Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography-tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 792, Issue 2, 2003, Pages 229-240

  Yang, Liyu ^a   Clement, Robert P ^a   Kantesaria, Bhavna ^a   Reyderman, Larisa ^a   Beaudry, Francis ^b   Grandmaison, Charles ^b   Di Donato, Lorella ^b   Masse, Robert ^b   Rudewicz, Patrick J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MDS Inc   (Canada)

Author keywords

3 Hydroxydesloratadine; Desloratadine

Indexed keywords

AROMATIC HYDROCARBONS; CALIBRATION; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

HUMAN PLASMAS;

BODY FLUIDS;

3 HYDROXYDESLORATADINE; DESLORATADINE; DRUG METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; AUTOMATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; FREEZING; HUMAN; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; REGRESSION ANALYSIS; ROOM TEMPERATURE; SOLID PHASE EXTRACTION; STANDARD; STATISTICAL SIGNIFICANCE; TANDEM MASS SPECTROMETRY;

EID: 0037631178     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(03)00267-8     Document Type: Article

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