Assessment of oral bioavailability enhancing approaches for SB-247083 using flow-through cell dissolution testing as one of the screens

International Journal of Pharmaceutics

Volumn 250, Issue 1, 2003, Pages 147-156

  Perng, Cherng Yih ^a   Kearney, Albert S ^a   Palepu, Nagesh R ^b   Smith, Brian R ^a   Azzarano, Leonard M ^a  

^a GLAXOSMITHKLINE   (United States)

^b Sonus Pharmaceuticals   (United States)

Author keywords

Bioavailability; Flow through cell dissolution; Salt selection; SB 247083

Indexed keywords

ALPHA [[1 BUTYL 4 [2 [2 (2 CARBOXYPHENYL)METHOXY] 4 CHLOROPHENYL] 1H PYRAZOL 4 YL]METHYLENE] 2,3 DIHYDRO 5 METHOXY 6 BENZOFURANPROPANOIC ACID; ENDOTHELIN RECEPTOR ANTAGONIST; INORGANIC SALT; SB 247083; UNCLASSIFIED DRUG; BENZOFURAN DERIVATIVE; ENDOTHELIN A RECEPTOR; ENDOTHELIN RECEPTOR; EXCIPIENT; PROPIONIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG SCREENING; DRUG SOLUBILITY; DRUG TRANSPORT; GASTROINTESTINAL TRACT; INTESTINE ABSORPTION; MALE; NONHUMAN; PH; PRIORITY JOURNAL; ANIMAL; BIOAVAILABILITY; CHEMISTRY; DOG; DRUG ANTAGONISM; ORAL DRUG ADMINISTRATION; SOLUBILITY;

ADMINISTRATION, ORAL; ANIMALS; BENZOFURANS; BIOLOGICAL AVAILABILITY; DOGS; EXCIPIENTS; MALE; PROPIONIC ACIDS; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; SOLUBILITY;

EID: 0037413414     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00521-5     Document Type: Article

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