Multiple functions of the IKK-related kinase IKKε in interferon-mediated antiviral immunity

Science

Volumn 315, Issue 5816, 2007, Pages 1274-1278

  TenOever, Benjamin R ^a   Ng, Sze Ling ^a   Chua, Mark A ^b   McWhirter, Sarah M ^a   García Sastre, Adolfo ^b   Maniatis, Tom ^a  

^a HARVARD UNIVERSITY   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; BETA INTERFERON; I KAPPA B KINASE EPSILON; I KAPPA B KINASE INHIBITOR; INTERFERON; INTERFERON STIMULATED GENE FACTOR 3; STAT1 PROTEIN; STAT2 PROTEIN;

ENZYME ACTIVITY; IMMUNITY; INHIBITOR; RODENT; VIRAL DISEASE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; INFECTION SENSITIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VIRUS INDUCTION;

ADENOSINE DEAMINASE; ANIMALS; CELLS, CULTURED; DIMERIZATION; GENE EXPRESSION REGULATION; I-KAPPA B KINASE; INFLUENZA A VIRUS, H1N1 SUBTYPE; INTERFERON-BETA; INTERFERON-STIMULATED GENE FACTOR 3; LUNG; MICE; MICE, KNOCKOUT; ORTHOMYXOVIRIDAE INFECTIONS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; VIRAL LOAD; VIRUS REPLICATION;

MUS;

EID: 33847687659     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1136567     Document Type: Article

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20. This work was supported by NIH grants to T.M. and A.G.-S. [RO1AI46954, PO1AI058113, and CIVIA, a National Institute for Allergy and Infectious Diseases (NIAID)-supported Center for Investigating Viral Immunity and Antagonism, U19AI62623]. B.R.t.O. is supported by a Canadian Institute of Health Research fellowship. S.L.N. is supported by an NSF and Soros fellowship. M.A.C. is supported by an NIAID predoctoral fellowship (F31 AIOS6678). We thank R. Cádagan for technical support, N. Silverman and K. Fitzgerald for manuscript reviews, B. Chang for recombinant STAT1ΔC, J. Zhang for microarray assistance, D. Panne for molecular modeling, and D. Hamilton for hematoxylin and eosin evaluation. Affymetrix data are available on National Center for Biotechnology Information's Geo database at accession number GSE6837.