Involvement of P2X2 and P2X3 receptors in neuropathic pain in a mouse model of chronic constriction injury

Drug Development Research

Volumn 59, Issue 1, 2003, Pages 104-111

  Ueno, Shinya ^a,c   Moriyama, Tomoko ^a   Honda, Kenji ^a   Kamiya, Hiro o ^a   Sakurada, Tsukasa ^b   Katsuragi, Takeshi ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b DAIICHI UNIVERSITY OF PHARMACY   (Japan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Dorsal root ganglion; Intrathecal administration; Mechanical allodynia; P2X receptor antagonist; Quantitative real time PCR

Indexed keywords

2' O (TRINITROPHENYL)ADENOSINE 5' TRIPHOSPHATE; DIINOSINE PENTAPHOSPHATE; MESSENGER RNA; PURINE P2X RECEPTOR; PURINE P2X RECEPTOR ANTAGONIST; PURINE P2X2 RECEPTOR; PURINE P2X3 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; CHRONIC CONSTRICTION INJURY; CONFERENCE PAPER; DOWN REGULATION; GENE EXPRESSION; HEAT; HYPERALGESIA; INJURY; MALE; MOUSE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL GANGLION; UPREGULATION;

EID: 0038651055     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10208     Document Type: Conference Paper

References (24)

1. Bennett GJ, Xie YK. 1988. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33:87-107.
2. Bland-ward PA, Humphrey PP. 1997. Acute nociception mediated by hindpaw P2X receptor activation in the rat. Br J Pharmacol 122:365-371.
3. Burnstock G. 2001. Purine-mediated signalling in pain and visceral perception. Trends Pharmacol Sci 22:182-188.
4. Chen CC, Akopian AN, Sivilotti L, Colquhoun D, Burnstock G, Wood JN. 1995. A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377:428-431.
5. Collo G, North RA, Kawashima E, Merlo Pich E, Neidhart S, Surprenant A, Buell G. 1996. Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci 16:2495-2507.
6. Edwards FA, Gibb AJ. 1992. ATP receptor-mediated synaptic currents in the central nervous system. Nature 359:144-147.
7. Fukui M, Nakagawa T, Minami M, Satoh M. 2001. Antinociceptive effects of intracerebroventricularly administered P2 purinoceptor agonists in the rat. Eur J Pharmacol 419:25-31.
8. Hylden JL, Wilcox GL. 1980. Intrathecal morphine in mice: a new technique. Eur J Pharmacol 67:313-316.
9. Inoue K, Koizumi S, Nakazawa K. 1995. Glutamate-evoked release of adenosine 5′-triphosphate causing an increase in intracellular calcium in hippocampal neurons. Neuroreport 6:437-440.
10. Lewis C, Neidhart S, Holy C, North RA, Buell G, Surprenant A. 1995. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 377:432-435.
11. Liu T, Tracey DJ. 2000. ATP P2X receptors play little role in the maintenance of neuropathic hyperalgesia. Neuroreport 11:1669-1672.
12. Malmberg AB, Basbaum AI. 1998. Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates. Pain 76:215-222.
13. Novakovic SD, Kassotakis LC, Oglesby IB, Smith JA, Eglen RM, Ford AP, Hunter JC. 1999. Immunocytochemical localization of P2X3 purinoceptors in sensory neurons in naive rats and following neuropathic injury. Pain 80:273-282.
14. Park SK, Chung K, Chung JM. 2000. Effects of purinergic and adrenergic antagonists in a rat model of painful peripheral neuropathy. Pain 87:171-179.
15. Petruska JC, Cooper BY, Gu JG, Rau KK, Johnson RD. 2000. Distribution of P2X1, P2X2, and P2X3 receptor subunits in rat primary afferents: relation to population markers and specific cell types. J Chem Neuroanat 20:141-162.
16. Petruska JC, Cooper BY, Johnson RD, Gu JG. 2000. Distribution patterns of different P2x receptor phenotypes in acutely dissociated dorsal root ganglion neurons of adult rats. Exp Brain Res 134:126-132.
17. Stanfa LC, Kontinen VK, Dickenson AH. 2000. Effects of spinally administered P2X receptor agonists and antagonists on the responses of dorsal horn neurones recorded in normal, carrageenan-inflamed and neuropathic rats. Br J Pharmacol 129:351-359.
18. Tal M, Bennett GJ. 1994. Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve. Pain 57:375-382.
19. Tsuda M, Ueno S, Inoue K. 1999. In vivo pathway of thermal hyperalgesia by intrathecal administration of alpha,beta-methylene ATP in mouse spinal cord: involvement of the glutamate-NMDA receptor system. Br J Pharmacol 127:449-456.
20. Tsuda M, Koizumi S, Kita A, Shigemoto Y, Ueno S, Inoue K. 2000. Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats: involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent neurons. J Neurosci 20:RC90 [online].
21. Tsuzuki K, Kondo E, Fukuoka T, Yi D, Tsujino H, Sakagami M, Noguchi K. 2001. Differential regulation of P2X(3) mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia. Pain 91:351-360.
22. Ueno S, Tsuda M, Iwanaga T, Inoue K. 1999. Cell type-specific ATP-activated responses in rat dorsal root ganglion neurons. Br J Pharmacol 126:429-436.
23. Ueno S, Yamada H, Moriyama T, Honda K, Takano Y, Kamiya H, Katsuragi T. 2002. Measurement of dorsal root ganglion P2X mRNA by SYBR Green fluorescence. Brain Res Brain Res Protoc 10:95-101.
24. Zimmerman M. 1983. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109-110.