Development and application of a new on-line SPE system combined with LC-MS/MS detection for high throughput direct analysis of pharmaceutical compounds in plasma

Journal of Chromatography A

Volumn 1080, Issue 2, 2005, Pages 99-106

  Alnouti, Yazen ^a   Srinivasan, Karthik ^a   Waddell, David ^a   Bi, Honggang ^a   Kavetskaia, Olga ^a   Gusev, Arkady I ^a  

^a PFIZER INC   (United States)

Author keywords

LC MS MS; Plasma; SPE

Indexed keywords

DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHASE SEPARATION;

MONOLITHIC COLUMNS; RAT PLASMA; SOLID PHASE EXTRACTION (SPE);

EXTRACTION;

DICLOFENAC; IBUPROFEN; KETOCONAZOLE; PROPRANOLOL;

ACCURACY; ANALYTIC METHOD; ARTICLE; AUTOMATION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH THROUGHPUT SCREENING; INJECTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; ONLINE SYSTEM; PRESSURE; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; SAMPLE; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; TIME; VALIDATION PROCESS;

CHEMICAL FRACTIONATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DICLOFENAC; IBUPROFEN; KETOCONAZOLE; MASS SPECTROMETRY; ONLINE SYSTEMS; PHARMACEUTICAL PREPARATIONS; PROPRANOLOL; REPRODUCIBILITY OF RESULTS;

EID: 20444481663     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2005.04.056     Document Type: Article

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