Increase of the LC-MS/MS sensitivity and detection limits using on-line sample preparation with large volume plasma injection

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 825, Issue 2, 2005, Pages 152-160

  Li, Ming ^a   Alnouti, Yazen ^a,b   Leverence, Rachael ^a,c   Bi, Honggang ^a   Gusev, Arkady I ^a  

^a PFIZER INC   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Bioanalytical; Large volume injection; LC MS MS; On line SPE; Sensitivity improvement

Indexed keywords

EXTRACTION; MASS SPECTROMETRY; PLASMAS; SIGNAL TO NOISE RATIO;

BIOANALYTICAL; LARGE VOLUME INJECTION; LC-MS/MS; ON-LINE SPE; SENSITIVITY IMPROVEMENT;

LIQUID CHROMATOGRAPHY;

KETOCONAZOLE; PROPRANOLOL;

ACCURACY; ARTICLE; CALIBRATION; LIQUID CHROMATOGRAPHY; NONHUMAN; ONLINE MONITORING; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; SIGNAL NOISE RATIO; SOLID PHASE EXTRACTION; STATISTICAL SIGNIFICANCE; TANDEM MASS SPECTROMETRY;

ANIMALS; CALIBRATION; CHROMATOGRAPHY, LIQUID; KETOCONAZOLE; PROPRANOLOL; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 26444437824     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2005.03.047     Document Type: Article

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