The role of the prostacyclin receptor antagonist RO3244019 in treating neurogenic detrusor overactivity after spinal cord injury in rats

BJU International

Volumn 99, Issue 2, 2007, Pages 442-446

  Khera, Mohit ^a   Boone, Timothy B ^a   Salas, Nilson ^a   Jett, Mary Frances ^b   Somogyi, George T ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b ROCHE BIOSCIENCE   (United States)

Author keywords

Detrusor overactivity; Prostacyclin receptor; Rat; Spinal cord injury

Indexed keywords

INDOMETACIN; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; RO 3244019; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER CONTRACTION; CONTROLLED STUDY; CYSTOMETRY; DATA ANALYSIS; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; EXPERIMENTAL STUDY; FEMALE; MICTURITION; NEUROGENIC BLADDER; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL SYSTEM PARAMETERS; SPINAL CORD INJURY; SPRAGUE DAWLEY RAT; STATISTICAL SIGNIFICANCE; STUDENT T TEST; URINE VOLUME;

ANIMALS; FEMALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, EPOPROSTENOL; SPINAL CORD INJURIES; URINARY BLADDER, NEUROGENIC; URINARY BLADDER, OVERACTIVE;

EID: 33846203436     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2007.06615.x     Document Type: Article

References (27)

1. Park JM, Yang T, Arend LJ, Smart AM, Schnermann JB, Briggs JP. Cyclooxygenase-2 is expressed in bladder during fetal development and stimulated by outlet obstruction. Am J Physiol 1997; 273: F538-44
2. Wheeler MA, Yoon JH, Olsson LE, Weiss RM. Cyclooxygenase-2 protein and prostaglandin E(2) production are up-regulated in a rat bladder inflammation model. Eur J Pharmacol 2001; 417: 239-48
3. Maggi CA. Prostanoids as local modulators of reflex micturition. Pharmacol Res 1992; 25: 13-20
4. Jeremy JY, Tsang V, Mikhailidis DP, Rogers H, Morgan RJ, Dandona P. Eicosanoid synthesis by human urinary bladder mucosa: pathological implications. Br J Urol 1987; 59: 36-9
5. Downie JW, Karmazyn M. Mechanical trauma to bladder epithelium liberates prostanoids which modulate neurotransmission in rabbit detrusor muscle. J Pharmacol Exp Ther 1984; 230: 445-9
6. Oner-Iyidogan Y, Kocak H, Gurdol F, Kocak T, Erol B. Urine 8-isoprostane F2alpha concentrations in patients with neurogenic bladder due to spinal cord injury. Clin Chim Acta 2004; 339: 43-7
7. Hu VY, Malley S, Dattilio A, Folsom JB, Zvara P, Vizzard MA. COX-2 and prostanoid expression in micturition pathways after cyclophosphamide- induced cystitis in the rat. Am J Physiol Regul Integr Comp Physiol 2003; 284: R574-85
8. Farkas A, Alajem D, Dekel S, Binderman I. Urinary prostaglandin E2 in acute bacterial cystitis. J Urol 1980; 124: 455-7
9. Azadzoi KM, Shinde VM, Tarcan T, Kozlowski R, Siroky MB. Increased leukotriene and prostaglandin release, and overactivity in the chronically ischemic bladder. J Urol 2003; 169: 1885-91
10. Ueno N, Murakami M, Tanioka T et al. Coupling between cyclooxygenase, terminal prostanoid synthase, and phospholipase A2. J Biol Chem 2001; 276: 34918-27
11. Andersson KE, Appell R, Cardozo LD et al. The pharmacological treatment of urinary incontinence. BJU Int 1999; 84: 923-47
12. Bley KR, Bhattacharya A, Daniels DV et al. RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br J Pharmacol 2006; 147: 335-45
13. Cefalu JS, Eggers AC, Nunn PA, Blue DR, Daniels DV, Ford AP. Effect of a selective IP receptor antagonist on the micturition reflex in anesthetized rats. Presented at the AUA 2004, San Francisico: May 9, 2004
14. Zhu QM, Tsung S, Daniels D, Nunn P, Ford A. Pharmacological evaluation of IP antagonists on citric acid-induced bladder hyperreflexia in conscious rats and mice. Presented at the AUA 2004, San Francisco, May 12, 2004
15. Clark RD, Jahangir A, Severance D et al. Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg Med Chem Lett 2004; 14: 1053-6
16. Yoshimura N. Bladder afferent pathway and spinal cord injury: possible mechanisms inducing hyperreflexia of the urinary bladder. Prog Neurobiol 1999; 57: 583-606
17. Zhou Y, Wang Y, Abdelhady M, Mourad MS, Hassouna MM. Change of vanilloid receptor 1 following neuromodulation in rats with spinal cord injury. J Surg Res 2002; 107: 140-4
18. Vaidyanathan S, van Velzen D, Krishnan KR et al. Nerve fibres in urothelium and submucosa of neuropathic urinary bladder: an immunohistochemical study with S-100 and neurofilament. Paraplegia 1996; 34: 137-51
19. Matsumura K, Watanabe Y, Onoe H, Watanabe Y. Prostacyclin receptor in the brain and central terminals of the primary sensory neurons: an autoradiographic study using a stable prostacyclin analogue [3H]iloprost. Neuroscience 1995; 65: 493-503
20. Oida H, Namba T, Sugimoto Y et al. In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs. Br J Pharmacol 1995; 116: 2828-37
21. Lawson SN. Morphological and Biochemical Cell Types of Sensory Neurons. New York: Oxford UP, 1992: 27-9
22. Smith JA, Amagasu SM, Eglen RM, Hunter JC, Bley KR. Characterization of prostanoid receptor-evoked responses in rat sensory neurones. Br J Pharmacol 1998; 124: 513-23
23. Paintal AS. Vagal afferent fibres. Ergeb Physiol 1963; 52: 74-156
24. Andersson KE, Sjogren C. Aspects on the physiology and pharmacology of the bladder and urethra. Prog Neurobiol 1982; 19: 71-89
25. Ishizuka O, Mattiasson A, Andersson KE. Prostaglandin E2-induced bladder hyperactivity in normal, conscious rats: involvement of tachykinins? J Urol 1995; 153: 2034-8
26. Andersson KE. Current concepts in the treatment of disorders of micturition. Drugs 1988; 35: 477-94
27. Park JM, Yang T, Arend LJ et al. Obstruction stimulates COX-2 expression in bladder smooth muscle cells via increased mechanical stretch. Am J Physiol 1999; 276: F129-36