ATP and P2X purinoceptors in urinary tract disorders

Handbook of Experimental Pharmacology

Volumn 202, Issue , 2011, Pages 485-526

  Ford, Anthony P D W ^a   Cockayne, Debra A ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Hoffmann La Roche   (United States)

Author keywords

Afferent; ATP; Hyperreflexia; P2X1; P2X2 3; P2X3; Purinergic; Purinoceptor; Reflex bladder; Sensitization

Indexed keywords

5 [[(3 PHENOXYBENZYL)(1,2,3,4 TETRAHYDRO 1 NAPHTHYL)AMINO]CARBONYL]TRIMELLITIC ACID; ADENOSINE TRIPHOSPHATE; AF 010; AF 130; AF 353; PURINERGIC P2X RECEPTOR; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X3 RECEPTOR; PURINERGIC P2X4 RECEPTOR; PURINERGIC P2X7 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; PURINERGIC P2 RECEPTOR; PURINERGIC P2X RECEPTOR ANTAGONIST;

ARTICLE; CHRONIC INFLAMMATION; CYSTITIS; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; HUMAN; LOWER URINARY TRACT SYMPTOM; MECHANOTRANSDUCTION; MICTURITION REFLEX; NEUROPATHIC PAIN; NEUROTRANSMITTER RELEASE; NONHUMAN; OVERACTIVE BLADDER; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; SPINAL GANGLION; URINARY DYSFUNCTION; URINARY TRACT DISEASE; URINARY TRACT FUNCTION; URINARY TRACT INFECTION; ANIMAL; DRUG EFFECT; INNERVATION; METABOLISM; NERVE TRACT; PATHOPHYSIOLOGY; REVIEW; URINARY TRACT;

ADENOSINE TRIPHOSPHATE; ANIMALS; HUMANS; NEURAL PATHWAYS; PURINERGIC P2X RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2; RECEPTORS, PURINERGIC P2X; SIGNAL TRANSDUCTION; URINARY TRACT; UROLOGIC DISEASES;

EID: 79952210836     PISSN: 01712004     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-16499-6_22     Document Type: Article

References (226)

1. Abbracchio MP, Burnstock G (1994) Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol Ther 64: 445-475
2. Abbracchio MP, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Miras-Portugal MT, King BF, Gachet C, Jacobson KA, Weisman GA, Burnstock G (2003) Characterization of the UDPglucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family, Trends Pharmacol Sci 24: 52-55 (Pubitemid 36135872)
3. Andersson KE (1993) Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol Rev 45: 253-308
4. Andersson KE, Wein A (2004) Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence. Pharmacol Rev 56: 581-631
5. Banks FC, Calvert RC, Burnstock G (2010) Changing P2X receptor localization on maturing sperm in the epididymides of mice, hamsters, rats, and humans: a preliminary study. Fertil Steril 93: 1415-1420
6. Barbe MT, Monyer H, Bruzzone R (2006) Cell-cell communication beyond connexins: the pannexin channels. Physiology (Bethesda) 21: 103-114 (Pubitemid 43752506)
7. 3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain. J Neurosci 22: 8139-8147
8. 2x receptors mediate fast synaptic transmission in the dorsal horn of the rat spinal cord, J Neurosci 17: 5297-5304
9. Bavan S, Straub VA, Blaxter ML, Ennion SJ (2009) A P2X receptor from the tardigrade species Hypsibius dujardini with fast kinetics and sensitivity to zinc and copper. BMC Evol Biol 9: 17
10. Bayliss M, Wu C, Newgreen D, Mundy AR, Fry CH (1999) A quantitative study of atropineresistant contractile responses in human detrusor smooth muscle, from stable, unstable and obstructed bladders. J Urol 162: 1833-1839 (Pubitemid 29474738)
11. Birder LA, Nakamura Y, Kiss S, Nealen ML, Barrick S, Kanai AJ, Wang E, Ruiz G, de Groat WC, Apodaca G, Watkins S, Caterina MJ (2002) Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1, Nat Neurosci 5: 856-860 (Pubitemid 34976650)
12. Birder LA, Barrick SR, Roppolo JR, Kanai AJ, de Groat WC, Kiss S, Buffington CA (2003) Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium. Am J Physiol Renal Physiol 285: F423-F429 (Pubitemid 37010852)
13. Birder LA, Ruan HZ, Chopra B, Xiang Z, Barrick S, Buffington CA, Roppolo JR, Ford APDW, de Groat WC, Burnstock G (2004) Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis. Am J Physiol Renal Physiol 287: F1084-F1091 (Pubitemid 39391107)
14. Bishara S, Gao Y, Malone-Lee M, Clark S, Lunawat R, Khan S, Khasriya R, King B, Malone-Lee J (2009) Increased ATP mediated contraction of isolated detrusor cells of patients with outflow obstruction. Neurourol Urodyn 28: 746-747
15. Bleehen T, Keele CA (1977) Observations on the algogenic actions of adenosine compounds on the human skin blister base preparation. Pain 3: 367-377 (Pubitemid 8164551)
16. Bleehen T, Hobbiger F, Keele CA (1976) Identification of algogenic substances in human erythrocytes, J Physiol (Lond) 262: 131-149
17. Bodin P, Bailey D, Burnstock G (1991) Increased flow-induced ATP release from isolated vascular endothelial cells but not smooth muscle cells. Br J Pharmacol 103: 1203-1205
18. Bodin P, Milner P, Winter R, Burnstock G ( 1992) Chronic hypoxia changes the ratio of endothelin to ATP release from rat aortic endothelial cells exposed to high flow. Proc Biol Sci 247: 131-135
19. Bradbury EJ, Burnstock G, McMahon SB (1998) The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor. Mol Cell Neurosci 12: 256-268 (Pubitemid 28536078)
20. Brading AF, Williams JH (1990) Contractile responses of smooth muscle strips from rat and guinea-pig urinary bladder to transmural stimulation: effects of atropine and alpha, betamethyl ene ATP. Br J Pharmacol 99: 493-498 (Pubitemid 20069151)
21. Brady CM, Apostolidis A, Yiangou Y, Baecker PA, Ford AP, Freeman A, Jacques TS, Fowler CJ, Anand P (2004) P2X3-immunoreactive nerve fibres in neurogenic detrusor overactivity and the effect of intravesical resiniferatoxin. Eur Urol 46: 247-253 (Pubitemid 38902749)
22. Brotherton-Pleiss CE, Dillon MP, Ford AP, Gever JR, Carter DS, Gleason SK, Lin CJ, Moore AG, Thompson AW, Villa M, Zhai Y (2010) Discovery and optimization of RO-85, a novel druglike, potent, and selective P2X3 receptor antagonist. Bioorg Med Chem Lett 20: 1031-1036
23. Burnstock G (1972) Purinergic nerves. Pharmacol Rev 24: 509-581
24. Burnstock G (1976) Do some nerve cells release more than one transmitter? Neuroscience 1: 239-248
25. Burnstock G (2000) Purinergic signalling in lower urinary tract. In: Abbracchio MP, Williams M (eds) Handbook of experimental pharmacology. Springer, Berlin, pp 423-515
26. Burnstock G (2001a) Purine-mediated signalling in pain and visceral perception, Trends Pharmacol Sci 22: 182-188
27. Burnstock G (2001b) Purinergic signalling. Springer, Berlin, pp 89-127
28. Burnstock G (2008) Unresolved issues and controversies in purinergic signalling. J Physiol (Lond) 586: 3307-3312
29. Burnstock G (2009) Autonomic neurotransmission: 60 years since Sir Henry Dale. Annu Rev Pharmacol Toxicol 49: 1-30
30. Burnstock G, Knight GE (2004) Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol 240: 31-304 (Pubitemid 39539202)
31. Burnstock G, Campbell G, Satchell DG, Smythe A (1970) Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Br J Pharmacol 40: 668-688
32. Burnstock G, Dumsday B, Smythe A (1972) Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide. Br J Pharmacol 44: 451-461
33. Burnstock G, Cocks T, Crowe R, Kasakov L (1978) Purinergic innervation of the guinea-pig urinary bladder. Br J Pharmacol 63: 125-138 (Pubitemid 8336419)
34. Calvert RC, Thompson CS, Burnstock G (2008) ATP release from the human ureter on distension and P2X(3) receptor expression on suburothelial sensory nerves, Purinergic Signal 4: 377-381
35. Carter DS, Alam M, Cai H, Dillon MP, Ford AP, Gever JR, Jahangir A, Lin C, Moore AG, Wagner PJ, Zhai Y (2009) Identification and SAR of novel diaminopyrimidines. Part 1 : the discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain, Bioorg Med Chem Lett 19: 1628-1631
36. Cefalu JS, Zhu QM, Eggers AC, Kaan TK, Ho MJ, Jett MF, Cockayne DA, Ford AP, Nunn PA (2007) Effects of the selective prostacyclin receptor antagonist RO3244019 on the micturition reflex in rats, J Urol 178: 2683-2688 (Pubitemid 350052147)
37. Chancellor MB, Kaplan SA, Blaivas JG (1992) The cholinergic and purinergic components of detrusor contractility in a whole rabbit bladder model. J Urol 148: 906-909
38. Chappie CR, Smith D (1994) The pathophysiological changes in the bladder obstructed by benign prostatic hyperplasia. Br J Urol 73: 117-123
39. Chen X, Gebhart GF (2010) Differential purinergic signaling in bladder sensory neurons of naive and bladder-inflamed mice. Pain 148: 462-472
40. Chen CC, Akopian AN, Sivilotti L, Colquhoun D, Burnstock G, Wood JN (1995) A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377: 428-431
41. Cheng Y, Allan W, Walsh C, Mansfield KJ, Burcher E, Moore KH (2009) ATP release during cystometry in women with detrusor overactivity and painful bladder syndrome: contributiion to "urgency"? Neurourol Urodyn 28: 838-839
42. Cheng Y, Mansfield KJ, Allen W, Walsh CA, Burcher E, Moore KH (2010) Does adenosine triphosphate released into voided urodynamic fluid contribute to urgency signaling in women with bladder dysfunction? J Urol 183: 1082-1086
43. Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, Egerton J, Murfin M, Richardson J, Peck WL, Grahames CB, Casula MA, Yiangou Y, Birch R, Anand P, Buell GN (2005) Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain 114: 386-396 (Pubitemid 40385877)
44. Clark AK, Staniland AA, Marchand F, Kaan TK, McMahon SB, Malcangio M (2010) P2X7dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide. J Neurosci 30: 573-582
45. Clemens JQ (2010a) Afferent neurourology: a novel paradigm. Neurourol Urodyn 29(Suppl 1): S29-S31
46. Clemens JQ (2010b) Afferent neurourology: an epidemiological perspective. J Urol 184: 432-439
47. Cockayne DA, Hamilton SG, Zhu QM, Dunn PM, Zhong Y, Novakovic S, Malmberg AB, Cain G, Berson A, Kassotakis L, Hedley L, Lachnit WG, Burnstock G, McMahon SB, Ford AP (2000) Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature 407: 1011-1015
48. 2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol 567: 621-639
49. Colgan SP, Eltzschig HK, Eckle T, Thompson LF (2006) Physiological roles for ecto-5′-nucleotidase (CD73). Purinergic Signal 2: 351-360
50. Collier HO, James GW, Schneider C (1966) Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5'- triphosphate, Nature 212: 411-412
51. Contreras-Sanz A, Kennedy-Lydon T, Bishara S, Lunawat R, Khasriya R, Taylor K, Malone-Lee J, Wildman SS (2009) Altered ATP signalling in urothelium of OAB patients with exacerbated symptoms. Neurourol Urodyn 28: 935
52. Corriden R, Insel PA (2010) Basal release of ATP: an autocrine-paracrine mechanism for cell regulation. Sci Signal 3: rel
53. Cotrina ML, Lin JH, Alves-Rodrigues A, Liu S, Li J, Azmi-Ghadimi H, Kang J, Naus CC, Nedergaard M (1998) Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci USA 95: 15735-15740 (Pubitemid 29018769)
54. Courts AA, Jorizzo JL, Eady RA, Greaves MW, Burnstock G (1981) Adenosine triphosphateevoked vascular changes in human skin: mechanism of action, Eur J Pharmacol 76: 391-401 (Pubitemid 12253536)
55. Cova R, Guarneri L, Angelico P, Velasco C, Leonardi A, Testa R (1999) Effects of intravesical suramin and PPADS on cystometrographic parameters in conscious rats. Urodinamica 9: 162-168
56. Cowan WD, Daniel EE (1983) Human female bladder and its noncholinergic contractile function, Can J Physiol Pharmacol 61: 1236-1246 (Pubitemid 14222170)
57. Dang K, Bielefeldt K, Gebhart GF (2005) Differential responses of bladder lumbosacral and thoracolumbar dorsal root ganglion neurons to purinergic agonists, protons, and capsaicin, J Neurosci. 25: 3973-3984 (Pubitemid 40570430)
58. Dang K, Lamb K, Cohen M, Bielefeldt K, Gebhart GF (2008) Cyclophosphamide-induced bladder inflammation sensitizes and enhances P2X receptor function in rat bladder sensory neurons. J Neurophysiol 99: 49-59
59. de Groat WC, Araki I, Vizzard MA, Yoshiyama M, Yoshimura N, Sugaya K, Tai C, Roppolo JR (1998) Developmental and injury induced plasticity in the micturition reflex pathway. Behav Brain Res 92: 127-140 (Pubitemid 28223584)
60. de Groat WC, Downie JW, Levin RM, Lin ATL, Morrison JFB, Nishizawa O, Steers WD, Thor KB (1999) Basic neurophysiology and neuropharmacology. In: Abrams P, Khoury S, Wein A (eds) Incontinence: 1st international consultation on incontinence, June 28-July I, 1998, Monaco. Health Publication, St. Helier, Jersey, UK, pp 105-154
61. Dean DM, Downie JW (1978) Contribution of adrenergic and "purinergic" neurotransmission to contraction in rabbit detrusor, J Pharmacol Exp Ther 207: 431-445 (Pubitemid 9100368)
62. DiVirgilio F (2005) Purinergic mechanism in the immune system: a signal of danger for dendritic cells. Purinergic Signal 1: 205-209
63. Dorn G, Patel S, Wotherspoon G, Hemmings-Mieszczak M, Barclay J, Natt FJC, Martin P, Bevan S, Fox A, Ganju P, Wishart W, Hall J (2004) siRNA relieves chronic neuropathic pain. Nucleic Acids Res 32: e49
64. Drury AN, Szent-Györgyi A (1929) The physiological activity of adenine compounds with especial reference to their action upon mammalian heart. J Physiol 68: 213-237
65. Dunn PM, Zhong Y, Burnstock G (2001) P2X receptors in peripheral neurons. Prog Neurobiol 65: 107-134 (Pubitemid 32524181)
66. 3 receptors in the rat and human urinary bladder. Pharmacology 63: 120-128
67. Faigle M, Seessle J, Zug S, El Kasmi KC, Eltzschig HK (2008) ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia. PLoS One 3: e2801
68. Ferguson DR, Kennedy I, Burton TJ (1997) ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes - a possible sensory mechanism? J Physiol 505: 503-511
69. Ford APDW, Gever JR, Nunn PA, Zhong Y, Cefalu JS, Dillon MP, Cockayne DA (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br J Pharmacol 147: S132-S143 (Pubitemid 43237579)
70. Fountain SJ, Parkinson K, Young MT, Cao L, Thompson CR, North RA (2007) An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum. Nature 448: 200-203 (Pubitemid 47067368)
71. Fry CH, Skennerton D, Wood D, Wu C (2002) The cellular basis of contraction in human detrusor smooth muscle from patients with stable and unstable bladders. Urology 59: 3-12 (Pubitemid 34462252)
72. Fujii K (1988) Evidence for adenosine triphosphate as an excitatory transmitter in guinea-pig, rabbit and pig urinary bladder. J Physiol 404: 39-52
73. Gever JR, Cockayne DA, Dillon MP, Burnstock G, Ford APDW (2006) Pharmacology of P2X channels. Pflugers Arch. 452: 513-537 (Pubitemid 44015088)
74. Gever JR, Soto R, Henningsen RA, Martin RS, Hackos DH, Panicker S, Rubas W, Oglesby IB, Dillon MP, Milla ME, Burnstock G, Ford AP (2010) AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol 160: 1387-1398
75. Gill K, Jeyakumar A, Brenton T, Khasriya R, Kupelian A, Malone-Lee J (2010) Urinary ATP a test to replace dipsticks and microscopy for pyuria. Neurourol Urodyn 29 (ICS/IUGA meeting abstracts - Toronto, Canada: Aug 2010):Abstract 337
76. Greig AV, James SE, McGrouther DA, Terenghi G, Burnstock G (2003a) Purinergic receptor expression in the regenerating epidermis in a rat model of normal and delayed wound healing, Exp Dermatol 12: 860-871 (Pubitemid 38028677)
77. Greig AV, Linge C, Cambrey A, Burnstock G (2003b) Purinergic receptors are part of a signaling system for keratinocyte proliferation, differentiation, and apoptosis in human fetal epidermis. J Invest Dermatol 121: 1145-1149 (Pubitemid 37430985)
78. Greig AV, Linge C, Healy V, Lim P, Clayton E, Rustin MH, McGrouther DA, Burnstock G (2003c) Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells. J Invest Dermatol 121: 315-327 (Pubitemid 36969906)
79. Greig AV, Linge C, Terenghi G, McGrouther DA, Burnstock G (2003d) Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. J Invest Dermatol 120: 1007-1015
80. Gu JG, MacDermott AB (1997) Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature 389: 749-753 (Pubitemid 27458964)
81. Gunosewoyo H, Kassiou M (2010) P2X purinergic receptor ligands: recently patented compounds, Expert Opin Ther Pat 20: 625-646
82. Habler HJ, Janig W, Koltzenburg M (1990) Activation of unmyelinated afferent fibres by mechanical stimuli and inflammation of the urinary bladder in the cat. J Physiol 425: 545-562 (Pubitemid 20191693)
83. Habler HJ, Janig W, Koltzenburg M (1993) Myelinated primary afferents of the sacral spinal cord responding to slow filling and distension of the cat urinary bladder. J Physiol 463: 449-460 (Pubitemid 23120596)
84. Hamilton SG, Warburton J, Bhattacharjee A, Ward J, McMahon SB (2000) ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia. Brain 123: 1238-1246 (Pubitemid 30312114)
85. Hansen MA, Balcar VJ, Barden JA, Bennett MR (1998) The distribution of single P2xl-receptor clusters on smooth muscle cells in relation to nerve varicosities in the rat urinary bladder. J Neurocytel 27: 529-539 (Pubitemid 29204656)
86. Harrington LS, Evans RJ, Wray J, Norling L, Swales KE, Vial C, Ali F, Carrier MJ, Mitchell JA (2007) Purinergic 2X1 receptors mediate endothelial dependent vasodilation to ATP. Mol Pharmacol 72: 1132-1136 (Pubitemid 350012587)
87. Harvey R (2002) The contractile potency of adenosine triphosphate and ecto-adenosine triphosphatase activity in guinea pig detrusor and detrusor from patients with a stable, unstable or obstructed bladder. J Urol 168: 1235-1239
88. Hausmann R, Rettinger J, Gerevich Z, Meis S, Kassack MU, liles P, Lambrecht G, Schmalzing G (2006) The suramin analog 4,4′,4″, 4‴-(carbonylbis(imino-5, 1, 3-benzenetriylbis (carbonylimino)))tetra-kis- benzenesulfonic acid (NFl 10) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups. Mol Pharmacol 69: 2058-2067 (Pubitemid 43894325)
89. Hegde SS, Mandel DA, Wilford MR, Briaud S, Ford APDW, Eglen RM (1998) Evidence for purinergic neurotransmission in the urinary bladder of pithed rats. Eur J Pharmacol 349: 75-82 (Pubitemid 28270659)
90. 2+ flashes and contractility evoked by muscarinic receptor activation in mouse urinary bladder smooth muscle. J Physiol 587: 5275-5288
91. Hilliges M, Weidner C, Schmelz M, Schmidt R, Orstavik K, Torebjork E, Handwerker H (2002) ATP responses in human C nociceptors. Pain 98: 59-68 (Pubitemid 34722469)
92. Holton P (1959) The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol 145: 494-504
93. 3 antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats. Pain 99: 11-19
94. Honore P, Mikusa J, Bianchi B, McDonald H, Cartmell J, Faltynek C, Jarvis MF (2002b) TNPATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics. Pain 96: 99-105 (Pubitemid 34270632)
95. 1 receptors in human platelets with potency in the low nanomolar range. Naunyn Schmiedebergs Arch Pharmacol 372: 1-13
96. Hourani SM, Chown JA (1989) The effects of some possible inhibitors of ectonucleotidases on the breakdown and pharmacological effects of ATP in the guinea-pig urinary bladder. Gen Pharmacol 20: 413-416 (Pubitemid 19161418)
97. Hoyle CHV (1996) Purinergic cotransmission: parasympathetic and enteric nerves. Semin Neurosci 8: 207-215
98. Hoyle CHV, Burnstock G (1985) Atropine-resistant excitatory junction potentials in rabbit bladder are blocked by α,β-methylene ATP. Eur J Pharmacol 114: 239-240 (Pubitemid 16255564)
99. Igawa Y, Mattiasson A, Andersson K-E (1993) Functional importance of cholinergic and purinergic neurotransmission for micturition contraction in the normal, unanaesthetized rat. Br J Pharmacol 109: 473-479 (Pubitemid 23161133)
100. Iglesias R, Dahl G, Qiu F, Spray DC, Scemes E (2009) Pannexin 1: the molecular substrate of astrocyte "hemichannels". J Neurosci 29: 7092-7097
101. Inoue R, Brading AF (1990) The properties of the ATP-induced depolarization and current in single cells isolated from the guinea-pig urinary bladder. Br J Pharmacol 100: 619-625 (Pubitemid 20222302)
102. Inoue R, Brading AF (1991) Human, pig and guinea-pig bladder smooth muscle cell generate similar inward currents in response to purinoceptor activation. Br J Pharmacol 103: 1840-1841
103. Inoue K, Tsuda M, Koizumi S (2003) ATP induced three types of pain behaviors, including allodynia. Drug Dev Res 59: 56-63 (Pubitemid 36682441)
104. Inoue K, Tsuda M, Koizumi S (2004) Chronic pain and microglia: the role of ATP. Novartis Found Symp 261: 55-64
105. 1, receptors in renal microvascular autoregulatory behavior. J Clin Invest 112: 1895-1905
106. Inscho EW, Cook AK, Imig JD, Vial C, Evans RJ (2004) Renal autoregulation in P2X1 knockout mice. Acta Physiol Scand 181: 445-453 (Pubitemid 39078841)
107. Ito K, Iwami A, Katsura H, Ikeda M (2008) Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491. on cyclophospham-induced-cystitis in rats. Naunyn Schmiedebergs Arch. Pharmacol 377: 483-490 (Pubitemid 351868524)
108. Jacobson KA, Costanzi S, Ohno M, Joshi BV, Besada P, Xu B, Tchilibon S (2004) Molecular recognition at purine and pyrimidine nucleotide (P2) receptors. Curr Top Med Chem 4: 805-819 (Pubitemid 38854839)
109. Jahangir A, Alam M, Carter DS, Dillon MP, Bois DJ, Ford AP, Gever JR, Lin C, Wagner PJ, Zhai Y, Zira J (2009) Identification and SAR of novel diaminopyrimidines. Part 2: the discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain, Bioorg Med Chem Lett 19: 1632-1635
110. 1 antagonist. Bioorg Med Chem Lett 15: 3292-3295
111. 3 homomeric and heteromeric channels to acute and chronic pain. Expert Opin Ther Targets 7: 513-522
112. Jarvis MF (2010) The neural-glial purinergic receptor ensemble in chronic pain states. Trends Neurosci 33: 48-57
113. Jarvis MF, Wismer CT, Schweitzer E, Yu H, van Biesen T, Lynch KJ, Burgard EC, Kowaluk EA (2001) Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X3 allosteric modulator, cibacron blue. Br J Pharmacol 132: 259-269 (Pubitemid 32128456)
114. 2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci USA 99: 17179-17184
115. Kaan TKY, Yip PK, Zhong Y, Nunn PA, Ford APDW, Malcangio M, McMahon SB (2009) Novel P2X3 and P2X2/3 receptor antagonist prevents and reverses bone cancer-induced pain beha-viour in rats. Soc for Neurosci Abstracts (39th Annual Meeting, Chicago USA)
116. Kaan TK, Yip PK, Grist J, Cefalu JS, Nunn PA, Ford AP, Zhong Y, McMahon SB (2010) Endogenous purinergic control of bladder activity via presynaptic P2X3 and P2X2/3 receptors in the spinal cord. J Neurosci 30: 4503-4507
117. Kang J, Rang N, Lovatt D, Torres A, Zhao Z, Lin J, Nedergaard M (2008) Connexin 43 hemichannels are permeable to ATP. J Neurosci 28: 4702-4711
118. Kasakov L, Burnstock G (1983) The use of the slowly degradable analog, α,β-methylene ATP, to produce desensitisation of the P2-purinoceptor: Effect on non-adrenergic, non-cholinergic responses of the guinea-pig urinary bladder, Eur J Pharmacol 86: 291-294 (Pubitemid 13220931)
119. Kawate T, Michel JC, Birdsong WT, Gouaux E (2009) Crystal structure of the ATP-gated P2X(4) ion channel in the closed state. Nature 460: 592-598
120. Khakh BS (2001) International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol Rev 53: 107-118
121. Khakh BS, North R (2006) P2X receptors as cell-surface ATP sensors in health and disease. Nature 442: 527-532 (Pubitemid 44167906)
122. Khera M, Somogyi GT, Kiss S, Boone TB, Smith CP (2004) Botulinum toxin A inhibits ATP release from bladder urothelium after chronic spinal cord injury. Neurochem Int 45: 987-993 (Pubitemid 39164923)
123. Khera M, Boone TB, Salas N, Jett MF, Somogyi GT (2007) The role of the prostacyclin receptor antagonist RO3244019 in treating neurogenic detrusor overactivity after spinal cord injury in rats. BJU Int 99: 442-446 (Pubitemid 46103131)
124. Kinder RB, Mundy AR (1987) Pathophysiology of idiopathic detrusor instability and detrusor hyper-reflexia, An in vitro study of human detrusor muscle. BrJ Urol 60: 509-515
125. King JA, Huddart H, Staff WG (1997) Purinergic modulation of rat urinary bladder detrusor smooth muscle. Gen Pharmacol 29: 597-604 (Pubitemid 27421427)
126. King BF, Knowles ID, Burnstock G, Ramage AG (2004) Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats, Br J Pharmacol 142: 519-530 (Pubitemid 38869866)
127. Knight GE, Bodin P, De Groat WC, Burnstock G (2002) ATP is released from guinea pig ureter epithelium on distension. Am J Physiol Renal Physiol 282: F281-F288 (Pubitemid 34654559)
128. Kumahashi N, Ochi M, Kataoka H, Uchio Y, Kakimaru H, Sugawara K, Enomoto K (2004) Involvement of ATP, increase of intracellular calcium and the early expression of c-fos in the repair of rat fetal articular cartilage. Cell Tissue Res 317: 117-128 (Pubitemid 39070611)
129. Kumahashi N, Naitou K, Nishi H, Oae K, Watanabe Y, Kuwata S, Ochi M, Ikeda M, Uchio Y (2010) Correlation of changes in pain intensity with synovial fluid adenosine triphosphate levels after treatment of patients with osteoarthritis of the knee with high-molecular-weight hyaluronic acid. Knee [June 18, epub ahead of print]
130. 2+ transients in mesenteric small arteries. Am J Physiol Heart Circ Physiol 291: H3106-H3113
131. Laupland KB, Church DL, Gregson DB (2003) Evaluation of a rapid bacterial ATP assay for screening BAL samples from ICU patients submitted for quantitative bacterial cultures. Diagn Microbiol Infect Dis 47: 465-69 (Pubitemid 37338510)
132. Lee HY, Bradini M, Burnstock G (2000) Distribution of P2X receptors in the urinary bladder and the ureter of the rat. J Urol 163: 2002-2007 (Pubitemid 30366802)
133. Levin RM, Wein AJ (1982) Response of the in vitro whole bladder (rabbit) preparation to autonomic agonists. J Urol 128: 1087-1090 (Pubitemid 13211679)
134. Levin RM, Longhurst PA, Kato K, McGuire EJ, Elbadawi A, Wein AJ (1990) Comparative physiology and pharmacology of the cat and rabbit urinary bladder. J Urol 143: 848-852 (Pubitemid 20112127)
135. 2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 377: 432-435
136. Lieu PK, Sa'adu A, Orugun EO, Malone-Lee JG (1997) The influence of age on isometric and isotonic rat detrusor contractions. J Gerontol A Biol Sci Med Sci 52: M94-M96
137. Lipinski CA (2000) Drug-like properties and the causes of poor solubility and poor permeability, J Pharmacol Toxicol Methods 44: 235-249
138. Lommatzsch M, Cicko S, Muller T, Lucattelli M, Bratke K, Stoll P, Grimm M, Durk T, Zissel G, Ferrari D, Di VF, Sorichter S, Lungarella G, Virchow JC, Idzko M (2010) Extracellular adenosine triphosphate and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 181: 928-934
139. Lu S, Fraser M, Chancellor M, Sun L, de Groat WC (2002) Evaluation of voiding dysfunction and purinergic mechanism in awake long-term spinal cord injured rats: comparison of metabolism cage and cystometrogram measurements. J Urol 167: 276
140. Lu SH, Groat WC, Lin AT, Chen KK, Chang LS (2007) Evaluation of purinergic mechanism for the treatment of voiding dysfunction: a study in conscious spinal cord-injured rats. J Chin Med Assoc 70: 439-444 (Pubitemid 350104265)
141. Ludlow MJ, Durai L, Ennion SJ (2009) Functional characterization of intracellular Dictyostelium discoideum P2X receptors. J Biol Chem 284: 35227-35239
142. Maehara Y, Kusumoto H, Anai H, Kusumoto T, Sugimachi K (1987) Human tumor tissues have higher ATP contents than normal tissues. Clin Chim Acta 169: 341-343
143. Masuda H, Chancellor M, Kihara K, de Groat W, Yoshimura N (2005) Evidence for the involvement of spinal endogenous ATP and P2X receptors in detrusor overactivity caused by acetic acid, acrolein or cyclophosphamide, Neurourol Urodyn 24: 401-598
144. 2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration. Br J Pharmacol 140: 1381-1388
145. Michel AD, Ng SW, Roman S, Clay WC, Dean DK, Walter DS (2009) Mechanism of action of species-selective P2X7 antagonists. Br J Pharmacol 156: 1312-1325
146. Mitsui T, Kakizaki H, Matsuura S, Ameda K, Yoshioka M, Koyanagi T (2001) Afferent fibers of the hypogastric nerves are involved in the facilitating effects of chemical bladder irritation in rats. J Neurophysiol 86: 2276-2284 (Pubitemid 34000590)
147. Mork H, Ashina M, Bendtsen L, Olesen J, Jensen R (2003) Experimental muscle pain and tenderness following infusion of endogenous substances in humans. Eur J Pain 7: 145-153 (Pubitemid 36330532)
148. Mortaz E, Braber S, Nazary M, Givi ME, Nijkamp FP, Folkerts G (2009) ATP in the pathogenesis of lung emphysema. Eur J Pharmacol 619: 92-96
149. Mortaz E, Folkerts G, Nijkamp FP, Henricks PA (2010) ATP and the pathogenesis of COPD. Eur J Pharmacol 638: 1-4
150. 1 receptors. Nature 403: 86-89
151. Nakatsuka T, Gu JG (2001) ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord, J Neurosci 21: 6522-6531 (Pubitemid 32781096)
152. Nakatsuka Tm Tsuzuki Km Ling JXm Sonobe H, Gu JG (2003) Distinct roles of P2X receptors in modulating glutamate release at different primary sensory synapses in rat spinal cord. J Neurophysiol 89: 3243-3252
153. Namasivayam S, Eardley I, Morrison JFB (1999) Purinergic sensory neurotransmission in the urinary bladder: an in vitro study in the rat. Br J Urol Int 84: 854-860 (Pubitemid 29500056)
154. Nergardh A, Kinn AC (1983) Neurotransmission in activation of the contractile response in the human urinary bladder. Scand J Urol Nephrol 17: 153-157 (Pubitemid 13070418)
155. Nicke A (2008) Homotrimeric complexes are the dominant assembly state of native P2X7 subunits. Biochem Biophys Res Commun 377: 803-808
156. Nicke A, Baeumert HG, Rettinger J, Eichele A, Lambrecht G, Mutschier E, Schmalzing G (1998) P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels. EMBO J 17: 3016-3028 (Pubitemid 28254374)
157. 4 subunits. J Neurochem 92: 925-933
158. Nishiguchi J, Sasaki K, Seki S, Chancellor MB, Erickson KA, de Groat WC, Kumon H, Yoshimura N (2004) Effects of isolectin B4-conjugated saporin, a targeting cytotoxin, on bladder overactivity induced by bladder irritation, Eur J Neurosci 20: 474-482 (Pubitemid 38969632)
159. North RA (1996a) Families of ion channels with two hydrophobic segments. Curr Opin Cell Biol 8474-483
160. North RA (1996b) P2X purinoceptor plethora. Sem Neurosci 8: 187-194
161. North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82: 1013-1067
162. North RA, Barnard EA (1997) Nucleotide receptors. Curr Opin Neurobiol 7: 346-357 (Pubitemid 27321026)
163. North RA, Surprenant A (2000) Pharmacology of cloned P2X receptors. Annu Rev Pharmacol Toxicol 40: 563-580 (Pubitemid 30340693)
164. Nunn PA, Newgreen DT (1999) An investigation into the bladder responses induced via pelvic nerve stimulation in the anesthetized rat. Br J Pharmacol 126: 227P
165. O'Reilly BA, Kosaka AH, Chang TK, Ford AP, Popert R, McMahon SB (2001) A quantitative analysis of purinoceptor expression in the bladders of patients with symptomatic outlet obstruction. BJU Int 87: 617-622 (Pubitemid 34293751)
166. O'Reilly BA, Kosaka AH, Knight GF, Chang TK, Ford APDW, Rymer JM, Popert R, Burnstock G, McMahon SB (2002) P2X receptors and their role in female idiopathic detrusor instability. J Urol 167: 157-164 (Pubitemid 34024522)
167. Orriss IR, Knight GE, Utting JC, Taylor SE, Burnstock G, Arnett TR (2009) Hypoxia stimulates vesicular ATP release from rat osteoblasts. J Cell Physiol 220: 155-162
168. Osterberg E, Hallander HO, Kallner A, Lundin A, Aberg H (1991) Evaluation of the adenosine triphosphate test in the diagnosis of urinary tract infection. Eur J Clin Microbiol Infect Dis 10: 70-73
169. Palea S, Artibani W, Ostardo E, Trist DG, Pietra C (1993) Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis. J Urol 150: 2007-2012 (Pubitemid 24350854)
170. Pandita RK, Andersson K-E (2002) Intravesical adenosine triphosphate stimulates the micturition reflex in awake, freely moving rats, J Urol 168: 1230-1234
171. Pearson JD, Gordon JL (1979) Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides. Nature 281: 384-386
172. Pellegatti P, Raffaghello L, Bianchi G, Piccardi F, Pistoia V, Di VF (2008) Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase. PLoS One 3: e2599
173. Rapp DE, Lyon MB, Bales GT, Cook SP (2005) A role for the P2X receptor in urinary tract physiology and in the pathophysiology of urinary dysfunction. Eur Urol 48: 303-308 (Pubitemid 40957109)
174. 1 receptor. Neuropharmacology 39: 2044-2053
175. Risholm L (1954) Studies on renal colic and its treatment by posterior splanchnic block. Acta Chir Scand Suppl 184: 5-64
176. Rong W, Burnstock G (2004) Activation of ureter nociceptors by exogenous and endogenous ATP in guinea pig. Neuropharmacology 47: 1093-1101 (Pubitemid 39535848)
177. Rong W, Spyer KM, Burnstock G (2002) Activation and sensitization of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder. J Physiol 541: 591-600 (Pubitemid 35190224)
178. Ruggieri MR (2006) Mechanisms of disease: role of purinergic signaling in the pathophysiology of bladder dysfunction. Nat Clin Pract Urol 3: 206-215
179. Ryan LM, Rachow JW, McCarty DJ (1991) Synovial fluid ATP: a potential substrate for the production of inorganic pyrophosphate. J Rheumatol 18: 716-720
180. Salas NA, Smith CP, Kiss S, Boone TB, Somogyi GT (2005) Intravesical cholinergic receptor activated spinal ATP release in normal and chronic spinal cord injured rats, J Urol 173: 45
181. Salas NA, Somogyi GT, Gangitano DA, Boone TB, Smith CP (2007) Receptor activated bladder and spinal ATP release in neurally intact and chronic spinal cord injured rats, Neurochem Int 50: 345-350 (Pubitemid 46097164)
182. Shabbir M, Burnstock G (2009) Purinergic receptor-mediated effects of adenosine 5′-triphosphate in urological malignant diseases, Int J Urol 16: 143-150
183. Sibley GN (1984) A comparison of spontaneous and nerve-mediated activity in bladder muscle from man, pig and rabbit. J Physiol 354: 431-443
184. Sjogren C, Andersson K-E, Husted S, Mattiasson A, Moller-Madsen B (1982) Atropine resistance of transmuralIy stimulated isolated human bladder muscle. J Urol 128: 1368-1371 (Pubitemid 13191036)
185. Smith CP, Vemulakonda VM, Kiss S, Boone TB, Somogyi GT (2005) Enhanced ATP release from rat bladder urothelium during chronic bladder inflammation: Effect of botulinum toxin A. Neurochem Int 47: 291-297 (Pubitemid 40943471)
186. Smith CP, Gangitano DA, Munoz A, Salas NA, Boone TB, Aoki KR, Francis J, Somogyi GT (2008) Botulinum toxin type A normalizes alterations in urothelial ATP and NO release induced by chronic spinal cord injury. Neurochem Int 52: 1068-1075
187. Soto F, Lambrecht G, Nickel P, Stuehmer W, Busch AE (1999) Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors. Neuropharmacology 38: 141-149 (Pubitemid 29073533)
188. 3 receptors, Nature 407: 1015-1017
189. Suadicani SO, Vink MJ, Spray DC (2000) Slow intercellular Ca(2+) signaling in wild-type and Cx43-null neonatal mouse cardiac myocytes. Am J Physiol Heart Circ Physiol 279: H3076-H3088 (Pubitemid 32005899)
190. Sun Y, Chai TC (2002) Effects of dimethyl sulphoxide and heparin on stretch-activated ATP release by bladder urothelial cells from patients with interstitial cystitis. BJU Int 90: 381-385 (Pubitemid 36124768)
191. 3 receptor during stretch of bladder urothelial cells from patients with interstitial cystitis. J Urol 171: 448-452
192. Sun Y, Keay S, DeDeyne P, Chai T (2001a) Stretch-activated release of adenosine triphosphate by bladder uroepithelia is augmented in interstitial cystitis. Urology 57: 131-135
193. Sun Y, Keay S, DeDeyne PG, Chai TC (2001b) Augmented stretch activated adenosine triphosphate release from bladder uroepithelial cells in patients with interstitial cystitis. J Urol 166: 1951-1956 (Pubitemid 32953463)
194. Sun Y, MaLossi J, Jacobs SC, Chai TC (2002) Effect of doxazosin on stretch-activated adenosine triphosphate release in bladder urothelial cells from patients with benign prostatic hyperplasia. Urology 60: 351-356 (Pubitemid 34831798)
195. Sun Y, Keay S, Lehrfeld TJ, Chai TC (2009) Changes in adenosine triphosphate-stimulated ATP release suggest association between cytokine and purinergic signaling in bladder urothelial cells. Urology 74: 1163-1168
196. Thuringer D (2004) The vascular endothelial growth factor-induced disruption of gap junctions is relayed by an autocrine communication via ATP release in coronary capillary endothelium, Ann NY Acad Sci 1030: 14-27
197. Tong YC, Hung YC, Shinozuka K, Kunitomo M, Cheng JT (1997) Evidence of adenosine 5′triphosphate release from nerve and P2x-purinoceptor mediated contraction during electrical stimulation of rat urinary bladder smooth muscle, J Urol 158: 1973-1977 (Pubitemid 27433197)
198. Tornroth-Horsefield S, Neutze R (2008) Opening and closing the metabolite gate. Proc Natl Acad Sci USA 105: 19565-19566
199. Tsuda M, Ueno S, Inoue K (1999a) Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice. Br J Pharmacol 128: 1497-1504
200. Tsuda M, Ueno S, Inoue K (1999b) In vivo pathway of thermal hyperalgesia by intrathecal administration of α,β-methylene ATP in mouse spinal cord: Involvement of the glutamateNMDA receptor system. Br J Pharmacol 127: 449-456
201. 3 receptors in neuropathic pain in a mouse model of chronic constriction injury. Drug Dev Res 59: 104-111
202. Ulmann L, Hatcher JP, Hughes JP, Chaumont S, Green PJ, Conquet F, Buell GN, Reeve AJ, Chessell IP, Rassendren F (2008) Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain. J Neurosci 28: 11263-11268
203. Ulmann L, Hirbec H, Rassendren F (2010) P2X4 receptors mediate PGE2 release by tissueresident macrophages and initiate inflammatory pain. EMBO J 29: 2290-2300
204. Velasco C, Guarnen L, Leonardi A, Testa R (2003) Effects of intravenous and infravesical administration of suramin, terazosin and BMY 7378 on bladder instability in conscious rats with bladder outlet obstruction. BJU Int 92: 131-136 (Pubitemid 36843043)
205. 1 receptors for functional P2X receptor responses in the mouse urinary bladder smooth muscle. Br J Pharmacol 131: 1489-1495
206. 2X1 receptors in mouse ileum, bladder and reproductive systems. Auton Neurosci 92: 56-64
207. 3 knock-out mice reveal a major sensory role for urothelially released ATP. J Neurosci. 21: 5670-5677
208. 3 receptor subunits in rat and monkey sensory neurons and their central terminals. Neuropharmacology 36: 1229-1242
209. 3 is expressed by DRG neurons that terminate in inner lamina II. Eur J Neurosci 10: 3470-3478
210. Wang ECY, Lee JM, Ruiz WG, Balestreire EM, von Bodungen M, Barrick S, Cockayne DA, Birder LA, Apodaca G (2005) ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells. J Clin Invest 115: 2412-2422 (Pubitemid 41266203)
211. Westfall TD, Kennedy C, Sneddon P (1997) The ecto-ATPase inhibitor ARL 67156 enhances parasympathetic neurotransmission in the guinea-pig urinary bladder. Eur J Pharmacol 329: 169-173 (Pubitemid 27270530)
212. White TD, Chaudhry A, Vohra MM, Webb D, Leslie RA (1985) Characteristics of P2 (nucleotide) receptors mediating contraction and relaxation of rat aortic strips: possible physiological relevance. Eur J Pharmacol 118: 37-44 (Pubitemid 16189569)
213. Windscheif U, Ralevic V, Baumert HG, Mutschler E, Lambrecht G, Burnstock G (1994) Vasoconstrictor and vasodilator responses to various agonists in the rat perfused mesenteric arterial bed - selective inhibition by ppads of contractions mediated via p-2x-purinoceptors. Br J Pharmacol 113: 1015-1021 (Pubitemid 24326848)
214. Wink MR, Lenz G, Braganhol E, Tamajusuku AS, Schwartsmann G, Sarkis JJ, Battastini AM (2003) Altered extracellular ATP, ADP and AMP catabolism in glioma cell lines. Cancer Lett 198: 211-218
215. Wu C (1999) A comparison of the mode of action of ATP and carbachol on isolated human detrusor smooth muscle. J Urol 162: 1840
216. 2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats. Eur J Pharmacol 504: 45-53
217. Wust M, Averbeck B, Reif S, Brater M, Ravens U (2002) Different responses to drugs against overactive bladder in detrusor muscle of pig, guinea pig and mouse. Eur J Pharmacol 454: 59-69 (Pubitemid 35284367)
218. Yang S, Cheek DJ, Westfall DP, Buxton IL (1994) Purinergic axis in cardiac blood vessels. Agonist-mediated release of ATP from cardiac endothelial cells, Circ Res 74: 401-407
219. 3 in human urinary bladder. BJU Int 87: 774-779
220. Yoshida M, Homma Y, Inadome A, Yono M, Seshita H, Miyamoto Y, Murakami S, Kawabe K, Ueda S (2001) Age-related changes in cholinergic and purinergic neurotransmission in human isolated bladder smooth muscle, Exp Gerontol 36: 99-109 (Pubitemid 32012570)
221. Yoshida M, Miyamae K, Iwashita H, Otani M, Inadome A (2004) Management of detrusor dysfunction in the elderly: changes in acetylcholine and adenosine triphosphate release during aging. Urology 63: 17-23 (Pubitemid 38317358)
222. Yoshimura N, de Groat WC (1999) Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation. J Neurosci 19: 4644-4653 (Pubitemid 29241112)
223. Yoshimura N, Seki S, Chancellor MB, de Groat WC, Ueda T (2002) Targeting afferent hyperexcitability for therapy of the painful bladder syndrome. Urology 59: 61-67 (Pubitemid 34462260)
224. Yoshimura N, Seki S, Erickson KA, Erickson VL, Chancellor MB, de Groat WC (2003) Histological and electrical properties of rat dorsal root ganglion neurons innervating the lower urinary tract. J Neurosci 23: 4355-4361 (Pubitemid 36958456)
225. Zhong Y, Banning AS, Cockayne DA, Ford APDW, Burnstock G, McMahon SB (2003) Bladder and cutaneous sensory neurons of the rat express different functional P2X receptors. Neuroscience 120: 667-675 (Pubitemid 36928065)
226. 2X-purinoceptor- mediated responses in the rabbit urinary bladder. Br J Pharmacol 110: 1491-1495