Simultaneously quantifying parent drugs and screening for metabolites in plasma pharmacokinetic samples using selected reaction monitoring information-dependent acquisition on a QTrap instrument

Rapid Communications in Mass Spectrometry

Volumn 19, Issue 14, 2005, Pages 1943-1950

  Li, Austin C ^a   Alton, Dennis ^a   Bryant, Matthew S ^a   Shou, Wilson Z ^a  

^a 206 Carnegie Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; IONIZATION OF LIQUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; SCREENING; WATER INJECTION;

BIOANALYTICAL; INFORMATION-DEPENDENT ACQUISITIONS; LC-MS-MS; LINEAR ION TRAP; MONITORING INFORMATION; PARENT COMPOUNDS; PHARMACOKINETIC STUDIES; SELECTED REACTION MONITORING; SPECTRA'S; TIME-CONCENTRATION PROFILES;

METABOLITES;

EID: 22744441263     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/rcm.2008     Document Type: Article

References (18)

1. Thompson TN. Med. Res. Rev. 2001; 21: 412.
2. Koppal T. Drug Discovery Development 2004; 7(11): 9.
3. Schultz L. Drug Discovery Development 2004; 7(11): 53.
4. Papac DI, Shahrokh Z. Pharmaceut. Res. 2001; 18: 131.
5. Poon GK, Kwei G, Wang R, Lyons K, Chen Q, Didolkar V, Hop CECA. Rapid Commun. Mass Spectrom. 1999; 13: 1943.
6. Kantharaj E, Tuytelaars A, Proost PEA, Ongel Z, van Assouw HP, Gilissen RAHJ. Rapid Commun. Mass Spectrom. 2003; 17: 2661.
7. Tiller PR, Romanyshyn LA. Rapid Commun. Mass Spectrom. 2002; 16: 1225.
8. Zhang N, Fountain ST, Bi H, Rossi DT. Anal. Chem. 2000; 72: 800.
9. King RC, Gundersdorf R, Fernandez-Metzler CL. Rapid Commun. Mass Spectrom. 2003; 17: 2413.
10. Hager JW. Rapid Commun. Mass Spectrom. 2002; 16: 512.
11. Hager JW, Yves Le Blanc JC. Rapid Commun. Mass Spectrom. 2003; 17: 1056.
12. Hager JW, Yves Le Blanc JC. J. Chromatogr. A 2003; 1020: 3.
13. Hopfgartner G, Husser C, Zell M. J. Mass Spectrom. 2003; 32: 138.
14. Xia Y-Q, Miller JD, Bakhtiar R, Franklin RB, Liu DQ. Rapid Commun. Mass Spectrom. 2003; 17: 1137.
15. Hopfgartner G, Zell M. Using Mass Spectrometry for Drug Metabolism Studies, Korfmacher WA (ed). CRC Press: Boca Raton, 2004; 277.
16. Sasaki TA, Jones EB, Du A. Proc. 52nd ASMS Conf. Mass Spectrometry and Allied Topics, Nashville, TN, May 23-27, 2004.
17. Frenette R, Blouin M, Brideau C, Chauret N, Ducharme Y, Friesen RW, Hamel P, Jones TR, Laliberte F, Li C, Masson P, McAuliffe M, Girard Y. Bioorg. Med. Chem. Lett. 2002; 12: 3009.
18. Wyatt PG, Allen MJ, Chilcott J, Hickin G, Miller ND, Woollard PM. Bioorg. Med. Chem. Lett. 2001; 11: 1301.