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Volumn 226, Issue 9, 2011, Pages 2215-2221

The p53 tumor suppressor protein regulates hematopoietic stem cell fate

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

EID: 78650968849     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22561     Document Type: Short Survey
Times cited : (80)

References (156)
  • 1
    • 0345560273 scopus 로고
    • Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia
    • Ahuja H, Bar-Eli M, Advani SH, Benchimol S, Cline MJ. 1989. Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia. Proc Natl Acad Sci USA 86: 6783-6787.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 6783-6787
    • Ahuja, H.1    Bar-Eli, M.2    Advani, S.H.3    Benchimol, S.4    Cline, M.J.5
  • 3
    • 3242669145 scopus 로고    scopus 로고
    • Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
    • Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, Ito K, Koh GY, Suda T. 2004. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118: 149-161.
    • (2004) Cell , vol.118 , pp. 149-161
    • Arai, F.1    Hirao, A.2    Ohmura, M.3    Sato, H.4    Matsuoka, S.5    Takubo, K.6    Ito, K.7    Koh, G.Y.8    Suda, T.9
  • 4
    • 8844251482 scopus 로고    scopus 로고
    • Regulation of hematopoietic stem cell growth
    • Attar EC, Scadden DT. 2004. Regulation of hematopoietic stem cell growth. Leukemia 18: 1760-1768.
    • (2004) Leukemia , vol.18 , pp. 1760-1768
    • Attar, E.C.1    Scadden, D.T.2
  • 6
    • 0035555650 scopus 로고    scopus 로고
    • Activation and activities of the p53 tumour suppressor protein
    • Balint EE, Vousden KH. 2001. Activation and activities of the p53 tumour suppressor protein. Br J Cancer 85: 1813-1823.
    • (2001) Br J Cancer , vol.85 , pp. 1813-1823
    • Balint, E.E.1    Vousden, K.H.2
  • 7
    • 0025858631 scopus 로고
    • Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication
    • Bargonetti J, Friedman PN, Kern SE, Vogelstein B, Prives C. 1991. Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Cell 65: 1083-1091.
    • (1991) Cell , vol.65 , pp. 1083-1091
    • Bargonetti, J.1    Friedman, P.N.2    Kern, S.E.3    Vogelstein, B.4    Prives, C.5
  • 10
    • 77949907107 scopus 로고    scopus 로고
    • p53-mediated hematopoietic stem and progenitor cell competition
    • Bondar T, Medzhitov R. 2010. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 6: 309-322.
    • (2010) Cell Stem Cell , vol.6 , pp. 309-322
    • Bondar, T.1    Medzhitov, R.2
  • 11
    • 0028958705 scopus 로고
    • Growth factor modulation of p53-mediated growth arrest versus apoptosis
    • Canman CE, Gilmer TM, Coutts SB, Kastan MB. 1995. Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev 9: 600-611.
    • (1995) Genes Dev , vol.9 , pp. 600-611
    • Canman, C.E.1    Gilmer, T.M.2    Coutts, S.B.3    Kastan, M.B.4
  • 12
    • 0033533612 scopus 로고    scopus 로고
    • 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
    • Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B. 1999. 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 401: 616-620.
    • (1999) Nature , vol.401 , pp. 616-620
    • Chan, T.A.1    Hermeking, H.2    Lengauer, C.3    Kinzler, K.W.4    Vogelstein, B.5
  • 13
    • 52049117400 scopus 로고    scopus 로고
    • Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice
    • Chen J, Ellison FM, Keyvanfar K, Omokaro SO, Desierto MJ, Eckhaus MA, Young NS. 2008. Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice. Exp Hematol 36: 1236-1243.
    • (2008) Exp Hematol , vol.36 , pp. 1236-1243
    • Chen, J.1    Ellison, F.M.2    Keyvanfar, K.3    Omokaro, S.O.4    Desierto, M.J.5    Eckhaus, M.A.6    Young, N.S.7
  • 15
    • 0035281739 scopus 로고    scopus 로고
    • Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis
    • Christiansen DH, Andersen MK, Pedersen-Bjergaard J. 2001. Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis. J Clin Oncol 19: 1405-1413.
    • (2001) J Clin Oncol , vol.19 , pp. 1405-1413
    • Christiansen, D.H.1    Andersen, M.K.2    Pedersen-Bjergaard, J.3
  • 18
    • 0034677173 scopus 로고    scopus 로고
    • The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential
    • Domen J, Cheshier SH, Weissman IL. 2000. The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential. J Exp Med 191: 253-264.
    • (2000) J Exp Med , vol.191 , pp. 253-264
    • Domen, J.1    Cheshier, S.H.2    Weissman, I.L.3
  • 24
    • 3242690522 scopus 로고    scopus 로고
    • In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation
    • Erster S, Mihara M, Kim RH, Petrenko O, Moll UM. 2004. In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol 24: 6728-6741.
    • (2004) Mol Cell Biol , vol.24 , pp. 6728-6741
    • Erster, S.1    Mihara, M.2    Kim, R.H.3    Petrenko, O.4    Moll, U.M.5
  • 28
    • 42649142267 scopus 로고    scopus 로고
    • Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence
    • Ficara F, Murphy MJ, Lin M, Cleary ML. 2008. Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence. Cell Stem Cell 2: 484-496.
    • (2008) Cell Stem Cell , vol.2 , pp. 484-496
    • Ficara, F.1    Murphy, M.J.2    Lin, M.3    Cleary, M.L.4
  • 29
    • 39749178390 scopus 로고    scopus 로고
    • Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo
    • Fleming HE, Janzen V, Lo Celso C, Guo J, Leahy KM, Kronenberg HM, Scadden DT. 2008. Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell 2: 274-283.
    • (2008) Cell Stem Cell , vol.2 , pp. 274-283
    • Fleming, H.E.1    Janzen, V.2    Lo Celso, C.3    Guo, J.4    Leahy, K.M.5    Kronenberg, H.M.6    Scadden, D.T.7
  • 32
    • 33846629387 scopus 로고    scopus 로고
    • Tumor suppressor dosage regulates stem cell dynamics during aging
    • Gatza C, Moore L, Dumble M, Donehower LA. 2007. Tumor suppressor dosage regulates stem cell dynamics during aging. Cell Cycle 6: 52-55.
    • (2007) Cell Cycle , vol.6 , pp. 52-55
    • Gatza, C.1    Moore, L.2    Dumble, M.3    Donehower, L.A.4
  • 33
    • 0027462484 scopus 로고
    • Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein
    • Gilks CB, Bear SE, Grimes HL, Tsichlis PN. 1993. Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein. Mol Cell Biol 13: 1759-1768.
    • (1993) Mol Cell Biol , vol.13 , pp. 1759-1768
    • Gilks, C.B.1    Bear, S.E.2    Grimes, H.L.3    Tsichlis, P.N.4
  • 34
    • 77949885536 scopus 로고    scopus 로고
    • Cell competition: Pirates on the tangled bank
    • Green DR. 2010. Cell competition: Pirates on the tangled bank. Cell Stem Cell 6: 287-288.
    • (2010) Cell Stem Cell , vol.6 , pp. 287-288
    • Green, D.R.1
  • 35
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt MS, Bennett WP, Hollstein M, Harris CC. 1994. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res 54: 4855-4878.
    • (1994) Cancer Res , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 37
    • 16844363378 scopus 로고    scopus 로고
    • The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
    • Guzman ML, Rossi RM, Karnischky L, Li X, Peterson DR, Howard DS, Jordan CT. 2005. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood 105: 4163-4169.
    • (2005) Blood , vol.105 , pp. 4163-4169
    • Guzman, M.L.1    Rossi, R.M.2    Karnischky, L.3    Li, X.4    Peterson, D.R.5    Howard, D.S.6    Jordan, C.T.7
  • 39
    • 49349140725 scopus 로고    scopus 로고
    • Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype
    • Haferlach C, Dicker F, Herholz H, Schnittger S, Kern W, Haferlach T. 2008. Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype. Leukemia 22: 1539-1541.
    • (2008) Leukemia , vol.22 , pp. 1539-1541
    • Haferlach, C.1    Dicker, F.2    Herholz, H.3    Schnittger, S.4    Kern, W.5    Haferlach, T.6
  • 41
    • 0027489384 scopus 로고
    • Clinical implications of the p53 tumor-suppressor gene
    • Harris CC, Hollstein M. 1993. Clinical implications of the p53 tumor-suppressor gene. N Engl J Med 329: 1318-1327.
    • (1993) N Engl J Med , vol.329 , pp. 1318-1327
    • Harris, C.C.1    Hollstein, M.2
  • 42
  • 43
    • 33847049119 scopus 로고    scopus 로고
    • Growth factor stimulation reduces residual quiescent chronic myelogenous leukemia progenitors remaining after imatinib treatment
    • Holtz M, Forman SJ, Bhatia R. 2007. Growth factor stimulation reduces residual quiescent chronic myelogenous leukemia progenitors remaining after imatinib treatment. Cancer Res 67: 1113-1120.
    • (2007) Cancer Res , vol.67 , pp. 1113-1120
    • Holtz, M.1    Forman, S.J.2    Bhatia, R.3
  • 45
    • 0042190656 scopus 로고    scopus 로고
    • A nuclear target for interleukin-1alpha: Interaction with the growth suppressor necdin modulates proliferation and collagen expression
    • Hu B, Wang S, Zhang Y, Feghali CA, Dingman JR, Wright TM. 2003. A nuclear target for interleukin-1alpha: Interaction with the growth suppressor necdin modulates proliferation and collagen expression. Proc Natl Acad Sci USA 100: 10008-10013.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10008-10013
    • Hu, B.1    Wang, S.2    Zhang, Y.3    Feghali, C.A.4    Dingman, J.R.5    Wright, T.M.6
  • 46
    • 0027942844 scopus 로고
    • p53 in hematologic malignancies
    • Imamura J, Miyoshi I, Koeffler HP. 1994. p53 in hematologic malignancies. Blood 84: 2412-2421.
    • (1994) Blood , vol.84 , pp. 2412-2421
    • Imamura, J.1    Miyoshi, I.2    Koeffler, H.P.3
  • 53
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones SN, Roe AE, Donehower LA, Bradley A. 1995. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378: 206-208.
    • (1995) Nature , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 54
    • 34548462072 scopus 로고    scopus 로고
    • Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors
    • Jude CD, Climer L, Xu D, Artinger E, Fisher JK, Ernst P. 2007. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell 1: 324-337.
    • (2007) Cell Stem Cell , vol.1 , pp. 324-337
    • Jude, C.D.1    Climer, L.2    Xu, D.3    Artinger, E.4    Fisher, J.K.5    Ernst, P.6
  • 57
    • 0024435565 scopus 로고
    • Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia
    • Kelman Z, Prokocimer M, Peller S, Kahn Y, Rechavi G, Manor Y, Cohen A, Rotter V. 1989. Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia. Blood 74: 2318-2324.
    • (1989) Blood , vol.74 , pp. 2318-2324
    • Kelman, Z.1    Prokocimer, M.2    Peller, S.3    Kahn, Y.4    Rechavi, G.5    Manor, Y.6    Cohen, A.7    Rotter, V.8
  • 60
    • 53449095193 scopus 로고    scopus 로고
    • Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia
    • Kojima K, Konopleva M, Tsao T, Nakakuma H, Andreeff M. 2008. Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia. Blood 112: 2886-2895.
    • (2008) Blood , vol.112 , pp. 2886-2895
    • Kojima, K.1    Konopleva, M.2    Tsao, T.3    Nakakuma, H.4    Andreeff, M.5
  • 62
    • 41549104612 scopus 로고    scopus 로고
    • Effect of cellular quiescence on the success of targeted CML therapy
    • Komarova NL, Wodarz D. 2007. Effect of cellular quiescence on the success of targeted CML therapy. PLoS ONE 2: e990.
    • (2007) PLoS ONE , vol.2
    • Komarova, N.L.1    Wodarz, D.2
  • 63
    • 2442681614 scopus 로고    scopus 로고
    • Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice
    • Komarova EA, Kondratov RV, Wang K, Christov K, Golovkina TV, Goldblum JR, Gudkov AV. 2004. Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene 23: 3265-3271.
    • (2004) Oncogene , vol.23 , pp. 3265-3271
    • Komarova, E.A.1    Kondratov, R.V.2    Wang, K.3    Christov, K.4    Golovkina, T.V.5    Goldblum, J.R.6    Gudkov, A.V.7
  • 65
    • 0344413639 scopus 로고    scopus 로고
    • In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein
    • Krosl J, Austin P, Beslu N, Kroon E, Humphries RK, Sauvageau G. 2003. In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nat Med 9: 1428-1432.
    • (2003) Nat Med , vol.9 , pp. 1428-1432
    • Krosl, J.1    Austin, P.2    Beslu, N.3    Kroon, E.4    Humphries, R.K.5    Sauvageau, G.6
  • 66
    • 33644819269 scopus 로고    scopus 로고
    • The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells
    • Lacorazza HD, Yamada T, Liu Y, Miyata Y, Sivina M, Nunes J, Nimer SD. 2006. The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells. Cancer Cell 9: 175-187.
    • (2006) Cancer Cell , vol.9 , pp. 175-187
    • Lacorazza, H.D.1    Yamada, T.2    Liu, Y.3    Miyata, Y.4    Sivina, M.5    Nunes, J.6    Nimer, S.D.7
  • 67
    • 0018348655 scopus 로고
    • T antigen is bound to a host protein in SV40-transformed cells
    • Lane DP, Crawford LV. 1979. T antigen is bound to a host protein in SV40-transformed cells. Nature 278: 261-263.
    • (1979) Nature , vol.278 , pp. 261-263
    • Lane, D.P.1    Crawford, L.V.2
  • 68
    • 0029814061 scopus 로고    scopus 로고
    • Anti-apoptotic activity of low levels of wild-type p53
    • Lassus P, Ferlin M, Piette J, Hibner U. 1996. Anti-apoptotic activity of low levels of wild-type p53. EMBO J 15: 4566-4573.
    • (1996) EMBO J , vol.15 , pp. 4566-4573
    • Lassus, P.1    Ferlin, M.2    Piette, J.3    Hibner, U.4
  • 70
    • 2342553892 scopus 로고    scopus 로고
    • Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
    • Leu JI, Dumont P, Hafey M, Murphy ME, George DL. 2004. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol 6: 443-450.
    • (2004) Nat Cell Biol , vol.6 , pp. 443-450
    • Leu, J.I.1    Dumont, P.2    Hafey, M.3    Murphy, M.E.4    George, D.L.5
  • 73
    • 0018760324 scopus 로고
    • Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
    • Linzer DI, Levine AJ. 1979. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17: 43-52.
    • (1979) Cell , vol.17 , pp. 43-52
    • Linzer, D.I.1    Levine, A.J.2
  • 76
    • 0027283604 scopus 로고
    • Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents
    • Lotem J, Sachs L. 1993. Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood 82: 1092-1096.
    • (1993) Blood , vol.82 , pp. 1092-1096
    • Lotem, J.1    Sachs, L.2
  • 77
    • 0030773594 scopus 로고    scopus 로고
    • The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse
    • MacDonald HR, Wevrick R. 1997. The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse. Hum Mol Genet 6: 1873-1878.
    • (1997) Hum Mol Genet , vol.6 , pp. 1873-1878
    • MacDonald, H.R.1    Wevrick, R.2
  • 82
    • 0025871554 scopus 로고
    • A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells
    • Maruyama K, Usami M, Aizawa T, Yoshikawa K. 1991. A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells. Biochem Biophys Res Commun 178: 291-296.
    • (1991) Biochem Biophys Res Commun , vol.178 , pp. 291-296
    • Maruyama, K.1    Usami, M.2    Aizawa, T.3    Yoshikawa, K.4
  • 84
    • 70349438994 scopus 로고    scopus 로고
    • Tumour suppression by p53: A role for the DNA damage response?
    • Meek DW. 2009. Tumour suppression by p53: A role for the DNA damage response? Nat Rev Cancer 9: 714-723.
    • (2009) Nat Rev Cancer , vol.9 , pp. 714-723
    • Meek, D.W.1
  • 89
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T, Reed JC. 1995. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 91
    • 0029860814 scopus 로고    scopus 로고
    • MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties
    • Miyazaki Y, Sun X, Uchida H, Zhang J, Nimer S. 1996. MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties. Oncogene 13: 1721-1729.
    • (1996) Oncogene , vol.13 , pp. 1721-1729
    • Miyazaki, Y.1    Sun, X.2    Uchida, H.3    Zhang, J.4    Nimer, S.5
  • 93
  • 94
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
    • Montes de Oca Luna R, Wagner DS, Lozano G. 1995. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378: 203-206.
    • (1995) Nature , vol.378 , pp. 203-206
    • Montes de Oca Luna, R.1    Wagner, D.S.2    Lozano, G.3
  • 95
    • 29144450333 scopus 로고    scopus 로고
    • The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: Implications for the Mre11 complex as a DNA damage sensor
    • Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH. 2005. The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: Implications for the Mre11 complex as a DNA damage sensor. Genes Dev 19: 3043-3054.
    • (2005) Genes Dev , vol.19 , pp. 3043-3054
    • Morales, M.1    Theunissen, J.W.2    Kim, C.F.3    Kitagawa, R.4    Kastan, M.B.5    Petrini, J.H.6
  • 96
    • 39749121971 scopus 로고    scopus 로고
    • Chromosomal aberrations in 17p predict in vitro drug resistance and short overall survival in acute myeloid leukemia
    • Nahi H, Lehmann S, Bengtzen S, Jansson M, Mollgard L, Paul C, Merup M. 2008. Chromosomal aberrations in 17p predict in vitro drug resistance and short overall survival in acute myeloid leukemia. Leuk Lymphoma 49: 508-516.
    • (2008) Leuk Lymphoma , vol.49 , pp. 508-516
    • Nahi, H.1    Lehmann, S.2    Bengtzen, S.3    Jansson, M.4    Mollgard, L.5    Paul, C.6    Merup, M.7
  • 97
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • Nakano K, Vousden KH. 2001. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7: 683-694.
    • (2001) Mol Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 99
    • 42249103574 scopus 로고    scopus 로고
    • CXCR4 is required for the quiescence of primitive hematopoietic cells
    • Nie Y, Han YC, Zou YR. 2008. CXCR4 is required for the quiescence of primitive hematopoietic cells. J Exp Med 205: 777-783.
    • (2008) J Exp Med , vol.205 , pp. 777-783
    • Nie, Y.1    Han, Y.C.2    Zou, Y.R.3
  • 103
    • 28544436371 scopus 로고    scopus 로고
    • Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    • Passegue E, Wagers AJ, Giuriato S, Anderson WC, Weissman IL. 2005. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med 202: 1599-1611.
    • (2005) J Exp Med , vol.202 , pp. 1599-1611
    • Passegue, E.1    Wagers, A.J.2    Giuriato, S.3    Anderson, W.C.4    Weissman, I.L.5
  • 104
    • 0037220020 scopus 로고    scopus 로고
    • TP53 in hematological cancer: Low incidence of mutations with significant clinical relevance
    • Peller S, Rotter V. 2003. TP53 in hematological cancer: Low incidence of mutations with significant clinical relevance. Hum Mutat 21: 277-284.
    • (2003) Hum Mutat , vol.21 , pp. 277-284
    • Peller, S.1    Rotter, V.2
  • 105
    • 43249087214 scopus 로고    scopus 로고
    • Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis
    • Perry JM, Li L. 2008. Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis. Genes Dev 22: 1107-1109.
    • (2008) Genes Dev , vol.22 , pp. 1107-1109
    • Perry, J.M.1    Li, L.2
  • 106
    • 0032528245 scopus 로고    scopus 로고
    • Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53
    • Resnick-Silverman L, St Clair S, Maurer M, Zhao K, Manfredi JJ. 1998. Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53. Genes Dev 12: 2102-2107.
    • (1998) Genes Dev , vol.12 , pp. 2102-2107
    • Resnick-Silverman, L.1    St Clair, S.2    Maurer, M.3    Zhao, K.4    Manfredi, J.J.5
  • 107
    • 33845185824 scopus 로고    scopus 로고
    • Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo
    • Ringshausen I, O'Shea CC, Finch AJ, Swigart LB, Evan GI. 2006. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell 10: 501-514.
    • (2006) Cancer Cell , vol.10 , pp. 501-514
    • Ringshausen, I.1    O'Shea, C.C.2    Finch, A.J.3    Swigart, L.B.4    Evan, G.I.5
  • 108
    • 34250007142 scopus 로고    scopus 로고
    • Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    • Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. 2007. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447: 725-729.
    • (2007) Nature , vol.447 , pp. 725-729
    • Rossi, D.J.1    Bryder, D.2    Seita, J.3    Nussenzweig, A.4    Hoeijmakers, J.5    Weissman, I.L.6
  • 109
    • 39149086121 scopus 로고    scopus 로고
    • Stems cells and the pathways to aging and cancer
    • Rossi DJ, Jamieson CH, Weissman IL. 2008. Stems cells and the pathways to aging and cancer. Cell 132: 681-696.
    • (2008) Cell , vol.132 , pp. 681-696
    • Rossi, D.J.1    Jamieson, C.H.2    Weissman, I.L.3
  • 111
    • 77749283145 scopus 로고    scopus 로고
    • Pharmacological activation of the p53 pathway in haematological malignancies
    • Saha MN, Micallef J, Qiu L, Chang H. 2010. Pharmacological activation of the p53 pathway in haematological malignancies. J Clin Pathol 63: 204-209.
    • (2010) J Clin Pathol , vol.63 , pp. 204-209
    • Saha, M.N.1    Micallef, J.2    Qiu, L.3    Chang, H.4
  • 112
    • 67650072923 scopus 로고    scopus 로고
    • ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation
    • Sashida G, Liu Y, Elf S, Miyata Y, Ohyashiki K, Izumi M, Menendez S, Nimer SD. 2009. ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation. Mol Cell Biol 29: 3687-3699.
    • (2009) Mol Cell Biol , vol.29 , pp. 3687-3699
    • Sashida, G.1    Liu, Y.2    Elf, S.3    Miyata, Y.4    Ohyashiki, K.5    Izumi, M.6    Menendez, S.7    Nimer, S.D.8
  • 113
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63: 1129-1136.
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 114
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. 1997. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a Cell 88: 593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 115
    • 53049108040 scopus 로고    scopus 로고
    • Targeting the MDM2-p53 interaction for cancer therapy
    • Shangary S, Wang S. 2008. Targeting the MDM2-p53 interaction for cancer therapy. Clin Cancer Res 14: 5318-5324.
    • (2008) Clin Cancer Res , vol.14 , pp. 5318-5324
    • Shangary, S.1    Wang, S.2
  • 116
    • 77954709903 scopus 로고    scopus 로고
    • Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation
    • Shao L, Sun Y, Zhang Z, Feng W, Gao Y, Cai Z, Wang ZZ, Look AT, Wu WS. 2010. Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. Blood 115: 4704-4714.
    • (2010) Blood , vol.115 , pp. 4704-4714
    • Shao, L.1    Sun, Y.2    Zhang, Z.3    Feng, W.4    Gao, Y.5    Cai, Z.6    Wang, Z.Z.7    Look, A.T.8    Wu, W.S.9
  • 117
    • 34548153747 scopus 로고    scopus 로고
    • How stem cells age and why this makes us grow old
    • Sharpless NE, DePinho RA. 2007. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8: 703-713.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 703-713
    • Sharpless, N.E.1    DePinho, R.A.2
  • 118
    • 0026523778 scopus 로고
    • Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line
    • Shaw P, Bovey R, Tardy S, Sahli R, Sordat B, Costa J. 1992. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Natl Acad Sci USA 89: 4495-4499.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4495-4499
    • Shaw, P.1    Bovey, R.2    Tardy, S.3    Sahli, R.4    Sordat, B.5    Costa, J.6
  • 120
    • 0029785634 scopus 로고    scopus 로고
    • Retroviral transduction of hematopoietic progenitor cells with mutant p53 promotes survival and proliferation, modifies differentiation potential and inhibits apoptosis
    • Shounan Y, Dolnikov A, MacKenzie KL, Miller M, Chan YY, Symonds G. 1996. Retroviral transduction of hematopoietic progenitor cells with mutant p53 promotes survival and proliferation, modifies differentiation potential and inhibits apoptosis. Leukemia 10: 1619-1628.
    • (1996) Leukemia , vol.10 , pp. 1619-1628
    • Shounan, Y.1    Dolnikov, A.2    MacKenzie, K.L.3    Miller, M.4    Chan, Y.Y.5    Symonds, G.6
  • 121
    • 0025804270 scopus 로고
    • Mutation of the p53 gene in human acute myelogenous leukemia
    • Slingerland JM, Minden MD, Benchimol S. 1991. Mutation of the p53 gene in human acute myelogenous leukemia. Blood 77: 1500-1507.
    • (1991) Blood , vol.77 , pp. 1500-1507
    • Slingerland, J.M.1    Minden, M.D.2    Benchimol, S.3
  • 123
    • 0036490983 scopus 로고    scopus 로고
    • BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation
    • Takimoto R, MacLachlan TK, Dicker DT, Niitsu Y, Mori T, el-Deiry WS. 2002. BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation. Cancer Biol Ther 1: 177-186.
    • (2002) Cancer Biol Ther , vol.1 , pp. 177-186
    • Takimoto, R.1    MacLachlan, T.K.2    Dicker, D.T.3    Niitsu, Y.4    Mori, T.5    el-Deiry, W.S.6
  • 124
    • 0033522919 scopus 로고    scopus 로고
    • Physical and functional interactions of neuronal growth suppressor necdin with p53
    • Taniura H, Matsumoto K, Yoshikawa K. 1999. Physical and functional interactions of neuronal growth suppressor necdin with p53. J Biol Chem 274: 16242-16248.
    • (1999) J Biol Chem , vol.274 , pp. 16242-16248
    • Taniura, H.1    Matsumoto, K.2    Yoshikawa, K.3
  • 125
    • 20444395224 scopus 로고    scopus 로고
    • Functional domains of necdin for protein-protein interaction, nuclear matrix targeting, and cell growth suppression
    • Taniura H, Kobayashi M, Yoshikawa K. 2005. Functional domains of necdin for protein-protein interaction, nuclear matrix targeting, and cell growth suppression. J Cell Biochem 94: 804-815.
    • (2005) J Cell Biochem , vol.94 , pp. 804-815
    • Taniura, H.1    Kobayashi, M.2    Yoshikawa, K.3
  • 126
    • 0037711685 scopus 로고    scopus 로고
    • Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice
    • TeKippe M, Harrison DE, Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31: 521-527.
    • (2003) Exp Hematol , vol.31 , pp. 521-527
    • TeKippe, M.1    Harrison, D.E.2    Chen, J.3
  • 127
    • 0036599406 scopus 로고    scopus 로고
    • p53 stabilization is decreased upon NFkappaB activation: A role for NFkappaB in acquisition of resistance to chemotherapy
    • Tergaonkar V, Pando M, Vafa O, Wahl G, Verma I. 2002. p53 stabilization is decreased upon NFkappaB activation: A role for NFkappaB in acquisition of resistance to chemotherapy. Cancer Cell 1: 493-503.
    • (2002) Cancer Cell , vol.1 , pp. 493-503
    • Tergaonkar, V.1    Pando, M.2    Vafa, O.3    Wahl, G.4    Verma, I.5
  • 130
    • 33845270990 scopus 로고    scopus 로고
    • Regulating the p53 pathway: In vitro hypotheses, in vivo veritas
    • Toledo F, Wahl GM. 2006. Regulating the p53 pathway: In vitro hypotheses, in vivo veritas. Nat Rev Cancer 6: 909-923.
    • (2006) Nat Rev Cancer , vol.6 , pp. 909-923
    • Toledo, F.1    Wahl, G.M.2
  • 139
    • 0028172868 scopus 로고
    • p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies
    • Wattel E, Preudhomme C, Hecquet B, Vanrumbeke M, Quesnel B, Dervite I, Morel P, Fenaux P. 1994. p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood 84: 3148-3157.
    • (1994) Blood , vol.84 , pp. 3148-3157
    • Wattel, E.1    Preudhomme, C.2    Hecquet, B.3    Vanrumbeke, M.4    Quesnel, B.5    Dervite, I.6    Morel, P.7    Fenaux, P.8
  • 140
    • 85047700405 scopus 로고    scopus 로고
    • Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways
    • Weber HO, Samuel T, Rauch P, Funk JO. 2002. Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways. Oncogene 21: 3207-3212.
    • (2002) Oncogene , vol.21 , pp. 3207-3212
    • Weber, H.O.1    Samuel, T.2    Rauch, P.3    Funk, J.O.4
  • 141
    • 0030879563 scopus 로고    scopus 로고
    • atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity
    • Westphal CH, Rowan S, Schmaltz C, Elson A, Fisher DE, Leder P. 1997. atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nat Genet 16: 397-401.
    • (1997) Nat Genet , vol.16 , pp. 397-401
    • Westphal, C.H.1    Rowan, S.2    Schmaltz, C.3    Elson, A.4    Fisher, D.E.5    Leder, P.6
  • 142
    • 33644827383 scopus 로고    scopus 로고
    • Bone-marrow haematopoietic-stem-cell niches
    • Wilson A, Trumpp A. 2006. Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol 6: 93-106.
    • (2006) Nat Rev Immunol , vol.6 , pp. 93-106
    • Wilson, A.1    Trumpp, A.2
  • 143
    • 27744547091 scopus 로고    scopus 로고
    • Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
    • Wu WS, Heinrichs S, Xu D, Garrison SP, Zambetti GP, Adams JM, Look AT. 2005. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123: 641-653.
    • (2005) Cell , vol.123 , pp. 641-653
    • Wu, W.S.1    Heinrichs, S.2    Xu, D.3    Garrison, S.P.4    Zambetti, G.P.5    Adams, J.M.6    Look, A.T.7
  • 145
  • 146
    • 0025784539 scopus 로고
    • Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
    • Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M. 1991. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352: 345-347.
    • (1991) Nature , vol.352 , pp. 345-347
    • Yonish-Rouach, E.1    Resnitzky, D.2    Lotem, J.3    Sachs, L.4    Kimchi, A.5    Oren, M.6
  • 148
  • 149
    • 77951753647 scopus 로고    scopus 로고
    • Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation
    • Yu H, Shen H, Yuan Y, XuFeng R, Hu X, Garrison SP, Zhang L, Yu J, Zambetti GP, Cheng T. 2010. Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation. Blood 115: 3472-3480.
    • (2010) Blood , vol.115 , pp. 3472-3480
    • Yu, H.1    Shen, H.2    Yuan, Y.3    XuFeng, R.4    Hu, X.5    Garrison, S.P.6    Zhang, L.7    Yu, J.8    Zambetti, G.P.9    Cheng, T.10
  • 150
    • 8144220648 scopus 로고    scopus 로고
    • Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells
    • Zeng H, Yucel R, Kosan C, Klein-Hitpass L, Moroy T. 2004. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J 23: 4116-4125.
    • (2004) EMBO J , vol.23 , pp. 4116-4125
    • Zeng, H.1    Yucel, R.2    Kosan, C.3    Klein-Hitpass, L.4    Moroy, T.5
  • 152
    • 77950212489 scopus 로고    scopus 로고
    • Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim
    • Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC, Andreeff M. 2010. Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. Cancer Res 70: 2424-2434.
    • (2010) Cancer Res , vol.70 , pp. 2424-2434
    • Zhang, W.1    Konopleva, M.2    Burks, J.K.3    Dywer, K.C.4    Schober, W.D.5    Yang, J.Y.6    McQueen, T.J.7    Hung, M.C.8    Andreeff, M.9
  • 153
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou BB, Elledge SJ. 2000. The DNA damage response: Putting checkpoints in perspective. Nature 408: 433-439.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 155
    • 43749110075 scopus 로고    scopus 로고
    • Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal
    • Zon LI. 2008. Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. Nature 453: 306-313.
    • (2008) Nature , vol.453 , pp. 306-313
    • Zon, L.I.1


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