-
1
-
-
0345560273
-
Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia
-
Ahuja H, Bar-Eli M, Advani SH, Benchimol S, Cline MJ. 1989. Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia. Proc Natl Acad Sci USA 86: 6783-6787.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 6783-6787
-
-
Ahuja, H.1
Bar-Eli, M.2
Advani, S.H.3
Benchimol, S.4
Cline, M.J.5
-
3
-
-
3242669145
-
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
-
Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, Ito K, Koh GY, Suda T. 2004. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118: 149-161.
-
(2004)
Cell
, vol.118
, pp. 149-161
-
-
Arai, F.1
Hirao, A.2
Ohmura, M.3
Sato, H.4
Matsuoka, S.5
Takubo, K.6
Ito, K.7
Koh, G.Y.8
Suda, T.9
-
4
-
-
8844251482
-
Regulation of hematopoietic stem cell growth
-
Attar EC, Scadden DT. 2004. Regulation of hematopoietic stem cell growth. Leukemia 18: 1760-1768.
-
(2004)
Leukemia
, vol.18
, pp. 1760-1768
-
-
Attar, E.C.1
Scadden, D.T.2
-
5
-
-
0024536654
-
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
-
Baker SJ, Fearon ER, Nigro JM, Hamilton SR, Preisinger AC, Jessup JM, vanTuinen P, Ledbetter DH, Barker DF, Nakamura Y, White R, Vogelstein B. 1989. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 244: 217-221.
-
(1989)
Science
, vol.244
, pp. 217-221
-
-
Baker, S.J.1
Fearon, E.R.2
Nigro, J.M.3
Hamilton, S.R.4
Preisinger, A.C.5
Jessup, J.M.6
vanTuinen, P.7
Ledbetter, D.H.8
Barker, D.F.9
Nakamura, Y.10
White, R.11
Vogelstein, B.12
-
6
-
-
0035555650
-
Activation and activities of the p53 tumour suppressor protein
-
Balint EE, Vousden KH. 2001. Activation and activities of the p53 tumour suppressor protein. Br J Cancer 85: 1813-1823.
-
(2001)
Br J Cancer
, vol.85
, pp. 1813-1823
-
-
Balint, E.E.1
Vousden, K.H.2
-
7
-
-
0025858631
-
Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication
-
Bargonetti J, Friedman PN, Kern SE, Vogelstein B, Prives C. 1991. Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Cell 65: 1083-1091.
-
(1991)
Cell
, vol.65
, pp. 1083-1091
-
-
Bargonetti, J.1
Friedman, P.N.2
Kern, S.E.3
Vogelstein, B.4
Prives, C.5
-
8
-
-
73849128091
-
A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome
-
Barlow JL, Drynan LF, Hewett DR, Holmes LR, Lorenzo-Abalde S, Lane AL, Jolin HE, Pannell R, Middleton AJ, Wong SH, Warren AJ, Wainscoat JS, Boultwood J, McKenzie AN. 2010. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med 16: 59-66.
-
(2010)
Nat Med
, vol.16
, pp. 59-66
-
-
Barlow, J.L.1
Drynan, L.F.2
Hewett, D.R.3
Holmes, L.R.4
Lorenzo-Abalde, S.5
Lane, A.L.6
Jolin, H.E.7
Pannell, R.8
Middleton, A.J.9
Wong, S.H.10
Warren, A.J.11
Wainscoat, J.S.12
Boultwood, J.13
McKenzie, A.N.14
-
9
-
-
0036713424
-
Cancer predisposition and hematopoietic failure in Rad50(S/S) mice
-
Bender CF, Sikes ML, Sullivan R, Huye LE, Le Beau MM, Roth DB, Mirzoeva OK, Oltz EM, Petrini JH. 2002. Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev 16: 2237-2251.
-
(2002)
Genes Dev
, vol.16
, pp. 2237-2251
-
-
Bender, C.F.1
Sikes, M.L.2
Sullivan, R.3
Huye, L.E.4
Le Beau, M.M.5
Roth, D.B.6
Mirzoeva, O.K.7
Oltz, E.M.8
Petrini, J.H.9
-
10
-
-
77949907107
-
p53-mediated hematopoietic stem and progenitor cell competition
-
Bondar T, Medzhitov R. 2010. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 6: 309-322.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 309-322
-
-
Bondar, T.1
Medzhitov, R.2
-
11
-
-
0028958705
-
Growth factor modulation of p53-mediated growth arrest versus apoptosis
-
Canman CE, Gilmer TM, Coutts SB, Kastan MB. 1995. Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev 9: 600-611.
-
(1995)
Genes Dev
, vol.9
, pp. 600-611
-
-
Canman, C.E.1
Gilmer, T.M.2
Coutts, S.B.3
Kastan, M.B.4
-
12
-
-
0033533612
-
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
-
Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B. 1999. 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 401: 616-620.
-
(1999)
Nature
, vol.401
, pp. 616-620
-
-
Chan, T.A.1
Hermeking, H.2
Lengauer, C.3
Kinzler, K.W.4
Vogelstein, B.5
-
13
-
-
52049117400
-
Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice
-
Chen J, Ellison FM, Keyvanfar K, Omokaro SO, Desierto MJ, Eckhaus MA, Young NS. 2008. Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice. Exp Hematol 36: 1236-1243.
-
(2008)
Exp Hematol
, vol.36
, pp. 1236-1243
-
-
Chen, J.1
Ellison, F.M.2
Keyvanfar, K.3
Omokaro, S.O.4
Desierto, M.J.5
Eckhaus, M.A.6
Young, N.S.7
-
14
-
-
0034629129
-
Hematopoietic stem cell quiescence maintained by p21cip1/waf1
-
Cheng T, Rodrigues N, Shen H, Yang Y, Dombkowski D, Sykes M, Scadden DT. 2000. Hematopoietic stem cell quiescence maintained by p21cip1/waf1 Science 287: 1804-1808.
-
(2000)
Science
, vol.287
, pp. 1804-1808
-
-
Cheng, T.1
Rodrigues, N.2
Shen, H.3
Yang, Y.4
Dombkowski, D.5
Sykes, M.6
Scadden, D.T.7
-
15
-
-
0035281739
-
Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis
-
Christiansen DH, Andersen MK, Pedersen-Bjergaard J. 2001. Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis. J Clin Oncol 19: 1405-1413.
-
(2001)
J Clin Oncol
, vol.19
, pp. 1405-1413
-
-
Christiansen, D.H.1
Andersen, M.K.2
Pedersen-Bjergaard, J.3
-
16
-
-
70349123829
-
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells
-
Cicalese A, Bonizzi G, Pasi CE, Faretta M, Ronzoni S, Giulini B, Brisken C, Minucci S, Di Fiore PP, Pelicci PG. 2009. The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell 138: 1083-1095.
-
(2009)
Cell
, vol.138
, pp. 1083-1095
-
-
Cicalese, A.1
Bonizzi, G.2
Pasi, C.E.3
Faretta, M.4
Ronzoni, S.5
Giulini, B.6
Brisken, C.7
Minucci, S.8
Di Fiore, P.P.9
Pelicci, P.G.10
-
17
-
-
0037329080
-
Myeloid leukemia in Prader-Willi syndrome
-
Davies HD, Leusink GL, McConnell A, Deyell M, Cassidy SB, Fick GH, Coppes MJ. 2003. Myeloid leukemia in Prader-Willi syndrome. J Pediatr 142: 174-178.
-
(2003)
J Pediatr
, vol.142
, pp. 174-178
-
-
Davies, H.D.1
Leusink, G.L.2
McConnell, A.3
Deyell, M.4
Cassidy, S.B.5
Fick, G.H.6
Coppes, M.J.7
-
18
-
-
0034677173
-
The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential
-
Domen J, Cheshier SH, Weissman IL. 2000. The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential. J Exp Med 191: 253-264.
-
(2000)
J Exp Med
, vol.191
, pp. 253-264
-
-
Domen, J.1
Cheshier, S.H.2
Weissman, I.L.3
-
19
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Jr., Butel JS, Bradley A. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356: 215-221.
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
Harvey, M.2
Slagle, B.L.3
McArthur, M.J.4
Montgomery Jr, C.A.5
Butel, J.S.6
Bradley, A.7
-
20
-
-
33846921755
-
The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
-
Dumble M, Moore L, Chambers SM, Geiger H, Van Zant G, Goodell MA, Donehower LA. 2007. The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood 109: 1736-1742.
-
(2007)
Blood
, vol.109
, pp. 1736-1742
-
-
Dumble, M.1
Moore, L.2
Chambers, S.M.3
Geiger, H.4
Van Zant, G.5
Goodell, M.A.6
Donehower, L.A.7
-
21
-
-
0026849821
-
Definition of a consensus binding site for p53
-
el-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B. 1992. Definition of a consensus binding site for p53. Nat Genet 1: 45-49.
-
(1992)
Nat Genet
, vol.1
, pp. 45-49
-
-
el-Deiry, W.S.1
Kern, S.E.2
Pietenpol, J.A.3
Kinzler, K.W.4
Vogelstein, B.5
-
22
-
-
0027359827
-
WAF1, a potential mediator of p53 tumor suppression
-
el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825.
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
el-Deiry, W.S.1
Tokino, T.2
Velculescu, V.E.3
Levy, D.B.4
Parsons, R.5
Trent, J.M.6
Lin, D.7
Mercer, W.E.8
Kinzler, K.W.9
Vogelstein, B.10
-
23
-
-
0036863624
-
REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species
-
Ellisen LW, Ramsayer KD, Johannessen CM, Yang A, Beppu H, Minda K, Oliner JD, McKeon F, Haber DA. 2002. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell 10: 995-1005.
-
(2002)
Mol Cell
, vol.10
, pp. 995-1005
-
-
Ellisen, L.W.1
Ramsayer, K.D.2
Johannessen, C.M.3
Yang, A.4
Beppu, H.5
Minda, K.6
Oliner, J.D.7
McKeon, F.8
Haber, D.A.9
-
24
-
-
3242690522
-
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation
-
Erster S, Mihara M, Kim RH, Petrenko O, Moll UM. 2004. In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol 24: 6728-6741.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6728-6741
-
-
Erster, S.1
Mihara, M.2
Kim, R.H.3
Petrenko, O.4
Moll, U.M.5
-
25
-
-
0026770424
-
Wild-type p53 activates transcription in vitro
-
Farmer G, Bargonetti J, Zhu H, Friedman P, Prywes R, Prives C. 1992. Wild-type p53 activates transcription in vitro Nature 358: 83-86.
-
(1992)
Nature
, vol.358
, pp. 83-86
-
-
Farmer, G.1
Bargonetti, J.2
Zhu, H.3
Friedman, P.4
Prywes, R.5
Prives, C.6
-
26
-
-
0025917065
-
p53 in chronic myelogenous leukemia in acute phase
-
Feinstein E, Cimino G, Gale RP, Alimena G, Berthier R, Kishi K, Goldman J, Zaccaria A, Berrebi A, Canaani E. 1991. p53 in chronic myelogenous leukemia in acute phase. Proc Natl Acad Sci USA 88: 6293-6297.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 6293-6297
-
-
Feinstein, E.1
Cimino, G.2
Gale, R.P.3
Alimena, G.4
Berthier, R.5
Kishi, K.6
Goldman, J.7
Zaccaria, A.8
Berrebi, A.9
Canaani, E.10
-
27
-
-
0026528809
-
Mutations of the P53 gene in acute myeloid leukaemia
-
Fenaux P, Preudhomme C, Quiquandon I, Jonveaux P, Lai JL, Vanrumbeke M, Loucheux-Lefebvre MH, Bauters F, Berger R, Kerckaert JP. 1992. Mutations of the P53 gene in acute myeloid leukaemia. Br J Haematol 80: 178-183.
-
(1992)
Br J Haematol
, vol.80
, pp. 178-183
-
-
Fenaux, P.1
Preudhomme, C.2
Quiquandon, I.3
Jonveaux, P.4
Lai, J.L.5
Vanrumbeke, M.6
Loucheux-Lefebvre, M.H.7
Bauters, F.8
Berger, R.9
Kerckaert, J.P.10
-
28
-
-
42649142267
-
Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence
-
Ficara F, Murphy MJ, Lin M, Cleary ML. 2008. Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence. Cell Stem Cell 2: 484-496.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 484-496
-
-
Ficara, F.1
Murphy, M.J.2
Lin, M.3
Cleary, M.L.4
-
29
-
-
39749178390
-
Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo
-
Fleming HE, Janzen V, Lo Celso C, Guo J, Leahy KM, Kronenberg HM, Scadden DT. 2008. Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell 2: 274-283.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 274-283
-
-
Fleming, H.E.1
Janzen, V.2
Lo Celso, C.3
Guo, J.4
Leahy, K.M.5
Kronenberg, H.M.6
Scadden, D.T.7
-
30
-
-
55449106913
-
Differential expression of novel potential regulators in hematopoietic stem cells
-
Forsberg EC, Prohaska SS, Katzman S, Heffner GC, Stuart JM, Weissman IL. 2005. Differential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet 1: e28.
-
(2005)
PLoS Genet
, vol.1
-
-
Forsberg, E.C.1
Prohaska, S.S.2
Katzman, S.3
Heffner, G.C.4
Stuart, J.M.5
Weissman, I.L.6
-
31
-
-
33745223517
-
Increased p53 activity does not accelerate telomere-driven ageing
-
Garcia-Cao I, Garcia-Cao M, Tomas-Loba A, Martin-Caballero J, Flores JM, Klatt P, Blasco MA, Serrano M. 2006. Increased p53 activity does not accelerate telomere-driven ageing. EMBO Rep 7: 546-552.
-
(2006)
EMBO Rep
, vol.7
, pp. 546-552
-
-
Garcia-Cao, I.1
Garcia-Cao, M.2
Tomas-Loba, A.3
Martin-Caballero, J.4
Flores, J.M.5
Klatt, P.6
Blasco, M.A.7
Serrano, M.8
-
32
-
-
33846629387
-
Tumor suppressor dosage regulates stem cell dynamics during aging
-
Gatza C, Moore L, Dumble M, Donehower LA. 2007. Tumor suppressor dosage regulates stem cell dynamics during aging. Cell Cycle 6: 52-55.
-
(2007)
Cell Cycle
, vol.6
, pp. 52-55
-
-
Gatza, C.1
Moore, L.2
Dumble, M.3
Donehower, L.A.4
-
33
-
-
0027462484
-
Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein
-
Gilks CB, Bear SE, Grimes HL, Tsichlis PN. 1993. Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein. Mol Cell Biol 13: 1759-1768.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 1759-1768
-
-
Gilks, C.B.1
Bear, S.E.2
Grimes, H.L.3
Tsichlis, P.N.4
-
34
-
-
77949885536
-
Cell competition: Pirates on the tangled bank
-
Green DR. 2010. Cell competition: Pirates on the tangled bank. Cell Stem Cell 6: 287-288.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 287-288
-
-
Green, D.R.1
-
35
-
-
0028071555
-
Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
-
Greenblatt MS, Bennett WP, Hollstein M, Harris CC. 1994. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res 54: 4855-4878.
-
(1994)
Cancer Res
, vol.54
, pp. 4855-4878
-
-
Greenblatt, M.S.1
Bennett, W.P.2
Hollstein, M.3
Harris, C.C.4
-
36
-
-
0037059012
-
Preferential induction of apoptosis for primary human leukemic stem cells
-
Guzman ML, Swiderski CF, Howard DS, Grimes BA, Rossi RM, Szilvassy SJ, Jordan CT. 2002. Preferential induction of apoptosis for primary human leukemic stem cells. Proc Natl Acad Sci USA 99: 16220-16225.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 16220-16225
-
-
Guzman, M.L.1
Swiderski, C.F.2
Howard, D.S.3
Grimes, B.A.4
Rossi, R.M.5
Szilvassy, S.J.6
Jordan, C.T.7
-
37
-
-
16844363378
-
The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
-
Guzman ML, Rossi RM, Karnischky L, Li X, Peterson DR, Howard DS, Jordan CT. 2005. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood 105: 4163-4169.
-
(2005)
Blood
, vol.105
, pp. 4163-4169
-
-
Guzman, M.L.1
Rossi, R.M.2
Karnischky, L.3
Li, X.4
Peterson, D.R.5
Howard, D.S.6
Jordan, C.T.7
-
38
-
-
39649125467
-
An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
-
Guzman ML, Rossi RM, Neelakantan S, Li X, Corbett CA, Hassane DC, Becker MW, Bennett JM, Sullivan E, Lachowicz JL, Vaughan A, Sweeney CJ, Matthews W, Carroll M, Liesveld JL, Crooks PA, Jordan CT. 2007. An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. Blood 110: 4427-4435.
-
(2007)
Blood
, vol.110
, pp. 4427-4435
-
-
Guzman, M.L.1
Rossi, R.M.2
Neelakantan, S.3
Li, X.4
Corbett, C.A.5
Hassane, D.C.6
Becker, M.W.7
Bennett, J.M.8
Sullivan, E.9
Lachowicz, J.L.10
Vaughan, A.11
Sweeney, C.J.12
Matthews, W.13
Carroll, M.14
Liesveld, J.L.15
Crooks, P.A.16
Jordan, C.T.17
-
39
-
-
49349140725
-
Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype
-
Haferlach C, Dicker F, Herholz H, Schnittger S, Kern W, Haferlach T. 2008. Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype. Leukemia 22: 1539-1541.
-
(2008)
Leukemia
, vol.22
, pp. 1539-1541
-
-
Haferlach, C.1
Dicker, F.2
Herholz, H.3
Schnittger, S.4
Kern, W.5
Haferlach, T.6
-
40
-
-
0035949470
-
Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals
-
Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ, Zhu L, Chittenden T. 2001. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci USA 98: 11318-11323.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 11318-11323
-
-
Han, J.1
Flemington, C.2
Houghton, A.B.3
Gu, Z.4
Zambetti, G.P.5
Lutz, R.J.6
Zhu, L.7
Chittenden, T.8
-
41
-
-
0027489384
-
Clinical implications of the p53 tumor-suppressor gene
-
Harris CC, Hollstein M. 1993. Clinical implications of the p53 tumor-suppressor gene. N Engl J Med 329: 1318-1327.
-
(1993)
N Engl J Med
, vol.329
, pp. 1318-1327
-
-
Harris, C.C.1
Hollstein, M.2
-
42
-
-
7244231429
-
Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells
-
Hock H, Hamblen MJ, Rooke HM, Schindler JW, Saleque S, Fujiwara Y, Orkin SH. 2004. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature 431: 1002-1007.
-
(2004)
Nature
, vol.431
, pp. 1002-1007
-
-
Hock, H.1
Hamblen, M.J.2
Rooke, H.M.3
Schindler, J.W.4
Saleque, S.5
Fujiwara, Y.6
Orkin, S.H.7
-
43
-
-
33847049119
-
Growth factor stimulation reduces residual quiescent chronic myelogenous leukemia progenitors remaining after imatinib treatment
-
Holtz M, Forman SJ, Bhatia R. 2007. Growth factor stimulation reduces residual quiescent chronic myelogenous leukemia progenitors remaining after imatinib treatment. Cancer Res 67: 1113-1120.
-
(2007)
Cancer Res
, vol.67
, pp. 1113-1120
-
-
Holtz, M.1
Forman, S.J.2
Bhatia, R.3
-
44
-
-
69349100179
-
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
-
Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, Okita K, Yamanaka S. 2009. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460: 1132-1135.
-
(2009)
Nature
, vol.460
, pp. 1132-1135
-
-
Hong, H.1
Takahashi, K.2
Ichisaka, T.3
Aoi, T.4
Kanagawa, O.5
Nakagawa, M.6
Okita, K.7
Yamanaka, S.8
-
45
-
-
0042190656
-
A nuclear target for interleukin-1alpha: Interaction with the growth suppressor necdin modulates proliferation and collagen expression
-
Hu B, Wang S, Zhang Y, Feghali CA, Dingman JR, Wright TM. 2003. A nuclear target for interleukin-1alpha: Interaction with the growth suppressor necdin modulates proliferation and collagen expression. Proc Natl Acad Sci USA 100: 10008-10013.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10008-10013
-
-
Hu, B.1
Wang, S.2
Zhang, Y.3
Feghali, C.A.4
Dingman, J.R.5
Wright, T.M.6
-
47
-
-
19044372843
-
Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo
-
Inoue A, Seidel MG, Wu W, Kamizono S, Ferrando AA, Bronson RT, Iwasaki H, Akashi K, Morimoto A, Hitzler JK, Pestina TI, Jackson CW, Tanaka R, Chong MJ, McKinnon PJ, Inukai T, Grosveld GC, Look AT. 2002. Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell 2: 279-288.
-
(2002)
Cancer Cell
, vol.2
, pp. 279-288
-
-
Inoue, A.1
Seidel, M.G.2
Wu, W.3
Kamizono, S.4
Ferrando, A.A.5
Bronson, R.T.6
Iwasaki, H.7
Akashi, K.8
Morimoto, A.9
Hitzler, J.K.10
Pestina, T.I.11
Jackson, C.W.12
Tanaka, R.13
Chong, M.J.14
McKinnon, P.J.15
Inukai, T.16
Grosveld, G.C.17
Look, A.T.18
-
48
-
-
33645730667
-
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
-
Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y, Suda T. 2006. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med 12: 446-451.
-
(2006)
Nat Med
, vol.12
, pp. 446-451
-
-
Ito, K.1
Hirao, A.2
Arai, F.3
Takubo, K.4
Matsuoka, S.5
Miyamoto, K.6
Ohmura, M.7
Naka, K.8
Hosokawa, K.9
Ikeda, Y.10
Suda, T.11
-
49
-
-
44349166602
-
PML targeting eradicates quiescent leukaemia-initiating cells
-
Ito K, Bernardi R, Morotti A, Matsuoka S, Saglio G, Ikeda Y, Rosenblatt J, Avigan DE, Teruya-Feldstein J, Pandolfi PP. 2008. PML targeting eradicates quiescent leukaemia-initiating cells. Nature 453: 1072-1078.
-
(2008)
Nature
, vol.453
, pp. 1072-1078
-
-
Ito, K.1
Bernardi, R.2
Morotti, A.3
Matsuoka, S.4
Saglio, G.5
Ikeda, Y.6
Rosenblatt, J.7
Avigan, D.E.8
Teruya-Feldstein, J.9
Pandolfi, P.P.10
-
50
-
-
33749172559
-
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
-
Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT. 2006. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443: 421-426.
-
(2006)
Nature
, vol.443
, pp. 421-426
-
-
Janzen, V.1
Forkert, R.2
Fleming, H.E.3
Saito, Y.4
Waring, M.T.5
Dombkowski, D.M.6
Cheng, T.7
DePinho, R.A.8
Sharpless, N.E.9
Scadden, D.T.10
-
51
-
-
16944363776
-
The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region
-
Jay P, Rougeulle C, Massacrier A, Moncla A, Mattei MG, Malzac P, Roeckel N, Taviaux S, Lefranc JL, Cau P, Berta P, Lalande M, Muscatelli F. 1997. The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region. Nat Genet 17: 357-361.
-
(1997)
Nat Genet
, vol.17
, pp. 357-361
-
-
Jay, P.1
Rougeulle, C.2
Massacrier, A.3
Moncla, A.4
Mattei, M.G.5
Malzac, P.6
Roeckel, N.7
Taviaux, S.8
Lefranc, J.L.9
Cau, P.10
Berta, P.11
Lalande, M.12
Muscatelli, F.13
-
52
-
-
10744228800
-
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
-
Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J, MacLean KH, Han J, Chittenden T, Ihle JN, McKinnon PJ, Cleveland JL, Zambetti GP. 2003. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4: 321-328.
-
(2003)
Cancer Cell
, vol.4
, pp. 321-328
-
-
Jeffers, J.R.1
Parganas, E.2
Lee, Y.3
Yang, C.4
Wang, J.5
Brennan, J.6
MacLean, K.H.7
Han, J.8
Chittenden, T.9
Ihle, J.N.10
McKinnon, P.J.11
Cleveland, J.L.12
Zambetti, G.P.13
-
53
-
-
0028834902
-
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
-
Jones SN, Roe AE, Donehower LA, Bradley A. 1995. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378: 206-208.
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
Bradley, A.4
-
54
-
-
34548462072
-
Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors
-
Jude CD, Climer L, Xu D, Artinger E, Fisher JK, Ernst P. 2007. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell 1: 324-337.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 324-337
-
-
Jude, C.D.1
Climer, L.2
Xu, D.3
Artinger, E.4
Fisher, J.K.5
Ernst, P.6
-
55
-
-
0025938384
-
Levels of p53 protein increase with maturation in human hematopoietic cells
-
Kastan MB, Radin AI, Kuerbitz SJ, Onyekwere O, Wolkow CA, Civin CI, Stone KD, Woo T, Ravindranath Y, Craig RW. 1991. Levels of p53 protein increase with maturation in human hematopoietic cells. Cancer Res 51: 4279-4286.
-
(1991)
Cancer Res
, vol.51
, pp. 4279-4286
-
-
Kastan, M.B.1
Radin, A.I.2
Kuerbitz, S.J.3
Onyekwere, O.4
Wolkow, C.A.5
Civin, C.I.6
Stone, K.D.7
Woo, T.8
Ravindranath, Y.9
Craig, R.W.10
-
56
-
-
69349100455
-
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
-
Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A, Wahl GM, Belmonte JC. 2009. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460: 1140-1144.
-
(2009)
Nature
, vol.460
, pp. 1140-1144
-
-
Kawamura, T.1
Suzuki, J.2
Wang, Y.V.3
Menendez, S.4
Morera, L.B.5
Raya, A.6
Wahl, G.M.7
Belmonte, J.C.8
-
57
-
-
0024435565
-
Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia
-
Kelman Z, Prokocimer M, Peller S, Kahn Y, Rechavi G, Manor Y, Cohen A, Rotter V. 1989. Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia. Blood 74: 2318-2324.
-
(1989)
Blood
, vol.74
, pp. 2318-2324
-
-
Kelman, Z.1
Prokocimer, M.2
Peller, S.3
Kahn, Y.4
Rechavi, G.5
Manor, Y.6
Cohen, A.7
Rotter, V.8
-
58
-
-
0025815451
-
Identification of p53 as a sequence-specific DNA-binding protein
-
Kern SE, Kinzler KW, Bruskin A, Jarosz D, Friedman P, Prives C, Vogelstein B. 1991. Identification of p53 as a sequence-specific DNA-binding protein. Science 252: 1708-1711.
-
(1991)
Science
, vol.252
, pp. 1708-1711
-
-
Kern, S.E.1
Kinzler, K.W.2
Bruskin, A.3
Jarosz, D.4
Friedman, P.5
Prives, C.6
Vogelstein, B.7
-
59
-
-
27644568226
-
MDM2 antagonists induce p53-dependent apoptosis in AML: Implications for leukemia therapy
-
Kojima K, Konopleva M, Samudio IJ, Shikami M, Cabreira-Hansen M, McQueen T, Ruvolo V, Tsao T, Zeng Z, Vassilev LT, Andreeff M. 2005. MDM2 antagonists induce p53-dependent apoptosis in AML: Implications for leukemia therapy. Blood 106: 3150-3159.
-
(2005)
Blood
, vol.106
, pp. 3150-3159
-
-
Kojima, K.1
Konopleva, M.2
Samudio, I.J.3
Shikami, M.4
Cabreira-Hansen, M.5
McQueen, T.6
Ruvolo, V.7
Tsao, T.8
Zeng, Z.9
Vassilev, L.T.10
Andreeff, M.11
-
60
-
-
53449095193
-
Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia
-
Kojima K, Konopleva M, Tsao T, Nakakuma H, Andreeff M. 2008. Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia. Blood 112: 2886-2895.
-
(2008)
Blood
, vol.112
, pp. 2886-2895
-
-
Kojima, K.1
Konopleva, M.2
Tsao, T.3
Nakakuma, H.4
Andreeff, M.5
-
61
-
-
0033543728
-
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
-
Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Coon JS, Chernov MV, Gudkov AV. 1999. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285: 1733-1737.
-
(1999)
Science
, vol.285
, pp. 1733-1737
-
-
Komarov, P.G.1
Komarova, E.A.2
Kondratov, R.V.3
Christov-Tselkov, K.4
Coon, J.S.5
Chernov, M.V.6
Gudkov, A.V.7
-
62
-
-
41549104612
-
Effect of cellular quiescence on the success of targeted CML therapy
-
Komarova NL, Wodarz D. 2007. Effect of cellular quiescence on the success of targeted CML therapy. PLoS ONE 2: e990.
-
(2007)
PLoS ONE
, vol.2
-
-
Komarova, N.L.1
Wodarz, D.2
-
63
-
-
2442681614
-
Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice
-
Komarova EA, Kondratov RV, Wang K, Christov K, Golovkina TV, Goldblum JR, Gudkov AV. 2004. Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene 23: 3265-3271.
-
(2004)
Oncogene
, vol.23
, pp. 3265-3271
-
-
Komarova, E.A.1
Kondratov, R.V.2
Wang, K.3
Christov, K.4
Golovkina, T.V.5
Goldblum, J.R.6
Gudkov, A.V.7
-
64
-
-
84900969225
-
Ink4a/Arf expression is a biomarker of aging
-
Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, Sharpless NE. 2004. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 114: 1299-1307.
-
(2004)
J Clin Invest
, vol.114
, pp. 1299-1307
-
-
Krishnamurthy, J.1
Torrice, C.2
Ramsey, M.R.3
Kovalev, G.I.4
Al-Regaiey, K.5
Su, L.6
Sharpless, N.E.7
-
65
-
-
0344413639
-
In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein
-
Krosl J, Austin P, Beslu N, Kroon E, Humphries RK, Sauvageau G. 2003. In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nat Med 9: 1428-1432.
-
(2003)
Nat Med
, vol.9
, pp. 1428-1432
-
-
Krosl, J.1
Austin, P.2
Beslu, N.3
Kroon, E.4
Humphries, R.K.5
Sauvageau, G.6
-
66
-
-
33644819269
-
The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells
-
Lacorazza HD, Yamada T, Liu Y, Miyata Y, Sivina M, Nunes J, Nimer SD. 2006. The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells. Cancer Cell 9: 175-187.
-
(2006)
Cancer Cell
, vol.9
, pp. 175-187
-
-
Lacorazza, H.D.1
Yamada, T.2
Liu, Y.3
Miyata, Y.4
Sivina, M.5
Nunes, J.6
Nimer, S.D.7
-
67
-
-
0018348655
-
T antigen is bound to a host protein in SV40-transformed cells
-
Lane DP, Crawford LV. 1979. T antigen is bound to a host protein in SV40-transformed cells. Nature 278: 261-263.
-
(1979)
Nature
, vol.278
, pp. 261-263
-
-
Lane, D.P.1
Crawford, L.V.2
-
68
-
-
0029814061
-
Anti-apoptotic activity of low levels of wild-type p53
-
Lassus P, Ferlin M, Piette J, Hibner U. 1996. Anti-apoptotic activity of low levels of wild-type p53. EMBO J 15: 4566-4573.
-
(1996)
EMBO J
, vol.15
, pp. 4566-4573
-
-
Lassus, P.1
Ferlin, M.2
Piette, J.3
Hibner, U.4
-
69
-
-
77953578553
-
A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice
-
Leonova KI, Shneyder J, Antoch MP, Toshkov IA, Novototskaya LR, Komarov PG, Komarova EA, Gudkov AV. 2010. A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice. Cell Cycle 9: 1434-1443.
-
(2010)
Cell Cycle
, vol.9
, pp. 1434-1443
-
-
Leonova, K.I.1
Shneyder, J.2
Antoch, M.P.3
Toshkov, I.A.4
Novototskaya, L.R.5
Komarov, P.G.6
Komarova, E.A.7
Gudkov, A.V.8
-
70
-
-
2342553892
-
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
-
Leu JI, Dumont P, Hafey M, Murphy ME, George DL. 2004. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol 6: 443-450.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 443-450
-
-
Leu, J.I.1
Dumont, P.2
Hafey, M.3
Murphy, M.E.4
George, D.L.5
-
71
-
-
69349103956
-
The Ink4/Arf locus is a barrier for iPS cell reprogramming
-
Li H, Collado M, Villasante A, Strati K, Ortega S, Canamero M, Blasco MA, Serrano M. 2009. The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 460: 1136-1139.
-
(2009)
Nature
, vol.460
, pp. 1136-1139
-
-
Li, H.1
Collado, M.2
Villasante, A.3
Strati, K.4
Ortega, S.5
Canamero, M.6
Blasco, M.A.7
Serrano, M.8
-
72
-
-
5444223724
-
GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells
-
Ling KW, Ottersbach K, van Hamburg JP, Oziemlak A, Tsai FY, Orkin SH, Ploemacher R, Hendriks RW, Dzierzak E. 2004. GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J Exp Med 200: 871-882.
-
(2004)
J Exp Med
, vol.200
, pp. 871-882
-
-
Ling, K.W.1
Ottersbach, K.2
van Hamburg, J.P.3
Oziemlak, A.4
Tsai, F.Y.5
Orkin, S.H.6
Ploemacher, R.7
Hendriks, R.W.8
Dzierzak, E.9
-
73
-
-
0018760324
-
Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
-
Linzer DI, Levine AJ. 1979. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17: 43-52.
-
(1979)
Cell
, vol.17
, pp. 43-52
-
-
Linzer, D.I.1
Levine, A.J.2
-
74
-
-
0346455759
-
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
-
Liu G, Parant JM, Lang G, Chau P, Chavez-Reyes A, El-Naggar AK, Multani A, Chang S, Lozano G. 2004. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet 36: 63-68.
-
(2004)
Nat Genet
, vol.36
, pp. 63-68
-
-
Liu, G.1
Parant, J.M.2
Lang, G.3
Chau, P.4
Chavez-Reyes, A.5
El-Naggar, A.K.6
Multani, A.7
Chang, S.8
Lozano, G.9
-
75
-
-
58049216794
-
p53 regulates hematopoietic stem cell quiescence
-
Liu Y, Elf SE, Miyata Y, Sashida G, Huang G, Di Giandomenico S, Lee JM, Deblasio A, Menendez S, Antipin J, Reva B, Koff A, Nimer SD. 2009. p53 regulates hematopoietic stem cell quiescence. Cell Stem Cell 4: 37-48.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 37-48
-
-
Liu, Y.1
Elf, S.E.2
Miyata, Y.3
Sashida, G.4
Huang, G.5
Di Giandomenico, S.6
Lee, J.M.7
Deblasio, A.8
Menendez, S.9
Antipin, J.10
Reva, B.11
Koff, A.12
Nimer, S.D.13
-
76
-
-
0027283604
-
Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents
-
Lotem J, Sachs L. 1993. Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood 82: 1092-1096.
-
(1993)
Blood
, vol.82
, pp. 1092-1096
-
-
Lotem, J.1
Sachs, L.2
-
77
-
-
0030773594
-
The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse
-
MacDonald HR, Wevrick R. 1997. The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse. Hum Mol Genet 6: 1873-1878.
-
(1997)
Hum Mol Genet
, vol.6
, pp. 1873-1878
-
-
MacDonald, H.R.1
Wevrick, R.2
-
78
-
-
1042266548
-
Modulation of mammalian life span by the short isoform of p53
-
Maier B, Gluba W, Bernier B, Turner T, Mohammad K, Guise T, Sutherland A, Thorner M, Scrable H. 2004. Modulation of mammalian life span by the short isoform of p53. Genes Dev 18: 306-319.
-
(2004)
Genes Dev
, vol.18
, pp. 306-319
-
-
Maier, B.1
Gluba, W.2
Bernier, B.3
Turner, T.4
Mohammad, K.5
Guise, T.6
Sutherland, A.7
Thorner, M.8
Scrable, H.9
-
79
-
-
58549090499
-
Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid
-
Mandal M, Crusio KM, Meng F, Liu S, Kinsella M, Clark MR, Takeuchi O, Aifantis I. 2008. Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid. Proc Natl Acad Sci USA 105: 20840-20845.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 20840-20845
-
-
Mandal, M.1
Crusio, K.M.2
Meng, F.3
Liu, S.4
Kinsella, M.5
Clark, M.R.6
Takeuchi, O.7
Aifantis, I.8
-
80
-
-
69349094006
-
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
-
Marion RM, Strati K, Li H, Murga M, Blanco R, Ortega S, Fernandez-Capetillo O, Serrano M, Blasco MA. 2009. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 460: 1149-1153.
-
(2009)
Nature
, vol.460
, pp. 1149-1153
-
-
Marion, R.M.1
Strati, K.2
Li, H.3
Murga, M.4
Blanco, R.5
Ortega, S.6
Fernandez-Capetillo, O.7
Serrano, M.8
Blasco, M.A.9
-
82
-
-
0025871554
-
A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells
-
Maruyama K, Usami M, Aizawa T, Yoshikawa K. 1991. A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells. Biochem Biophys Res Commun 178: 291-296.
-
(1991)
Biochem Biophys Res Commun
, vol.178
, pp. 291-296
-
-
Maruyama, K.1
Usami, M.2
Aizawa, T.3
Yoshikawa, K.4
-
83
-
-
42149132696
-
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
-
Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI, Suda T. 2008. Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev 22: 986-991.
-
(2008)
Genes Dev
, vol.22
, pp. 986-991
-
-
Matsuoka, S.1
Oike, Y.2
Onoyama, I.3
Iwama, A.4
Arai, F.5
Takubo, K.6
Mashimo, Y.7
Oguro, H.8
Nitta, E.9
Ito, K.10
Miyamoto, K.11
Yoshiwara, H.12
Hosokawa, K.13
Nakamura, Y.14
Gomei, Y.15
Iwasaki, H.16
Hayashi, Y.17
Matsuzaki, Y.18
Nakayama, K.19
Ikeda, Y.20
Hata, A.21
Chiba, S.22
Nakayama, K.I.23
Suda, T.24
more..
-
84
-
-
70349438994
-
Tumour suppression by p53: A role for the DNA damage response?
-
Meek DW. 2009. Tumour suppression by p53: A role for the DNA damage response? Nat Rev Cancer 9: 714-723.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 714-723
-
-
Meek, D.W.1
-
85
-
-
32244436592
-
p53 suppresses the self-renewal of adult neural stem cells
-
Meletis K, Wirta V, Hede SM, Nister M, Lundeberg J, Frisen J. 2006. p53 suppresses the self-renewal of adult neural stem cells. Development 133: 363-369.
-
(2006)
Development
, vol.133
, pp. 363-369
-
-
Meletis, K.1
Wirta, V.2
Hede, S.M.3
Nister, M.4
Lundeberg, J.5
Frisen, J.6
-
86
-
-
0025040367
-
Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53
-
Mercer WE, Shields MT, Amin M, Sauve GJ, Appella E, Romano JW, Ullrich SJ. 1990. Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53. Proc Natl Acad Sci USA 87: 6166-6170.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 6166-6170
-
-
Mercer, W.E.1
Shields, M.T.2
Amin, M.3
Sauve, G.J.4
Appella, E.5
Romano, J.W.6
Ullrich, S.J.7
-
87
-
-
0037349289
-
p53 has a direct apoptogenic role at the mitochondria
-
Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM. 2003. p53 has a direct apoptogenic role at the mitochondria. Mol Cell 11: 577-590.
-
(2003)
Mol Cell
, vol.11
, pp. 577-590
-
-
Mihara, M.1
Erster, S.2
Zaika, A.3
Petrenko, O.4
Chittenden, T.5
Pancoska, P.6
Moll, U.M.7
-
88
-
-
34249882777
-
Foxo3a is essential for maintenance of the hematopoietic stem cell pool
-
Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, Hirao A. 2007. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 1: 101-112.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 101-112
-
-
Miyamoto, K.1
Araki, K.Y.2
Naka, K.3
Arai, F.4
Takubo, K.5
Yamazaki, S.6
Matsuoka, S.7
Miyamoto, T.8
Ito, K.9
Ohmura, M.10
Chen, C.11
Hosokawa, K.12
Nakauchi, H.13
Nakayama, K.14
Nakayama, K.I.15
Harada, M.16
Motoyama, N.17
Suda, T.18
Hirao, A.19
-
89
-
-
0028883179
-
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
-
Miyashita T, Reed JC. 1995. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299.
-
(1995)
Cell
, vol.80
, pp. 293-299
-
-
Miyashita, T.1
Reed, J.C.2
-
90
-
-
77149132161
-
Cyclin C regulates human hematopoietic stem/progenitor cell quiescence
-
Miyata Y, Liu Y, Jankovic V, Sashida G, Lee JM, Shieh JH, Naoe T, Moore M, Nimer SD. 2010. Cyclin C regulates human hematopoietic stem/progenitor cell quiescence. Stem Cells 28: 308-317.
-
(2010)
Stem Cells
, vol.28
, pp. 308-317
-
-
Miyata, Y.1
Liu, Y.2
Jankovic, V.3
Sashida, G.4
Lee, J.M.5
Shieh, J.H.6
Naoe, T.7
Moore, M.8
Nimer, S.D.9
-
91
-
-
0029860814
-
MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties
-
Miyazaki Y, Sun X, Uchida H, Zhang J, Nimer S. 1996. MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties. Oncogene 13: 1721-1729.
-
(1996)
Oncogene
, vol.13
, pp. 1721-1729
-
-
Miyazaki, Y.1
Sun, X.2
Uchida, H.3
Zhang, J.4
Nimer, S.5
-
92
-
-
77956251480
-
Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis
-
Mohrin M, Bourke E, Alexander D, Warr MR, Barry-Holson K, Le Beau MM, Morrison CG, Passegue E. 2010. Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell 7: 174-185.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 174-185
-
-
Mohrin, M.1
Bourke, E.2
Alexander, D.3
Warr, M.R.4
Barry-Holson, K.5
Le Beau, M.M.6
Morrison, C.G.7
Passegue, E.8
-
94
-
-
0028823020
-
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
-
Montes de Oca Luna R, Wagner DS, Lozano G. 1995. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378: 203-206.
-
(1995)
Nature
, vol.378
, pp. 203-206
-
-
Montes de Oca Luna, R.1
Wagner, D.S.2
Lozano, G.3
-
95
-
-
29144450333
-
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: Implications for the Mre11 complex as a DNA damage sensor
-
Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH. 2005. The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: Implications for the Mre11 complex as a DNA damage sensor. Genes Dev 19: 3043-3054.
-
(2005)
Genes Dev
, vol.19
, pp. 3043-3054
-
-
Morales, M.1
Theunissen, J.W.2
Kim, C.F.3
Kitagawa, R.4
Kastan, M.B.5
Petrini, J.H.6
-
96
-
-
39749121971
-
Chromosomal aberrations in 17p predict in vitro drug resistance and short overall survival in acute myeloid leukemia
-
Nahi H, Lehmann S, Bengtzen S, Jansson M, Mollgard L, Paul C, Merup M. 2008. Chromosomal aberrations in 17p predict in vitro drug resistance and short overall survival in acute myeloid leukemia. Leuk Lymphoma 49: 508-516.
-
(2008)
Leuk Lymphoma
, vol.49
, pp. 508-516
-
-
Nahi, H.1
Lehmann, S.2
Bengtzen, S.3
Jansson, M.4
Mollgard, L.5
Paul, C.6
Merup, M.7
-
97
-
-
0035265686
-
PUMA, a novel proapoptotic gene, is induced by p53
-
Nakano K, Vousden KH. 2001. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7: 683-694.
-
(2001)
Mol Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
98
-
-
0033934763
-
Prognostic value of p53 gene mutations and the product expression in de novo acute myeloid leukemia
-
Nakano Y, Naoe T, Kiyoi H, Kitamura K, Minami S, Miyawaki S, Asou N, Kuriyama K, Kusumoto S, Shimazaki C, Akiyama H, Saito K, Nishimura M, Motoji T, Shinagawa K, Saito H, Ohno R. 2000. Prognostic value of p53 gene mutations and the product expression in de novo acute myeloid leukemia. Eur J Haematol 65: 23-31.
-
(2000)
Eur J Haematol
, vol.65
, pp. 23-31
-
-
Nakano, Y.1
Naoe, T.2
Kiyoi, H.3
Kitamura, K.4
Minami, S.5
Miyawaki, S.6
Asou, N.7
Kuriyama, K.8
Kusumoto, S.9
Shimazaki, C.10
Akiyama, H.11
Saito, K.12
Nishimura, M.13
Motoji, T.14
Shinagawa, K.15
Saito, H.16
Ohno, R.17
-
99
-
-
42249103574
-
CXCR4 is required for the quiescence of primitive hematopoietic cells
-
Nie Y, Han YC, Zou YR. 2008. CXCR4 is required for the quiescence of primitive hematopoietic cells. J Exp Med 205: 777-783.
-
(2008)
J Exp Med
, vol.205
, pp. 777-783
-
-
Nie, Y.1
Han, Y.C.2
Zou, Y.R.3
-
100
-
-
0034640281
-
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
-
Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N. 2000. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288: 1053-1058.
-
(2000)
Science
, vol.288
, pp. 1053-1058
-
-
Oda, E.1
Ohki, R.2
Murasawa, H.3
Nemoto, J.4
Shibue, T.5
Yamashita, T.6
Tokino, T.7
Taniguchi, T.8
Tanaka, N.9
-
101
-
-
17344371122
-
RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: A 10-year follow-up
-
Padua RA, Guinn BA, Al-Sabah AI, Smith M, Taylor C, Pettersson T, Ridge S, Carter G, White D, Oscier D, Chevret S, West R. 1998. RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: A 10-year follow-up. Leukemia 12: 887-892.
-
(1998)
Leukemia
, vol.12
, pp. 887-892
-
-
Padua, R.A.1
Guinn, B.A.2
Al-Sabah, A.I.3
Smith, M.4
Taylor, C.5
Pettersson, T.6
Ridge, S.7
Carter, G.8
White, D.9
Oscier, D.10
Chevret, S.11
West, R.12
-
102
-
-
0038349957
-
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
-
Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ, Clarke MF. 2003. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423: 302-305.
-
(2003)
Nature
, vol.423
, pp. 302-305
-
-
Park, I.K.1
Qian, D.2
Kiel, M.3
Becker, M.W.4
Pihalja, M.5
Weissman, I.L.6
Morrison, S.J.7
Clarke, M.F.8
-
103
-
-
28544436371
-
Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
-
Passegue E, Wagers AJ, Giuriato S, Anderson WC, Weissman IL. 2005. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med 202: 1599-1611.
-
(2005)
J Exp Med
, vol.202
, pp. 1599-1611
-
-
Passegue, E.1
Wagers, A.J.2
Giuriato, S.3
Anderson, W.C.4
Weissman, I.L.5
-
104
-
-
0037220020
-
TP53 in hematological cancer: Low incidence of mutations with significant clinical relevance
-
Peller S, Rotter V. 2003. TP53 in hematological cancer: Low incidence of mutations with significant clinical relevance. Hum Mutat 21: 277-284.
-
(2003)
Hum Mutat
, vol.21
, pp. 277-284
-
-
Peller, S.1
Rotter, V.2
-
105
-
-
43249087214
-
Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis
-
Perry JM, Li L. 2008. Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis. Genes Dev 22: 1107-1109.
-
(2008)
Genes Dev
, vol.22
, pp. 1107-1109
-
-
Perry, J.M.1
Li, L.2
-
106
-
-
0032528245
-
Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53
-
Resnick-Silverman L, St Clair S, Maurer M, Zhao K, Manfredi JJ. 1998. Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53. Genes Dev 12: 2102-2107.
-
(1998)
Genes Dev
, vol.12
, pp. 2102-2107
-
-
Resnick-Silverman, L.1
St Clair, S.2
Maurer, M.3
Zhao, K.4
Manfredi, J.J.5
-
107
-
-
33845185824
-
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo
-
Ringshausen I, O'Shea CC, Finch AJ, Swigart LB, Evan GI. 2006. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell 10: 501-514.
-
(2006)
Cancer Cell
, vol.10
, pp. 501-514
-
-
Ringshausen, I.1
O'Shea, C.C.2
Finch, A.J.3
Swigart, L.B.4
Evan, G.I.5
-
108
-
-
34250007142
-
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
-
Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. 2007. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447: 725-729.
-
(2007)
Nature
, vol.447
, pp. 725-729
-
-
Rossi, D.J.1
Bryder, D.2
Seita, J.3
Nussenzweig, A.4
Hoeijmakers, J.5
Weissman, I.L.6
-
109
-
-
39149086121
-
Stems cells and the pathways to aging and cancer
-
Rossi DJ, Jamieson CH, Weissman IL. 2008. Stems cells and the pathways to aging and cancer. Cell 132: 681-696.
-
(2008)
Cell
, vol.132
, pp. 681-696
-
-
Rossi, D.J.1
Jamieson, C.H.2
Weissman, I.L.3
-
110
-
-
28644447272
-
The antioxidant function of the p53 tumor suppressor
-
Sablina AA, Budanov AV, Ilyinskaya GV, Agapova LS, Kravchenko JE, Chumakov PM. 2005. The antioxidant function of the p53 tumor suppressor. Nat Med 11: 1306-1313.
-
(2005)
Nat Med
, vol.11
, pp. 1306-1313
-
-
Sablina, A.A.1
Budanov, A.V.2
Ilyinskaya, G.V.3
Agapova, L.S.4
Kravchenko, J.E.5
Chumakov, P.M.6
-
111
-
-
77749283145
-
Pharmacological activation of the p53 pathway in haematological malignancies
-
Saha MN, Micallef J, Qiu L, Chang H. 2010. Pharmacological activation of the p53 pathway in haematological malignancies. J Clin Pathol 63: 204-209.
-
(2010)
J Clin Pathol
, vol.63
, pp. 204-209
-
-
Saha, M.N.1
Micallef, J.2
Qiu, L.3
Chang, H.4
-
112
-
-
67650072923
-
ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation
-
Sashida G, Liu Y, Elf S, Miyata Y, Ohyashiki K, Izumi M, Menendez S, Nimer SD. 2009. ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation. Mol Cell Biol 29: 3687-3699.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 3687-3699
-
-
Sashida, G.1
Liu, Y.2
Elf, S.3
Miyata, Y.4
Ohyashiki, K.5
Izumi, M.6
Menendez, S.7
Nimer, S.D.8
-
113
-
-
0025639158
-
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
-
Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63: 1129-1136.
-
(1990)
Cell
, vol.63
, pp. 1129-1136
-
-
Scheffner, M.1
Werness, B.A.2
Huibregtse, J.M.3
Levine, A.J.4
Howley, P.M.5
-
114
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. 1997. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a Cell 88: 593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
115
-
-
53049108040
-
Targeting the MDM2-p53 interaction for cancer therapy
-
Shangary S, Wang S. 2008. Targeting the MDM2-p53 interaction for cancer therapy. Clin Cancer Res 14: 5318-5324.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5318-5324
-
-
Shangary, S.1
Wang, S.2
-
116
-
-
77954709903
-
Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation
-
Shao L, Sun Y, Zhang Z, Feng W, Gao Y, Cai Z, Wang ZZ, Look AT, Wu WS. 2010. Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. Blood 115: 4704-4714.
-
(2010)
Blood
, vol.115
, pp. 4704-4714
-
-
Shao, L.1
Sun, Y.2
Zhang, Z.3
Feng, W.4
Gao, Y.5
Cai, Z.6
Wang, Z.Z.7
Look, A.T.8
Wu, W.S.9
-
117
-
-
34548153747
-
How stem cells age and why this makes us grow old
-
Sharpless NE, DePinho RA. 2007. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8: 703-713.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 703-713
-
-
Sharpless, N.E.1
DePinho, R.A.2
-
118
-
-
0026523778
-
Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line
-
Shaw P, Bovey R, Tardy S, Sahli R, Sordat B, Costa J. 1992. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Natl Acad Sci USA 89: 4495-4499.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 4495-4499
-
-
Shaw, P.1
Bovey, R.2
Tardy, S.3
Sahli, R.4
Sordat, B.5
Costa, J.6
-
119
-
-
36849080028
-
Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice
-
Shing DC, Trubia M, Marchesi F, Radaelli E, Belloni E, Tapinassi C, Scanziani E, Mecucci C, Crescenzi B, Lahortiga I, Odero MD, Zardo G, Gruszka A, Minucci S, Di Fiore PP, Pelicci PG. 2007. Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice. J Clin Invest 117: 3696-3707.
-
(2007)
J Clin Invest
, vol.117
, pp. 3696-3707
-
-
Shing, D.C.1
Trubia, M.2
Marchesi, F.3
Radaelli, E.4
Belloni, E.5
Tapinassi, C.6
Scanziani, E.7
Mecucci, C.8
Crescenzi, B.9
Lahortiga, I.10
Odero, M.D.11
Zardo, G.12
Gruszka, A.13
Minucci, S.14
Di Fiore, P.P.15
Pelicci, P.G.16
-
120
-
-
0029785634
-
Retroviral transduction of hematopoietic progenitor cells with mutant p53 promotes survival and proliferation, modifies differentiation potential and inhibits apoptosis
-
Shounan Y, Dolnikov A, MacKenzie KL, Miller M, Chan YY, Symonds G. 1996. Retroviral transduction of hematopoietic progenitor cells with mutant p53 promotes survival and proliferation, modifies differentiation potential and inhibits apoptosis. Leukemia 10: 1619-1628.
-
(1996)
Leukemia
, vol.10
, pp. 1619-1628
-
-
Shounan, Y.1
Dolnikov, A.2
MacKenzie, K.L.3
Miller, M.4
Chan, Y.Y.5
Symonds, G.6
-
121
-
-
0025804270
-
Mutation of the p53 gene in human acute myelogenous leukemia
-
Slingerland JM, Minden MD, Benchimol S. 1991. Mutation of the p53 gene in human acute myelogenous leukemia. Blood 77: 1500-1507.
-
(1991)
Blood
, vol.77
, pp. 1500-1507
-
-
Slingerland, J.M.1
Minden, M.D.2
Benchimol, S.3
-
122
-
-
0035383768
-
FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia
-
Stirewalt DL, Kopecky KJ, Meshinchi S, Appelbaum FR, Slovak ML, Willman CL, Radich JP. 2001. FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia. Blood 97: 3589-3595.
-
(2001)
Blood
, vol.97
, pp. 3589-3595
-
-
Stirewalt, D.L.1
Kopecky, K.J.2
Meshinchi, S.3
Appelbaum, F.R.4
Slovak, M.L.5
Willman, C.L.6
Radich, J.P.7
-
123
-
-
0036490983
-
BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation
-
Takimoto R, MacLachlan TK, Dicker DT, Niitsu Y, Mori T, el-Deiry WS. 2002. BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation. Cancer Biol Ther 1: 177-186.
-
(2002)
Cancer Biol Ther
, vol.1
, pp. 177-186
-
-
Takimoto, R.1
MacLachlan, T.K.2
Dicker, D.T.3
Niitsu, Y.4
Mori, T.5
el-Deiry, W.S.6
-
124
-
-
0033522919
-
Physical and functional interactions of neuronal growth suppressor necdin with p53
-
Taniura H, Matsumoto K, Yoshikawa K. 1999. Physical and functional interactions of neuronal growth suppressor necdin with p53. J Biol Chem 274: 16242-16248.
-
(1999)
J Biol Chem
, vol.274
, pp. 16242-16248
-
-
Taniura, H.1
Matsumoto, K.2
Yoshikawa, K.3
-
125
-
-
20444395224
-
Functional domains of necdin for protein-protein interaction, nuclear matrix targeting, and cell growth suppression
-
Taniura H, Kobayashi M, Yoshikawa K. 2005. Functional domains of necdin for protein-protein interaction, nuclear matrix targeting, and cell growth suppression. J Cell Biochem 94: 804-815.
-
(2005)
J Cell Biochem
, vol.94
, pp. 804-815
-
-
Taniura, H.1
Kobayashi, M.2
Yoshikawa, K.3
-
126
-
-
0037711685
-
Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice
-
TeKippe M, Harrison DE, Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31: 521-527.
-
(2003)
Exp Hematol
, vol.31
, pp. 521-527
-
-
TeKippe, M.1
Harrison, D.E.2
Chen, J.3
-
127
-
-
0036599406
-
p53 stabilization is decreased upon NFkappaB activation: A role for NFkappaB in acquisition of resistance to chemotherapy
-
Tergaonkar V, Pando M, Vafa O, Wahl G, Verma I. 2002. p53 stabilization is decreased upon NFkappaB activation: A role for NFkappaB in acquisition of resistance to chemotherapy. Cancer Cell 1: 493-503.
-
(2002)
Cancer Cell
, vol.1
, pp. 493-503
-
-
Tergaonkar, V.1
Pando, M.2
Vafa, O.3
Wahl, G.4
Verma, I.5
-
128
-
-
45149123052
-
Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
-
Thompson BJ, Jankovic V, Gao J, Buonamici S, Vest A, Lee JM, Zavadil J, Nimer SD, Aifantis I. 2008. Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med 205: 1395-1408.
-
(2008)
J Exp Med
, vol.205
, pp. 1395-1408
-
-
Thompson, B.J.1
Jankovic, V.2
Gao, J.3
Buonamici, S.4
Vest, A.5
Lee, J.M.6
Zavadil, J.7
Nimer, S.D.8
Aifantis, I.9
-
129
-
-
63849118537
-
High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle
-
Tipping AJ, Pina C, Castor A, Hong D, Rodrigues NP, Lazzari L, May GE, Jacobsen SE, Enver T. 2009. High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle. Blood 113: 2661-2672.
-
(2009)
Blood
, vol.113
, pp. 2661-2672
-
-
Tipping, A.J.1
Pina, C.2
Castor, A.3
Hong, D.4
Rodrigues, N.P.5
Lazzari, L.6
May, G.E.7
Jacobsen, S.E.8
Enver, T.9
-
130
-
-
33845270990
-
Regulating the p53 pathway: In vitro hypotheses, in vivo veritas
-
Toledo F, Wahl GM. 2006. Regulating the p53 pathway: In vitro hypotheses, in vivo veritas. Nat Rev Cancer 6: 909-923.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 909-923
-
-
Toledo, F.1
Wahl, G.M.2
-
131
-
-
32444449180
-
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy
-
Tovar C, Rosinski J, Filipovic Z, Higgins B, Kolinsky K, Hilton H, Zhao X, Vu BT, Qing W, Packman K, Myklebost O, Heimbrook DC, Vassilev LT. 2006. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy. Proc Natl Acad Sci USA 103: 1888-1893.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 1888-1893
-
-
Tovar, C.1
Rosinski, J.2
Filipovic, Z.3
Higgins, B.4
Kolinsky, K.5
Hilton, H.6
Zhao, X.7
Vu, B.T.8
Qing, W.9
Packman, K.10
Myklebost, O.11
Heimbrook, D.C.12
Vassilev, L.T.13
-
132
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Hee Park S, Thompson T, Karsenty G, Bradley A, Donehower LA. 2002. p53 mutant mice that display early ageing-associated phenotypes. Nature 415: 45-53.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
Igelmann, H.6
Lu, X.7
Soron, G.8
Cooper, B.9
Brayton, C.10
Hee Park, S.11
Thompson, T.12
Karsenty, G.13
Bradley, A.14
Donehower, L.A.15
-
133
-
-
69349098273
-
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
-
Utikal J, Polo JM, Stadtfeld M, Maherali N, Kulalert W, Walsh RM, Khalil A, Rheinwald JG, Hochedlinger K. 2009. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 460: 1145-1148.
-
(2009)
Nature
, vol.460
, pp. 1145-1148
-
-
Utikal, J.1
Polo, J.M.2
Stadtfeld, M.3
Maherali, N.4
Kulalert, W.5
Walsh, R.M.6
Khalil, A.7
Rheinwald, J.G.8
Hochedlinger, K.9
-
134
-
-
34147168247
-
A limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning
-
van Os R, Kamminga LM, Ausema A, Bystrykh LV, Draijer DP, van Pelt K, Dontje B, de Haan G. 2007. A limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning. Stem Cells 25: 836-843.
-
(2007)
Stem Cells
, vol.25
, pp. 836-843
-
-
van Os, R.1
Kamminga, L.M.2
Ausema, A.3
Bystrykh, L.V.4
Draijer, D.P.5
van Pelt, K.6
Dontje, B.7
de Haan, G.8
-
135
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA. 2004. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303: 844-848.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
Fotouhi, N.11
Liu, E.A.12
-
136
-
-
0242410719
-
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
-
Villunger A, Michalak EM, Coultas L, Mullauer F, Bock G, Ausserlechner MJ, Adams JM, Strasser A. 2003. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302: 1036-1038.
-
(2003)
Science
, vol.302
, pp. 1036-1038
-
-
Villunger, A.1
Michalak, E.M.2
Coultas, L.3
Mullauer, F.4
Bock, G.5
Ausserlechner, M.J.6
Adams, J.M.7
Strasser, A.8
-
139
-
-
0028172868
-
p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies
-
Wattel E, Preudhomme C, Hecquet B, Vanrumbeke M, Quesnel B, Dervite I, Morel P, Fenaux P. 1994. p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood 84: 3148-3157.
-
(1994)
Blood
, vol.84
, pp. 3148-3157
-
-
Wattel, E.1
Preudhomme, C.2
Hecquet, B.3
Vanrumbeke, M.4
Quesnel, B.5
Dervite, I.6
Morel, P.7
Fenaux, P.8
-
140
-
-
85047700405
-
Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways
-
Weber HO, Samuel T, Rauch P, Funk JO. 2002. Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways. Oncogene 21: 3207-3212.
-
(2002)
Oncogene
, vol.21
, pp. 3207-3212
-
-
Weber, H.O.1
Samuel, T.2
Rauch, P.3
Funk, J.O.4
-
141
-
-
0030879563
-
atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity
-
Westphal CH, Rowan S, Schmaltz C, Elson A, Fisher DE, Leder P. 1997. atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nat Genet 16: 397-401.
-
(1997)
Nat Genet
, vol.16
, pp. 397-401
-
-
Westphal, C.H.1
Rowan, S.2
Schmaltz, C.3
Elson, A.4
Fisher, D.E.5
Leder, P.6
-
142
-
-
33644827383
-
Bone-marrow haematopoietic-stem-cell niches
-
Wilson A, Trumpp A. 2006. Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol 6: 93-106.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 93-106
-
-
Wilson, A.1
Trumpp, A.2
-
143
-
-
27744547091
-
Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
-
Wu WS, Heinrichs S, Xu D, Garrison SP, Zambetti GP, Adams JM, Look AT. 2005. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123: 641-653.
-
(2005)
Cell
, vol.123
, pp. 641-653
-
-
Wu, W.S.1
Heinrichs, S.2
Xu, D.3
Garrison, S.P.4
Zambetti, G.P.5
Adams, J.M.6
Look, A.T.7
-
144
-
-
34250030216
-
Tumor promoting properties of the ETS protein MEF in ovarian cancer
-
Yao JJ, Liu Y, Lacorazza HD, Soslow RA, Scandura JM, Nimer SD, Hedvat CV. 2007. Tumor promoting properties of the ETS protein MEF in ovarian cancer. Oncogene 26: 4032-4037.
-
(2007)
Oncogene
, vol.26
, pp. 4032-4037
-
-
Yao, J.J.1
Liu, Y.2
Lacorazza, H.D.3
Soslow, R.A.4
Scandura, J.M.5
Nimer, S.D.6
Hedvat, C.V.7
-
145
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
Yilmaz OH, Valdez R, Theisen BK, Guo W, Ferguson DO, Wu H, Morrison SJ. 2006. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441: 475-482.
-
(2006)
Nature
, vol.441
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
Guo, W.4
Ferguson, D.O.5
Wu, H.6
Morrison, S.J.7
-
146
-
-
0025784539
-
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
-
Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M. 1991. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352: 345-347.
-
(1991)
Nature
, vol.352
, pp. 345-347
-
-
Yonish-Rouach, E.1
Resnitzky, D.2
Lotem, J.3
Sachs, L.4
Kimchi, A.5
Oren, M.6
-
147
-
-
36748999351
-
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche
-
Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyamoto K, Miyazaki H, Takahashi T, Suda T. 2007. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell 1: 685-697.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 685-697
-
-
Yoshihara, H.1
Arai, F.2
Hosokawa, K.3
Hagiwara, T.4
Takubo, K.5
Nakamura, Y.6
Gomei, Y.7
Iwasaki, H.8
Matsuoka, S.9
Miyamoto, K.10
Miyazaki, H.11
Takahashi, T.12
Suda, T.13
-
148
-
-
0035265823
-
PUMA induces the rapid apoptosis of colorectal cancer cells
-
Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. 2001. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 7: 673-682.
-
(2001)
Mol Cell
, vol.7
, pp. 673-682
-
-
Yu, J.1
Zhang, L.2
Hwang, P.M.3
Kinzler, K.W.4
Vogelstein, B.5
-
149
-
-
77951753647
-
Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation
-
Yu H, Shen H, Yuan Y, XuFeng R, Hu X, Garrison SP, Zhang L, Yu J, Zambetti GP, Cheng T. 2010. Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation. Blood 115: 3472-3480.
-
(2010)
Blood
, vol.115
, pp. 3472-3480
-
-
Yu, H.1
Shen, H.2
Yuan, Y.3
XuFeng, R.4
Hu, X.5
Garrison, S.P.6
Zhang, L.7
Yu, J.8
Zambetti, G.P.9
Cheng, T.10
-
150
-
-
8144220648
-
Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells
-
Zeng H, Yucel R, Kosan C, Klein-Hitpass L, Moroy T. 2004. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J 23: 4116-4125.
-
(2004)
EMBO J
, vol.23
, pp. 4116-4125
-
-
Zeng, H.1
Yucel, R.2
Kosan, C.3
Klein-Hitpass, L.4
Moroy, T.5
-
151
-
-
33646351002
-
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
-
Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, Wu H, Li L. 2006. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature 441: 518-522.
-
(2006)
Nature
, vol.441
, pp. 518-522
-
-
Zhang, J.1
Grindley, J.C.2
Yin, T.3
Jayasinghe, S.4
He, X.C.5
Ross, J.T.6
Haug, J.S.7
Rupp, D.8
Porter-Westpfahl, K.S.9
Wiedemann, L.M.10
Wu, H.11
Li, L.12
-
152
-
-
77950212489
-
Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim
-
Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC, Andreeff M. 2010. Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. Cancer Res 70: 2424-2434.
-
(2010)
Cancer Res
, vol.70
, pp. 2424-2434
-
-
Zhang, W.1
Konopleva, M.2
Burks, J.K.3
Dywer, K.C.4
Schober, W.D.5
Yang, J.Y.6
McQueen, T.J.7
Hung, M.C.8
Andreeff, M.9
-
153
-
-
0034707047
-
The DNA damage response: Putting checkpoints in perspective
-
Zhou BB, Elledge SJ. 2000. The DNA damage response: Putting checkpoints in perspective. Nature 408: 433-439.
-
(2000)
Nature
, vol.408
, pp. 433-439
-
-
Zhou, B.B.1
Elledge, S.J.2
-
154
-
-
0036284957
-
Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation
-
Zhu J, Guo L, Min B, Watson CJ, Hu-Li J, Young HA, Tsichlis PN, Paul WE. 2002. Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. Immunity 16: 733-744.
-
(2002)
Immunity
, vol.16
, pp. 733-744
-
-
Zhu, J.1
Guo, L.2
Min, B.3
Watson, C.J.4
Hu-Li, J.5
Young, H.A.6
Tsichlis, P.N.7
Paul, W.E.8
-
155
-
-
43749110075
-
Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal
-
Zon LI. 2008. Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. Nature 453: 306-313.
-
(2008)
Nature
, vol.453
, pp. 306-313
-
-
Zon, L.I.1
-
156
-
-
64349109459
-
Mouse models of human AML accurately predict chemotherapy response
-
Zuber J, Radtke I, Pardee TS, Zhao Z, Rappaport AR, Luo W, McCurrach ME, Yang MM, Dolan ME, Kogan SC, Downing JR, Lowe SW. 2009. Mouse models of human AML accurately predict chemotherapy response. Genes Dev 23: 877-889.
-
(2009)
Genes Dev
, vol.23
, pp. 877-889
-
-
Zuber, J.1
Radtke, I.2
Pardee, T.S.3
Zhao, Z.4
Rappaport, A.R.5
Luo, W.6
McCurrach, M.E.7
Yang, M.M.8
Dolan, M.E.9
Kogan, S.C.10
Downing, J.R.11
Lowe, S.W.12
|