanal. Chem. 385:114-121.
    • (2006) Anal. Bioanal. Chem. , vol.385 , pp. 114-121
    • O'Connor, D.1    Mortishire-Smith, R.2
  • 210
    • 33644648441 scopus 로고    scopus 로고
    • Ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry for robust, high-throughput quantitative analysis of an automated metabolic stability assay, with simultaneous determination of metabolic data
    • O'Connor, D., Mortishire-Smith, R., Morrison, D., Davies, A., and Dominguez, M. (2006). Ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry for robust, high-throughput quantitative analysis of an automated metabolic stability assay, with simultaneous determination of metabolic data. Rapid Commun. Mass Spectrom. 20:851-857.
    • (2006) Rapid Commun. Mass Spectrom. , vol.20 , pp. 851-857
    • O'Connor, D.1    Mortishire-Smith, R.2    Morrison, D.3    Davies, A.4    Dominguez, M.5
  • 212
    • 1142285519 scopus 로고    scopus 로고
    • Biopharmaceutic and pharmacokinetic aspects of variable bioavailability of rifampicin
    • Panchagnula, R., and Agrawal, S. (2004). Biopharmaceutic and pharmacokinetic aspects of variable bioavailability of rifampicin. Int. J. Pharm. 271:1-4.
    • (2004) Int. J. Pharm. , vol.271 , pp. 1-4
    • Panchagnula, R.1    Agrawal, S.2
  • 215
    • 0037234905 scopus 로고    scopus 로고
    • Accurate mass measurement at enhanced mass-resolution on a triple quadrupole mass-spectrometer for the identification of a reaction impurity and collisionally-induced fragment ions of cabergoline
    • Paul, G., Winnik, W., Hughes, N., Schweingruber, H., Heller, R., and Schoen, A. (2003). Accurate mass measurement at enhanced mass-resolution on a triple quadrupole mass-spectrometer for the identification of a reaction impurity and collisionally-induced fragment ions of cabergoline. Rapid Commun. Mass Spectrom. 17:561-568.
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 561-568
    • Paul, G.1    Winnik, W.2    Hughes, N.3    Schweingruber, H.4    Heller, R.5    Schoen, A.6
  • 216
    • 34447293729 scopus 로고    scopus 로고
    • New perspectives in bio-analytical techniques for preclinical characterization of a drug candidate: UPLC-MS/MS in in vitro metabolism and pharmacokinetic studies
    • Pedraglio, S., Rozio, M. G., Misiano, P., Reali, V., Dondio, G., and Bigogno, C. (2007). New perspectives in bio-analytical techniques for preclinical characterization of a drug candidate: UPLC-MS/MS in in vitro metabolism and pharmacokinetic studies. J. Pharm. Biomed. Anal. 44:665-673.
    • (2007) J. Pharm. Biomed. Anal. , vol.44 , pp. 665-673
    • Pedraglio, S.1    Rozio, M.G.2    Misiano, P.3    Reali, V.4    Dondio, G.5    Bigogno, C.6
  • 217
    • 33644858668 scopus 로고    scopus 로고
    • In vitro screening of drug metabolism during drug development:Can we trust the predictions? Expert Opin
    • Pelkonen, O., and Raunio, H. (2005). In vitro screening of drug metabolism during drug development:Can we trust the predictions? Expert Opin. Drug Metab. Toxicol. 1:49-59.
    • (2005) Drug Metab. Toxicol. , vol.1 , pp. 49-59
    • Pelkonen, O.1    Raunio, H.2
  • 218
    • 0037413414 scopus 로고    scopus 로고
    • Assessment of oral bioavailability enhancing approaches for SB-247083 using flowthrough cell dissolution testing as one of the screens
    • Perng, C. Y., Kearney, A. S., Palepu, N. R., Smith, B. R., and Azzarano, L. M. (2003). Assessment of oral bioavailability enhancing approaches for SB-247083 using flowthrough cell dissolution testing as one of the screens. Int. J. Pharm. 250:147-156.
    • (2003) Int. J. Pharm. , vol.250 , pp. 147-156
    • Perng, C.Y.1    Kearney, A.S.2    Palepu, N.R.3    Smith, B.R.4    Azzarano, L.M.5
  • 219
    • 33645506491 scopus 로고    scopus 로고
    • The use of a hybrid linear trap/FTICR mass spectrometer for on-line high resolution/high mass accuracy bottom-up sequencing
    • Peterman, S. M., Dufresne, C. P., and Horning, S. (2005). The use of a hybrid linear trap/FTICR mass spectrometer for on-line high resolution/high mass accuracy bottom-up sequencing. J. Biomol. Tech. 16:112-124.
    • (2005) J. Biomol. Tech. , vol.16 , pp. 112-124
    • Peterman, S.M.1    Dufresne, C.P.2    Horning, S.3
  • 220
    • 33947232511 scopus 로고    scopus 로고
    • Pharmaceutical Industry Profile 2006
    • PhRMA. Pharmaceutical Research and Manufacturers of America, Washington, DC
    • PhRMA (2006). Pharmaceutical Industry Profile 2006. Pharmaceutical Research and Manufacturers of America, Washington, DC.
    • (2006)
  • 221
    • 4644265806 scopus 로고    scopus 로고
    • Ultraperformance liquid chromatography coupled to quadrupole-orthogonal time-of-flight mass spectrometry
    • Plumb, R., Castro-Perez, J., Granger, J., Beattie, I., Joncour, K., and Wright, A. (2004). Ultraperformance liquid chromatography coupled to quadrupole-orthogonal time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 18:2331-2337.
    • (2004) Rapid Commun. Mass Spectrom. , vol.18 , pp. 2331-2337
    • Plumb, R.1    Castro-Perez, J.2    Granger, J.3    Beattie, I.4    Joncour, K.5    Wright, A.6
  • 223
    • 0023947965 scopus 로고
    • Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985)
    • Prentis, R. A., Lis, Y., and Walker, S. R. (1988). Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985). Br. J. Clin. Pharmacol. 25:387-396.
    • (1988) Br. J. Clin. Pharmacol. , vol.25 , pp. 387-396
    • Prentis, R.A.1    Lis, Y.2    Walker, S.R.3
  • 224
    • 33751249069 scopus 로고    scopus 로고
    • Complicating factors in safety testing of drug metabolites: Kinetic differences between generated and preformed metabolites
    • Prueksaritanont, T., Lin, J. H. et al. (2006). Complicating factors in safety testing of drug metabolites: Kinetic differences between generated and preformed metabolites. Toxicol. Appl. Pharmacol. 217(2):143-152.
    • (2006) Toxicol. Appl. Pharmacol. , vol.217 , Issue.2 , pp. 143-152
    • Prueksaritanont, T.1    Lin, J.H.2
  • 225
    • 0033168983 scopus 로고    scopus 로고
    • Electrospray ionization high-field asymmetric waveform ion mobility spectrometry-mass spectrometry
    • Purves, R. W., and Guevremont, R. (1999). Electrospray ionization high-field asymmetric waveform ion mobility spectrometry-mass spectrometry. Anal. Chem. 71:2346-2357.
    • (1999) Anal. Chem. , vol.71 , pp. 2346-2357
    • Purves, R.W.1    Guevremont, R.2
  • 226
    • 0032324858 scopus 로고    scopus 로고
    • Mass spectrometric characterization of a high-field asymmetric waveform ion mobility spectrometer
    • Purves, R. W., Guevremont, R., Day, S., Pipich, C. W., and Matyjaszczyk, M. S. (1998). Mass spectrometric characterization of a high-field asymmetric waveform ion mobility spectrometer. Rev. Sci. Instrum. 69:4094-4105.
    • (1998) Rev. Sci. Instrum. , vol.69 , pp. 4094-4105
    • Purves, R.W.1    Guevremont, R.2    Day, S.3    Pipich, C.W.4    Matyjaszczyk, M.S.5
  • 227
    • 55049140981 scopus 로고    scopus 로고
    • Oxidative metabolites of drugs and xenobiotics: LC-MS methods to identify and characterize in biological matrices
    • In Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS (Chowdhury, S. K., Ed.). Elsevier, Amsterdam, The Netherlands
    • Ramanathan, R., Chowdhury, S. K., and Alton, K. B. (2005). Oxidative metabolites of drugs and xenobiotics: LC-MS methods to identify and characterize in biological matrices. In Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS (Chowdhury, S. K., Ed.). Elsevier, Amsterdam, The Netherlands, pp. 225-276.
    • (2005) , pp. 225-276
    • Ramanathan, R.1    Chowdhury, S.K.2    Alton, K.B.3
  • 231
    • 84889368011 scopus 로고    scopus 로고
    • Quantitative assessment of metabolites early in the clinical program: Potential for using LCNanospray-MS
    • Eastern Analytical Symposium and Exposition, Somerset, NJ
    • Ramanathan, R., Zhong, R., Blumenkrantz, N., Chowdhury, S. K., and Alton, K. B. (2007d). Quantitative assessment of metabolites early in the clinical program: Potential for using LCNanospray-MS. Eastern Analytical Symposium and Exposition, Somerset, NJ.
    • (2007)
    • Ramanathan, R.1    Zhong, R.2    Blumenkrantz, N.3    Chowdhury, S.K.4    Alton, K.B.5
  • 232
    • 0035100495 scopus 로고    scopus 로고
    • Ultra-fast gradient vs. fast isocratic chromatography in bioanalytical quantification by liquid chromatography/tandem mass spectrometry
    • Romanyshyn, L., Tiller, P. R., Alvaro, R., Pereira, A., and Hop, C. E. C. A. (2001). Ultra-fast gradient vs. fast isocratic chromatography in bioanalytical quantification by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 15:313-319.
    • (2001) Rapid Commun. Mass Spectrom. , vol.15 , pp. 313-319
    • Romanyshyn, L.1    Tiller, P.R.2    Alvaro, R.3    Pereira, A.4    Hop, C.E.C.A.5
  • 233
    • 0033827448 scopus 로고    scopus 로고
    • Bioanalytical applications of "fast chromatography" to high-throughput liquid chromatography/tandem mass spectrometric quantitation
    • Romanyshyn, L., Tiller, P. R., and Hop, C. E. (2000). Bioanalytical applications of "fast chromatography" to high-throughput liquid chromatography/tandem mass spectrometric quantitation. Rapid Commun. Mass Spectrom. 14:1662-1668.
    • (2000) Rapid Commun. Mass Spectrom. , vol.14 , pp. 1662-1668
    • Romanyshyn, L.1    Tiller, P.R.2    Hop, C.E.3
  • 234
    • 39749201504 scopus 로고    scopus 로고
    • An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques:Application to indinavir metabolite detection
    • Ruan, Q., Peterman, S., Szewc, M. A., Ma, L., Cui, D., Humphreys, W. G., and Zhu, M. (2008). An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques:Application to indinavir metabolite detection. J. Mass Spectrom. 43:251-261.
    • (2008) J. Mass Spectrom. , vol.43 , pp. 251-261
    • Ruan, Q.1    Peterman, S.2    Szewc, M.A.3    Ma, L.4    Cui, D.5    Humphreys, W.G.6    Zhu, M.7
  • 235
    • 0001944223 scopus 로고    scopus 로고
    • Novel approaches to high throughput quantitative LC-MS/MS in a regulated environment
    • Rudewicz, P. J., and Yang, L. (2001). Novel approaches to high throughput quantitative LC-MS/MS in a regulated environment. Am. Pharm. Rev. 4:64, 66, 68, 70.
    • (2001) Am. Pharm. Rev. , vol.4
    • Rudewicz, P.J.1    Yang, L.2
  • 236
    • 0003683483 scopus 로고    scopus 로고
    • Troubleshooting HPLC Systems: A Bench Manual
    • Wiley, New York
    • Sadek, P. C. (2000). Troubleshooting HPLC Systems: A Bench Manual. Wiley, New York.
    • (2000)
    • Sadek, P.C.1
  • 237
    • 0344628660 scopus 로고    scopus 로고
    • Determination of glimepiride in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry
    • Salem, I. I., Idrees, J., and Al Tamimi, J. I. (2004). Determination of glimepiride in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 799:103-109.
    • (2004) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.799 , pp. 103-109
    • Salem, I.I.1    Idrees, J.2    Al Tamimi, J.I.3
  • 238
    • 33745758510 scopus 로고    scopus 로고
    • Utility of the hybrid LTQ-FTMS for drug metabolism applications
    • Sanders, M., Shipkova, P. A., Zhang, H., and Warrack, B. M. (2006). Utility of the hybrid LTQ-FTMS for drug metabolism applications. Curr. Drug Metab. 7:547-555.
    • (2006) Curr. Drug Metab. , vol.7 , pp. 547-555
    • Sanders, M.1    Shipkova, P.A.2    Zhang, H.3    Warrack, B.M.4
  • 241
    • 84889499752 scopus 로고    scopus 로고
    • Detection of circulating metabolites of carbamazepine in microdosing studies in rats using LC-MS/MS
    • In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN
    • Seto, C., Ni, J., Ouyang, F., Ellis, R., Aiello, M., Jones, E. B., Welty, D., and Acheampong, A. (2007). Detection of circulating metabolites of carbamazepine in microdosing studies in rats using LC-MS/MS. In Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Indianapolis, IN.
    • (2007)
    • Seto, C.1    Ni, J.2    Ouyang, F.3    Ellis, R.4    Aiello, M.5    Jones, E.B.6    Welty, D.7    Acheampong, A.8
  • 242
    • 33847397009 scopus 로고    scopus 로고
    • The history of bioanalytical method validation and regulation: Evolution of a guidance document on bioanalytical methods validation
    • Shah, V. P. (2007). The history of bioanalytical method validation and regulation: Evolution of a guidance document on bioanalytical methods validation. AAPS J. 9:E43-E47.
    • (2007) AAPS J. , vol.9
    • Shah, V.P.1
  • 244
    • 32444451631 scopus 로고    scopus 로고
    • Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL
    • Shen, J. X., Wang, H., Tadros, S., and Hayes, R. N. (2006). Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL. J. Pharm. Biomed. Anal. 40:689-706.
    • (2006) J. Pharm. Biomed. Anal. , vol.40 , pp. 689-706
    • Shen, J.X.1    Wang, H.2    Tadros, S.3    Hayes, R.N.4
  • 245
    • 84889315305 scopus 로고    scopus 로고
    • Mass-Spectrometry-Based Drug Screening Assays for Early Phases in Drug Discovery
    • Wiley, Hoboken, NJ
    • Siegel, M. M. (2005). Mass-Spectrometry-Based Drug Screening Assays for Early Phases in Drug Discovery. Wiley, Hoboken, NJ.
    • (2005)
    • Siegel, M.M.1
  • 246
    • 34250722613 scopus 로고    scopus 로고
    • Development of a quantitative LC-MS/MS analytical method coupled with turbulent flow chromatography for digoxin for the in vitro P-gp inhibition assay
    • Smalley, J., Marino, A. M., Xin, B., Olah, T., and Balimane, P. V. (2007). Development of a quantitative LC-MS/MS analytical method coupled with turbulent flow chromatography for digoxin for the in vitro P-gp inhibition assay. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 854:260-267.
    • (2007) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.854 , pp. 260-267
    • Smalley, J.1    Marino, A.M.2    Xin, B.3    Olah, T.4    Balimane, P.V.5
  • 247
    • 0029865450 scopus 로고    scopus 로고
    • Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics
    • Smith, D. A., Jones, B. C., and Walker, D. K. (1996). Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics. Med. Res. Rev. 16:243-266.
    • (1996) Med. Res. Rev. , vol.16 , pp. 243-266
    • Smith, D.A.1    Jones, B.C.2    Walker, D.K.3
  • 248
    • 24944563781 scopus 로고    scopus 로고
    • Seeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing
    • Smith, D. A. and Obach, R. S. (2005). Seeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing. Drug. Metab. Dispos. 33(10):1409-1417.
    • (2005) Drug. Metab. Dispos. , vol.33 , Issue.10 , pp. 1409-1417
    • Smith, D.A.1    Obach, R.S.2
  • 249
    • 33845748169 scopus 로고    scopus 로고
    • Metabolites and safety: what are the concerns, and how should we address them? Chem
    • Smith, D. A., and Obach, R. S. (2006). Metabolites and safety: what are the concerns, and how should we address them? Chem. Res. Toxicol. 19:1570-1579.
    • (2006) Res. Toxicol. , vol.19 , pp. 1570-1579
    • Smith, D.A.1    Obach, R.S.2
  • 250
    • 0037086063 scopus 로고    scopus 로고
    • A tandem mass spectrometer for improved transmission and analysis of large macromolecular assemblies
    • Sobott, F., Hernandez, H., McCammon, M. G., Tito, M. A., and Robinson, C. V. (2002). A tandem mass spectrometer for improved transmission and analysis of large macromolecular assemblies. Anal. Chem. 74:1402-1407.
    • (2002) Anal. Chem. , vol.74 , pp. 1402-1407
    • Sobott, F.1    Hernandez, H.2    McCammon, M.G.3    Tito, M.A.4    Robinson, C.V.5
  • 251
    • 8444250979 scopus 로고    scopus 로고
    • Matrix effect in LC-ESI-MS and LCAPCI-MS with off-line and on-line extraction procedures
    • Souverain, S., Rudaz, S., and Veuthey, J. L. (2004a). Matrix effect in LC-ESI-MS and LCAPCI-MS with off-line and on-line extraction procedures. J. Chromatogr. A 1058:61-66.
    • (2004) J. Chromatogr. A , vol.1058 , pp. 61-66
    • Souverain, S.1    Rudaz, S.2    Veuthey, J.L.3
  • 252
    • 1642564155 scopus 로고    scopus 로고
    • Restricted access materials and large particle supports for on-line sample preparation: An attractive approach for biological fluids analysis
    • Souverain, S., Rudaz, S., and Veuthey, J. L. (2004b). Restricted access materials and large particle supports for on-line sample preparation: An attractive approach for biological fluids analysis. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 801:141-156.
    • (2004) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.801 , pp. 141-156
    • Souverain, S.1    Rudaz, S.2    Veuthey, J.L.3
  • 253
    • 48349114546 scopus 로고    scopus 로고
    • Mass Spec Desk Reference
    • Global View Publishing, Pittsburgh, PA
    • Sparkman, O. D. (2006). Mass Spec Desk Reference. Global View Publishing, Pittsburgh, PA.
    • (2006)
    • Sparkman, O.D.1
  • 254
    • 41549123661 scopus 로고    scopus 로고
    • Changing need for bioanalysis during drug development
    • Srinivas, N. R. (2007). Changing need for bioanalysis during drug development. Biomed. Chromatogr. 22:235-243.
    • (2007) Biomed. Chromatogr. , vol.22 , pp. 235-243
    • Srinivas, N.R.1
  • 255
    • 13444293453 scopus 로고    scopus 로고
    • Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: Necessity or not? Rapid Commun
    • Stokvis, E., Rosing, H., and Beijnen, J. H. (2005). Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: Necessity or not? Rapid Commun. Mass Spectrom. 19:401-407.
    • (2005) Mass Spectrom. , vol.19 , pp. 401-407
    • Stokvis, E.1    Rosing, H.2    Beijnen, J.H.3
  • 256
    • 23444451450 scopus 로고    scopus 로고
    • Simultaneous determination of loratadine and pseudoephedrine sulfate in human plasma by liquid chromatography-electrospray mass spectrometry for pharmacokinetic studies
    • Sun, J., Wang, G., Wang, W., Zhao, S., Gu, Y., Zhang, J., Huang, M., Shao, F., Li, H., Zhang, Q., and Xie, H. (2005). Simultaneous determination of loratadine and pseudoephedrine sulfate in human plasma by liquid chromatography-electrospray mass spectrometry for pharmacokinetic studies. J. Pharm. Biomed. Anal. 39:217-224.
    • (2005) J. Pharm. Biomed. Anal. , vol.39 , pp. 217-224
    • Sun, J.1    Wang, G.2    Wang, W.3    Zhao, S.4    Gu, Y.5    Zhang, J.6    Huang, M.7    Shao, F.8    Li, H.9    Zhang, Q.10    Xie, H.11
  • 257
    • 20044384005 scopus 로고    scopus 로고
    • Ultra performance liquid chromatography (UPLC): An introduction
    • Swartz, M. E. (2005a). Ultra performance liquid chromatography (UPLC): An introduction. LCGC N. Am. 8-14.
    • (2005) LCGC N. Am. , pp. 8-14
    • Swartz, M.E.1
  • 259
    • 0142104153 scopus 로고    scopus 로고
    • Small molecules asmathematical partitions
    • Sweeney, D. L. (2003). Small molecules asmathematical partitions. Anal. Chem. 75:5362-5373.
    • (2003) Anal. Chem. , vol.75 , pp. 5362-5373
    • Sweeney, D.L.1
  • 260
  • 261
    • 27644598142 scopus 로고    scopus 로고
    • Ambient mass spectrometry using desorption electrospray ionization (DESI): Instrumentation, mechanisms and applications in forensics, chemistry, and biology
    • Takats, Z., Wiseman, J. M., and Cooks, R. G. (2005). Ambient mass spectrometry using desorption electrospray ionization (DESI): Instrumentation, mechanisms and applications in forensics, chemistry, and biology. J. Mass Spectrom. 40:1261-1275.
    • (2005) J. Mass Spectrom. , vol.40 , pp. 1261-1275
    • Takats, Z.1    Wiseman, J.M.2    Cooks, R.G.3
  • 262
    • 33846424247 scopus 로고    scopus 로고
    • The failure of torcetrapib: Was it the molecule or the mechanism? Arterioscler
    • Tall, A. R., Yvan-Charvet, L., and Wang, N. (2007). The failure of torcetrapib: Was it the molecule or the mechanism? Arterioscler. Thromb. Vasc. Biol. 27:257-260.
    • (2007) Thromb. Vasc. Biol. , vol.27 , pp. 257-260
    • Tall, A.R.1    Yvan-Charvet, L.2    Wang, N.3
  • 263
    • 0037008227 scopus 로고    scopus 로고
    • J. Chromatogr. A
    • Tanaka, et al. (2002). J. Chromatogr. A 965:35-49.
    • (2002) , vol.965 , pp. 35-49
    • Tanaka1
  • 264
    • 0034331391 scopus 로고    scopus 로고
    • Expediting the method development and quality control of reversed-phase liquid chromatography electrospray ionization mass spectrometry for pharmaceutical analysis by using an LC/MS performance test mix
    • Tang, L., Fitch, W. L., Alexander, M. S., and Dolan, J. W. (2000). Expediting the method development and quality control of reversed-phase liquid chromatography electrospray ionization mass spectrometry for pharmaceutical analysis by using an LC/MS performance test mix. Anal. Chem. 72:5211-5218.
    • (2000) Anal. Chem. , vol.72 , pp. 5211-5218
    • Tang, L.1    Fitch, W.L.2    Alexander, M.S.3    Dolan, J.W.4
  • 265
    • 0025294115 scopus 로고
    • High-performance membrane chromatography. A novel method of protein separation
    • Tennikova, T. B., Svec, F., and Belenkii, B. G. (1990). High-performance membrane chromatography. A novel method of protein separation. J. Liquid Chromatogr. Related Technol. 13:63-70.
    • (1990) J. Liquid Chromatogr. Related Technol. , vol.13 , pp. 63-70
    • Tennikova, T.B.1    Svec, F.2    Belenkii, B.G.3
  • 266
    • 41549139685 scopus 로고    scopus 로고
    • High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-offlight system as a 'first-line' approach for metabolite identification studies
    • Tiller, P. R., Yu, S., Castro-Perez, J., Fillgrove, K. L., and Baillie, T. A. (2008). High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-offlight system as a 'first-line' approach for metabolite identification studies. Rapid Commun. Mass Spectrom. 22:1053-1061.
    • (2008) Rapid Commun. Mass Spectrom. , vol.22 , pp. 1053-1061
    • Tiller, P.R.1    Yu, S.2    Castro-Perez, J.3    Fillgrove, K.L.4    Baillie, T.A.5
  • 267
    • 23044488827 scopus 로고    scopus 로고
    • Predicting drug metabolism: An evaluation of the expert system METEOR
    • Testa, B., Balmat, A. L., Long, A., and Judson, P. (2005). Predicting drug metabolism: An evaluation of the expert system METEOR. Chem Biodivers 2:872-885.
    • (2005) Chem Biodivers , vol.2 , pp. 872-885
    • Testa, B.1    Balmat, A.L.2    Long, A.3    Judson, P.4
  • 268
    • 0034329374 scopus 로고    scopus 로고
    • Early ADME in support of drug discovery: The role of metabolic stability studies
    • Thompson, T. N. (2000). Early ADME in support of drug discovery: The role of metabolic stability studies. Curr. Drug. Metab. 1:215-241.
    • (2000) Curr. Drug. Metab. , vol.1 , pp. 215-241
    • Thompson, T.N.1
  • 269
    • 0034890106 scopus 로고    scopus 로고
    • Optimization of metabolic stability as a goal of modern drug design
    • Thompson, T. N. (2001). Optimization of metabolic stability as a goal of modern drug design. Med. Res. Rev. 21:412-449.
    • (2001) Med. Res. Rev. , vol.21 , pp. 412-449
    • Thompson, T.N.1
  • 270
    • 85056545610 scopus 로고    scopus 로고
    • Drug metabolism in vitro and in vivo results: How do these data support drug discovery?
    • In Using Mass Spectrometry for Drug Metabolism Studies (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, FL
    • Thompson, T. N. (2005). Drug metabolism in vitro and in vivo results: How do these data support drug discovery? In Using Mass Spectrometry for Drug Metabolism Studies (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, FL, pp. 35-81.
    • (2005) , pp. 35-81
    • Thompson, T.N.1
  • 271
    • 33750569204 scopus 로고    scopus 로고
    • Accurate-mass identification of chlorinated and brominated products of 4-nonylphenol, nonylphenol dimers, and other endocrine disrupters
    • Thurman, E. M. (2006). Accurate-mass identification of chlorinated and brominated products of 4-nonylphenol, nonylphenol dimers, and other endocrine disrupters. J. Mass Spectrom. 41:1287-1297.
    • (2006) J. Mass Spectrom. , vol.41 , pp. 1287-1297
    • Thurman, E.M.1
  • 272
    • 0035387613 scopus 로고    scopus 로고
    • Very high pressure gradient LC/MS/MS
    • Tolley, L., Jorgenson, J.W., and Moseley, M. A. (2001). Very high pressure gradient LC/MS/MS. Anal. Chem. 73:2985-2991.
    • (2001) Anal. Chem. , vol.73 , pp. 2985-2991
    • Tolley, L.1    Jorgenson, J.W.2    Moseley, M.A.3
  • 273
    • 0032796151 scopus 로고    scopus 로고
    • Characterization of a technique for rapid pharmacokinetic studies of multiple co-eluting compounds by LC/MS/MS
    • Tong, X., Ita, I. E., Wang, J., and Pivnichny, J. V. (1999). Characterization of a technique for rapid pharmacokinetic studies of multiple co-eluting compounds by LC/MS/MS. J. Pharm. Biomed. Anal. 20:773-784.
    • (1999) J. Pharm. Biomed. Anal. , vol.20 , pp. 773-784
    • Tong, X.1    Ita, I.E.2    Wang, J.3    Pivnichny, J.V.4
  • 274
    • 84889266731 scopus 로고    scopus 로고
    • High-throughput screening and quantification of doping agents in urine using LDTD-APCI-MS/MS
    • In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO
    • Tremblay, P., Groleau, P. E., Ayotte, C., Picard, P., and Viel, E. (2008). High-throughput screening and quantification of doping agents in urine using LDTD-APCI-MS/MS. In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO.
    • (2008)
    • Tremblay, P.1    Groleau, P.E.2    Ayotte, C.3    Picard, P.4    Viel, E.5
  • 275
    • 39749109563 scopus 로고    scopus 로고
    • Particle packed columns and monolithic columns in high-performance liquid chromatography-comparison and critical appraisal
    • Unger, K. K., Skudas, R., and Schult, M. M. (2008). Particle packed columns and monolithic columns in high-performance liquid chromatography-comparison and critical appraisal. J. Chromatogr. A. 1184:393-415.
    • (2008) J. Chromatogr. A. , vol.1184 , pp. 393-415
    • Unger, K.K.1    Skudas, R.2    Schult, M.M.3
  • 276
    • 84889492387 scopus 로고    scopus 로고
    • Advancing approaches in detecting polymorphism
    • Van Arnum, P. (2007). Advancing approaches in detecting polymorphism. Pharm. Technol. 16:S18-S23.
    • (2007) Pharm. Technol. , vol.16
    • Van Arnum, P.1
  • 277
    • 85010246622 scopus 로고
    • Longitudinal diffusion and resistance to mass transfer as causes of nonideality in chromatography
    • van Deemter, J. J., Zuiderweg, F. J., and Klinkenbergm, A. (1956). Longitudinal diffusion and resistance to mass transfer as causes of nonideality in chromatography. Chem. Eng. Sci. 5:271-289.
    • (1956) Chem. Eng. Sci. , vol.5 , pp. 271-289
    • Van Deemter, J.J.1    Zuiderweg, F.J.2    Klinkenbergm, A.3
  • 278
    • 0035953319 scopus 로고    scopus 로고
    • Propertybased design: Optimization of drug absorption and pharmacokinetics
    • van De Waterbeemd, H., Smith, D. A., Beaumont, K., and Walker, D. K. (2001). Propertybased design: Optimization of drug absorption and pharmacokinetics. J. Med. Chem. 44:1313-1333.
    • (2001) J. Med. Chem. , vol.44 , pp. 1313-1333
    • Van De Waterbeemd, H.1    Smith, D.A.2    Beaumont, K.3    Walker, D.K.4
  • 280
    • 30044433072 scopus 로고    scopus 로고
    • Enhancement in proteomics analyses using nano LC-MS and FAIMS
    • Venne, K., Bonneil, E., Eng, K., and Thibault, P. (2004). Enhancement in proteomics analyses using nano LC-MS and FAIMS. PharmaGenomics 4:30-32, 34, 36, 38, 40.
    • (2004) PharmaGenomics , vol.4
    • Venne, K.1    Bonneil, E.2    Eng, K.3    Thibault, P.4
  • 281
    • 16244366808 scopus 로고    scopus 로고
    • Improvement in peptide detection for proteomics analyses using nano LC-MS and high-field asymmetry waveform ion mobility mass spectrometry
    • Venne, K., Bonneil, E., Eng, K., and Thibault, P. (2005). Improvement in peptide detection for proteomics analyses using nano LC-MS and high-field asymmetry waveform ion mobility mass spectrometry. Anal. Chem. 77:2176-2186.
    • (2005) Anal. Chem. , vol.77 , pp. 2176-2186
    • Venne, K.1    Bonneil, E.2    Eng, K.3    Thibault, P.4
  • 282
    • 14444286468 scopus 로고
    • Relationship between drug distribution and therapeutic effects in man
    • Vesell, E. S. (1974). Relationship between drug distribution and therapeutic effects in man. Annu. Rev. Pharmacol. 14:249-270.
    • (1974) Annu. Rev. Pharmacol. , vol.14 , pp. 249-270
    • Vesell, E.S.1
  • 284
    • 34447105570 scopus 로고    scopus 로고
    • Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection
    • Vlase, L., Imre, S., Muntean, D., and Leucuta, S. E. (2007). Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection. J. Pharm. Biomed. Anal. 44:652-657.
    • (2007) J. Pharm. Biomed. Anal. , vol.44 , pp. 652-657
    • Vlase, L.1    Imre, S.2    Muntean, D.3    Leucuta, S.E.4
  • 285
    • 40049109721 scopus 로고    scopus 로고
    • Advances in predicting CYP-mediated drug interactions in the drug discovery setting
    • Wahlstrom, J. L., Rock, D. A., Slatter, J. G., and Wienkers, L. C. (2006). Advances in predicting CYP-mediated drug interactions in the drug discovery setting. Expert Opin. Drug Discov. 1:677-691.
    • (2006) Expert Opin. Drug Discov. , vol.1 , pp. 677-691
    • Wahlstrom, J.L.1    Rock, D.A.2    Slatter, J.G.3    Wienkers, L.C.4
  • 286
    • 33745902227 scopus 로고    scopus 로고
    • Ultra-performance liquid chromatography/tandem mass spectrometric determination of testosterone and its metabolites in in vitro samples
    • Wang, G., Hsieh, Y., Cui, X., Cheng, K. C., and Korfmacher,W. A. (2006). Ultra-performance liquid chromatography/tandem mass spectrometric determination of testosterone and its metabolites in in vitro samples. Rapid Commun. Mass Spectrom. 20:2215-2221.
    • (2006) Rapid Commun. Mass Spectrom. , vol.20 , pp. 2215-2221
    • Wang, G.1    Hsieh, Y.2    Cui, X.3    Cheng, K.C.4    Korfmacher, W.A.5
  • 287
    • 31544457026 scopus 로고    scopus 로고
    • Introduction to Mass Spectrometry:Instrumentation, Applications, and Strategies for Data Interpretation
    • John Wiley & Sons, Inc., New York, NY
    • Watson, J. T., and Sparkman, O. D. (2007). Introduction to Mass Spectrometry:Instrumentation, Applications, and Strategies for Data Interpretation. John Wiley & Sons, Inc., New York, NY.
    • (2007)
    • Watson, J.T.1    Sparkman, O.D.2
  • 288
    • 34547636487 scopus 로고    scopus 로고
    • Investigation of the advanced functionalities of a hybrid quadrupole orthogonal acceleration time-of-flight mass spectrometer
    • Weaver, P. J., Laures, A. M. F., and Wolff, J. C. (2007). Investigation of the advanced functionalities of a hybrid quadrupole orthogonal acceleration time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom. 21:2415-2421.
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , pp. 2415-2421
    • Weaver, P.J.1    Laures, A.M.F.2    Wolff, J.C.3
  • 289
    • 33748253250 scopus 로고    scopus 로고
    • Identification and reduction of ion suppression effects on pharmacokinetic parameters by polyethylene glycol 400
    • Weaver, R., and Riley, R. J. (2006). Identification and reduction of ion suppression effects on pharmacokinetic parameters by polyethylene glycol 400. Rapid Commun. Mass Spectrom. 20:2559-2564.
    • (2006) Rapid Commun. Mass Spectrom. , vol.20 , pp. 2559-2564
    • Weaver, R.1    Riley, R.J.2
  • 290
    • 0035412284 scopus 로고    scopus 로고
    • Column robustness case study for a liquid chromatographic method validated in compliance with ICH, VICH, and GMP guidelines
    • Webster, G. K., Li, H., Sanders, W. J., Basel, C. L., and Huang, G. (2001). Column robustness case study for a liquid chromatographic method validated in compliance with ICH, VICH, and GMP guidelines. J. Chromatogr. Sci. 39:273-279.
    • (2001) J. Chromatogr. Sci. , vol.39 , pp. 273-279
    • Webster, G.K.1    Li, H.2    Sanders, W.J.3    Basel, C.L.4    Huang, G.5
  • 291
    • 0035166156 scopus 로고    scopus 로고
    • Systematic troubleshooting for LC/MS/MS Part 1:Sample preparation and chromatography
    • Weng, N., and Halls, T. D. J. (2001). Systematic troubleshooting for LC/MS/MS Part 1:Sample preparation and chromatography. BioPharm. 14:28, 30, 32, 34, 36, 38.
    • (2001) BioPharm. , vol.14
    • Weng, N.1    Halls, T.D.J.2
  • 292
    • 0036144001 scopus 로고    scopus 로고
    • Systematic troubleshooting for LC/MS/MS-Part 2:Large-scale LC/MS/MS and automation
    • Weng, N., and Halls, T. D. J. (2002). Systematic troubleshooting for LC/MS/MS-Part 2:Large-scale LC/MS/MS and automation. BioPharm. 15:22-27.
    • (2002) BioPharm. , vol.15 , pp. 22-27
    • Weng, N.1    Halls, T.D.J.2
  • 293
    • 0035949182 scopus 로고    scopus 로고
    • Selective and rapid liquid chromatography-mass spectrometry method for the quantification of rofecoxib in pharmacokinetic studies with humans
    • Werner, U., Werner, D., Mundkowski, R., Gillich, M., and Brune, K. (2001). Selective and rapid liquid chromatography-mass spectrometry method for the quantification of rofecoxib in pharmacokinetic studies with humans. J. Chromatogr. B Biomed. Sci. Appl. 760:83-90.
    • (2001) J. Chromatogr. B Biomed. Sci. Appl. , vol.760 , pp. 83-90
    • Werner, U.1    Werner, D.2    Mundkowski, R.3    Gillich, M.4    Brune, K.5
  • 294
    • 0036163827 scopus 로고    scopus 로고
    • Investigation of the pharmacokinetics of celecoxib by liquid chromatography-mass spectrometry
    • Werner, U., Werner, D., Pahl, A., Mundkowski, R., Gillich, M., and Brune, K. (2002). Investigation of the pharmacokinetics of celecoxib by liquid chromatography-mass spectrometry. Biomed. Chromatogr. 16:56-60.
    • (2002) Biomed. Chromatogr. , vol.16 , pp. 56-60
    • Werner, U.1    Werner, D.2    Pahl, A.3    Mundkowski, R.4    Gillich, M.5    Brune, K.6
  • 295
    • 0033788742 scopus 로고    scopus 로고
    • AutoScan: An automated workstation for rapid determination of mass and tandem mass spectrometry conditions for quantitative bioanalytical mass spectrometry
    • Whalen, K. M., Rogers, K. J., Cole, M. J., and Janiszewski, J. S. (2000). AutoScan: An automated workstation for rapid determination of mass and tandem mass spectrometry conditions for quantitative bioanalytical mass spectrometry. Rapid Commun. Mass Spectrom. 14:2074-2079.
    • (2000) Rapid Commun. Mass Spectrom. , vol.14 , pp. 2074-2079
    • Whalen, K.M.1    Rogers, K.J.2    Cole, M.J.3    Janiszewski, J.S.4
  • 296
    • 33845460840 scopus 로고    scopus 로고
    • A review of nanoelectrospray ionization applications for drug metabolism and pharmacokinetics
    • Wickremsinhe, E. R., Singh, G., Ackermann, B. L., Gillespie, T. A., and Chaudhary, A. K. (2006). A review of nanoelectrospray ionization applications for drug metabolism and pharmacokinetics. Curr. Drug Metab. 7:913-928.
    • (2006) Curr. Drug Metab. , vol.7 , pp. 913-928
    • Wickremsinhe, E.R.1    Singh, G.2    Ackermann, B.L.3    Gillespie, T.A.4    Chaudhary, A.K.5
  • 297
    • 0032562528 scopus 로고    scopus 로고
    • Quantitative liquid chromatographictandem mass spectrometric determination of orlistat in plasma with a quadrupole ion trap
    • Wieboldt, R., Campbell, D. A., and Henion, J. (1998). Quantitative liquid chromatographictandem mass spectrometric determination of orlistat in plasma with a quadrupole ion trap. J. Chromatogr. B Biomed. Sci. Appl. 708:121-129.
    • (1998) J. Chromatogr. B Biomed. Sci. Appl. , vol.708 , pp. 121-129
    • Wieboldt, R.1    Campbell, D.A.2    Henion, J.3
  • 298
    • 0036107494 scopus 로고    scopus 로고
    • LC-MS-MS experiences with internal standards
    • Wieling, J. (2002). LC-MS-MS experiences with internal standards. Chromatographia 55:S107-S113.
    • (2002) Chromatographia , vol.55
    • Wieling, J.1
  • 299
    • 33646249136 scopus 로고    scopus 로고
    • The use of recently described ionization techniques for the rapid analysis of some common drugs and samples of biological origin
    • Williams, J. P., Patel, V. J., Holland, R. D., and Scrivens, J. H. (2006). The use of recently described ionization techniques for the rapid analysis of some common drugs and samples of biological origin. Rapid Commun. Mass Spectrom. 20:1447-1456.
    • (2006) Rapid Commun. Mass Spectrom. , vol.20 , pp. 1447-1456
    • Williams, J.P.1    Patel, V.J.2    Holland, R.D.3    Scrivens, J.H.4
  • 300
    • 0029685702 scopus 로고    scopus 로고
    • Analytical properties of the nanoelectrospray ion source
    • Wilm, M., and Mann, M. (1996). Analytical properties of the nanoelectrospray ion source. Anal. Chem. 68:1-8.
    • (1996) Anal. Chem. , vol.68 , pp. 1-8
    • Wilm, M.1    Mann, M.2
  • 301
    • 0034867912 scopus 로고    scopus 로고
    • High throughput log D determination using liquid chromatography-mass spectrometry
    • Wilson, D. M., Wang, X., Walsh, E., and Rourick, R. A. (2001). High throughput log D determination using liquid chromatography-mass spectrometry. Comb. Chem. High Throughput Screen. 4:511-519.
    • (2001) Comb. Chem. High Throughput Screen. , vol.4 , pp. 511-519
    • Wilson, D.M.1    Wang, X.2    Walsh, E.3    Rourick, R.A.4
  • 302
    • 13744251595 scopus 로고    scopus 로고
    • Direct characterization of enzyme-substrate complexes by using electrosonic spray ionization mass spectrometry
    • Wiseman, J. M., Takats, Z., Gologan, B., Davisson, V. J., and Cooks, R. G. (2005). Direct characterization of enzyme-substrate complexes by using electrosonic spray ionization mass spectrometry. Angew Chem. Int. Ed. Engl. 44:913-916.
    • (2005) Angew Chem. Int. Ed. Engl. , vol.44 , pp. 913-916
    • Wiseman, J.M.1    Takats, Z.2    Gologan, B.3    Davisson, V.J.4    Cooks, R.G.5
  • 303
    • 19544379199 scopus 로고    scopus 로고
    • Peak capacity in gradient ultra performance liquid chromatography (UPLC)
    • Wren, S. A. C. (2005). Peak capacity in gradient ultra performance liquid chromatography (UPLC). J. Pharm. Biomed. Anal. 38:337-343.
    • (2005) J. Pharm. Biomed. Anal. , vol.38 , pp. 337-343
    • Wren, S.A.C.1
  • 304
    • 0034954020 scopus 로고    scopus 로고
    • High-speed liquid chromatography/tandem mass spectrometry using a monolithic column for high-throughput bioanalysis
    • Wu, J. T., Zeng, H., Deng, Y., and Unger, S. E. (2001). High-speed liquid chromatography/tandem mass spectrometry using a monolithic column for high-throughput bioanalysis. Rapid Commun. Mass Spectrom. 15:1113-1119.
    • (2001) Rapid Commun. Mass Spectrom. , vol.15 , pp. 1113-1119
    • Wu, J.T.1    Zeng, H.2    Deng, Y.3    Unger, S.E.4
  • 305
    • 36248952562 scopus 로고    scopus 로고
    • High-field asymmetric waveform ion mobility spectrometry coupled with liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-FAIMS-MS/MS) multicomponent bioanalytical method development, performance evaluation and demonstration of the constancy of the compensation voltage with change of mobile phase composition or flow rate
    • Wu, S. T., Xia, Y. Q., and Jemal, M. (2007). High-field asymmetric waveform ion mobility spectrometry coupled with liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-FAIMS-MS/MS) multicomponent bioanalytical method development, performance evaluation and demonstration of the constancy of the compensation voltage with change of mobile phase composition or flow rate. Rapid Commun. Mass Spectrom. 21:3667-3676.
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , pp. 3667-3676
    • Wu, S.T.1    Xia, Y.Q.2    Jemal, M.3
  • 306
    • 0035170716 scopus 로고    scopus 로고
    • Parallel extraction columns and parallel analytical columns coupled with liquid chromatography/tandem mass spectrometry for on-line simultaneous quantification of a drug candidate and its six metabolites in dog plasma
    • Xia, Y. Q., Hop, C. E., Liu, D. Q., Vincent, S. H., and Chiu, S. H. (2001). Parallel extraction columns and parallel analytical columns coupled with liquid chromatography/tandem mass spectrometry for on-line simultaneous quantification of a drug candidate and its six metabolites in dog plasma. Rapid Commun. Mass Spectrom. 15:2135-2144.
    • (2001) Rapid Commun. Mass Spectrom. , vol.15 , pp. 2135-2144
    • Xia, Y.Q.1    Hop, C.E.2    Liu, D.Q.3    Vincent, S.H.4    Chiu, S.H.5
  • 307
    • 34249938957 scopus 로고    scopus 로고
    • Recent advances in high-throughput quantitative bioanalysis by LC-MS/MS
    • Xu, R. N., Fan, L., Rieser, M. J., and El-Shourbagy, T. A. (2007). Recent advances in high-throughput quantitative bioanalysis by LC-MS/MS. J. Pharm. Biomed. Anal. 44:342-355.
    • (2007) J. Pharm. Biomed. Anal. , vol.44 , pp. 342-355
    • Xu, R.N.1    Fan, L.2    Rieser, M.J.3    El-Shourbagy, T.A.4
  • 308
    • 85056511400 scopus 로고    scopus 로고
    • Utilizing higher mass resolution in quantitative assays
    • In Using Mass Spectrometry for Drug Metabolism Studies (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, FL
    • Xu, X. (2005). Utilizing higher mass resolution in quantitative assays. In Using Mass Spectrometry for Drug Metabolism Studies (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, FL, pp. 203-228.
    • (2005) , pp. 203-228
    • Xu, X.1
  • 309
    • 0037260829 scopus 로고    scopus 로고
    • Comparison of conventional and enhanced mass resolution triple-quadrupole mass spectrometers for discovery bioanalytical applications
    • Xu, X., Veals, J., and Korfmacher, W. A. (2003). Comparison of conventional and enhanced mass resolution triple-quadrupole mass spectrometers for discovery bioanalytical applications. Rapid Commun. Mass Spectrom. 17:832-837.
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 832-837
    • Xu, X.1    Veals, J.2    Korfmacher, W.A.3
  • 310
    • 31544467317 scopus 로고    scopus 로고
    • A 96-well single-pot protein precipitation, liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the determination of muraglitazar, a novel diabetes drug, in human plasma
    • Xue, Y. J., Liu, J., Pursley, J., and Unger, S. (2006). A 96-well single-pot protein precipitation, liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the determination of muraglitazar, a novel diabetes drug, in human plasma. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 831:213-222.
    • (2006) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.831 , pp. 213-222
    • Xue, Y.J.1    Liu, J.2    Pursley, J.3    Unger, S.4
  • 311
    • 34848908357 scopus 로고    scopus 로고
    • Microdose clinical trial: Quantitative determination of fexofenadine in human plasma using liquid
    • Yamane, N., Tozuka, Z., Sugiyama, Y., Tanimoto, T., Yamazaki, A., and Kumagai, Y. (2007). Microdose clinical trial: Quantitative determination of fexofenadine in human plasma using liquid. J. Chromatogr. B 858:118-128.
    • (2007) J. Chromatogr. B , vol.858 , pp. 118-128
    • Yamane, N.1    Tozuka, Z.2    Sugiyama, Y.3    Tanimoto, T.4    Yamazaki, A.5    Kumagai, Y.6
  • 312
    • 0036032589 scopus 로고    scopus 로고
    • Investigation of an enhanced resolution triple quadrupole mass spectrometer for high-throughput liquid chromatography/tandem mass spectrometry assays
    • Yang, L., Amad, M., Winnik, W. M., Schoen, A. E., Schweingruber, H., Mylchreest, I., and Rudewicz, P. J. (2002). Investigation of an enhanced resolution triple quadrupole mass spectrometer for high-throughput liquid chromatography/tandem mass spectrometry assays. Rapid Commun. Mass Spectrom. 16:2060-2066.
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , pp. 2060-2066
    • Yang, L.1    Amad, M.2    Winnik, W.M.3    Schoen, A.E.4    Schweingruber, H.5    Mylchreest, I.6    Rudewicz, P.J.7
  • 313
    • 0037631178 scopus 로고    scopus 로고
    • Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography-tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma
    • Yang, L., Clement, R. P., Kantesaria, B., Reyderman, L., Beaudry, F., Grandmaison, C., Di Donato, L., Masse, R., and Rudewicz, P. J. (2003). Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography-tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 792:229-240.
    • (2003) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.792 , pp. 229-240
    • Yang, L.1    Clement, R.P.2    Kantesaria, B.3    Reyderman, L.4    Beaudry, F.5    Grandmaison, C.6    Di Donato, L.7    Masse, R.8    Rudewicz, P.J.9
  • 314
    • 0035870154 scopus 로고    scopus 로고
    • Evaluation of a four-channel multiplexed electrospray triple quadrupole mass spectrometer for the simultaneous validation of LC/MS/MS methods in four different preclinical matrixes
    • Yang, L., Mann, T. D., Little, D., Wu, N., Clement, R. P., and Rudewicz, P. J. (2001a). Evaluation of a four-channel multiplexed electrospray triple quadrupole mass spectrometer for the simultaneous validation of LC/MS/MS methods in four different preclinical matrixes. Anal. Chem. 73:1740-1747.
    • (2001) Anal. Chem. , vol.73 , pp. 1740-1747
    • Yang, L.1    Mann, T.D.2    Little, D.3    Wu, N.4    Clement, R.P.5    Rudewicz, P.J.6
  • 315
    • 0035839185 scopus 로고    scopus 로고
    • Applications of new liquid chromatographytandem mass spectrometry technologies for drug development support
    • Yang, L., Wu, N., and Rudewicz, P. J. (2001b). Applications of new liquid chromatographytandem mass spectrometry technologies for drug development support. J. Chromatogr. A 926:43-55.
    • (2001) J. Chromatogr. A , vol.926 , pp. 43-55
    • Yang, L.1    Wu, N.2    Rudewicz, P.J.3
  • 316
    • 33846512989 scopus 로고    scopus 로고
    • Assessment of dose proportionality of muraglitazar after repeated oral dosing in rats via a sparse sampling methodology
    • Yao, M., Swaminathan, A., and Srinivas, N. (2007). Assessment of dose proportionality of muraglitazar after repeated oral dosing in rats via a sparse sampling methodology. Biopharm. Drug Dispos. 28:35-42.
    • (2007) Biopharm. Drug Dispos. , vol.28 , pp. 35-42
    • Yao, M.1    Swaminathan, A.2    Srinivas, N.3
  • 317
    • 33947252777 scopus 로고    scopus 로고
    • Ultra-performance liquid chromatography/tandem mass spectrometric quantification of structurally diverse drug mixtures using an ESI-APCI multimode ionization source
    • Yu, K., Di, L., Kerns, E. H., Li, S. Q., Alden, P., and Plumb, R. S. (2007). Ultra-performance liquid chromatography/tandem mass spectrometric quantification of structurally diverse drug mixtures using an ESI-APCI multimode ionization source. Rapid Commun. Mass Spectrom. 21:893-902.
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , pp. 893-902
    • Yu, K.1    Di, L.2    Kerns, E.H.3    Li, S.Q.4    Alden, P.5    Plumb, R.S.6
  • 318
    • 32544446573 scopus 로고    scopus 로고
    • High-throughput quantification for a drug mixture in rat plasma-A comparison of ultra performance liquid chromatography/tandem mass spectrometry with high-performance liquid chromatography/tandem mass spectrometry
    • Yu, K., Little, D., Plumb, R., and Smith, B. (2006). High-throughput quantification for a drug mixture in rat plasma-A comparison of ultra performance liquid chromatography/tandem mass spectrometry with high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 20:544-552.
    • (2006) Rapid Commun. Mass Spectrom. , vol.20 , pp. 544-552
    • Yu, K.1    Little, D.2    Plumb, R.3    Smith, B.4
  • 320
    • 0035811188 scopus 로고    scopus 로고
    • Comparison between liquid chromatography-time-of-flight mass spectrometry and selected reaction monitoring liquid chromatography-mass spectrometry for quantitative determination of idoxifene in human plasma
    • Zhang, H., and Henion, J. (2001). Comparison between liquid chromatography-time-of-flight mass spectrometry and selected reaction monitoring liquid chromatography-mass spectrometry for quantitative determination of idoxifene in human plasma. J. Chromatogr. B Biomed. Sci. Appl. 757:151-159.
    • (2001) J. Chromatogr. B Biomed. Sci. Appl. , vol.757 , pp. 151-159
    • Zhang, H.1    Henion, J.2
  • 321
    • 0034652244 scopus 로고    scopus 로고
    • Quantification and rapid metabolite identification in drug discovery using API time-of-flight LC/MS
    • Zhang, N., Fountain, S. T., Bi, H., and Rossi, D. T. (2000). Quantification and rapid metabolite identification in drug discovery using API time-of-flight LC/MS. Anal. Chem. 72:800-806.
    • (2000) Anal. Chem. , vol.72 , pp. 800-806
    • Zhang, N.1    Fountain, S.T.2    Bi, H.3    Rossi, D.T.4
  • 322
    • 0034212552 scopus 로고    scopus 로고
    • Bioanalytical high-throughput selected reaction monitoring-LC/MS determination of selected estrogen receptor modulators in human plasma: 2000 samples/day
    • Zweigenbaum, J., and Henion, J. (2000). Bioanalytical high-throughput selected reaction monitoring-LC/MS determination of selected estrogen receptor modulators in human plasma: 2000 samples/day. Anal. Chem. 72:2446-2454.
    • (2000) Anal. Chem. , vol.72 , pp. 2446-2454
    • Zweigenbaum, J.1    Henion, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.