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Soto F, Garcia-Guzman M, Gomez-Hernandez JM, Hollmann M, Karschin C, Stühmer W. P2X4: an ATP-activated ionotropic receptor cloned from rat brain. Proc Natl Acad Sci USA. 93:1996;3684-3688.
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Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissue.
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The findings of this study are relevant to the question of which purinoceptor underlies the responses of insulin-secreting cells to extracellular ATP. of special interest
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Wang C, Namba N, Gonoi T, Inagaki N, Seino S. Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissue. Biochem Biophys Res Commun. 220:1996;196-202 The findings of this study are relevant to the question of which purinoceptor underlies the responses of insulin-secreting cells to extracellular ATP. of special interest.
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Wang, C.1
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Seguela P, Haghihi A, Soghomonian J-J, Cooper E. A novel neuronal P2X ATP receptor ion channel with widespread distribution in the brain. J Neurosci. 16:1996;448-455.
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Garcia-Guzman M, Sotot F, Laube B, Stühmer W. Molecular cloning and functional expression of a novel rat heart P2X purinoceptor. FEBS Lett. 388:1996;123-127.
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0029665112
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7)
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7 receptor cDNA was isolated from rat brain, but the properties of the expressed receptor correspond closely to those previously attributed to the P2Z receptor of macrophages (cf. [4]). of special interest
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7 receptor cDNA was isolated from rat brain, but the properties of the expressed receptor correspond closely to those previously attributed to the P2Z receptor of macrophages (cf. [4]). of special interest.
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Surprenant, A.1
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Characterization and chromosomal localization of a human P2X receptor from urinary bladder
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Valera S, Talabot F, Evans RJ, Gos A, Antonarakis SE, Morris MA, Buell GN. Characterization and chromosomal localization of a human P2X receptor from urinary bladder. Recept Channels. 3:1995;283-289.
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Valera, S.1
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0343144816
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3 receptor
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3 receptors had hitherto been thought to be restricted to a subset of sensory neurons; this paper shows that the RNA is also abundant in heart (from which the human cDNA was isolated) and found in the spinal cord. in press.
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Mol Brain Res
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Garcia-Guzman, M.1
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0031052095
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7): Cloning and expression of a human cDNA
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ATP and its 2′,3′-(benzoyl-4-benzoyl) analogue are less effective at permeabilizing cells expressing the human P2X7 receptor than cells expressing the rat P2X7 receptor. Expression of rat/human chimeras indicates that the difference results, in part, from differences in the long carboxy-terminal tail of the protein. of special interest
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7): cloning and expression of a human cDNA. J Biol Chem. 272:1997;5482-5486 ATP and its 2′,3′-(benzoyl-4-benzoyl) analogue are less effective at permeabilizing cells expressing the human P2X7 receptor than cells expressing the rat P2X7 receptor. Expression of rat/human chimeras indicates that the difference results, in part, from differences in the long carboxy-terminal tail of the protein. of special interest.
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Rassendren, F.1
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6. of special interest.
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Brandle, U.1
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Identification of a short form of the P2XR1-purinoceptor subunit produced by alternative splicing in the pituitary and choclea
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Housley GD, Greenwood D, Bennett T, Ryan AF. Identification of a short form of the P2XR1-purinoceptor subunit produced by alternative splicing in the pituitary and choclea. Biochem Biophys Res Commun. 212:1995;501-508.
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Housley, G.D.1
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Buell G, Michel AD, Lewis C, Collo G, Humphrey PPA, Surprenant A. P2X1 receptor activation in HL60 cells. Blood. 87:1996;2659-2664.
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MacKenzie AB, Mahaut-Smith MP, Sage SO. Activation of receptor-operated cation channels via P2X not P2T purinoceptors in human platelets. J Biol Chem. 271:1996;2879-2881.
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MacKenzie, A.B.1
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Families of ion channels with two hydrophobic segments
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+ channels, the other major class of membrane channels with two transmembrane domains and a large extracellular loop in each subunit. of special interest
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+ channels, the other major class of membrane channels with two transmembrane domains and a large extracellular loop in each subunit. of special interest.
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North, R.A.1
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27
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0030005332
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Michel AD, Lundstrom K, Buell GN, Surprenant A, Valera S, Humphrey PPA. A comparison of the binding characteristics of recombinant P2X1 and P2X2 purinoceptors. Br J Pharmacol. 118:1996;1806-1813.
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Identification of amino acid residues contributing to the pore of a P2X receptor
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2 receptor contribute to the lining of the ionic pore. of special interest
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2 receptor contribute to the lining of the ionic pore. of special interest.
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0029819859
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Vulchanova L, Arvidsson U, Riedl M, Wang J, Buell G, Surprenant A, North RA, Elde RP. Differential distribution of two ATP-gated ion channels (P2X receptors) determined by immunocytochemistry. Proc Natl Acad Sci USA. 93:1996;8063-8067.
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ATP-gated cation channels (P2X purinoceptors) in trigeminal mesencephalic nucleus neurones of the rat
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Khakh BS, Humphrey PPA, Henderson G. ATP-gated cation channels (P2X purinoceptors) in trigeminal mesencephalic nucleus neurones of the rat. J Physiol. 498:1997;709-715.
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0029958091
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P2X purinoceptors in cultured myenteric neurons of guinea pig small intestine
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A proportion of guinea pig myenteric neurons have synaptic potentials medicated by ATP acting at P2X receptors. This paper indicates that the myenteric neurons, like dorsal root ganglion cells (see [41] and references therein to earlier work) express two types of P2X receptor: one is activated by both ATP and αβmeATP and undergoes rapid desensitization, whereas the other is not activated by αβmeATP and shows little desensitization. of special interest
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Zhou X, Galligan JJ. P2X purinoceptors in cultured myenteric neurons of guinea pig small intestine. J Physiol. 496:1996;719-729 A proportion of guinea pig myenteric neurons have synaptic potentials medicated by ATP acting at P2X receptors. This paper indicates that the myenteric neurons, like dorsal root ganglion cells (see [41] and references therein to earlier work) express two types of P2X receptor: one is activated by both ATP and αβmeATP and undergoes rapid desensitization, whereas the other is not activated by αβmeATP and shows little desensitization. of special interest.
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Zhou, X.1
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48
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0031037082
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An ATP-gated cation channel with some P2Z-like characteristics in gastric smooth muscle cells of toad
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7 receptors, but ATP does not permeabilize the cells. of special interest
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7 receptors, but ATP does not permeabilize the cells. of special interest.
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Ugur, M.1
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49
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Variation in expression of the outer hair cell P2X receptor conductance along the guinea-pig cochlea
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Modulation by purines of calcium-activated non-selective cation channels in the outer hair cells of the guinea pig cochlea
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ATP activates non-selective cation channels and calcium release in inner hair cells of the guinea-pig cochlea
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0344705013
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An ATP-activated, ligand-gated ion channel on a cholinergic presynaptic nerve terminal
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0030219922
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Henderson DJ, Elliot DG, Smith GM, Webb TE, Dainty IA. Cloning and characterization of a bovine P2Y receptor. Biochem Biophys Res Commun. 212:1995;648-656.
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Léon C, Vial C, Cazenave J-P, Cachet C. Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor. Gene. 171:1996;295-297.
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73
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Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy
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Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch IH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proc Natl Acad Sci USA. 91:1994;3275-3279.
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Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor
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Chen Z-P, Krull N, Xu S, Levy A, Lightman SL. Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor. Endocrinology. 137:1996;1833-1840.
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3) activated preferentially by nucleoside diphosphates
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3) activated preferentially by nucleoside diphosphates. Mol Pharmacol. 50:1996;258-265.
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78
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Cloning and functional expression of a human uridine nucleotide receptor
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See annotation [79]. of special interest
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Communi D, Pirotton S, Parmentier M, Boeynaems J-M. Cloning and functional expression of a human uridine nucleotide receptor. J Biol Chem. 270:1995;30849-30852 See annotation [79]. of special interest.
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Communi, D.1
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79
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Cloning, expression and chromosomal localization of the uridine nucleotide receptor gene
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4) at which uridine nucleotides are highly active and ATP is of only low potency (i.e. a pyrimidinoceptor); such a receptor had been hypothesized to exist, based on tissue responses, by several authors earlier. of special interest
-
4) at which uridine nucleotides are highly active and ATP is of only low potency (i.e. a pyrimidinoceptor); such a receptor had been hypothesized to exist, based on tissue responses, by several authors earlier. of special interest.
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Nguyen, T.1
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81
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Discrimination by PPADS between endothelial P2Y- And P2U-purinoceptors in the rat isolated mesenteric arterial bed
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Ralevic V, Burnstock G. Discrimination by PPADS between endothelial P2Y- and P2U-purinoceptors in the rat isolated mesenteric arterial bed. Br J Pharmacol. 118:1996;428-434.
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Identification of a G protein coupled receptor induced in activated T cells
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Kaplan MH, Smith DI, Sundick RS. Identification of a G protein coupled receptor induced in activated T cells. J Immunol. 151:1993;628-636.
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84
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0031024529
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Transient up-regulation of P2Y(2) nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes
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2). This is deduced to be an immediate early gene response, providing feedback signalling from extracellular ATP. of special interest
-
2). This is deduced to be an immediate early gene response, providing feedback signalling from extracellular ATP. of special interest.
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(1997)
Proc Natl Acad Sci USA
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Koshiba, M.1
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87
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Molecular cloning of a novel P2 purinoceptor from human erythro-leukaemia cells
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2+ transients. It was used here to clone the cDNA for a P2Y-related sequence (see Note added in proof). of special interest
-
2+ transients. It was used here to clone the cDNA for a P2Y-related sequence (see Note added in proof). of special interest.
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(1996)
J Biol Chem
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Akbar, G.K.M.1
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88
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Early expression of a novel nucleotide receptor in the neural plate of Xenopus embryos
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Bogdanov YD, Dale L, King BF, Whittock N, Bumstock G. Early expression of a novel nucleotide receptor in the neural plate of Xenopus embryos. J Biol Chem. 272:1997;12583-12590.
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90
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0028987857
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Site-directed mutagenesis of P2U purinoceptors
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2). Mutagenesis to remove the positive charge at several sidechains in TM6 and TM7 markedly decreased nucleotide potencies. of special interest
-
2). Mutagenesis to remove the positive charge at several sidechains in TM6 and TM7 markedly decreased nucleotide potencies. of special interest.
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(1995)
J Biol Chem
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Erb, L.1
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92
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A comprehensive listing of the effects of all mutation and domain exchanges reported for the seven-transmembrane receptors (in general). A large number of positions can affect small-ligand agonist or antagonist activity, especially in TM3, TM5, TM6 and TM7. Direct versus indirect effects of the mutations have in most cases not been distinguishable. of special interest
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Van Rhee AM, Jacobson KA. Molecular architecture of G protein-coupled receptors. Drug Dev Res. 37:1996;1-38 A comprehensive listing of the effects of all mutation and domain exchanges reported for the seven-transmembrane receptors (in general). A large number of positions can affect small-ligand agonist or antagonist activity, especially in TM3, TM5, TM6 and TM7. Direct versus indirect effects of the mutations have in most cases not been distinguishable. of special interest.
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94
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The P2Y purinoceptor in rat-brain microvascular endothelial cells couples to inhibition of adenylate-cyclase
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1 receptors, determined by their intracellular environment. of special interest
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1 receptors, determined by their intracellular environment. of special interest.
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(1996)
Br J Pharmacol
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Webb, T.E.1
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2 purinoceptor-operated potassium channel in rat cerebellar neurons
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2 purinoceptor-operated potassium channel in rat cerebellar neurons. Biochem Biophys Res Commun. 218:1996;67-71.
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97
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0030050383
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+ channel by P2 purinoceptors via pertussis toxin-sensitive G proteins in guinea pig atrial cells
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+ channels that can be opened through muscarinic receptors (see also [96]). of special interest
-
+ channels that can be opened through muscarinic receptors (see also [96]). of special interest.
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Activation of nucleotide receptors inhibits high-threshold calcium currents in NG108-15 neuronal hybrid cells
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Filippov AK, Brown DA. Activation of nucleotide receptors inhibits high-threshold calcium currents in NG108-15 neuronal hybrid cells. Eur J Neurosci. 8:1996;1149-1155.
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2+ channel currents in cultured bovine adrenal chromaffin cells
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2+ channel currents in cultured bovine adrenal chromaffin cells. Neuron. 16:1996;1027-1036.
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1 purinergic receptors in sensory neurons: Contributions to touch-induced impulse generation
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1 purinergic receptors in sensory neurons: contributions to touch-induced impulse generation. Proc Natl Acad Sci USA. 93:1996;10465-10470.
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Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides
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Schlosser SF, Burgstahler AD, Nathanson MH. Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides. Proc Natl Acad Sci USA. 93:1996;9948-9953.
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Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation
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Wang Y, Roman R, Lidofsky SD, Fitz JG. Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation. Proc Natl Acad Sci USA. 93:1996;12020-12025.
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Dale N, Gilday D. Regulation of rhythmic movements by purinergic neurotransmitters in frog embryos. Nature. 383:1996;259-262.
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