A-317491, a selective P2X 3/P2X 2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats

European Journal of Pharmacology

Volumn 504, Issue 1-2, 2004, Pages 45-53

  Wu, Gang ^a   Whiteside, Garth T ^a   Lee, Gary ^a   Nolan, Scott ^a   Niosi, Mark ^a   Pearson, Michelle S ^a   Ilyin, Victor I ^a  

^a Purdue Pharma Discovery Research   (United States)

Author keywords

Hyperalgesia; Inflammation; Mechanosensitivity; P2X receptors; Pain; Peripheral sensitization

Indexed keywords

5 [[(3 PHENOXYBENZYL)(1,2,3,4 TETRAHYDRO 1 NAPHTHALENYL)AMINO]CARBONYL] 1,2,4 BENZENETRICARBOXYLIC ACID; A 317491; ANALGESIC AGENT; PURINE P2X2 RECEPTOR; PURINE P2X3 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; A-317491; NONSTEROID ANTIINFLAMMATORY AGENT; PHENOL DERIVATIVE; POLYCYCLIC HYDROCARBON; PURINE P2 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG PENETRATION; HYPERALGESIA; MALE; NERVE FIBER C; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIZATION; SKIN INFLAMMATION; SKIN NERVE; ANIMAL; COMPARATIVE STUDY; DRUG ANTAGONISM; METHODOLOGY; PAIN ASSESSMENT; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; STIMULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERALGESIA; MALE; PAIN MEASUREMENT; PHENOLS; PHYSICAL STIMULATION; POLYCYCLIC COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2;

EID: 6944246360     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.09.056     Document Type: Article

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